Clinical Trials Updated in 2026

NCT05508867 | COMPLETED | PHASE2

203 participants

A Study of Coformulated Favezelimab/Pembrolizumab (MK-4280A) Versus Physician's Choice Chemotherapy in PD-(L)1-refractory, Relapsed or Refractory Classical Hodgkin Lymphoma (MK-4280A-008)

Study Type:: INTERVENTIONAL
Last Updated:: 2026-09-01
Start Date:: 2022-10-18
Completion:: 2025-09-03

Conditions

Hodgkin Lymphoma

Interventions

BIOLOGICAL
DRUG

Results Available

NCT05495854 | TERMINATED | NA

245 participants

New Strategy for the Detection and Treatment of Helicobacter Pylori Infections in Primary Care Guided by a Non-invasive PCR in Stool

Study Type:: INTERVENTIONAL
Last Updated:: 2026-09-01
Start Date:: 2023-02-03
Completion:: 2025-10-20

Conditions

Helicobacter Pylori Infection

Interventions

DIAGNOSTIC_TEST

No Results Yet

NCT05468437 | ACTIVE_NOT_RECRUITING | NA

96 participants

Telenutrition for Individuals With SCI

Study Type:: INTERVENTIONAL
Last Updated:: 2026-09-01
Start Date:: 2022-06-13
Completion:: 2027-03-01

Conditions

Spinal Cord Injuries
Obesity
Cardiometabolic Syndrome

Interventions

BEHAVIORAL

No Results Yet

NCT05467150 | COMPLETED | NA

29 participants

Maternal Probiotic Supplementation for Improved Outcomes in Infants of Diabetic Mothers

Study Type:: INTERVENTIONAL
Last Updated:: 2026-09-01
Start Date:: 2022-10-17
Completion:: 2026-08-01

Conditions

Infant of Diabetic Mother

Interventions

DIETARY_SUPPLEMENT

No Results Yet

NCT05438667 | TERMINATED | EARLY_PHASE1

1 participants

TCR-T Cell Therapy on Advanced Solid Tumors

Study Type:: INTERVENTIONAL
Last Updated:: 2026-09-01
Start Date:: 2023-06-01
Completion:: 2026-06-16

Conditions

Pancreatic Cancer

Interventions

BIOLOGICAL

No Results Yet

NCT05429736 | ACTIVE_NOT_RECRUITING | NA

28 participants

Activating Spinal Circuits to Improve Walking, Balance, Strength, and Reduce Spasticity

Study Type:: INTERVENTIONAL
Last Updated:: 2026-09-01
Start Date:: 2022-03-01
Completion:: 2026-09-30

Conditions

Incomplete Spinal Cord Injury
Spasticity, Muscle

Interventions

BEHAVIORAL
DEVICE

No Results Yet

NCT05388838 | COMPLETED | NA

60 participants

Screening for Oculocerebral Lymphoma With the Phenotype of NK Cells in Patients With Uveitis

Study Type:: INTERVENTIONAL
Last Updated:: 2026-09-01
Start Date:: 2022-06-01
Completion:: 2025-03-17

Conditions

Uveitis
Lymphoma
NK-Cell Lymphoma

Interventions

BIOLOGICAL

No Results Yet

NCT05378763 | SUSPENDED | PHASE3

268 participants

A Study of Poziotinib in Previously Treated Participants With Locally Advanced or Metastatic NSCLC Harboring HER2 Exon 20 Mutations

Study Type:: INTERVENTIONAL
Last Updated:: 2026-09-01
Start Date:: 2022-05-12
Completion:: 2027-12-25

Conditions

NSCLC

Interventions

DRUG

No Results Yet

NCT05375812 | RECRUITING

85 participants

NIH Investigative Deep Phenotyping Study of Gulf War Veteran Health (Project NIH IN-DEPTH)

Study Type:: OBSERVATIONAL
Last Updated:: 2026-09-01
Start Date:: 2023-04-16
Completion:: 2030-12-31

Conditions

Gulf War Illness

No Results Yet

NCT05355701 | ACTIVE_NOT_RECRUITING | PHASE1

103 participants

A Study to Learn About the Study Medicine Called PF-07799933 in People With Advanced Solid Tumors With BRAF Alterations.

Study Type:: INTERVENTIONAL
Last Updated:: 2026-09-01
Start Date:: 2022-07-05
Completion:: 2027-08-31

Conditions

Melanoma
Non-Small-Cell Lung Cancer
Thyroid Cancer
Glioma
Advanced Colorectal Cancer (Part 1)

Interventions

DRUG
BIOLOGICAL

No Results Yet

NCT05330221 | ACTIVE_NOT_RECRUITING | NA

364 participants

Project 2: ACHIEVE- HF

Study Type:: INTERVENTIONAL
Last Updated:: 2026-09-01
Start Date:: 2023-01-18
Completion:: 2027-06-30

Conditions

Heart Failure
Hypertension

Interventions

BEHAVIORAL
DRUG

No Results Yet

NCT05327946 | ACTIVE_NOT_RECRUITING | PHASE1

42 participants

A Study in People With Advanced Cancer to Test How Well Different Doses of BI 770371 Alone or in Combination With Ezabenlimab Are Tolerated

Study Type:: INTERVENTIONAL
Last Updated:: 2026-09-01
Start Date:: 2022-05-17
Completion:: 2024-07-16

Conditions

Solid Tumors

Interventions

DRUG

No Results Yet

NCT05327530 | ACTIVE_NOT_RECRUITING | PHASE2

256 participants

A Study of the Safety and Efficacy of Various Combinations of Avelumab as Therapy in Locally Advanced or Metastatic Urothelial Carcinoma (JAVELIN Bladder Medley)

Study Type:: INTERVENTIONAL
Last Updated:: 2026-09-01
Start Date:: 2022-08-17
Completion:: 2025-06-20

Conditions

Locally Advanced or Metastatic Urothelial Carcinoma

Interventions

DRUG

Results Available

NCT05322850 | RECRUITING | PHASE1/PHASE2

40 participants

Phase I/II Trial: Engineered Donor Graft (Orca Q) for Pediatric Hematopoietic Cell Transplant (HCT)

Study Type:: INTERVENTIONAL
Last Updated:: 2026-09-01
Start Date:: 2022-08-16
Completion:: 2026-09-30

Conditions

Acute Myeloid Leukemia
Acute Lymphoid Leukemia
Mixed Phenotype Acute Leukemia
Acute Undifferentiated Leukemia
Chronic Myeloid Leukemia in Myeloid Blast Crisis
Chronic Myeloid Leukemia in Lymphoid Blast Crisis (Diagnosis)
Chronic Myeloid Leukemia - Accelerated Phase

Interventions

BIOLOGICAL

No Results Yet

NCT05319522 | COMPLETED | NA

11 participants

The Relationship Between Irisin and Bone Health in Individuals With Spinal Cord Injury

Study Type:: INTERVENTIONAL
Last Updated:: 2026-09-01
Start Date:: 2023-05-05
Completion:: 2025-04-30

Conditions

Spinal Cord Injury

Interventions

BEHAVIORAL

Results Available

NCT05317728 | ACTIVE_NOT_RECRUITING | NA

175 participants

Clinical Study of a Fluid Accommodating Intraocular Lens (IOL) Design

Study Type:: INTERVENTIONAL
Last Updated:: 2026-09-01
Start Date:: 2023-03-31
Completion:: 2026-11-30

Conditions

Cataract

Interventions

DEVICE
PROCEDURE

No Results Yet

NCT05313321 | ACTIVE_NOT_RECRUITING

100 participants

Survival of the Insignia Stem in Total Hip Arthroplasty

Study Type:: OBSERVATIONAL
Last Updated:: 2026-09-01
Start Date:: 2022-03-17
Completion:: 2028-03-31

Conditions

Primary Total Hip Arthroplasty

Interventions

DEVICE

No Results Yet

NCT05304481 | RECRUITING | PHASE2

95 participants

Efficacy and Safety of Activated T Lymphocytes (ATL) in Hepatocellular Carcinoma

Study Type:: INTERVENTIONAL
Last Updated:: 2026-09-01
Start Date:: 2022-05-14
Completion:: 2027-12-31

Conditions

Hepatocellular Carcinoma

Interventions

BIOLOGICAL

No Results Yet

NCT05289856 | COMPLETED | PHASE2

30 participants

Cabozantinib in Combination With Avelumab in Patients Refractory to Standard Chemotherapy With Advanced Neuroendocrine Neoplasias G3 (NEN G3)

Study Type:: INTERVENTIONAL
Last Updated:: 2026-09-01
Start Date:: 2022-03-28
Completion:: 2025-01-03

Conditions

Cancer

Interventions

DRUG

No Results Yet

NCT05287321 | RECRUITING | PHASE3

58 participants

The Efficacy of Aspirin Combined With Hydroxychloroquine Treatment in High Risk Pregnancies for Preeclampsia

Study Type:: INTERVENTIONAL
Last Updated:: 2026-09-01
Start Date:: 2022-05-31
Completion:: 2026-12-31

Conditions

Preeclampsia

Interventions

DRUG

No Results Yet

NCT05285891 | ACTIVE_NOT_RECRUITING | PHASE4

123 participants

Ocrelizumab Discontinuation in Relapsing Multiple Sclerosis

Study Type:: INTERVENTIONAL
Last Updated:: 2026-09-01
Start Date:: 2023-02-07
Completion:: 2031-08-25

Conditions

Multiple Sclerosis

Interventions

DRUG

No Results Yet

NCT05279300 | SUSPENDED | PHASE1

480 participants

A Study of CS5001 in Patients With Advanced Solid Tumors and Lymphomas

Study Type:: INTERVENTIONAL
Last Updated:: 2026-09-01
Start Date:: 2022-03-28
Completion:: 2027-06-30

Conditions

Advanced Solid Tumor
Advanced Lymphoma

Interventions

DRUG
BIOLOGICAL

No Results Yet

NCT05277948 | COMPLETED | NA

240 participants

Effect of Thumbtack Needle (TN) on Ovarian Reserve Function of Women With Diminished Ovarian Reserve (DOR)

Study Type:: INTERVENTIONAL
Last Updated:: 2026-09-01
Start Date:: 2021-10-18
Completion:: 2025-11-28

Conditions

Diminished Ovarian Reserve

Interventions

OTHER

No Results Yet

NCT05276973 | ACTIVE_NOT_RECRUITING | PHASE1

25 participants

Testing the Addition of Ipatasertib to the Usual Chemotherapy Treatment (Paclitaxel and Carboplatin) for Stage III or IV Epithelial Ovarian Cancer

Study Type:: INTERVENTIONAL
Last Updated:: 2026-09-01
Start Date:: 2022-09-08
Completion:: 2025-01-30

Conditions

Fallopian Tube Endometrioid Adenocarcinoma
Fallopian Tube High Grade Serous Adenocarcinoma
Ovarian Endometrioid Adenocarcinoma
Ovarian High Grade Serous Adenocarcinoma
Primary Peritoneal Endometrioid Adenocarcinoma
Primary Peritoneal High Grade Serous Adenocarcinoma
Stage III Fallopian Tube Cancer AJCC v8
Stage III Ovarian Cancer AJCC v8
Stage III Primary Peritoneal Cancer AJCC v8
Stage IV Fallopian Tube Cancer AJCC v8
Stage IV Ovarian Cancer AJCC v8
Stage IV Primary Peritoneal Cancer AJCC v8
Unresectable Fallopian Tube Endometrioid Adenocarcinoma
Unresectable Fallopian Tube High Grade Serous Adenocarcinoma
Unresectable Ovarian Endometrioid Adenocarcinoma
Unresectable Ovarian High Grade Serous Adenocarcinoma
Unresectable Primary Peritoneal Endometrioid Adenocarcinoma
Unresectable Primary Peritoneal High Grade Serous Adenocarcinoma

Interventions

PROCEDURE
DRUG

Results Available

NCT05268250 | RECRUITING | NA

180 participants

Remedy to Diabetes Distress (R2D2): A Scalable Screen to Treat Program for School-age Families

Study Type:: INTERVENTIONAL
Last Updated:: 2026-09-01
Start Date:: 2024-02-26
Completion:: 2027-08-31

Conditions

Type 1 Diabetes

Interventions

BEHAVIORAL

No Results Yet

NCT05237973 | RECRUITING

150 participants

Investigational Use of Neuromuscular Ultrasound

Study Type:: OBSERVATIONAL
Last Updated:: 2026-09-01
Start Date:: 2022-04-18
Completion:: 2027-08-03

Conditions

Muscular Dystrophy
Peripheral Neuropathy
Motor Neuron Disorder
Normal Physiology

No Results Yet

NCT05206188 | ACTIVE_NOT_RECRUITING | NA

60 participants

Mastering the World of Work (MWW): RCT

Study Type:: INTERVENTIONAL
Last Updated:: 2026-09-01
Start Date:: 2022-06-24
Completion:: 2026-09-30

Conditions

Mental Disorders
Employment
Metacognition
Employment, Supported

Interventions

BEHAVIORAL

No Results Yet

NCT05189925 | RECRUITING | PHASE1

25 participants

NADPH Oxidase Correction in mRNA-transfected Granulocyte-enriched Cells in Chronic Granulomatous Disease (CGD)

Study Type:: INTERVENTIONAL
Last Updated:: 2026-09-01
Start Date:: 2022-07-22
Completion:: 2027-07-01

Conditions

Chronic Granulomatous Disease
Infection

Interventions

BIOLOGICAL

No Results Yet

NCT05159219 | COMPLETED | PHASE2

100 participants

Colchicine for the Prevention of Vascular Events After an Acute Intracerebral Hemorrhage

Study Type:: INTERVENTIONAL
Last Updated:: 2026-09-01
Start Date:: 2022-08-04
Completion:: 2024-12-03

Conditions

Intracranial Hemorrhages

Interventions

DRUG
OTHER

No Results Yet

NCT05155046 | RECRUITING | PHASE2

130 participants

18F-DCFPyL Imaging as a Method to Assess Treatment Response to Stereotactic Body Radiation Therapy

Study Type:: INTERVENTIONAL
Last Updated:: 2026-09-01
Start Date:: 2022-08-31
Completion:: 2028-12-31

Conditions

Localized Prostate Cancer

Interventions

DRUG

No Results Yet

NCT05152147 | ACTIVE_NOT_RECRUITING | PHASE3

920 participants

A Study of Zanidatamab in Combination With Chemotherapy Plus or Minus Tislelizumab in Patients With HER2-positive Advanced or Metastatic Gastric and Esophageal Cancers

Study Type:: INTERVENTIONAL
Last Updated:: 2026-09-01
Start Date:: 2021-12-02
Completion:: 2026-09-30

Conditions

Gastric Neoplasms
Gastroesophageal Adenocarcinoma
Esophageal Adenocarcinoma

Interventions

DRUG

No Results Yet

NCT05148845 | COMPLETED | PHASE3

500000 participants

Sisonke 2 - A COVID-19 Vaccine Boost Open Label Study.

Study Type:: INTERVENTIONAL
Last Updated:: 2026-09-01
Start Date:: 2021-11-10
Completion:: 2022-01-31

Conditions

SARS CoV 2 Infection

Interventions

BIOLOGICAL
DRUG

No Results Yet

NCT05142241 | ACTIVE_NOT_RECRUITING | PHASE2

14 participants

Testing the Combination of Anti-Cancer Drugs Talazoparib and Temozolomide in Patients With Advanced Stage Rare Cancers, RARE 2 Trial

Study Type:: INTERVENTIONAL
Last Updated:: 2026-09-01
Start Date:: 2022-07-11
Completion:: 2025-09-26

Conditions

Malignant Solid Neoplasm

Interventions

PROCEDURE
DRUG

Results Available

NCT05139056 | SUSPENDED | PHASE1

36 participants

Multiple Intracerebral Doses of Neural Stem Cell-Based Virotherapy (NSC-CRAd-S-pk7) for the Treatment of Recurrent High-Grade Gliomas

Study Type:: INTERVENTIONAL
Last Updated:: 2026-09-01
Start Date:: 2023-05-02
Completion:: 2027-08-04

Conditions

Currently Only Enrolling Glioblastoma Patients at First Recurrence

Interventions

BIOLOGICAL
PROCEDURE

No Results Yet

NCT05125302 | RECRUITING | PHASE3

1059 participants

Study to Assess Adverse Events and Disease Activity of Oral Ubrogepant Tablets for the Acute Treatment of Migraine in Children and Adolescents (Ages 6-17)

Study Type:: INTERVENTIONAL
Last Updated:: 2026-09-01
Start Date:: 2022-01-13
Completion:: 2027-05-31

Conditions

Migraine

Interventions

DRUG

No Results Yet

NCT05121974 | COMPLETED | PHASE2

132 participants

Tebipenem Trial in Children With Shigellosis

Study Type:: INTERVENTIONAL
Last Updated:: 2026-09-01
Start Date:: 2022-08-18
Completion:: 2025-03-15

Conditions

Shigellosis

Interventions

DRUG

No Results Yet

NCT05119868 | COMPLETED | NA

276 participants

Effects of the Mediterranean Diet During Pregnancy on the Onset of Allergies in the Offspring

Study Type:: INTERVENTIONAL
Last Updated:: 2026-09-01
Start Date:: 2021-11-02
Completion:: 2025-01-10

Conditions

Allergies
Obesity
Gestational Complications
Gestational Weight Gain
Perinatal Condition
Birth Weight
Chronic Diseases in Children
Breast Feeding

Interventions

OTHER

No Results Yet

NCT05112185 | COMPLETED | NA

1034 participants

Childcare Healthy Beverage Access, Food and Beverage Intake, and Obesity

Study Type:: INTERVENTIONAL
Last Updated:: 2026-09-01
Start Date:: 2022-10-19
Completion:: 2025-08-12

Conditions

Obesity

Interventions

BEHAVIORAL

Results Available

NCT05082987 | WITHHELD

[Trial of device that is not approved or cleared by the U.S. FDA]

Last Updated:: 2026-09-01

No Results Yet

NCT05067543 | RECRUITING

300 participants

Perform Humeral System Study

Study Type:: OBSERVATIONAL
Last Updated:: 2026-09-01
Start Date:: 2021-09-12
Completion:: 2037-06-30

Conditions

Osteoarthritis Shoulder
Avascular Necrosis
Post-traumatic Arthrosis of Other Joints, Shoulder Region
Rotator Cuff Tear Arthropathy

Interventions

DEVICE

No Results Yet