Clinical Trials Updated in 2026

NCT04411147 | ACTIVE_NOT_RECRUITING

583 participants

A Longitudinal Study of COVID-19 Sequelae and Immunity

Study Type:: OBSERVATIONAL
Last Updated:: 2026-09-01
Start Date:: 2020-06-17
Completion:: 2027-12-31

Conditions

COVID-19

No Results Yet

NCT04362293 | ACTIVE_NOT_RECRUITING | PHASE2

46 participants

Reduced Intensity Transplantation for Severe Sickle Cell Disease

Study Type:: INTERVENTIONAL
Last Updated:: 2026-09-01
Start Date:: 2020-04-30
Completion:: 2026-06-16

Conditions

Sickle Cell Disease

Interventions

DRUG

No Results Yet

NCT04360018 | COMPLETED | PHASE1

20 participants

Effect of Acute Alcohol Intoxication on Neural Processes During Decisions to Engage in HIV Risk Behaviors

Study Type:: INTERVENTIONAL
Last Updated:: 2026-09-01
Start Date:: 2021-03-18
Completion:: 2025-04-02

Conditions

Alcohol Consumption

Interventions

OTHER

No Results Yet

NCT04343157 | RECRUITING | PHASE2

90 participants

UCSD Image-Guided Cognitive-Sparing Radiosurgery for Brain Metastases

Study Type:: INTERVENTIONAL
Last Updated:: 2026-09-01
Start Date:: 2019-05-01
Completion:: 2028-12-31

Conditions

Brain Metastases, Adult
Neurocognitive Function
Cancer

Interventions

RADIATION

No Results Yet

NCT04315324 | ACTIVE_NOT_RECRUITING | PHASE1/PHASE2

67 participants

Study to Test OBI-3424 in Patients With T-Cell Acute Lymphoblastic Leukemia (T-ALL) or T-Cell Lymphoblastic Lymphoma (T-LBL)

Study Type:: INTERVENTIONAL
Last Updated:: 2026-09-01
Start Date:: 2021-02-08
Completion:: 2025-10-28

Conditions

Recurrent T Acute Lymphoblastic Leukemia
Refractory T Acute Lymphoblastic Leukemia
Refractory T Lymphoblastic Lymphoma
T Lymphoblastic Lymphoma

Interventions

DRUG
PROCEDURE

No Results Yet

NCT04307277 | RECRUITING | PHASE3

600 participants

Interest of Peri Operative CHemotherapy In Patients With CINSARC High-risk Localized Soft Tissue Sarcoma

Study Type:: INTERVENTIONAL
Last Updated:: 2026-09-01
Start Date:: 2020-10-09
Completion:: 2032-10-31

Conditions

Soft Tissue Sarcoma

Interventions

DRUG
OTHER

No Results Yet

NCT04305041 | COMPLETED | PHASE1/PHASE2

100 participants

Substudy 02A: Safety and Efficacy of Pembrolizumab in Combination With Investigational Agents in Participants With Programmed Cell-death 1 (PD-1) Refractory Melanoma (MK-3475-02A/KEYMAKER-U02)

Study Type:: INTERVENTIONAL
Last Updated:: 2026-09-01
Start Date:: 2020-06-26
Completion:: 2025-08-25

Conditions

Melanoma

Interventions

BIOLOGICAL
DRUG

Results Available

NCT04269239 | COMPLETED | NA

73 participants

Effectiveness of Healthy Habits for Hospitalized Older Adults to Optimize Rehabilitation

Study Type:: INTERVENTIONAL
Last Updated:: 2026-09-01
Start Date:: 2021-04-30
Completion:: 2024-09-30

Conditions

Insomnia
Pain
Osteoarthritis, Knee
Osteoarthritis, Hip

Interventions

BEHAVIORAL

Results Available

NCT04266704 | COMPLETED | NA

50 participants

Building a Multidisciplinary Research Program to Address Hypertension Disparities: Exploring the Neurocognitive Mechanisms of a Self-Management Intervention for African American Women

Study Type:: INTERVENTIONAL
Last Updated:: 2026-09-01
Start Date:: 2023-06-13
Completion:: 2025-04-25

Conditions

Hypertension

Interventions

BEHAVIORAL

Results Available

NCT04266093 | ENROLLING_BY_INVITATION

1000 participants

Gene Therapy Follow up Protocol for Subjects Previously Enrolled in NCI Center for Immuno-Oncology Studies

Study Type:: OBSERVATIONAL
Last Updated:: 2026-09-01
Start Date:: 2020-05-08
Completion:: 2035-10-01

Conditions

Cervical Intraepithelial Neoplasia
Cervical Neoplasms
Oropharyngeal Neoplasms
Squamous Intraepithelial Lesions of the Cervix
Hematologic Malignacies

Interventions

DRUG

No Results Yet

NCT04262843 | ACTIVE_NOT_RECRUITING | PHASE2

33 participants

Total Marrow and Lymphoid Irradiation as Conditioning Regimen Before Hematopoietic Cell Transplantation in Patients With Myelodysplastic Syndrome or Acute Leukemia

Study Type:: INTERVENTIONAL
Last Updated:: 2026-09-01
Start Date:: 2020-02-07
Completion:: 2027-05-11

Conditions

Acute Lymphoblastic Leukemia
Acute Myeloid Leukemia
High Risk Myelodysplastic Syndrome
Myelodysplastic Syndrome

Interventions

DRUG
BIOLOGICAL
PROCEDURE

No Results Yet

NCT04262206 | RECRUITING | PHASE4

20000 participants

Pragmatic Evaluation of Events And Benefits of Lipid-lowering in Older Adults

Study Type:: INTERVENTIONAL
Last Updated:: 2026-09-01
Start Date:: 2020-09-01
Completion:: 2026-12-31

Conditions

Cognitive Impairment, Mild
Dementia
Cardiovascular Diseases

Interventions

DRUG

No Results Yet

NCT04235777 | ACTIVE_NOT_RECRUITING | PHASE1

22 participants

Bintrafusp Alfa (M7824) and PDS01ADC Alone and in Combination With Stereotactic Body Radiation Therapy (SBRT) in Adults With Metastatic Non-Prostate Genitourinary Malignancies

Study Type:: INTERVENTIONAL
Last Updated:: 2026-09-01
Start Date:: 2020-07-13
Completion:: 2026-08-31

Conditions

Urothelial Cancer
Bladder Cancer
Genitourinary Cancer
Urogenital Neoplasms
Urogenital Cancer

Interventions

RADIATION
DRUG

No Results Yet

NCT04235764 | RECRUITING

25 participants

En-bloc Transurethral Resection of Bladder Tumor (En-bloc TURBT) Specimens Using a Redesigned Surgical Resectoscope Device

Study Type:: OBSERVATIONAL
Last Updated:: 2026-09-01
Start Date:: 2020-09-09
Completion:: 2026-09-30

Conditions

Bladder Cancer

Interventions

DEVICE
PROCEDURE

No Results Yet

NCT04233736 | WITHDRAWN | NA

0 participants

Erector Spinae Plane Blocks (ESP) for Postoperative Pain in Lumbo-sacral Spine Surgery

Study Type:: INTERVENTIONAL
Last Updated:: 2026-09-01
Start Date:: 2021-07-01
Completion:: 2021-11-01

Conditions

Erector Spinae Plane Block
Lumbar Spine Surgery

Interventions

PROCEDURE

No Results Yet

NCT04209686 | COMPLETED | PHASE2

19 participants

Paclitaxel, Pembrolizumab and Olaparib in Previously Treated Advanced Gastric Adenocarcinoma

Study Type:: INTERVENTIONAL
Last Updated:: 2026-09-01
Start Date:: 2020-07-31
Completion:: 2025-11-17

Conditions

Advanced Gastric Adenocarcinoma

Interventions

DRUG

Results Available

NCT04172532 | RECRUITING | PHASE1/PHASE2

92 participants

Testing the Addition of a New Anti-cancer Drug, M3814 (Peposertib), to the Usual Radiotherapy in Patients With Locally Advanced Pancreatic Cancer

Study Type:: INTERVENTIONAL
Last Updated:: 2026-09-01
Start Date:: 2021-01-11
Completion:: 2027-08-01

Conditions

Locally Advanced Pancreatic Adenocarcinoma
Stage III Pancreatic Cancer AJCC v8

Interventions

PROCEDURE
RADIATION
DRUG
OTHER

No Results Yet

NCT04141709 | ACTIVE_NOT_RECRUITING | NA

66 participants

Local Ablative Radiotherapy for OLIgoprogressive Castration Resistant Prostate Cancer

Study Type:: INTERVENTIONAL
Last Updated:: 2026-09-01
Start Date:: 2019-12-01
Completion:: 2027-04-28

Conditions

Oligometastatic Disease
Prostatic Cancer, Castration-Resistant

Interventions

RADIATION

No Results Yet

NCT04125563 | COMPLETED | PHASE2

55 participants

Influence on Cough and Airway Symptoms by Oral Capsaicin

Study Type:: INTERVENTIONAL
Last Updated:: 2026-09-01
Start Date:: 2019-06-01
Completion:: 2022-06-28

Conditions

Cough

Interventions

DRUG

No Results Yet

NCT04124341 | RECRUITING | NA

15 participants

PCS in Severe Treatment Resistant Depression

Study Type:: INTERVENTIONAL
Last Updated:: 2026-09-01
Start Date:: 2021-09-29
Completion:: 2031-12-31

Conditions

Treatment Resistant Depression

Interventions

DEVICE

No Results Yet

NCT04124029 | RECRUITING

800 participants

Contributions of mTBI to Neurodegeneration Due to Chronic Traumatic Encephalopathy (CTE) and Alzheimer's Disease (AD)

Study Type:: OBSERVATIONAL
Last Updated:: 2026-09-01
Start Date:: 2021-07-01
Completion:: 2026-12-31

Conditions

Mild Traumatic Brain Injury
Moderate Traumatic Brain Injury
Mild Cognitive Impairment

Interventions

DEVICE
PROCEDURE

No Results Yet

NCT04106349 | ACTIVE_NOT_RECRUITING

150 participants

Observational Real-life Study of Cabozantinib in Monotherapy or in Combination With Nivolumab in Advanced Renal Cell Carcinoma (RCC)

Study Type:: OBSERVATIONAL
Last Updated:: 2026-09-01
Start Date:: 2020-03-03
Completion:: 2027-03-31

Conditions

Advanced or Metastatic Renal Cell Carcinoma

No Results Yet

NCT04086485 | RECRUITING | PHASE1/PHASE2

56 participants

Lu-177-DOTATATE (Lutathera) in Combination With Olaparib in Inoperable Gastroenteropancreatico Neuroendocrine Tumors (GEP-NET)

Study Type:: INTERVENTIONAL
Last Updated:: 2026-09-01
Start Date:: 2022-10-03
Completion:: 2027-07-01

Conditions

Gastroenteropancreatico Tumors
Neuroendocrine Tumors
Neuroendocrine Neoplasms

Interventions

DRUG
DIAGNOSTIC_TEST

No Results Yet

NCT04077086 | ACTIVE_NOT_RECRUITING | NA

10000 participants

Correcting Myopia Among Secondary School Children to Increase Academic High School Attendance Rates in Rural Communities

Study Type:: INTERVENTIONAL
Last Updated:: 2026-09-01
Start Date:: 2024-11-28
Completion:: 2027-08-30

Conditions

Refractive Errors

Interventions

DEVICE

No Results Yet

NCT04034264 | RECRUITING

6500 participants

Febrile Disease Landscape in Cambodia Via Metagenomic Pathogen Sequencing

Study Type:: OBSERVATIONAL
Last Updated:: 2026-09-01
Start Date:: 2019-07-23
Completion:: 2027-07-01

Conditions

Vector-Borne Diseases
Emerging Pathogens

No Results Yet

NCT04014387 | COMPLETED | PHASE4

40 participants

Treatment of Disturbed Sleep in Progressive Supranuclear Palsy (PSP)

Study Type:: INTERVENTIONAL
Last Updated:: 2026-09-01
Start Date:: 2019-06-02
Completion:: 2025-06-30

Conditions

Progressive Supranuclear Palsy(PSP)
Insomnia

Interventions

DRUG

No Results Yet

NCT04008706 | COMPLETED | PHASE3

552 participants

Acalabrutinib Safety Study in Untreated and Relapsed or Refractory Chronic Lymphocytic Leukemia Patients

Study Type:: INTERVENTIONAL
Last Updated:: 2026-09-01
Start Date:: 2019-09-17
Completion:: 2025-11-04

Conditions

Chronic Lymphocytic Leukemia

Interventions

DRUG

Results Available

NCT03998254 | ACTIVE_NOT_RECRUITING | PHASE3

6000 participants

Efficacy, Immunogenicity and Safety of V503 in Chinese Women Aged 20-45 Years (V503-023)

Study Type:: INTERVENTIONAL
Last Updated:: 2026-09-01
Start Date:: 2019-06-26
Completion:: 2028-03-31

Conditions

Papillomavirus Infections

Interventions

DRUG

No Results Yet

NCT03976843 | ACTIVE_NOT_RECRUITING | PHASE2

175 participants

Prostate Specific Membrane Antigen (PMSA)-Based PET Imaging of High Risk Prostate Cancer

Study Type:: INTERVENTIONAL
Last Updated:: 2026-09-01
Start Date:: 2019-12-04
Completion:: 2027-11-19

Conditions

Prostate Cancer

Interventions

DRUG

No Results Yet

NCT03950076 | COMPLETED | PHASE4

948 participants

EdoxabaN foR IntraCranial Hemorrhage Survivors With Atrial Fibrillation (ENRICH-AF)

Study Type:: INTERVENTIONAL
Last Updated:: 2026-09-01
Start Date:: 2019-09-20
Completion:: 2026-07-22

Conditions

Intracranial Hemorrhages
Atrial Fibrillation

Interventions

DRUG
OTHER

No Results Yet

NCT03937830 | ACTIVE_NOT_RECRUITING | PHASE2

27 participants

Combined Treatment of Durvalumab, Bevacizumab, Tremelimumab and Transarterial Chemoembolization (TACE) in Subjects With Hepatocellular Carcinoma or Biliary Tract Carcinoma

Study Type:: INTERVENTIONAL
Last Updated:: 2026-09-01
Start Date:: 2021-03-10
Completion:: 2026-12-31

Conditions

Hepatocellular Cancer
Hepatocellular Carcinoma
Metastatic Hepatocellular Carcinoma

Interventions

DRUG
PROCEDURE

No Results Yet

NCT03937817 | RECRUITING

300 participants

Collection of Human Biospecimens for Basic and Clinical Research Into Globin Variants

Study Type:: OBSERVATIONAL
Last Updated:: 2026-09-01
Start Date:: 2019-09-25
Completion:: 2029-03-31

Conditions

Alpha and Beta Thalassemia
Sickle Cell Disease
Malaria
Human Physiology

No Results Yet

NCT03937804 | COMPLETED

83 participants

New Approaches for Empowering Studies of Asthma in Populations of African Descent

Study Type:: OBSERVATIONAL
Last Updated:: 2026-09-01
Start Date:: 2019-09-23
Completion:: 2021-07-15

Conditions

Asthma

No Results Yet

NCT03929601 | ACTIVE_NOT_RECRUITING | PHASE2

74 participants

Rituximab-pvvr and Abatacept vs Rituximab-pvvr Alone in New Onset Type 1 Diabetes

Study Type:: INTERVENTIONAL
Last Updated:: 2026-09-01
Start Date:: 2023-10-30
Completion:: 2027-03-31

Conditions

Type 1 Diabetes Mellitus

Interventions

DRUG

No Results Yet

NCT03922724 | ACTIVE_NOT_RECRUITING | PHASE2

91 participants

Allogeneic Hematopoietic Cell Transplantation for Peripheral T Cell Lymphoma

Study Type:: INTERVENTIONAL
Last Updated:: 2026-09-01
Start Date:: 2019-04-18
Completion:: 2027-06-01

Conditions

Peripheral T-cell Lymphomas
Lymphoproliferative Disorders
Immune System Diseases

Interventions

DRUG
PROCEDURE

No Results Yet

NCT03910452 | ACTIVE_NOT_RECRUITING | EARLY_PHASE1

4 participants

Haploidentical Transplant for People With Chronic Granulomatous Disease (CGD) Using Alemtuzumab, Busulfan and TBI With Post-Transplant Cyclophosphamide

Study Type:: INTERVENTIONAL
Last Updated:: 2026-09-01
Start Date:: 2019-10-28
Completion:: 2034-06-15

Conditions

Chronic Granulomatous Disease

Interventions

DRUG
RADIATION
BIOLOGICAL

No Results Yet

NCT03900793 | RECRUITING | PHASE1

41 participants

Losartan + Sunitinib in Treatment of Osteosarcoma

Study Type:: INTERVENTIONAL
Last Updated:: 2026-09-01
Start Date:: 2019-08-26
Completion:: 2027-08-01

Conditions

Osteosarcoma

Interventions

DRUG

No Results Yet

NCT03886246 | ACTIVE_NOT_RECRUITING | PHASE2

131 participants

Effisayil™ ON: A Study to Test Long-term Treatment With Spesolimab in People With Generalized Pustular Psoriasis Who Took Part in a Previous Study

Study Type:: INTERVENTIONAL
Last Updated:: 2026-09-01
Start Date:: 2019-05-29
Completion:: 2027-09-30

Conditions

Generalized Pustular Psoriasis

Interventions

DRUG

No Results Yet

NCT03867448 | RECRUITING

1000 participants

Study of Endocrine-Related Conditions and Physiology

Study Type:: OBSERVATIONAL
Last Updated:: 2026-09-01
Start Date:: 2019-03-27
Completion:: 2036-01-01

Conditions

Endocrine Disease

Interventions

DEVICE

No Results Yet

NCT03831958 | RECRUITING

600 participants

Long-Term Follow-Up of Survivors of Pediatric Cushing Disease

Study Type:: OBSERVATIONAL
Last Updated:: 2026-09-01
Start Date:: 2019-03-04
Completion:: 2040-01-03

Conditions

Cushing Disease

No Results Yet