Clinical Trials

NCT04609046 | RECRUITING | PHASE1

47 participants

Testing the Addition of Lenalidomide and Nivolumab to the Usual Treatment for Primary CNS Lymphoma

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-01

Start Date:

2021-05-24

Completion:

2027-04-01

Conditions

• Primary Diffuse Large B-Cell Lymphoma of the Central Nervous System

Interventions

• PROCEDURE
• DRUG
• BIOLOGICAL

No Results Yet

NCT04595760 | ACTIVE_NOT_RECRUITING

231 participants

Factors Influencing Fertility or Pregnancy Health

Study Type:

OBSERVATIONAL

Last Updated:

2026-09-01

Start Date:

2020-10-19

Completion:

2030-12-31

Conditions

• Menstrual Cycles
• Conception
• Early Pregnancy Loss
• Pregnancy Outcomes

No Results Yet

NCT04570956 | TERMINATED | PHASE2

65 participants

Oral Tamoxifen vs. TamGel vs. Control in Women With Atypical Hyperplasia, Lobular Carcinoma In Situ, or Increased Breast Cancer Risk

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-01

Start Date:

2021-07-26

Completion:

2024-10-15

Conditions

• Breast Atypical Hyperplasia
• Breast Lobular Carcinoma in Situ
• Breast Atypical Lobular Hyperplasia
• Breast Carcinoma

Interventions

• DRUG
• OTHER

Results Available

NCT04570423 | RECRUITING | PHASE2

40 participants

A Study to Evaluate the Safety and Pharmacokinetics of Eflapegrastim in Pediatric Participants With Solid Tumors or Lymphomas and Treated With Myelosuppressive Chemotherapy

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-01

Start Date:

2021-05-20

Completion:

2027-10-31

Conditions

• Solid Tumors
• Lymphoma

Interventions

• DRUG

No Results Yet

NCT04557956 | ACTIVE_NOT_RECRUITING | PHASE1/PHASE2

16 participants

Testing the Addition of the Anti-cancer Drug, Tazemetostat, to (Dabrafenib and Trametinib) for Metastatic Melanoma That Has Progressed on the Usual Treatment

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-01

Start Date:

2021-08-19

Completion:

2025-10-15

Conditions

• Clinical Stage IV Cutaneous Melanoma AJCC v8
• Metastatic Melanoma

Interventions

• PROCEDURE
• DRUG

Results Available

NCT04553211 | COMPLETED | NA

663 participants

Expedited Partner Therapy and the HIV Prevention Cascade

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-01

Start Date:

2022-04-25

Completion:

2024-04-30

Conditions

• HIV-1-infection
• Gonorrhea Male
• Chlamydia
• Partner Communication

Interventions

• BEHAVIORAL

Results Available

NCT04546399 | RECRUITING | PHASE2

461 participants

A Study to Compare Blinatumomab Alone to Blinatumomab With Nivolumab in Patients Diagnosed With First Relapse B-Cell Acute Lymphoblastic Leukemia (B-ALL)

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-01

Start Date:

2020-12-17

Completion:

2028-06-30

Conditions

• Down Syndrome
• Recurrent B Acute Lymphoblastic Leukemia

Interventions

• RADIATION
• DRUG
• PROCEDURE
• BIOLOGICAL

No Results Yet

NCT04526665 | ACTIVE_NOT_RECRUITING | PHASE3

161 participants

Study of Elafibranor in Patients With Primary Biliary Cholangitis (PBC)

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-01

Start Date:

2020-09-24

Completion:

2023-06-01

Conditions

• Primary Biliary Cirrhosis

Interventions

• DRUG

Results Available

NCT04521803 | COMPLETED | PHASE2

52 participants

High vs. Standard Dose Rifampicin for Effusive Tuberculous Pericarditis

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-01

Start Date:

2022-01-10

Completion:

2026-03-26

Conditions

• Tuberculous Pericarditis
• HIV Status

Interventions

• DRUG

No Results Yet

NCT04501861 | COMPLETED | PHASE3

164 participants

Hemodynamic Effect of Norepinephrine Versus Vasopressin on the Pulmonary Circulation in Cardiac Surgery Patients:

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-01

Start Date:

2020-11-05

Completion:

2023-08-22

Conditions

• Cardiac Disease

Interventions

• DRUG

Results Available

NCT04484272 | COMPLETED | NA

239 participants

A Stress and Pain Self-management m-Health App for Adult Outpatients With Sickle Cell Disease

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-01

Start Date:

2021-04-29

Completion:

2026-03-02

Conditions

• Sickle Cell Disease

Interventions

• BEHAVIORAL

No Results Yet

NCT04464980 | ACTIVE_NOT_RECRUITING | PHASE2

1516 participants

Optimizing Retention, Duration and Discontinuation Strategies for Opioid Use Disorder Pharmacotherapy (RDD)

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-01

Start Date:

2021-06-08

Completion:

2026-12-31

Conditions

• Opioid Use Disorder (OUD)

Interventions

• DRUG
• BEHAVIORAL

No Results Yet

NCT04446910 | COMPLETED | NA

50 participants

Using Technology to Reduce Youth Substance Use

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-01

Start Date:

2020-05-01

Completion:

2025-04-01

Conditions

• Drug Use

Interventions

• BEHAVIORAL

Results Available

NCT04442451 | RECRUITING | NA

80 participants

Mechanisms of Fatigability With Diabetes

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-01

Start Date:

2022-09-01

Completion:

2027-07-01

Conditions

• Pre-diabetes
• Type 2 Diabetes

Interventions

• OTHER

No Results Yet

NCT04431024 | RECRUITING

300 participants

Prospective Evaluation of High Resolution Dual Energy Computed Tomographic Imaging, Noninvasive (Liquid) Biopsies, and Minimally Invasive Surgical Surveillance for Early Detection of Mesotheliomas in Patients With BAP1 Tumor Predisposition Syndrome

Study Type:

OBSERVATIONAL

Last Updated:

2026-09-01

Start Date:

2021-03-30

Completion:

2038-06-30

Conditions

• Familial Cancer
• BRCA1-Associated Protein-1 (BAP1) Mutations
• Tumor Predisposition Syndrome (TPDS)
• Mesothelioma

No Results Yet

NCT04411147 | ACTIVE_NOT_RECRUITING

583 participants

A Longitudinal Study of COVID-19 Sequelae and Immunity

Study Type:

OBSERVATIONAL

Last Updated:

2026-09-01

Start Date:

2020-06-17

Completion:

2027-12-31

Conditions

• COVID-19

No Results Yet

NCT04402788 | RECRUITING | PHASE2/PHASE3

138 participants

Testing the Addition of Radiation Therapy to the Usual Immune Therapy Treatment (Atezolizumab) for Extensive Stage Small Cell Lung Cancer, The RAPTOR Trial

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-01

Start Date:

2021-01-07

Completion:

2027-04-30

Conditions

• Extensive Stage Lung Small Cell Carcinoma

Interventions

• DRUG
• PROCEDURE
• RADIATION

No Results Yet

NCT04362293 | ACTIVE_NOT_RECRUITING | PHASE2

46 participants

Reduced Intensity Transplantation for Severe Sickle Cell Disease

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-01

Start Date:

2020-04-30

Completion:

2026-06-16

Conditions

• Sickle Cell Disease

Interventions

• DRUG

No Results Yet

NCT04360018 | COMPLETED | PHASE1

20 participants

Effect of Acute Alcohol Intoxication on Neural Processes During Decisions to Engage in HIV Risk Behaviors

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-01

Start Date:

2021-03-18

Completion:

2025-04-02

Conditions

• Alcohol Consumption

Interventions

• OTHER

No Results Yet

NCT04343157 | RECRUITING | PHASE2

90 participants

UCSD Image-Guided Cognitive-Sparing Radiosurgery for Brain Metastases

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-01

Start Date:

2019-05-01

Completion:

2028-12-31

Conditions

• Brain Metastases, Adult
• Neurocognitive Function
• Cancer

Interventions

• RADIATION

No Results Yet

NCT04315324 | ACTIVE_NOT_RECRUITING | PHASE1/PHASE2

67 participants

Study to Test OBI-3424 in Patients With T-Cell Acute Lymphoblastic Leukemia (T-ALL) or T-Cell Lymphoblastic Lymphoma (T-LBL)

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-01

Start Date:

2021-02-08

Completion:

2025-10-28

Conditions

• Recurrent T Acute Lymphoblastic Leukemia
• Refractory T Acute Lymphoblastic Leukemia
• Refractory T Lymphoblastic Lymphoma
• T Lymphoblastic Lymphoma

Interventions

• DRUG
• PROCEDURE

No Results Yet

NCT04307277 | RECRUITING | PHASE3

600 participants

Interest of Peri Operative CHemotherapy In Patients With CINSARC High-risk Localized Soft Tissue Sarcoma

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-01

Start Date:

2020-10-09

Completion:

2032-10-31

Conditions

• Soft Tissue Sarcoma

Interventions

• DRUG
• OTHER

No Results Yet

NCT04305041 | COMPLETED | PHASE1/PHASE2

100 participants

Substudy 02A: Safety and Efficacy of Pembrolizumab in Combination With Investigational Agents in Participants With Programmed Cell-death 1 (PD-1) Refractory Melanoma (MK-3475-02A/KEYMAKER-U02)

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-01

Start Date:

2020-06-26

Completion:

2025-08-25

Conditions

• Melanoma

Interventions

• BIOLOGICAL
• DRUG

Results Available

NCT04269902 | RECRUITING | PHASE3

247 participants

Testing Early Treatment for Patients With High-Risk Chronic Lymphocytic Leukemia (CLL) or Small Lymphocytic Leukemia (SLL), EVOLVE CLL/SLL Study

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-01

Start Date:

2021-03-02

Completion:

2028-10-01

Conditions

• Chronic Lymphocytic Leukemia
• Small Lymphocytic Lymphoma

Interventions

• PROCEDURE
• BIOLOGICAL
• OTHER
• DRUG

No Results Yet

NCT04269239 | COMPLETED | NA

73 participants

Effectiveness of Healthy Habits for Hospitalized Older Adults to Optimize Rehabilitation

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-01

Start Date:

2021-04-30

Completion:

2024-09-30

Conditions

• Insomnia
• Pain
• Osteoarthritis, Knee
• Osteoarthritis, Hip

Interventions

• BEHAVIORAL

Results Available

NCT04267848 | RECRUITING | PHASE3

1210 participants

Testing the Addition of a Type of Drug Called Immunotherapy to the Usual Chemotherapy Treatment for Non-small Cell Lung Cancer, an ALCHEMIST Treatment Trial (Chemo-IO [ACCIO])

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-01

Start Date:

2020-06-16

Completion:

2027-01-31

Conditions

• Lung Non-Small Cell Carcinoma
• Lung Non-Small Cell Squamous Carcinoma
• Lung Non-Squamous Non-Small Cell Carcinoma
• Stage II Lung Cancer AJCC v8
• Stage IIIA Lung Cancer AJCC v8
• Stage IIIB Lung Cancer AJCC v8

Interventions

• PROCEDURE
• DRUG
• OTHER
• BIOLOGICAL

No Results Yet

NCT04266704 | COMPLETED | NA

50 participants

Building a Multidisciplinary Research Program to Address Hypertension Disparities: Exploring the Neurocognitive Mechanisms of a Self-Management Intervention for African American Women

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-01

Start Date:

2023-06-13

Completion:

2025-04-25

Conditions

• Hypertension

Interventions

• BEHAVIORAL

Results Available

NCT04266093 | ENROLLING_BY_INVITATION

1000 participants

Gene Therapy Follow up Protocol for Subjects Previously Enrolled in NCI Center for Immuno-Oncology Studies

Study Type:

OBSERVATIONAL

Last Updated:

2026-09-01

Start Date:

2020-05-08

Completion:

2035-10-01

Conditions

• Cervical Intraepithelial Neoplasia
• Cervical Neoplasms
• Oropharyngeal Neoplasms
• Squamous Intraepithelial Lesions of the Cervix
• Hematologic Malignacies

Interventions

• DRUG

No Results Yet

NCT04262843 | ACTIVE_NOT_RECRUITING | PHASE2

33 participants

Total Marrow and Lymphoid Irradiation as Conditioning Regimen Before Hematopoietic Cell Transplantation in Patients With Myelodysplastic Syndrome or Acute Leukemia

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-01

Start Date:

2020-02-07

Completion:

2027-05-11

Conditions

• Acute Lymphoblastic Leukemia
• Acute Myeloid Leukemia
• High Risk Myelodysplastic Syndrome
• Myelodysplastic Syndrome

Interventions

• DRUG
• BIOLOGICAL
• PROCEDURE

No Results Yet

NCT04262206 | RECRUITING | PHASE4

20000 participants

Pragmatic Evaluation of Events And Benefits of Lipid-lowering in Older Adults

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-01

Start Date:

2020-09-01

Completion:

2026-12-31

Conditions

• Cognitive Impairment, Mild
• Dementia
• Cardiovascular Diseases

Interventions

• DRUG

No Results Yet

NCT04250116 | COMPLETED | PHASE4

960 participants

Appropriate Duration of Anti-Platelet and Thrombotic Strategy After 12 Months in Patients With Atrial Fibrillation Treated With Drug Eluting Stents

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-01

Start Date:

2020-04-28

Completion:

2026-05-08

Conditions

• Atrial Fibrillation

Interventions

• DRUG

No Results Yet

NCT04235777 | ACTIVE_NOT_RECRUITING | PHASE1

22 participants

Bintrafusp Alfa (M7824) and PDS01ADC Alone and in Combination With Stereotactic Body Radiation Therapy (SBRT) in Adults With Metastatic Non-Prostate Genitourinary Malignancies

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-01

Start Date:

2020-07-13

Completion:

2026-08-31

Conditions

• Urothelial Cancer
• Bladder Cancer
• Genitourinary Cancer
• Urogenital Neoplasms
• Urogenital Cancer

Interventions

• RADIATION
• DRUG

No Results Yet

NCT04235764 | RECRUITING

25 participants

En-bloc Transurethral Resection of Bladder Tumor (En-bloc TURBT) Specimens Using a Redesigned Surgical Resectoscope Device

Study Type:

OBSERVATIONAL

Last Updated:

2026-09-01

Start Date:

2020-09-09

Completion:

2026-09-30

Conditions

• Bladder Cancer

Interventions

• DEVICE
• PROCEDURE

No Results Yet

NCT04233736 | WITHDRAWN | NA

0 participants

Erector Spinae Plane Blocks (ESP) for Postoperative Pain in Lumbo-sacral Spine Surgery

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-01

Start Date:

2021-07-01

Completion:

2021-11-01

Conditions

• Erector Spinae Plane Block
• Lumbar Spine Surgery

Interventions

• PROCEDURE

No Results Yet

NCT04209686 | COMPLETED | PHASE2

19 participants

Paclitaxel, Pembrolizumab and Olaparib in Previously Treated Advanced Gastric Adenocarcinoma

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-01

Start Date:

2020-07-31

Completion:

2025-11-17

Conditions

• Advanced Gastric Adenocarcinoma

Interventions

• DRUG

Results Available

NCT04181060 | RECRUITING | PHASE3

300 participants

Osimertinib With or Without Bevacizumab as Initial Treatment for Patients With EGFR-Mutant Lung Cancer

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-01

Start Date:

2020-12-28

Completion:

2026-12-31

Conditions

• Advanced Lung Non-Squamous Non-Small Cell Carcinoma
• Metastatic Lung Non-Squamous Non-Small Cell Carcinoma
• Recurrent Lung Non-Squamous Non-Small Cell Carcinoma
• Stage IIIB Lung Cancer AJCC v8
• Stage IV Lung Cancer AJCC v8

Interventions

• BIOLOGICAL
• PROCEDURE
• DRUG

No Results Yet

NCT04172532 | RECRUITING | PHASE1/PHASE2

92 participants

Testing the Addition of a New Anti-cancer Drug, M3814 (Peposertib), to the Usual Radiotherapy in Patients With Locally Advanced Pancreatic Cancer

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-01

Start Date:

2021-01-11

Completion:

2027-08-01

Conditions

• Locally Advanced Pancreatic Adenocarcinoma
• Stage III Pancreatic Cancer AJCC v8

Interventions

• PROCEDURE
• RADIATION
• DRUG
• OTHER

No Results Yet

NCT04141709 | ACTIVE_NOT_RECRUITING | NA

66 participants

Local Ablative Radiotherapy for OLIgoprogressive Castration Resistant Prostate Cancer

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-01

Start Date:

2019-12-01

Completion:

2027-04-28

Conditions

• Oligometastatic Disease
• Prostatic Cancer, Castration-Resistant

Interventions

• RADIATION

No Results Yet

NCT04125563 | COMPLETED | PHASE2

55 participants

Influence on Cough and Airway Symptoms by Oral Capsaicin

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-01

Start Date:

2019-06-01

Completion:

2022-06-28

Conditions

• Cough

Interventions

• DRUG

No Results Yet

NCT04124341 | RECRUITING | NA

15 participants

PCS in Severe Treatment Resistant Depression

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-01

Start Date:

2021-09-29

Completion:

2031-12-31

Conditions

• Treatment Resistant Depression

Interventions

• DEVICE

No Results Yet