Clinical Trials

NCT03510442 | RECRUITING

2000 participants

Natural History, Genetics, and Pathophysiology of Systemic Juvenile Idiopathic Arthritis, Adult-Onset Still's Disease, and Related Conditions

Study Type:

OBSERVATIONAL

Last Updated:

2026-09-01

Start Date:

2018-05-21

Completion:

2050-01-01

Conditions

• Still's Disease, Adult-Onset
• Systemic Inflammation
• Arthritis
• Autoinflammatory Syndrome

No Results Yet

NCT03500315 | COMPLETED | NA

207 participants

HOPE in Action Prospective Multicenter, Clinical Trial of Deceased HIVD+ Kidney Transplants for HIV+ Recipients

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-01

Start Date:

2018-04-19

Completion:

2022-09-30

Conditions

• Hiv

Interventions

• OTHER

Results Available

NCT03486873 | RECRUITING | PHASE3

3500 participants

Long-term Safety and Efficacy Extension Study for Participants With Advanced Tumors Who Are Currently on Treatment or in Follow-up in a Pembrolizumab (MK-3475) Study (MK-3475-587/KEYNOTE-587)

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-01

Start Date:

2018-08-21

Completion:

2043-08-04

Conditions

• Solid Tumors
• Hematologic Malignancies

Interventions

• DRUG
• BIOLOGICAL

No Results Yet

NCT03481829 | RECRUITING

1500 participants

Early Tracking of Childhood Health Determinants (ETCHED) Study

Study Type:

OBSERVATIONAL

Last Updated:

2026-09-01

Start Date:

2022-04-14

Completion:

2041-12-31

Conditions

• Diabetes Mellitus
• Obesity
• Fatty Liver

No Results Yet

NCT03449836 | COMPLETED | PHASE3

60 participants

Effects of the Direct Interaction Between Streptococcus Salivarius 24SMBc and Streptococcus Oralis 89a and the Respiratory Epithelium in Children

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-01

Start Date:

2018-03-01

Completion:

2018-09-30

Conditions

• Allergy

Interventions

• COMBINATION_PRODUCT
• OTHER

No Results Yet

NCT03445988 | COMPLETED | NA

1462 participants

Cognitive Behavioral Therapy and Chronic Pain Self-Management Within the Context of Opioid Reduction: The EMPOWER Study

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-01

Start Date:

2018-07-24

Completion:

2023-11-06

Conditions

• Chronic Pain

Interventions

• BEHAVIORAL
• OTHER

Results Available

NCT03407079 | RECRUITING | PHASE2

150 participants

Effects of Sucralose on Drug Absorption and Metabolism (The SweetMeds Study)

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-01

Start Date:

2018-04-05

Completion:

2027-12-26

Conditions

• Healthy Volunteers
• Overweight

Interventions

• OTHER

No Results Yet

NCT03401385 | ACTIVE_NOT_RECRUITING | PHASE1

890 participants

First-in-human Study of DS-1062a for Advanced Solid Tumors (TROPION-PanTumor01)

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-01

Start Date:

2018-01-31

Completion:

2028-01-01

Conditions

• Hormone Receptor Positive Breast Cancer
• Triple Negative Breast Cancer
• Non-small Cell Lung Cancer

Interventions

• DRUG
• OTHER

No Results Yet

NCT03394053 | RECRUITING

2500 participants

The Mechanistic Biology of Primary Immunodeficiency Disorders

Study Type:

OBSERVATIONAL

Last Updated:

2026-09-01

Start Date:

2018-05-30

Completion:

2029-12-31

Conditions

• Primary Immunodeficiency Disorders

No Results Yet

NCT03378856 | RECRUITING

1500 participants

Evaluation of Technological Innovation in Radiotherapy

Study Type:

OBSERVATIONAL

Last Updated:

2026-09-01

Start Date:

2017-11-01

Completion:

2040-10-31

Conditions

• Cancer
• Radiotherapy Side Effect

No Results Yet

NCT03374215 | RECRUITING

1150 participants

Clinical and Molecular Characteristics of Primary Aldosteronism in Blacks

Study Type:

OBSERVATIONAL

Last Updated:

2026-09-01

Start Date:

2017-12-14

Completion:

2026-12-31

Conditions

• Adrenal Gland Neoplasm
• Hypertension
• Bone Diseases, Metabolic
• Cardiovascular Disease
• Hyperinsulinemia

No Results Yet

NCT03366168 | RECRUITING

250 participants

Taste Bud-Derived Stem Cells in Humans

Study Type:

OBSERVATIONAL

Last Updated:

2026-09-01

Start Date:

2017-12-18

Completion:

2026-12-31

Conditions

• Diabetes

No Results Yet

NCT03366116 | RECRUITING | PHASE1

75 participants

5-aza-4'-Thio-2'-Deoxycytidine (Aza-TdC) in People With Advanced Solid Tumors

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-01

Start Date:

2018-11-05

Completion:

2026-09-30

Conditions

• Neoplasms
• Solid Tumors

Interventions

• DRUG

No Results Yet

NCT03354416 | RECRUITING

10000 participants

Profiling of Radiological Factors in Treatment and Outcomes in Prostate Cancer

Study Type:

OBSERVATIONAL

Last Updated:

2026-09-01

Start Date:

2018-02-26

Completion:

2030-12-31

Conditions

• Prostatic Cancer
• Prostatic Neoplams
• Prostatic Hyperplasia
• Prostate Cancer
• Cancer Of Prostate

No Results Yet

NCT03351764 | COMPLETED | NA

83 participants

Development of Non-Invasive Brain Stimulation Techniques

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-01

Start Date:

2018-01-11

Completion:

2025-12-15

Conditions

• Normal Physiology

Interventions

• DEVICE

No Results Yet

NCT03307317 | RECRUITING

200 participants

Mirror Neuron Network Dysfunction as an Early Biomarker of Neurodevelopmental Disorder

Study Type:

OBSERVATIONAL

Last Updated:

2026-09-01

Start Date:

2018-08-30

Completion:

2030-02-01

Conditions

• Developmental Delay

No Results Yet

NCT03307304 | RECRUITING

300 participants

Investigations of Juvenile Neuronal Ceroid Lipofuscinosis

Study Type:

OBSERVATIONAL

Last Updated:

2026-09-01

Start Date:

2017-11-27

Completion:

2050-12-31

Conditions

• Juvenile Neuronal Ceroid Lipofuscinosis (CLN3)
• Batten Disease

No Results Yet

NCT03304665 | RECRUITING

2000 participants

Recruitment and Characterization of Healthy Research Volunteers for NIMH Intramural Studies

Study Type:

OBSERVATIONAL

Last Updated:

2026-09-01

Start Date:

2017-11-01

Completion:

2027-04-26

Conditions

• Healthy Volunteer

No Results Yet

NCT03300830 | RECRUITING

280 participants

Molecular Characterization of Viral-associated Tumors, Tumors Occurring in the Setting of HIV or Other Immune Disorders and Castleman Disease

Study Type:

OBSERVATIONAL

Last Updated:

2026-09-01

Start Date:

2017-12-20

Completion:

2037-06-07

Conditions

• Human Immunodeficiency Virus
• Castleman's Disease
• Kaposi's Sarcoma
• Viral-Associated Cancer

No Results Yet

NCT03269578 | RECRUITING

3000 participants

Sample Collection and Tracking for the Developmental Therapeutics Clinic

Study Type:

OBSERVATIONAL

Last Updated:

2026-09-01

Start Date:

2017-08-28

Completion:

2027-05-23

Conditions

• Neoplasms
• Lymphoma

No Results Yet

NCT03258580 | RECRUITING | NA

700 participants

Sociocultural & Biobehavioral Influences on Pain Expression and Assessment

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-01

Start Date:

2018-05-09

Completion:

2027-05-17

Conditions

• Normal Physiology
• Healthy Volunteers
• Pain

Interventions

• DEVICE
• BEHAVIORAL

No Results Yet

NCT03253705 | RECRUITING

1000 participants

Samples From Human Subjects to Facilitate Basic, Translational and Clinical Research

Study Type:

OBSERVATIONAL

Last Updated:

2026-09-01

Start Date:

2017-09-14

Completion:

2027-08-01

Conditions

• Endothelial Dysfunction
• Inflammation in Cardiopulmonary and Vascular Disease States
• Healthy Volunteers

No Results Yet

NCT03251989 | COMPLETED

326 participants

Rare CNS Tumors Outcomes &Risk

Study Type:

OBSERVATIONAL

Last Updated:

2026-09-01

Start Date:

2017-08-21

Completion:

2025-05-06

Conditions

• High Grade Meningioma
• Ependymoma
• Medulloblastoma
• PNET
• Primary CNS Sarcoma

No Results Yet

NCT03244397 | COMPLETED | NA

120 participants

Physical Therapy on Pelvic Organ Prolapse

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-01

Start Date:

2017-08-08

Completion:

2020-12-10

Conditions

• Pelvic Organ Prolapse

Interventions

• OTHER
• BEHAVIORAL

No Results Yet

NCT03225131 | COMPLETED

57 participants

Dark Adaptation in Participants With Age-Related Macular Degeneration

Study Type:

OBSERVATIONAL

Last Updated:

2026-09-01

Start Date:

2017-06-16

Completion:

2025-08-15

Conditions

• Age-Related Macular Degeneration

No Results Yet

NCT03217032 | NOT_YET_RECRUITING | PHASE1

10 participants

Lentiviral FVIII Gene Therapy

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-01

Start Date:

2027-06-01

Completion:

2028-05-31

Conditions

• Hemophilia A

Interventions

• BIOLOGICAL

No Results Yet

NCT03206099 | RECRUITING

20000 participants

NIAID Centralized Sequencing Protocol

Study Type:

OBSERVATIONAL

Last Updated:

2026-09-01

Start Date:

2017-07-31

Completion:

2029-12-31

Conditions

• Atopy
• Primary Immunodeficiency
• Autoimmunity
• Autoinflammation

No Results Yet

NCT03190954 | COMPLETED | EARLY_PHASE1

153 participants

Brain Dopaminergic Signaling in Opioid Use Disorders

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-01

Start Date:

2017-08-17

Completion:

2025-10-27

Conditions

• Normal Physiology
• Opioid Use Disorders

Interventions

• DRUG

No Results Yet

NCT03170167 | COMPLETED

88 participants

Communitas: A Program for Teens Living With Chronic Illness and Their Families

Study Type:

OBSERVATIONAL

Last Updated:

2026-09-01

Start Date:

2016-10-31

Completion:

2019-09-04

Conditions

• Chronic Illness

No Results Yet

NCT03157635 | COMPLETED | PHASE1/PHASE2

59 participants

Study to Assess Safety, Efficacy, Pharmacokinetics, and Pharmacodynamics of Crovalimab in Healthy Volunteers and Participants With Paroxysmal Nocturnal Hemoglobinuria

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-01

Start Date:

2016-11-14

Completion:

2026-08-13

Conditions

• Paroxysmal Hemoglobinuria, Nocturnal

Interventions

• DRUG

No Results Yet

NCT03072927 | RECRUITING

8000 participants

MILD® Percutaneous Image-Guided Lumbar Decompression: A Medicare Claims Study

Study Type:

OBSERVATIONAL

Last Updated:

2026-09-01

Start Date:

2017-03-10

Completion:

2026-12-31

Conditions

• Lumbar Spinal Stenosis

Interventions

• DEVICE

No Results Yet

NCT03065335 | RECRUITING | PHASE1

150 participants

Neuropharmacologic Imaging and Biomarker Assessments of Response to Acute and Repeated-Dosed Ketamine Infusions in Major Depressive Disorder

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-01

Start Date:

2017-05-25

Completion:

2027-01-01

Conditions

• Healthy Volunteer
• Major Depressive Disorder
• Depression

Interventions

• DRUG
• OTHER
• DEVICE

No Results Yet

NCT03057106 | ACTIVE_NOT_RECRUITING | PHASE2

301 participants

Durvalumab and Tremelimumab ± Platinum-Based Chemotherapy in Patients With Metastatic Squamous or Non-Squamous NSCLC

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-01

Start Date:

2017-03-28

Completion:

2020-02-24

Conditions

• Lung Cancer Metastatic

Interventions

• DRUG

Results Available

NCT03030404 | COMPLETED

733 participants

Hereditary Gastric Cancer Syndromes: An Integrated Genomic and Clinicopathologic Study of the Predisposition to Gastric Cancer

Study Type:

OBSERVATIONAL

Last Updated:

2026-09-01

Start Date:

2017-01-27

Completion:

2025-03-31

Conditions

• Stomach Neoplasms
• Stomach Cancer
• Gastric Adenocarcinoma and Proximal Polyposis of the Stomach (GAPPS)
• Hereditary Diffuse Gastric Cancer (HDGC)
• Familial Diffuse Gastric Cancer

No Results Yet

NCT03021460 | COMPLETED | PHASE1

20 participants

Pembrolizumab and Ibrutinib in Treating Patients With Stage III-IV Melanoma That Cannot Be Removed by Surgery

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-01

Start Date:

2017-01-31

Completion:

2025-12-31

Conditions

• Metastatic Melanoma
• Stage III Cutaneous Melanoma AJCC v7
• Stage IIIA Cutaneous Melanoma AJCC v7
• Stage IIIB Cutaneous Melanoma AJCC v7
• Stage IIIC Cutaneous Melanoma AJCC v7
• Stage IV Cutaneous Melanoma AJCC v6 and v7
• Unresectable Melanoma

Interventions

• DRUG
• OTHER
• BIOLOGICAL

No Results Yet

NCT02997553 | COMPLETED | PHASE3

744 participants

Fluorescence for Sentinel Lymph Node Identification in Cancer Surgery

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-01

Start Date:

2017-11-29

Completion:

2022-09-19

Conditions

• Breast Carcinoma
• Head and Neck Cancer
• Melanoma (Skin)
• Squamous Cell Carcinoma, Skin
• Cervix Cancer
• Endometrium Cancer
• Ovary Cancer
• Vulva Cancer
• Anus Cancer
• Rectum Cancer

Interventions

• DRUG
• DEVICE

No Results Yet

NCT02892786 | COMPLETED | NA

40 participants

Detection in Peripheral Blood of Circulating Tumor Cells in Patient With Head and Neck Squamous Cell Carcinoma

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-01

Start Date:

2010-12-08

Completion:

2017-12-31

Conditions

• Head and Neck Cancer

Interventions

• OTHER

No Results Yet

NCT02890342 | RECRUITING

1045 participants

Natural History, Physiology, Microbiome and Biochemistry Studies of Propionic Acidemia

Study Type:

OBSERVATIONAL

Last Updated:

2026-09-01

Start Date:

2016-11-29

Completion:

2036-08-31

Conditions

• Metabolic Disease
• Propionic Acidemia
• Organic Acidemia

No Results Yet

NCT02880007 | COMPLETED | PHASE2

48 participants

Dose Optimization in 3D Pulsed Dose Rate Brachytherapy for Patients With Locally Advanced Cervical Cancer

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-01

Start Date:

2011-06-06

Completion:

2014-02-10

Conditions

• Cervical Adenocarcinoma
• Stage IB Cervical Cancer
• Stage II Cervical Cancer
• Stage III Cervical Cancer

Interventions

• RADIATION
• DRUG

No Results Yet

NCT02860000 | COMPLETED | PHASE2

96 participants

Alisertib With or Without Fulvestrant in Treating Patients With Locally Advanced or Metastatic, Endocrine-Resistant Breast Cancer

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-01

Start Date:

2017-07-06

Completion:

2022-01-10

Conditions

• Estrogen Receptor Status
• HER2/Neu Negative
• Invasive Breast Carcinoma
• Postmenopausal
• Stage III Breast Cancer
• Stage IIIA Breast Cancer
• Stage IIIB Breast Cancer
• Stage IIIC Breast Cancer
• Stage IV Breast Cancer

Interventions

• DRUG
• OTHER

Results Available