Clinical Trials

NCT03253705 | RECRUITING

1000 participants

Samples From Human Subjects to Facilitate Basic, Translational and Clinical Research

Study Type:

OBSERVATIONAL

Last Updated:

2026-09-01

Start Date:

2017-09-14

Completion:

2027-08-01

Conditions

• Endothelial Dysfunction
• Inflammation in Cardiopulmonary and Vascular Disease States
• Healthy Volunteers

No Results Yet

NCT03251989 | COMPLETED

326 participants

Rare CNS Tumors Outcomes &Risk

Study Type:

OBSERVATIONAL

Last Updated:

2026-09-01

Start Date:

2017-08-21

Completion:

2025-05-06

Conditions

• High Grade Meningioma
• Ependymoma
• Medulloblastoma
• PNET
• Primary CNS Sarcoma

No Results Yet

NCT03244397 | COMPLETED | NA

120 participants

Physical Therapy on Pelvic Organ Prolapse

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-01

Start Date:

2017-08-08

Completion:

2020-12-10

Conditions

• Pelvic Organ Prolapse

Interventions

• OTHER
• BEHAVIORAL

No Results Yet

NCT03225131 | COMPLETED

57 participants

Dark Adaptation in Participants With Age-Related Macular Degeneration

Study Type:

OBSERVATIONAL

Last Updated:

2026-09-01

Start Date:

2017-06-16

Completion:

2025-08-15

Conditions

• Age-Related Macular Degeneration

No Results Yet

NCT03217032 | NOT_YET_RECRUITING | PHASE1

10 participants

Lentiviral FVIII Gene Therapy

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-01

Start Date:

2027-06-01

Completion:

2028-05-31

Conditions

• Hemophilia A

Interventions

• BIOLOGICAL

No Results Yet

NCT03206099 | RECRUITING

20000 participants

NIAID Centralized Sequencing Protocol

Study Type:

OBSERVATIONAL

Last Updated:

2026-09-01

Start Date:

2017-07-31

Completion:

2029-12-31

Conditions

• Atopy
• Primary Immunodeficiency
• Autoimmunity
• Autoinflammation

No Results Yet

NCT03190954 | COMPLETED | EARLY_PHASE1

153 participants

Brain Dopaminergic Signaling in Opioid Use Disorders

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-01

Start Date:

2017-08-17

Completion:

2025-10-27

Conditions

• Normal Physiology
• Opioid Use Disorders

Interventions

• DRUG

No Results Yet

NCT03170167 | COMPLETED

88 participants

Communitas: A Program for Teens Living With Chronic Illness and Their Families

Study Type:

OBSERVATIONAL

Last Updated:

2026-09-01

Start Date:

2016-10-31

Completion:

2019-09-04

Conditions

• Chronic Illness

No Results Yet

NCT03157635 | COMPLETED | PHASE1/PHASE2

59 participants

Study to Assess Safety, Efficacy, Pharmacokinetics, and Pharmacodynamics of Crovalimab in Healthy Volunteers and Participants With Paroxysmal Nocturnal Hemoglobinuria

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-01

Start Date:

2016-11-14

Completion:

2026-08-13

Conditions

• Paroxysmal Hemoglobinuria, Nocturnal

Interventions

• DRUG

No Results Yet

NCT03065335 | RECRUITING | PHASE1

150 participants

Neuropharmacologic Imaging and Biomarker Assessments of Response to Acute and Repeated-Dosed Ketamine Infusions in Major Depressive Disorder

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-01

Start Date:

2017-05-25

Completion:

2027-01-01

Conditions

• Healthy Volunteer
• Major Depressive Disorder
• Depression

Interventions

• DRUG
• OTHER
• DEVICE

No Results Yet

NCT03057106 | ACTIVE_NOT_RECRUITING | PHASE2

301 participants

Durvalumab and Tremelimumab ± Platinum-Based Chemotherapy in Patients With Metastatic Squamous or Non-Squamous NSCLC

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-01

Start Date:

2017-03-28

Completion:

2020-02-24

Conditions

• Lung Cancer Metastatic

Interventions

• DRUG

Results Available

NCT03030404 | COMPLETED

733 participants

Hereditary Gastric Cancer Syndromes: An Integrated Genomic and Clinicopathologic Study of the Predisposition to Gastric Cancer

Study Type:

OBSERVATIONAL

Last Updated:

2026-09-01

Start Date:

2017-01-27

Completion:

2025-03-31

Conditions

• Stomach Neoplasms
• Stomach Cancer
• Gastric Adenocarcinoma and Proximal Polyposis of the Stomach (GAPPS)
• Hereditary Diffuse Gastric Cancer (HDGC)
• Familial Diffuse Gastric Cancer

No Results Yet

NCT03021460 | COMPLETED | PHASE1

20 participants

Pembrolizumab and Ibrutinib in Treating Patients With Stage III-IV Melanoma That Cannot Be Removed by Surgery

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-01

Start Date:

2017-01-31

Completion:

2025-12-31

Conditions

• Metastatic Melanoma
• Stage III Cutaneous Melanoma AJCC v7
• Stage IIIA Cutaneous Melanoma AJCC v7
• Stage IIIB Cutaneous Melanoma AJCC v7
• Stage IIIC Cutaneous Melanoma AJCC v7
• Stage IV Cutaneous Melanoma AJCC v6 and v7
• Unresectable Melanoma

Interventions

• DRUG
• OTHER
• BIOLOGICAL

No Results Yet

NCT02997553 | COMPLETED | PHASE3

744 participants

Fluorescence for Sentinel Lymph Node Identification in Cancer Surgery

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-01

Start Date:

2017-11-29

Completion:

2022-09-19

Conditions

• Breast Carcinoma
• Head and Neck Cancer
• Melanoma (Skin)
• Squamous Cell Carcinoma, Skin
• Cervix Cancer
• Endometrium Cancer
• Ovary Cancer
• Vulva Cancer
• Anus Cancer
• Rectum Cancer

Interventions

• DRUG
• DEVICE

No Results Yet

NCT02892786 | COMPLETED | NA

40 participants

Detection in Peripheral Blood of Circulating Tumor Cells in Patient With Head and Neck Squamous Cell Carcinoma

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-01

Start Date:

2010-12-08

Completion:

2017-12-31

Conditions

• Head and Neck Cancer

Interventions

• OTHER

No Results Yet

NCT02890342 | RECRUITING

1045 participants

Natural History, Physiology, Microbiome and Biochemistry Studies of Propionic Acidemia

Study Type:

OBSERVATIONAL

Last Updated:

2026-09-01

Start Date:

2016-11-29

Completion:

2036-08-31

Conditions

• Metabolic Disease
• Propionic Acidemia
• Organic Acidemia

No Results Yet

NCT02880007 | COMPLETED | PHASE2

48 participants

Dose Optimization in 3D Pulsed Dose Rate Brachytherapy for Patients With Locally Advanced Cervical Cancer

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-01

Start Date:

2011-06-06

Completion:

2014-02-10

Conditions

• Cervical Adenocarcinoma
• Stage IB Cervical Cancer
• Stage II Cervical Cancer
• Stage III Cervical Cancer

Interventions

• RADIATION
• DRUG

No Results Yet

NCT02860000 | COMPLETED | PHASE2

96 participants

Alisertib With or Without Fulvestrant in Treating Patients With Locally Advanced or Metastatic, Endocrine-Resistant Breast Cancer

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-01

Start Date:

2017-07-06

Completion:

2022-01-10

Conditions

• Estrogen Receptor Status
• HER2/Neu Negative
• Invasive Breast Carcinoma
• Postmenopausal
• Stage III Breast Cancer
• Stage IIIA Breast Cancer
• Stage IIIB Breast Cancer
• Stage IIIC Breast Cancer
• Stage IV Breast Cancer

Interventions

• DRUG
• OTHER

Results Available

NCT02856594 | COMPLETED | PHASE2/PHASE3

469 participants

Minimizing ICU Neurological Dysfunction With Dexmedetomidine-induced Sleep

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-01

Start Date:

2017-03-06

Completion:

2022-02-11

Conditions

• Postoperative Delirium
• Sleep
• Anesthesia

Interventions

• DRUG

Results Available

NCT02840448 | COMPLETED

159 participants

Impact of Elastin Mediated Vascular Stiffness on End Organs

Study Type:

OBSERVATIONAL

Last Updated:

2026-09-01

Start Date:

2016-12-02

Completion:

2024-04-06

Conditions

• Williams Syndrome
• Supravalvular Aortic Stenosis
• Cardiovascular Disease

No Results Yet

NCT02821767 | RECRUITING

1000 participants

Natural History, Pathogenesis, and Outcome of Ocular Disorders

Study Type:

OBSERVATIONAL

Last Updated:

2026-09-01

Start Date:

2016-08-03

Completion:

2027-07-01

Conditions

• Eye Disease

No Results Yet

NCT02784210 | RECRUITING | PHASE2

30 participants

Effect of Corticosteroids on Inflammation at the Edge of Acute Multiple Sclerosis Plaques

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-01

Start Date:

2016-10-05

Completion:

2028-12-31

Conditions

• Multiple Sclerosis

Interventions

• DRUG

No Results Yet

NCT02766686 | COMPLETED | NA

180 participants

Preference-based Comparative Study on Definitive Radiotherapy of Prostate Cancer With Protons

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-01

Start Date:

2016-09-30

Completion:

2026-02-28

Conditions

• Prostate Cancer

Interventions

• RADIATION

No Results Yet

NCT02743468 | COMPLETED

20 participants

Cytochrome P450 Epoxygenase Pathway Regulation of Macrophage Function

Study Type:

OBSERVATIONAL

Last Updated:

2026-09-01

Start Date:

2019-01-08

Completion:

2019-12-18

Conditions

• Polymorphism
• Lung Inflammation

No Results Yet

NCT02693535 | RECRUITING | PHASE2

4200 participants

TAPUR: Testing the Use of Food and Drug Administration (FDA) Approved Drugs That Target a Specific Abnormality in a Tumor Gene in People With Advanced Stage Cancer

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-01

Start Date:

2016-03-14

Completion:

2027-12-31

Conditions

• Lymphoma, Non-Hodgkin
• Multiple Myeloma
• Advanced Solid Tumors

Interventions

• DRUG

No Results Yet

NCT02689466 | COMPLETED

31 participants

Cholinergic Receptor Imaging in Dystonia

Study Type:

OBSERVATIONAL

Last Updated:

2026-09-01

Start Date:

2016-12-16

Completion:

2021-11-26

Conditions

• Cervical Dystonia
• Dystonia
• Movement Disorder
• Focal Dystonia

Interventions

• DRUG

No Results Yet

NCT02682667 | RECRUITING

500 participants

Biospecimen Procurement for Center for Immuno-Oncology Immunotherapy Protocols

Study Type:

OBSERVATIONAL

Last Updated:

2026-09-01

Start Date:

2016-04-11

Completion:

2030-12-01

Conditions

• Multiple Myeloma
• Lymphoma, Non-Hodgkin
• Leukemia-Lymphoma, Adult T-Cell
• Hodgkin Disease
• Non-Small Cell Lung Cancer

No Results Yet

NCT02676349 | COMPLETED | PHASE2

130 participants

Neoadjuvant mFolfirinox With or Without Preoperative Concomitant Chemoradiotherapy in Patients With Borderline Resectable Pancreatic Carcinoma (PANDAS-PRODIGE 44)

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-01

Start Date:

2016-10-13

Completion:

2024-04-19

Conditions

• Pancreatic Carcinoma

Interventions

• DRUG
• RADIATION
• PROCEDURE

No Results Yet

NCT02669251 | ACTIVE_NOT_RECRUITING | PHASE1/PHASE2

14 participants

Alvelestat (MPH966), an Oral Neutrophil Elastase Inhibitor, in Bronchiolitis Obliterans Syndrome After Allogeneic Hematopoietic Stem Cell Transplantation

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-01

Start Date:

2016-04-28

Completion:

2027-12-01

Conditions

• Chronic Graft vs Host Disease
• Chronic Graft-Versus-Host Disease
• Bronchiolitis Obliterans Syndrome

Interventions

• DRUG

No Results Yet

NCT02669225 | COMPLETED | EARLY_PHASE1

22 participants

Brain Amyloid- Retention During Wakefulness and Following Emergence From Sleep in Healthy People

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-01

Start Date:

2016-05-02

Completion:

2017-01-24

Conditions

• Normal Physiology

Interventions

• OTHER

No Results Yet

NCT02629120 | ACTIVE_NOT_RECRUITING | PHASE1/PHASE2

45 participants

High Dose Peripheral Blood Stem Cell Transplantation With Post Transplant Cyclophosphamide for Patients With Chronic Granulomatous Disease

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-01

Start Date:

2015-12-17

Completion:

2027-12-30

Conditions

• Chronic Granulomatous Disease Transplant

Interventions

• DRUG
• RADIATION
• BIOLOGICAL

No Results Yet

NCT02594202 | RECRUITING

3000 participants

Care of the Prostate Cancer Patient and Prospective Procurement of Prostate Cancer Tissue

Study Type:

OBSERVATIONAL

Last Updated:

2026-09-01

Start Date:

2015-12-21

Completion:

2036-01-01

Conditions

• Prostate Cancer

No Results Yet

NCT02583646 | RECRUITING

150 participants

Investigating the Impact of Obesity on Pubertal Development in Girls

Study Type:

OBSERVATIONAL

Last Updated:

2026-09-01

Start Date:

2015-12-15

Completion:

2026-09-30

Conditions

• Obesity
• Puberty
• Normal Physiology

No Results Yet

NCT02582697 | RECRUITING | PHASE3

500 participants

Accelerated v's Standard BEP Chemotherapy for Patients With Intermediate and Poor-risk Metastatic Germ Cell Tumours

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-01

Start Date:

2014-02-28

Completion:

2029-12-31

Conditions

• Germ Cell Tumor

Interventions

• DRUG

No Results Yet

NCT02579967 | RECRUITING | PHASE2

354 participants

Pilot Trial of Allogeneic Blood or Marrow Transplantation for Primary Immunodeficiencies

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-01

Start Date:

2015-11-19

Completion:

2031-12-31

Conditions

• Primary T-cell Immunodeficiency Disorders
• Common Variable Immunodeficiency
• Immune System Diseases
• Autoimmune Lymphoproliferative
• Lymphoproliferative Disorders

Interventions

• DRUG
• PROCEDURE

No Results Yet

NCT02544022 | RECRUITING

476 participants

Development and Validation of Patient Reported Outcome (PRO) Measures for Individuals With Neurofibromatosis 1 (NF1) and Plexiform Neurofibromas (pNFs)

Study Type:

OBSERVATIONAL

Last Updated:

2026-09-01

Start Date:

2015-11-13

Completion:

2027-06-30

Conditions

• Neurofibromatosis 1
• Plexiform Neurofibromas

No Results Yet

NCT02543996 | RECRUITING

10000 participants

Human Biospecimen Procurement Protocol: Biorepository to Support Translational Research to Identify Disease Mechanism(s)

Study Type:

OBSERVATIONAL

Last Updated:

2026-09-01

Start Date:

2015-09-17

Completion:

2040-06-04

Conditions

• Undiagnosed Diseases
• Cardiovascular Disease

No Results Yet

NCT02543983 | RECRUITING | PHASE2

325 participants

Neurobiology of Suicide

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-01

Start Date:

2015-12-01

Completion:

2030-07-21

Conditions

• Healthy Volunteers
• Depression

Interventions

• DEVICE
• DRUG

No Results Yet

NCT02535702 | RECRUITING | NA

192 participants

Development Of Neuroimaging Methods To Assess The Neurobiology Of Addiction

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-01

Start Date:

2016-06-28

Completion:

2026-12-31

Conditions

• Normal Physiology

Interventions

• OTHER

No Results Yet

NCT02531893 | RECRUITING

200 participants

Psychological Treatments for Youth With Severe Irritability.

Study Type:

OBSERVATIONAL

Last Updated:

2026-09-01

Start Date:

2015-11-17

Completion:

2028-05-08

Conditions

• Irritability

No Results Yet