Clinical Trials Updated in 2026

NCT04452344 | COMPLETED | PHASE3

1815 participants

Opioid Analgesic Reduction Study

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-31
Start Date:: 2021-01-04
Completion:: 2023-07-07

Conditions

Opioid Use

Interventions

DRUG

Results Available

NCT04450927 | ENROLLING_BY_INVITATION

10000 participants

Data Collection of Standard Care and Evaluation of NHLBI Patients and Donors

Study Type:: OBSERVATIONAL
Last Updated:: 2026-08-31
Start Date:: 2020-06-16
Completion:: 2040-12-31

Conditions

Wide Spectrum of Diseases
Hematologic Diseases

No Results Yet

NCT04449549 | RECRUITING | PHASE2

82 participants

Rapid Analysis and Response Evaluation of Combination Anti-Neoplastic Agents in Rare Tumors (RARE CANCER) Trial: RARE 1 Nilotinib and Paclitaxel

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-31
Start Date:: 2020-08-24
Completion:: 2027-04-02

Conditions

Neoplasms

Interventions

DRUG

No Results Yet

NCT04430426 | ENROLLING_BY_INVITATION | NA

4 participants

Heterozygous Individuals for AGXT and Kidney Stones

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-31
Start Date:: 2027-07-01
Completion:: 2031-08-01

Conditions

Kidney Stone
Urolithiasis, Calcium Oxalate

Interventions

OTHER

No Results Yet

NCT04416269 | TERMINATED | PHASE4

85 participants

Oral Anti Diabetic Agents in the Hospital

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-31
Start Date:: 2020-08-07
Completion:: 2025-04-11

Conditions

Diabetes Mellitus

Interventions

DRUG
DEVICE

Results Available

NCT04401449 | COMPLETED

202 participants

Cardiopulmonary Inflammation and Multi-System Imaging During the Clinical Course of COVID-19 Infection in Asymptomatic and Symptomatic Persons

Study Type:: OBSERVATIONAL
Last Updated:: 2026-08-31
Start Date:: 2020-05-21
Completion:: 2023-08-31

Conditions

Acute and Long Term Effects of COVID-19 on Systemic Inflammation
Acute and Long Term Effects of COVID-19 on Lung Function
Acute and Long Term Effects of COVID-19 on Cardiac Function
Acute and Long Term Effects of COVID-19 on Kidney Function
Acute and Long Term Effects of COVID-19 on Brain Function

No Results Yet

NCT04388332 | RECRUITING | NA

60 participants

ACDF Using Structural Allograft vs. Tritanium C

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-31
Start Date:: 2020-08-20
Completion:: 2026-12-31

Conditions

Degenerative Disc Disease

Interventions

PROCEDURE
DEVICE

No Results Yet

NCT04376489 | COMPLETED | NA

114 participants

Project MARS: Mobile-Assistance for Regulating Smoking

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-31
Start Date:: 2020-08-27
Completion:: 2023-10-20

Conditions

Current Smoker
Tobacco Smoking

Interventions

BEHAVIORAL

Results Available

NCT04370093 | COMPLETED | PHASE4

29 participants

Pathogenesis of Uric Acid Nephrolithiasis: Role of Pioglitazone/Weight Loss

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-31
Start Date:: 2019-10-17
Completion:: 2025-05-28

Conditions

Nephrolithiasis, Uric Acid

Interventions

DRUG
BEHAVIORAL
OTHER

Results Available

NCT04355195 | RECRUITING

18100 participants

Quality Contract: Prevention of Postoperative Delirium in the Care of Older Patients (QV-POD-2)

Study Type:: OBSERVATIONAL
Last Updated:: 2026-08-31
Start Date:: 2020-04-20
Completion:: 2028-06-30

Conditions

Delirium in Old Age

No Results Yet

NCT04354077 | RECRUITING | NA

3 participants

Deep Brain Stimulation Effects In Patients With Opioid Use Disorder

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-31
Start Date:: 2022-02-07
Completion:: 2029-01-31

Conditions

Opioid-use Disorder

Interventions

DEVICE

No Results Yet

NCT04349475 | ACTIVE_NOT_RECRUITING | NA

40 participants

Therapeutic Omegas for Triglyceride Suppression

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-31
Start Date:: 2021-11-29
Completion:: 2026-04-30

Conditions

Pregnancy

Interventions

DIETARY_SUPPLEMENT

No Results Yet

NCT04308278 | RECRUITING | PHASE4

88 participants

Study to Evaluate the Efficacy of 2LEBV® and 2LXFS® on Asthenia in Patients With an Epstein-Barr Virus Infection

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-31
Start Date:: 2021-01-22
Completion:: 2028-08-22

Conditions

EBV Infection

Interventions

DRUG

No Results Yet

NCT04298541 | WITHDRAWN | PHASE2

0 participants

Direct Comparison of Ga-68-DOTATATE and Ga-68-DOTATOC

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-31
Start Date:: 2026-08-31
Completion:: 2026-08-31

Conditions

Meningioma

Interventions

DRUG

No Results Yet

NCT04269213 | COMPLETED | PHASE2

21 participants

CPX-351 for the Treatment of Secondary Acute Myeloid Leukemia in Patients Younger Than 60 Years Old

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-31
Start Date:: 2021-07-29
Completion:: 2025-05-27

Conditions

Acute Myeloid Leukemia Arising From Previous Myelodysplastic Syndrome
Acute Myeloid Leukemia With Myelodysplasia-Related Changes
Secondary Acute Myeloid Leukemia
Therapy-Related Acute Myeloid Leukemia

Interventions

DRUG

Results Available

NCT04267861 | ACTIVE_NOT_RECRUITING

232 participants

M7824 Related Adverse Effects in Adults With Cancer

Study Type:: OBSERVATIONAL
Last Updated:: 2026-08-31
Start Date:: 2020-01-28
Completion:: 2027-11-01

Conditions

Neoplasms
Skin Neoplasms

No Results Yet

NCT04249843 | TERMINATED | PHASE1

109 participants

Study of Safety, Pharmacokinetics, and Antitumor Activity of BGB-3245 in Participants With Advanced or Refractory Tumors

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-31
Start Date:: 2020-02-10
Completion:: 2025-08-08

Conditions

Solid Tumor
B-Raf Mutation-Related Tumors

Interventions

DRUG

Results Available

NCT04201873 | COMPLETED | PHASE1

46 participants

Pembrolizumab and a Vaccine (ATL-DC) for the Treatment of Surgically Accessible Recurrent Glioblastoma

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-31
Start Date:: 2020-01-08
Completion:: 2026-08-13

Conditions

Recurrent Glioblastoma

Interventions

BIOLOGICAL
OTHER
DRUG

No Results Yet

NCT04190420 | ACTIVE_NOT_RECRUITING

310 participants

The Transition From Hypertension to Hypertensive Heart Disease and Heart Failure, the PREFERS Hypertension Study

Study Type:: OBSERVATIONAL
Last Updated:: 2026-08-31
Start Date:: 2018-10-01
Completion:: 2030-09-30

Conditions

Hypertension
Heart Failure
Hypertensive Heart Disease
Diastolic Dysfunction

No Results Yet

NCT04181827 | ACTIVE_NOT_RECRUITING | PHASE3

419 participants

A Study Comparing JNJ-68284528, a CAR-T Therapy Directed Against B-cell Maturation Antigen (BCMA), Versus Pomalidomide, Bortezomib and Dexamethasone (PVd) or Daratumumab, Pomalidomide and Dexamethasone (DPd) in Participants With Relapsed and Lenalidomide-Refractory Multiple Myeloma

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-31
Start Date:: 2020-06-12
Completion:: 2024-05-01

Conditions

Multiple Myeloma

Interventions

DRUG

Results Available

NCT04145115 | ACTIVE_NOT_RECRUITING | PHASE2

37 participants

A Study Testing the Effect of Immunotherapy (Ipilimumab and Nivolumab) in Patients With Recurrent Glioma With Elevated Mutational Burden

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-31
Start Date:: 2020-12-24
Completion:: 2026-12-31

Conditions

Astrocytoma, IDH-Mutant, Grade 4
Diffuse Glioma
Glioblastoma, IDH-Wildtype
Secondary Glioblastoma

Interventions

BIOLOGICAL
PROCEDURE

No Results Yet

NCT04133636 | ACTIVE_NOT_RECRUITING | PHASE2

208 participants

A Study of JNJ-68284528, a Chimeric Antigen Receptor T Cell (CAR-T) Therapy Directed Against B-cell Maturation Antigen (BCMA) in Participants With Multiple Myeloma

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-31
Start Date:: 2019-11-07
Completion:: 2027-02-26

Conditions

Multiple Myeloma

Interventions

DRUG

No Results Yet

NCT04119050 | ACTIVE_NOT_RECRUITING | PHASE2/PHASE3

118 participants

Efficacy and Safety of M281 in Adults With Warm Autoimmune Hemolytic Anemia

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-31
Start Date:: 2019-08-15
Completion:: 2025-02-02

Conditions

Warm Autoimmune Hemolytic Anemia

Interventions

DRUG

No Results Yet

NCT04071236 | SUSPENDED | PHASE1/PHASE2

90 participants

Radiation Medication (Radium-223 Dichloride) Versus Radium-223 Dichloride Plus Radiation Enhancing Medication (M3814) Versus Radium-223 Dichloride Plus M3814 Plus Avelumab (a Type of Immunotherapy) for Advanced Prostate Cancer Not Responsive to Hormonal Therapy

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-31
Start Date:: 2020-10-14
Completion:: 2027-04-30

Conditions

Metastatic Castration-Resistant Prostate Carcinoma
Metastatic Malignant Neoplasm in the Bone
Metastatic Malignant Neoplasm in the Lymph Nodes
Stage IVB Prostate Cancer AJCC v8

Interventions

DRUG
PROCEDURE
OTHER
RADIATION

No Results Yet

NCT04061720 | COMPLETED | NA

502 participants

Identifying Effective Treatment for Veterans Unwilling to Quit Smoking

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-31
Start Date:: 2019-11-12
Completion:: 2025-09-26

Conditions

Tobacco Dependence
Veterans

Interventions

BEHAVIORAL

Results Available

NCT04055077 | COMPLETED | NA

176 participants

Influence of HFNO on Spontaneous Breathing Support in Patients of Different ASA Risk During Moderate Multimodal Analgo-sedation for Pars Plana Vitrectomy

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-31
Start Date:: 2022-06-01
Completion:: 2023-06-01

Conditions

Hypoxia
Pars Plana Vitrectomy
Respiratory Complications

Interventions

DEVICE

No Results Yet

NCT04044001 | COMPLETED | PHASE1/PHASE2

78 participants

BTZ-043 - Multiple Ascending Dose (MAD) to Evaluate Safety, Tolerability and Early Bactericidal Activity (EBA)

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-31
Start Date:: 2019-11-15
Completion:: 2022-03-03

Conditions

Pulmonary Tuberculoses
Other Specified Pulmonary Tuberculosis

Interventions

DRUG

Results Available

NCT04033445 | ACTIVE_NOT_RECRUITING | PHASE2/PHASE3

1064 participants

A Study of Guselkumab in Participants With Moderately to Severely Active Ulcerative Colitis

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-31
Start Date:: 2019-09-26
Completion:: 2023-09-19

Conditions

Ulcerative Colitis

Interventions

DRUG

Results Available

NCT04006522 | ACTIVE_NOT_RECRUITING | PHASE2

46 participants

89Zr-DFO-Atezolizumab ImmunoPET/CT in Patients With Locally Advanced or Metastatic Renal Cell Carcinoma

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-31
Start Date:: 2019-10-02
Completion:: 2026-08-06

Conditions

Renal Cell Carcinoma

Interventions

DRUG
PROCEDURE

No Results Yet

NCT03995966 | ACTIVE_NOT_RECRUITING | NA

16 participants

A Clinical Trial for Self-Injurious Behavior

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-31
Start Date:: 2019-06-04
Completion:: 2025-09-09

Conditions

Self-Injurious Behavior

Interventions

BEHAVIORAL

No Results Yet

NCT03988595 | ACTIVE_NOT_RECRUITING | PHASE1

54 participants

Exercise Treatment With Standard Therapy for Metastatic Breast Cancer

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-31
Start Date:: 2019-06-12
Completion:: 2027-08-01

Conditions

Hormone Receptor Positive Metastatic Breast Cancer

Interventions

OTHER

No Results Yet

NCT03977753 | RECRUITING | PHASE4

162 participants

Randomized, Placebo-controlled, Double Blind Study to Evaluate the Efficacy of 2LVERU®JUNIOR and 2LVERU® on the Treatment of Warts

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-31
Start Date:: 2020-02-17
Completion:: 2028-12-16

Conditions

Common Wart
Flat Wart
Plantar Wart

Interventions

DRUG

No Results Yet

NCT03973281 | COMPLETED | NA

420 participants

EASE: The Materna Prep Pivotal Study

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-31
Start Date:: 2019-12-11
Completion:: 2026-07-30

Conditions

Vaginal Delivery
Pelvic Organ Prolapse

Interventions

DEVICE
OTHER

No Results Yet

NCT03948724 | COMPLETED | NA

412 participants

Impact of Therapeutic Patient Education on the Toxicity of Immune Checkpoint Inhibitors in Oncology

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-31
Start Date:: 2019-12-11
Completion:: 2023-08-04

Conditions

Therapeutic Patient Education
Immune Checkpoint Inhibitors
Melanoma
Advanced Non-small Cell Lung Cancer
Renal Cell Carcinoma
Head and Neck Cancer
Immune-related Adverse Event

Interventions

BEHAVIORAL

Results Available

NCT03944226 | COMPLETED | NA

1 participants

Is Dietary Nitrate Effective in Reducing Aerobic Glycolysis in Breast Cancer?

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-31
Start Date:: 2019-08-01
Completion:: 2022-11-28

Conditions

Malignant Breast Tissue Neoplasm

Interventions

DIETARY_SUPPLEMENT

No Results Yet

NCT03923205 | COMPLETED | NA

28 participants

Assessing the Effects of a Buckwheat Beverage on Postprandial Glucose Metabolism on Healthy and T2D Individuals

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-31
Start Date:: 2019-03-07
Completion:: 2022-03-31

Conditions

Healthy
Type2 Diabetes

Interventions

OTHER

No Results Yet

NCT03827343 | ACTIVE_NOT_RECRUITING

500 participants

Retrospective Study of Immunotherapy Related Toxicities and Factors Impacting Outcomes in Children and Adults With Cancer

Study Type:: OBSERVATIONAL
Last Updated:: 2026-08-31
Start Date:: 2019-01-23
Completion:: 2026-12-31

Conditions

Macrophage Activation Syndrome
Primary Hemophagocytic Lymphohistiocytosis

No Results Yet

NCT03805919 | RECRUITING

500 participants

Men at High Genetic Risk for Prostate Cancer

Study Type:: OBSERVATIONAL
Last Updated:: 2026-08-31
Start Date:: 2019-03-27
Completion:: 2029-01-01

Conditions

Prostatic Neoplasms

No Results Yet

NCT03793166 | ACTIVE_NOT_RECRUITING | PHASE3

1175 participants

Immunotherapy With Nivolumab and Ipilimumab Followed by Nivolumab or Nivolumab With Cabozantinib for Patients With Advanced Kidney Cancer, The PDIGREE Study

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-31
Start Date:: 2019-06-07
Completion:: 2028-01-25

Conditions

Clear Cell Renal Cell Carcinoma
Metastatic Malignant Neoplasm in the Bone
Metastatic Malignant Neoplasm in the Lymph Nodes
Metastatic Malignant Neoplasm in the Soft Tissue
Metastatic Malignant Neoplasm in the Viscera
Rhabdoid Tumor of the Kidney
Sarcomatoid Renal Cell Carcinoma
Stage III Renal Cell Cancer AJCC v8
Stage IV Renal Cell Cancer AJCC v8

Interventions

PROCEDURE
DRUG
BIOLOGICAL
OTHER

No Results Yet

NCT03776162 | ACTIVE_NOT_RECRUITING | NA

150 participants

A Comparison of ACL Repair With BEAR Device vs. Autograft Patellar Tendon ACL Reconstruction

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-31
Start Date:: 2021-08-30
Completion:: 2027-07-31

Conditions

Anterior Cruciate Ligament Tear

Interventions

PROCEDURE
DEVICE

No Results Yet