Clinical Trials

NCT04640623 | ACTIVE_NOT_RECRUITING | PHASE2

220 participants

A Study of TAR-200 in Combination With Cetrelimab, TAR-200 Alone, or Cetrelimab Alone in Participants With Non-Muscle Invasive Bladder Cancer (NMIBC) Unresponsive to Intravesical Bacillus Calmette-Guérin Who Are Ineligible for or Elected Not to Undergo Radical Cystectomy

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-28

Start Date:

2020-12-18

Completion:

2025-07-03

Conditions

• Urinary Bladder Neoplasms

Interventions

• DRUG
• BIOLOGICAL

Results Available

NCT04639830 | RECRUITING

244 participants

Electrophysiologic Sleep Phenotyping and Sleep-Dependent Neuro-maturation in Clinical and Healthy Pediatric Populations

Study Type:

OBSERVATIONAL

Last Updated:

2026-08-28

Start Date:

2021-11-09

Completion:

2027-04-15

Conditions

• Healthy Children
• Children With Neurodevelopmental Disorders
• Children With Neuropsychiatric Disorders
• Children With Behavioral Syndromes

No Results Yet

NCT04634552 | RECRUITING | PHASE2

510 participants

A Study of Talquetamab in Participants With Relapsed or Refractory Multiple Myeloma

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-28

Start Date:

2021-02-01

Completion:

2027-06-30

Conditions

• Hematological Malignancies

Interventions

• DRUG

No Results Yet

NCT04616560 | RECRUITING | PHASE2

55 participants

Trastuzumab Deruxtecan (DS-8201a) for the Treatment of Recurrent or Refractory Osteosarcoma, Wilms Tumor, and Desmoplastic Small Round Cell Tumor

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-28

Start Date:

2021-03-08

Completion:

2027-12-31

Conditions

• Desmoplastic Small Round Cell Tumor
• Osteosarcoma
• Recurrent Desmoplastic Small Round Cell Tumor
• Recurrent Kidney Wilms Tumor
• Recurrent Osteosarcoma
• Refractory Desmoplastic Small Round Cell Tumor
• Refractory Wilms Tumor
• Wilms Tumor

Interventions

• PROCEDURE
• BIOLOGICAL

No Results Yet

NCT04609072 | RECRUITING

200000 participants

Connect for Cancer Prevention Study (Connect)

Study Type:

OBSERVATIONAL

Last Updated:

2026-08-28

Start Date:

2021-07-26

Completion:

2070-12-31

Conditions

• Cancer
• General Research Use

No Results Yet

NCT04606381 | ACTIVE_NOT_RECRUITING | PHASE1

158 participants

A Study of Amivantamab Subcutaneous (SC) Administration for the Treatment of Advanced Solid Malignancies

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-28

Start Date:

2020-11-10

Completion:

2024-07-11

Conditions

• Neoplasms

Interventions

• DRUG

No Results Yet

NCT04585958 | RECRUITING | PHASE1

55 participants

Testing the Combination of DS-8201a and Olaparib in HER2-Expressing Cancers With Expansion in Patients With Platinum Resistant Ovarian Cancer

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-28

Start Date:

2021-05-21

Completion:

2026-12-31

Conditions

• Metastatic Malignant Solid Neoplasm
• Platinum-Resistant Ovarian High Grade Serous Adenocarcinoma
• Unresectable Malignant Solid Neoplasm

Interventions

• PROCEDURE
• DRUG
• BIOLOGICAL

No Results Yet

NCT04577833 | ACTIVE_NOT_RECRUITING | PHASE1

136 participants

A Study of Comparative Formulations of Niraparib and Abiraterone Acetate (AA) in Men With Prostate Cancer

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-28

Start Date:

2020-11-13

Completion:

2021-10-15

Conditions

• Prostatic Neoplasms

Interventions

• DRUG

No Results Yet

NCT04563494 | COMPLETED | PHASE4

126 participants

The Effects of IV vs Oral Dexamethasone on Postoperative Nausea, Vomiting, and Pain

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-28

Start Date:

2020-10-23

Completion:

2023-05-24

Conditions

• Nausea and Vomiting, Postoperative

Interventions

• DRUG

Results Available

NCT04558866 | COMPLETED | PHASE2

51 participants

Extreme Bipolar Androgen Therapy With Darolutamide and Testosterone Cypionate in Patients With Metastatic Castration-Resistant Prostate Cancer (ExBAT Trial)

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-28

Start Date:

2021-06-09

Completion:

2023-03-28

Conditions

• Prostate Cancer

Interventions

• DRUG

No Results Yet

NCT04557059 | ACTIVE_NOT_RECRUITING | PHASE3

691 participants

A Study of Adding Apalutamide to Radiotherapy and LHRH Agonist in High-Risk Patients With Hormone-Sensitive Prostate Cancer

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-28

Start Date:

2020-11-12

Completion:

2029-08-27

Conditions

• Prostatic Neoplasms

Interventions

• RADIATION
• DRUG

No Results Yet

NCT04541030 | ACTIVE_NOT_RECRUITING

241 participants

Integrated Genomic Prostate Score With MRI Targeted Prostate Biopsies

Study Type:

OBSERVATIONAL

Last Updated:

2026-08-28

Start Date:

2020-09-02

Completion:

2027-07-01

Conditions

• Prostate Cancer

No Results Yet

NCT04530565 | ACTIVE_NOT_RECRUITING | PHASE3

348 participants

Testing the Use of Steroids and Tyrosine Kinase Inhibitors With Blinatumomab or Chemotherapy for Newly Diagnosed BCR-ABL-Positive Acute Lymphoblastic Leukemia in Adults

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-28

Start Date:

2021-01-25

Completion:

2028-07-01

Conditions

• B Acute Lymphoblastic Leukemia With t(9;22)(q34.1;q11.2); BCR-ABL1

Interventions

• PROCEDURE
• BIOLOGICAL
• DRUG

No Results Yet

NCT04504968 | COMPLETED | NA

713 participants

Effectiveness of a Multimodal Intervention on Function in Older Frail People With Diabetes in Latinamerican

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-28

Start Date:

2022-02-14

Completion:

2024-04-30

Conditions

• Frailty Syndrome
• Frail Elderly Syndrome
• Diabetes Mellitus, Type 2

Interventions

• OTHER

No Results Yet

NCT04487080 | ACTIVE_NOT_RECRUITING | PHASE3

1074 participants

A Study of Amivantamab and Lazertinib Combination Therapy Versus Osimertinib in Locally Advanced or Metastatic Non-Small Cell Lung Cancer

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-28

Start Date:

2020-09-30

Completion:

2023-08-11

Conditions

• Carcinoma, Non-Small-Cell Lung

Interventions

• DRUG

Results Available

NCT04486378 | ACTIVE_NOT_RECRUITING | PHASE2

327 participants

A Phase II Clinical Trial Comparing the Efficacy of RO7198457 Versus Watchful Waiting in Patients With ctDNA-positive, Resected Stage II (High Risk) and Stage III Colorectal Cancer

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-28

Start Date:

2021-03-08

Completion:

2026-11-30

Conditions

• Colorectal Cancer Stage II
• Colorectal Cancer Stage III

Interventions

• DRUG
• OTHER

No Results Yet

NCT04477486 | COMPLETED | PHASE2

13 participants

Study to Assess Effect of Oral Venetoclax Tablet in Combination With Oral Ibrutinib Capsule on Best Overall Response of Complete Response in Adult Japanese Participants With Relapsed/Refractory Mantle Cell Lymphoma

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-28

Start Date:

2020-09-23

Completion:

2022-02-09

Conditions

• Mantle Cell Lymphoma (MCL)

Interventions

• DRUG

Results Available

NCT04449874 | ACTIVE_NOT_RECRUITING | PHASE1

498 participants

A Study to Evaluate the Safety, Pharmacokinetics, and Activity of GDC-6036 Alone or in Combination in Participants With Advanced or Metastatic Solid Tumors With a KRAS G12C Mutation

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-28

Start Date:

2020-07-29

Completion:

2027-12-31

Conditions

• Non-Small Cell Lung Cancer
• Colorectal Cancer
• Advanced Solid Tumors

Interventions

• DRUG

No Results Yet

NCT04444921 | ACTIVE_NOT_RECRUITING | PHASE3

205 participants

EA2176: Phase 3 Clinical Trial of Carboplatin and Paclitaxel +/- Nivolumab in Metastatic Anal Cancer Patients

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-28

Start Date:

2020-11-17

Completion:

2027-03-31

Conditions

• Anal Basaloid Carcinoma
• Anal Canal Cloacogenic Carcinoma
• Metastatic Anal Squamous Cell Carcinoma
• Recurrent Anal Squamous Cell Carcinoma
• Stage III Anal Cancer AJCC v8
• Stage IV Anal Cancer AJCC v8
• Unresectable Anal Squamous Cell Carcinoma

Interventions

• DRUG
• BIOLOGICAL

No Results Yet

NCT04431011 | COMPLETED

40 participants

Layer-specific Contribution to Consolidation of Skill Learning in the Primary Motor Cortex

Study Type:

OBSERVATIONAL

Last Updated:

2026-08-28

Start Date:

2021-04-21

Completion:

2024-12-09

Conditions

• Normal Physiology

No Results Yet

NCT04427709 | TERMINATED | PHASE2

4 participants

Generate and Test the Reliability of a PD Model of OXT on Pupillary Hippus as a Measure of CNS Activity

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-28

Start Date:

2020-11-30

Completion:

2026-08-01

Conditions

• Chronic Pain
• Osteoarthritis, Knee

Interventions

• DRUG

No Results Yet

NCT04427293 | ACTIVE_NOT_RECRUITING | PHASE1

12 participants

Preoperative Lenvatinib Plus Pembrolizumab in Early-Stage Triple-Negative Breast Cancer (TNBC)

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-28

Start Date:

2020-07-09

Completion:

2027-07-31

Conditions

• Triple Negative Breast Cancer

Interventions

• DRUG

No Results Yet

NCT04417660 | ACTIVE_NOT_RECRUITING | PHASE2

9 participants

Bintrafusp Alfa (M7824) in Subjects With Thymoma and Thymic Carcinoma

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-28

Start Date:

2020-12-26

Completion:

2026-12-31

Conditions

• Thymic Epithelial Tumor
• Recurrent Thymoma
• Thymic Cancer

Interventions

• DRUG

No Results Yet

NCT04416581 | RECRUITING | PHASE4

3320 participants

Potassium-Competitive Acid Blocker Versus pROton-Pump Inhibitor for GastroproTECTion Strategies In Patients at High Gastro-Intestinal Bleeding Risk Receiving Antithrombotic Therapy

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-28

Start Date:

2021-05-12

Completion:

2027-12-31

Conditions

• Coronary Artery Disease
• Percutaneous Coronary Intervention
• Acute Coronary Syndrome
• Myocardial Infarction

Interventions

• DRUG

No Results Yet

NCT04387656 | ACTIVE_NOT_RECRUITING

1877 participants

NCI COVID-19 in Cancer Patients, NCCAPS Study

Study Type:

OBSERVATIONAL

Last Updated:

2026-08-28

Start Date:

2020-06-05

Completion:

2024-03-20

Conditions

• COVID-19 Infection
• Hematopoietic and Lymphatic System Neoplasm
• Malignant Solid Neoplasm
• Metastatic Malignant Solid Neoplasm

Interventions

• PROCEDURE
• OTHER

No Results Yet

NCT04379596 | ACTIVE_NOT_RECRUITING | PHASE2

452 participants

Ph1b/2 Study of the Safety and Efficacy of T-DXd Combinations in Advanced HER2-expressing Gastric Cancer (DESTINY-Gastric03)

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-28

Start Date:

2020-06-03

Completion:

2027-05-04

Conditions

• Gastric Cancer

Interventions

• DRUG
• BIOLOGICAL

No Results Yet

NCT04372108 | RECRUITING

1536 participants

A Study to Assess the Long-Term Safety of Ustekinumab Versus Other Biologics in Patients With Crohn's Disease and Ulcerative Colitis

Study Type:

OBSERVATIONAL

Last Updated:

2026-08-28

Start Date:

2021-06-24

Completion:

2029-08-31

Conditions

• Crohn Disease
• Colitis, Ulcerative

Interventions

• DRUG

No Results Yet

NCT04371055 | ACTIVE_NOT_RECRUITING | NA

5227 participants

Intensive Rhythm Monitoring to Decrease Ischemic Stroke and Systemic Embolism - the Find-AF 2 Study

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-28

Start Date:

2020-07-07

Completion:

2027-06-30

Conditions

• Ischemic Stroke
• Atrial Fibrillation

Interventions

• OTHER

No Results Yet

NCT04357821 | COMPLETED | PHASE1/PHASE2

11 participants

Combinatorial Therapy to Induce an HIV Remission

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-28

Start Date:

2020-08-01

Completion:

2024-01-29

Conditions

• HIV/AIDS

Interventions

• DRUG

Results Available

NCT04325828 | ACTIVE_NOT_RECRUITING | PHASE2

31 participants

A Study of Apalutamide Combined With GnRH Agonist in Participants With Androgen Receptor Positive Salivary Gland Carcinoma

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-28

Start Date:

2020-04-07

Completion:

2021-06-09

Conditions

• Salivary Gland Neoplasms

Interventions

• DRUG

Results Available

NCT04319068 | ACTIVE_NOT_RECRUITING

600 participants

Sodium Storage in Singaporeans

Study Type:

OBSERVATIONAL

Last Updated:

2026-08-28

Start Date:

2019-07-02

Completion:

2028-12-31

Conditions

• Healthy
• Hypertension

No Results Yet

NCT04289480 | ACTIVE_NOT_RECRUITING

164 participants

Safety and Effectiveness of ENTERPRISE 2 Device in the Endovascular Treatment of Intracranial Aneurysms

Study Type:

OBSERVATIONAL

Last Updated:

2026-08-28

Start Date:

2020-07-30

Completion:

2022-04-22

Conditions

• Intracranial Aneurysm

Interventions

• DEVICE

No Results Yet

NCT04273945 | ACTIVE_NOT_RECRUITING | PHASE3

935 participants

Outcome Study Assessing a 75 Milligrams (mg) Dose of Macitentan in Patients With Pulmonary Arterial Hypertension

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-28

Start Date:

2020-06-30

Completion:

2025-10-07

Conditions

• Pulmonary Arterial Hypertension

Interventions

• DRUG

No Results Yet

NCT04267705 | ACTIVE_NOT_RECRUITING | NA

103 participants

Pulses Consumption and Its Role in Managing Systemic Inflammation, Insulin Sensitivity and Gut Microbiome in Human

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-28

Start Date:

2020-02-24

Completion:

2023-05-30

Conditions

• Insulin Sensitivity
• Overweight or Obesity
• Inflammatory Response

Interventions

• OTHER

No Results Yet

NCT04256486 | COMPLETED | NA

321 participants

Family Model Diabetes Self-Management Education in Faith Based Organizations

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-28

Start Date:

2022-04-21

Completion:

2025-08-22

Conditions

• Type 2 Diabetes

Interventions

• BEHAVIORAL

No Results Yet

NCT04253392 | ACTIVE_NOT_RECRUITING

500 participants

RETHINK REFLUX Registry

Study Type:

OBSERVATIONAL

Last Updated:

2026-08-28

Start Date:

2020-07-08

Completion:

2032-07-31

Conditions

• Gastroesophageal Reflux

Interventions

• DEVICE

No Results Yet

NCT04216342 | RECRUITING | PHASE1

64 participants

Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Fx-5A in Healthy Volunteers

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-28

Start Date:

2021-09-29

Completion:

2027-06-30

Conditions

• Cardiovascular Disease

Interventions

• BIOLOGICAL

No Results Yet

NCT04205500 | ACTIVE_NOT_RECRUITING | NA

30 participants

Treatment With Specific Carbohydrate Diet in Children With Juvenile Idiopathic Arthritis

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-28

Start Date:

2017-09-01

Completion:

2026-12-31

Conditions

• Juvenile Idiopathic Arthritis

Interventions

• OTHER

No Results Yet

NCT04195217 | COMPLETED | NA

86 participants

" Application of Art Therapy in Oncology: Evaluation of the Symptomatic of Patients Suffering From a Cancerous Disease"

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-28

Start Date:

2020-01-07

Completion:

2025-03-17

Conditions

• Therapy-Associated Cancer

Interventions

• BEHAVIORAL

Results Available

NCT04181684 | ACTIVE_NOT_RECRUITING | NA

39 participants

LITT Followed by Hypofractionated RT for Recurrent Gliomas

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-28

Start Date:

2020-01-08

Completion:

2026-12-31

Conditions

• Glioblastoma
• Brain Tumor
• Glioma
• Neoplasms

Interventions

• DEVICE
• RADIATION

No Results Yet