Clinical Trials

NCT04444921 | ACTIVE_NOT_RECRUITING | PHASE3

205 participants

EA2176: Phase 3 Clinical Trial of Carboplatin and Paclitaxel +/- Nivolumab in Metastatic Anal Cancer Patients

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-28

Start Date:

2020-11-17

Completion:

2027-03-31

Conditions

• Anal Basaloid Carcinoma
• Anal Canal Cloacogenic Carcinoma
• Metastatic Anal Squamous Cell Carcinoma
• Recurrent Anal Squamous Cell Carcinoma
• Stage III Anal Cancer AJCC v8
• Stage IV Anal Cancer AJCC v8
• Unresectable Anal Squamous Cell Carcinoma

Interventions

• DRUG
• BIOLOGICAL

No Results Yet

NCT04431011 | COMPLETED

40 participants

Layer-specific Contribution to Consolidation of Skill Learning in the Primary Motor Cortex

Study Type:

OBSERVATIONAL

Last Updated:

2026-08-28

Start Date:

2021-04-21

Completion:

2024-12-09

Conditions

• Normal Physiology

No Results Yet

NCT04427709 | TERMINATED | PHASE2

4 participants

Generate and Test the Reliability of a PD Model of OXT on Pupillary Hippus as a Measure of CNS Activity

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-28

Start Date:

2020-11-30

Completion:

2026-08-01

Conditions

• Chronic Pain
• Osteoarthritis, Knee

Interventions

• DRUG

No Results Yet

NCT04427293 | ACTIVE_NOT_RECRUITING | PHASE1

12 participants

Preoperative Lenvatinib Plus Pembrolizumab in Early-Stage Triple-Negative Breast Cancer (TNBC)

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-28

Start Date:

2020-07-09

Completion:

2027-07-31

Conditions

• Triple Negative Breast Cancer

Interventions

• DRUG

No Results Yet

NCT04417660 | ACTIVE_NOT_RECRUITING | PHASE2

9 participants

Bintrafusp Alfa (M7824) in Subjects With Thymoma and Thymic Carcinoma

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-28

Start Date:

2020-12-26

Completion:

2026-12-31

Conditions

• Thymic Epithelial Tumor
• Recurrent Thymoma
• Thymic Cancer

Interventions

• DRUG

No Results Yet

NCT04416581 | RECRUITING | PHASE4

3320 participants

Potassium-Competitive Acid Blocker Versus pROton-Pump Inhibitor for GastroproTECTion Strategies In Patients at High Gastro-Intestinal Bleeding Risk Receiving Antithrombotic Therapy

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-28

Start Date:

2021-05-12

Completion:

2027-12-31

Conditions

• Coronary Artery Disease
• Percutaneous Coronary Intervention
• Acute Coronary Syndrome
• Myocardial Infarction

Interventions

• DRUG

No Results Yet

NCT04387656 | ACTIVE_NOT_RECRUITING

1877 participants

NCI COVID-19 in Cancer Patients, NCCAPS Study

Study Type:

OBSERVATIONAL

Last Updated:

2026-08-28

Start Date:

2020-06-05

Completion:

2024-03-20

Conditions

• COVID-19 Infection
• Hematopoietic and Lymphatic System Neoplasm
• Malignant Solid Neoplasm
• Metastatic Malignant Solid Neoplasm

Interventions

• PROCEDURE
• OTHER

No Results Yet

NCT04379596 | ACTIVE_NOT_RECRUITING | PHASE2

452 participants

Ph1b/2 Study of the Safety and Efficacy of T-DXd Combinations in Advanced HER2-expressing Gastric Cancer (DESTINY-Gastric03)

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-28

Start Date:

2020-06-03

Completion:

2027-05-04

Conditions

• Gastric Cancer

Interventions

• DRUG
• BIOLOGICAL

No Results Yet

NCT04372108 | RECRUITING

1536 participants

A Study to Assess the Long-Term Safety of Ustekinumab Versus Other Biologics in Patients With Crohn's Disease and Ulcerative Colitis

Study Type:

OBSERVATIONAL

Last Updated:

2026-08-28

Start Date:

2021-06-24

Completion:

2029-08-31

Conditions

• Crohn Disease
• Colitis, Ulcerative

Interventions

• DRUG

No Results Yet

NCT04371055 | ACTIVE_NOT_RECRUITING | NA

5227 participants

Intensive Rhythm Monitoring to Decrease Ischemic Stroke and Systemic Embolism - the Find-AF 2 Study

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-28

Start Date:

2020-07-07

Completion:

2027-06-30

Conditions

• Ischemic Stroke
• Atrial Fibrillation

Interventions

• OTHER

No Results Yet

NCT04360018 | COMPLETED | PHASE1

20 participants

Effect of Acute Alcohol Intoxication on Neural Processes During Decisions to Engage in HIV Risk Behaviors

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-28

Start Date:

2021-03-18

Completion:

2025-04-02

Conditions

• Alcohol Consumption

Interventions

• OTHER

No Results Yet

NCT04357821 | COMPLETED | PHASE1/PHASE2

11 participants

Combinatorial Therapy to Induce an HIV Remission

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-28

Start Date:

2020-08-01

Completion:

2024-01-29

Conditions

• HIV/AIDS

Interventions

• DRUG

Results Available

NCT04325828 | ACTIVE_NOT_RECRUITING | PHASE2

31 participants

A Study of Apalutamide Combined With GnRH Agonist in Participants With Androgen Receptor Positive Salivary Gland Carcinoma

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-28

Start Date:

2020-04-07

Completion:

2021-06-09

Conditions

• Salivary Gland Neoplasms

Interventions

• DRUG

Results Available

NCT04319068 | ACTIVE_NOT_RECRUITING

600 participants

Sodium Storage in Singaporeans

Study Type:

OBSERVATIONAL

Last Updated:

2026-08-28

Start Date:

2019-07-02

Completion:

2028-12-31

Conditions

• Healthy
• Hypertension

No Results Yet

NCT04289480 | ACTIVE_NOT_RECRUITING

164 participants

Safety and Effectiveness of ENTERPRISE 2 Device in the Endovascular Treatment of Intracranial Aneurysms

Study Type:

OBSERVATIONAL

Last Updated:

2026-08-28

Start Date:

2020-07-30

Completion:

2022-04-22

Conditions

• Intracranial Aneurysm

Interventions

• DEVICE

No Results Yet

NCT04273945 | ACTIVE_NOT_RECRUITING | PHASE3

935 participants

Outcome Study Assessing a 75 Milligrams (mg) Dose of Macitentan in Patients With Pulmonary Arterial Hypertension

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-28

Start Date:

2020-06-30

Completion:

2025-10-07

Conditions

• Pulmonary Arterial Hypertension

Interventions

• DRUG

No Results Yet

NCT04267705 | ACTIVE_NOT_RECRUITING | NA

103 participants

Pulses Consumption and Its Role in Managing Systemic Inflammation, Insulin Sensitivity and Gut Microbiome in Human

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-28

Start Date:

2020-02-24

Completion:

2023-05-30

Conditions

• Insulin Sensitivity
• Overweight or Obesity
• Inflammatory Response

Interventions

• OTHER

No Results Yet

NCT04256486 | COMPLETED | NA

321 participants

Family Model Diabetes Self-Management Education in Faith Based Organizations

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-28

Start Date:

2022-04-21

Completion:

2025-08-22

Conditions

• Type 2 Diabetes

Interventions

• BEHAVIORAL

No Results Yet

NCT04253392 | ACTIVE_NOT_RECRUITING

500 participants

RETHINK REFLUX Registry

Study Type:

OBSERVATIONAL

Last Updated:

2026-08-28

Start Date:

2020-07-08

Completion:

2032-07-31

Conditions

• Gastroesophageal Reflux

Interventions

• DEVICE

No Results Yet

NCT04216342 | RECRUITING | PHASE1

64 participants

Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Fx-5A in Healthy Volunteers

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-28

Start Date:

2021-09-29

Completion:

2027-06-30

Conditions

• Cardiovascular Disease

Interventions

• BIOLOGICAL

No Results Yet

NCT04205500 | ACTIVE_NOT_RECRUITING | NA

30 participants

Treatment With Specific Carbohydrate Diet in Children With Juvenile Idiopathic Arthritis

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-28

Start Date:

2017-09-01

Completion:

2026-12-31

Conditions

• Juvenile Idiopathic Arthritis

Interventions

• OTHER

No Results Yet

NCT04195217 | COMPLETED | NA

86 participants

" Application of Art Therapy in Oncology: Evaluation of the Symptomatic of Patients Suffering From a Cancerous Disease"

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-28

Start Date:

2020-01-07

Completion:

2025-03-17

Conditions

• Therapy-Associated Cancer

Interventions

• BEHAVIORAL

Results Available

NCT04181684 | ACTIVE_NOT_RECRUITING | NA

39 participants

LITT Followed by Hypofractionated RT for Recurrent Gliomas

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-28

Start Date:

2020-01-08

Completion:

2026-12-31

Conditions

• Glioblastoma
• Brain Tumor
• Glioma
• Neoplasms

Interventions

• DEVICE
• RADIATION

No Results Yet

NCT04175600 | ACTIVE_NOT_RECRUITING | PHASE3

138 participants

A Study of Selexipag as Add-On Treatment to Standard of Care in Children With Pulmonary Arterial Hypertension

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-28

Start Date:

2020-01-16

Completion:

2024-10-11

Conditions

• Hypertension, Pulmonary

Interventions

• DRUG

Results Available

NCT04170283 | ACTIVE_NOT_RECRUITING | PHASE3

955 participants

A Study to Evaluate Long-term Safety of Zanubrutinib Regimens in Participants With B-Cell Malignancies Who Participated in BeiGene Parent Studies of Zanubrutinib

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-28

Start Date:

2020-01-16

Completion:

2026-12-31

Conditions

• B-cell Malignancies

Interventions

• DRUG

No Results Yet

NCT04126161 | COMPLETED | NA

18 participants

HIP: Hip Imaging Protocol

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-28

Start Date:

2019-11-01

Completion:

2025-07-10

Conditions

• Metabolic Profiling Muscle

Interventions

• PROCEDURE
• DEVICE

Results Available

NCT04124341 | RECRUITING | NA

15 participants

PCS in Severe Treatment Resistant Depression

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-28

Start Date:

2021-09-29

Completion:

2031-12-31

Conditions

• Treatment Resistant Depression

Interventions

• DEVICE

No Results Yet

NCT04108195 | ACTIVE_NOT_RECRUITING | PHASE1

290 participants

A Study of Subcutaneous Daratumumab Regimens in Combination With Bispecific T Cell Redirection Antibodies for the Treatment of Participants With Multiple Myeloma

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-28

Start Date:

2020-02-21

Completion:

2027-04-07

Conditions

• Multiple Myeloma

Interventions

• DRUG

No Results Yet

NCT04090710 | COMPLETED | PHASE2

66 participants

SBRT With Combination Ipilimumab/Nivolumab for Metastatic Kidney Cancer

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-28

Start Date:

2020-01-29

Completion:

2026-04-23

Conditions

• Metastatic Renal Cell Carcinoma

Interventions

• DRUG
• RADIATION

No Results Yet

NCT04065438 | RECRUITING | NA

35 participants

Post Approval Study for Treatment of Drug-resistant Adult and Pediatric Primary FSGS Using the LIPOSORBER® LA-15 System

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-28

Start Date:

2020-01-01

Completion:

2027-09-30

Conditions

• Focal Segmental Glomerulosclerosis

Interventions

• DEVICE

No Results Yet

NCT04039087 | COMPLETED | PHASE2/PHASE3

31 participants

Sildenafil Exercise: Role of PDE5 Inhibition

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-28

Start Date:

2019-09-05

Completion:

2024-06-30

Conditions

• Cystic Fibrosis

Interventions

• DRUG

Results Available

NCT04034264 | RECRUITING

6500 participants

Febrile Disease Landscape in Cambodia Via Metagenomic Pathogen Sequencing

Study Type:

OBSERVATIONAL

Last Updated:

2026-08-28

Start Date:

2019-07-23

Completion:

2027-07-01

Conditions

• Vector-Borne Diseases
• Emerging Pathogens

No Results Yet

NCT04023552 | COMPLETED | PHASE3

8323 participants

Assessing the Impact of Lipoprotein (a) Lowering With Pelacarsen (TQJ230) on Major Cardiovascular Events in Patients With CVD

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-28

Start Date:

2019-12-12

Completion:

2026-07-16

Conditions

• Cardiovascular Disease and Lipoprotein(a)

Interventions

• DRUG

No Results Yet

NCT04014348 | RECRUITING

250 participants

Geospatial Analysis of Neighborhood Environmental Stress in Relation to Biological Markers of Cardiovascular Health and Health Behaviors in Women

Study Type:

OBSERVATIONAL

Last Updated:

2026-08-28

Start Date:

2021-10-20

Completion:

2026-12-10

Conditions

• Cardiovascular (CV) Risk

No Results Yet

NCT03964090 | ACTIVE_NOT_RECRUITING | PHASE2

48 participants

Temozolomide, Etoposide, Doxil, Dexamethasone, Ibrutinib, and Rituximab (TEDDI-R) in Aggressive B-cell Lymphomas With Secondary Involvement of the Central Nervous System (CNS)

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-28

Start Date:

2019-06-27

Completion:

2027-07-01

Conditions

• Central Nervous System Lymphoma
• Secondary Central Nervous System Lymphoma

Interventions

• DRUG

No Results Yet

NCT03963349 | ACTIVE_NOT_RECRUITING

150 participants

THERMOCOOL SMARTTOUCH®SF Catheters With Ablation Index Study

Study Type:

OBSERVATIONAL

Last Updated:

2026-08-28

Start Date:

2019-06-24

Completion:

2026-12-31

Conditions

• Paroxysmal Atrial Fibrillation

No Results Yet

NCT03937882 | COMPLETED | PHASE3

700 participants

Assessment of the Safety and Efficacy of RGN-259 Ophthalmic Solutions for Dry Eye Syndrome: ARISE-3

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-28

Start Date:

2019-05-24

Completion:

2020-11-08

Conditions

• Dry Eye Syndromes
• Dry Eye

Interventions

• DRUG

Results Available

NCT03867448 | RECRUITING

1000 participants

Study of Endocrine-Related Conditions and Physiology

Study Type:

OBSERVATIONAL

Last Updated:

2026-08-28

Start Date:

2019-03-27

Completion:

2036-01-01

Conditions

• Endocrine Disease

Interventions

• DEVICE

No Results Yet

NCT03866382 | RECRUITING | PHASE2

314 participants

Testing the Effectiveness of Two Immunotherapy Drugs (Nivolumab and Ipilimumab) With One Anti-cancer Targeted Drug (Cabozantinib) for Rare Genitourinary Tumors

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-28

Start Date:

2019-05-13

Completion:

2027-02-28

Conditions

• Bladder Adenocarcinoma
• Bladder Clear Cell Adenocarcinoma
• Bladder Mixed Adenocarcinoma
• Bladder Neuroendocrine Carcinoma
• Bladder Small Cell Neuroendocrine Carcinoma
• Bladder Squamous Cell Carcinoma
• Chromophobe Renal Cell Carcinoma
• Collecting Duct Carcinoma
• Invasive Bladder Giant Cell Urothelial Carcinoma
• Invasive Bladder Lymphoepithelioma-Like Carcinoma
• Invasive Bladder Nested Urothelial Carcinoma
• Invasive Bladder Plasmacytoid Urothelial Carcinoma
• Invasive Bladder Sarcomatoid Urothelial Carcinoma
• Invasive Bladder Urothelial Carcinoma
• Kidney Medullary Carcinoma
• Large Cell Neuroendocrine Carcinoma
• Malignant Testicular Leydig Cell Tumor
• Malignant Testicular Sertoli Cell Tumor
• Metastatic Bladder Carcinoma
• Metastatic Bladder Clear Cell (Glycogen-Rich) Urothelial Carcinoma
• Metastatic Bladder Giant Cell Urothelial Carcinoma
• Metastatic Bladder Large Cell Neuroendocrine Carcinoma
• Metastatic Bladder Lipid-Rich Urothelial Carcinoma
• Metastatic Bladder Micropapillary Urothelial Carcinoma
• Metastatic Bladder Plasmacytoid Urothelial Carcinoma
• Metastatic Bladder Sarcomatoid Urothelial Carcinoma
• Metastatic Bladder Small Cell Neuroendocrine Carcinoma
• Metastatic Bladder Squamous Cell Carcinoma
• Metastatic Chromophobe Renal Cell Carcinoma
• Metastatic Kidney Medullary Carcinoma
• Metastatic Malignant Genitourinary System Neoplasm
• Metastatic Papillary Renal Cell Carcinoma
• Metastatic Penile Carcinoma
• Metastatic Prostate Small Cell Neuroendocrine Carcinoma
• Metastatic Sarcomatoid Renal Cell Carcinoma
• Metastatic Urethral Carcinoma
• Papillary Renal Cell Carcinoma
• Sarcomatoid Renal Cell Carcinoma
• Stage IV Bladder Cancer AJCC v8
• Stage IV Penile Cancer AJCC v8
• Stage IV Renal Cell Cancer AJCC v8
• Stage IV Urethral Cancer AJCC v8
• Stage IVB Prostate Cancer AJCC v8
• Urachal Adenocarcinoma
• Urethral Clear Cell Adenocarcinoma

Interventions

• PROCEDURE
• DRUG
• BIOLOGICAL

No Results Yet

NCT03854318 | RECRUITING

1000 participants

Longitudinal Studies of Patient With FPDMM

Study Type:

OBSERVATIONAL

Last Updated:

2026-08-28

Start Date:

2019-03-28

Completion:

2028-12-31

Conditions

• Inherited Hematological Diseases
• Rare Diseases
• FPDMM

No Results Yet