Clinical Trials

NCT03964090 | ACTIVE_NOT_RECRUITING | PHASE2

48 participants

Temozolomide, Etoposide, Doxil, Dexamethasone, Ibrutinib, and Rituximab (TEDDI-R) in Aggressive B-cell Lymphomas With Secondary Involvement of the Central Nervous System (CNS)

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-28

Start Date:

2019-06-27

Completion:

2027-07-01

Conditions

• Central Nervous System Lymphoma
• Secondary Central Nervous System Lymphoma

Interventions

• DRUG

No Results Yet

NCT03963349 | ACTIVE_NOT_RECRUITING

150 participants

THERMOCOOL SMARTTOUCH®SF Catheters With Ablation Index Study

Study Type:

OBSERVATIONAL

Last Updated:

2026-08-28

Start Date:

2019-06-24

Completion:

2026-12-31

Conditions

• Paroxysmal Atrial Fibrillation

No Results Yet

NCT03937882 | COMPLETED | PHASE3

700 participants

Assessment of the Safety and Efficacy of RGN-259 Ophthalmic Solutions for Dry Eye Syndrome: ARISE-3

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-28

Start Date:

2019-05-24

Completion:

2020-11-08

Conditions

• Dry Eye Syndromes
• Dry Eye

Interventions

• DRUG

Results Available

NCT03866382 | RECRUITING | PHASE2

314 participants

Testing the Effectiveness of Two Immunotherapy Drugs (Nivolumab and Ipilimumab) With One Anti-cancer Targeted Drug (Cabozantinib) for Rare Genitourinary Tumors

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-28

Start Date:

2019-05-13

Completion:

2027-02-28

Conditions

• Bladder Adenocarcinoma
• Bladder Clear Cell Adenocarcinoma
• Bladder Mixed Adenocarcinoma
• Bladder Neuroendocrine Carcinoma
• Bladder Small Cell Neuroendocrine Carcinoma
• Bladder Squamous Cell Carcinoma
• Chromophobe Renal Cell Carcinoma
• Collecting Duct Carcinoma
• Invasive Bladder Giant Cell Urothelial Carcinoma
• Invasive Bladder Lymphoepithelioma-Like Carcinoma
• Invasive Bladder Nested Urothelial Carcinoma
• Invasive Bladder Plasmacytoid Urothelial Carcinoma
• Invasive Bladder Sarcomatoid Urothelial Carcinoma
• Invasive Bladder Urothelial Carcinoma
• Kidney Medullary Carcinoma
• Large Cell Neuroendocrine Carcinoma
• Malignant Testicular Leydig Cell Tumor
• Malignant Testicular Sertoli Cell Tumor
• Metastatic Bladder Carcinoma
• Metastatic Bladder Clear Cell (Glycogen-Rich) Urothelial Carcinoma
• Metastatic Bladder Giant Cell Urothelial Carcinoma
• Metastatic Bladder Large Cell Neuroendocrine Carcinoma
• Metastatic Bladder Lipid-Rich Urothelial Carcinoma
• Metastatic Bladder Micropapillary Urothelial Carcinoma
• Metastatic Bladder Plasmacytoid Urothelial Carcinoma
• Metastatic Bladder Sarcomatoid Urothelial Carcinoma
• Metastatic Bladder Small Cell Neuroendocrine Carcinoma
• Metastatic Bladder Squamous Cell Carcinoma
• Metastatic Chromophobe Renal Cell Carcinoma
• Metastatic Kidney Medullary Carcinoma
• Metastatic Malignant Genitourinary System Neoplasm
• Metastatic Papillary Renal Cell Carcinoma
• Metastatic Penile Carcinoma
• Metastatic Prostate Small Cell Neuroendocrine Carcinoma
• Metastatic Sarcomatoid Renal Cell Carcinoma
• Metastatic Urethral Carcinoma
• Papillary Renal Cell Carcinoma
• Sarcomatoid Renal Cell Carcinoma
• Stage IV Bladder Cancer AJCC v8
• Stage IV Penile Cancer AJCC v8
• Stage IV Renal Cell Cancer AJCC v8
• Stage IV Urethral Cancer AJCC v8
• Stage IVB Prostate Cancer AJCC v8
• Urachal Adenocarcinoma
• Urethral Clear Cell Adenocarcinoma

Interventions

• PROCEDURE
• DRUG
• BIOLOGICAL

No Results Yet

NCT03854318 | RECRUITING

1000 participants

Longitudinal Studies of Patient With FPDMM

Study Type:

OBSERVATIONAL

Last Updated:

2026-08-28

Start Date:

2019-03-28

Completion:

2028-12-31

Conditions

• Inherited Hematological Diseases
• Rare Diseases
• FPDMM

No Results Yet

NCT03841617 | RECRUITING | PHASE2

30 participants

The Use of 124-I-PET/CT Whole Body and Lesional Dosimetry in Differentiated Thyroid Cancer

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-28

Start Date:

2019-07-29

Completion:

2035-11-01

Conditions

• Thyroid Cancer

Interventions

• DRUG
• RADIATION
• OTHER

No Results Yet

NCT03793179 | ACTIVE_NOT_RECRUITING | PHASE3

600 participants

Testing the Timing of Pembrolizumab Alone or With Chemotherapy as First Line Treatment and Maintenance in Non-small Cell Lung Cancer

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-28

Start Date:

2019-04-05

Completion:

2027-09-30

Conditions

• Lung Non-Squamous Non-Small Cell Carcinoma
• Stage IIIB Lung Cancer AJCC v8
• Stage IIIC Lung Cancer AJCC v8
• Stage IV Lung Cancer AJCC v8

Interventions

• PROCEDURE
• DRUG
• BIOLOGICAL

No Results Yet

NCT03783143 | COMPLETED

8524 participants

Prevalence and Incidence of Lassa Virus Infection in Southern Mali

Study Type:

OBSERVATIONAL

Last Updated:

2026-08-28

Start Date:

2020-12-04

Completion:

2024-07-25

Conditions

• Lassa Virus Infection

No Results Yet

NCT03775265 | ACTIVE_NOT_RECRUITING | PHASE3

475 participants

Chemoradiotherapy With or Without Atezolizumab in Treating Patients With Localized Muscle Invasive Bladder Cancer

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-28

Start Date:

2019-06-03

Completion:

2027-06-01

Conditions

• Bladder Urothelial Carcinoma
• Muscle Invasive Bladder Carcinoma
• Stage II Bladder Cancer AJCC v8
• Stage IIIA Bladder Cancer AJCC v8

Interventions

• DRUG
• PROCEDURE
• OTHER
• RADIATION

No Results Yet

NCT03767244 | ACTIVE_NOT_RECRUITING | PHASE3

2517 participants

A Study of Apalutamide in Participants With High-Risk, Localized or Locally Advanced Prostate Cancer Who Are Candidates for Radical Prostatectomy

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-28

Start Date:

2019-06-11

Completion:

2026-12-01

Conditions

• Prostatic Neoplasms

Interventions

• DRUG

No Results Yet

NCT03737981 | ACTIVE_NOT_RECRUITING | PHASE3

465 participants

Testing the Addition of a New Anti-cancer Drug, Venetoclax, to the Usual Treatment (Ibrutinib and Obinutuzumab) in Untreated, Older Patients With Chronic Lymphocytic Leukemia

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-28

Start Date:

2019-01-31

Completion:

2025-01-17

Conditions

• Chronic Lymphocytic Leukemia
• Small Lymphocytic Lymphoma

Interventions

• DRUG
• BIOLOGICAL
• OTHER

Results Available

NCT03701282 | ACTIVE_NOT_RECRUITING | PHASE3

720 participants

Assessing the Ability of Combination Treatment With Venetoclax to Permit Time Limited Therapy in Chronic Lymphocytic Leukemia

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-28

Start Date:

2019-02-12

Completion:

2028-05-07

Conditions

• Chronic Lymphocytic Leukemia
• Small Lymphocytic Lymphoma

Interventions

• PROCEDURE
• DRUG
• BIOLOGICAL
• OTHER

No Results Yet

NCT03660826 | ACTIVE_NOT_RECRUITING | PHASE2

288 participants

Testing the Combination of Olaparib and Durvalumab, Cediranib and Durvalumab, Olaparib and Capivasertib, and Cediranib Alone in Recurrent or Refractory Endometrial Cancer Following the Earlier Phase of the Study That Tested Olaparib and Cediranib in Comparison to Cediranib Alone, and Olaparib Alone

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-28

Start Date:

2018-09-27

Completion:

2024-12-06

Conditions

• Endometrial Adenocarcinoma
• Endometrial Mixed Cell Adenocarcinoma
• Endometrial Serous Adenocarcinoma
• Endometrial Undifferentiated Carcinoma
• Endometrioid Adenocarcinoma
• Stage IV Uterine Corpus Carcinoma or Carcinosarcoma AJCC v8

Interventions

• PROCEDURE
• DRUG
• BIOLOGICAL

Results Available

NCT03651505 | ACTIVE_NOT_RECRUITING

782 participants

X-linked Hypophosphatemia Disease Monitoring Program

Study Type:

OBSERVATIONAL

Last Updated:

2026-08-28

Start Date:

2018-07-16

Completion:

2032-12-31

Conditions

• X-linked Hypophosphatemia
• Hypophosphatemic Rickets

Interventions

• OTHER

No Results Yet

NCT03619551 | ACTIVE_NOT_RECRUITING | PHASE2

56 participants

Conditioning SCID Infants Diagnosed Early

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-28

Start Date:

2018-10-22

Completion:

2027-12-01

Conditions

• SCID

Interventions

• DRUG
• DEVICE

No Results Yet

NCT03595124 | ACTIVE_NOT_RECRUITING | PHASE2

15 participants

A Study to Compare Treatments for a Type of Kidney Cancer Called TFE/Translocation Renal Cell Carcinoma (tRCC)

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-28

Start Date:

2019-01-08

Completion:

2024-09-30

Conditions

• Metastatic Renal Cell Carcinoma
• Stage III Renal Cell Cancer AJCC v8
• Stage IV Renal Cell Cancer AJCC v8
• TFE3-Rearranged Renal Cell Carcinoma
• Unresectable Renal Cell Carcinoma

Interventions

• DRUG
• BIOLOGICAL

Results Available

NCT03523442 | ACTIVE_NOT_RECRUITING | PHASE1

19 participants

A Study of Androgen Receptor (AR) Antagonist Apalutamide in Chinese Participants With Metastatic Castration-Resistant Prostate Cancer

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-28

Start Date:

2018-08-31

Completion:

2019-07-09

Conditions

• Prostatic Neoplasms

Interventions

• DRUG

No Results Yet

NCT03492177 | ACTIVE_NOT_RECRUITING | PHASE2

63 participants

A Clinical Study of to Confirm the Doses of Selexipag in Children With Pulmonary Arterial Hypertension

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-28

Start Date:

2018-07-23

Completion:

2022-03-28

Conditions

• Pulmonary Arterial Hypertension

Interventions

• DRUG

Results Available

NCT03473743 | ACTIVE_NOT_RECRUITING | PHASE1/PHASE2

125 participants

A Study of Erdafitinib in Participants With Metastatic or Locally Advanced Urothelial Cancer

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-28

Start Date:

2018-04-05

Completion:

2022-09-30

Conditions

• Urothelial Carcinoma

Interventions

• DRUG

Results Available

NCT03457948 | COMPLETED | PHASE2

32 participants

Pembrolizumab With Liver-Directed or Peptide Receptor Radionuclide Therapy for Neuroendocrine Tumors and Liver Metastases

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-28

Start Date:

2018-08-27

Completion:

2025-07-31

Conditions

• Metastatic Malignant Neoplasm in the Liver
• Neuroendocrine Neoplasm

Interventions

• PROCEDURE
• BIOLOGICAL
• DEVICE

Results Available

NCT03431350 | ACTIVE_NOT_RECRUITING | PHASE2

136 participants

A Study of Niraparib Combination Therapies for the Treatment of Metastatic Castration-Resistant Prostate Cancer

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-28

Start Date:

2018-03-02

Completion:

2021-08-31

Conditions

• Prostatic Neoplasms, Castration-Resistant

Interventions

• DRUG

Results Available

NCT03429036 | RECRUITING

1000 participants

Biospecimen Procurement for Head and Neck Disorders

Study Type:

OBSERVATIONAL

Last Updated:

2026-08-28

Start Date:

2018-05-23

Completion:

2029-06-03

Conditions

• Hearing Disorder
• Oral Mucosal Disease
• Pharyngeal Neoplasm
• Head and Neck Neoplasms
• Laryngeal Disease

No Results Yet

NCT03388619 | COMPLETED | PHASE1

30 participants

Highly Conformal, Hypofractionated, Focally Dose Escalated Post-Prostatectomy Radiotherapy

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-28

Start Date:

2018-01-17

Completion:

2023-12-29

Conditions

• Cancer Of Prostate
• Prostate Neoplasms
• Prostate Cancer
• Neoplasms of Prostate
• Prostatic Cancer

Interventions

• RADIATION
• DIAGNOSTIC_TEST
• DRUG

Results Available

NCT03388606 | RECRUITING

4100 participants

Characterization and Treatment of Adolescent Depression

Study Type:

OBSERVATIONAL

Last Updated:

2026-08-28

Start Date:

2017-12-28

Completion:

2027-07-01

Conditions

• Depression

Interventions

• BEHAVIORAL

No Results Yet

NCT03375242 | COMPLETED

97 participants

Safety and Efficacy of Xalkori ROS1

Study Type:

OBSERVATIONAL

Last Updated:

2026-08-28

Start Date:

2017-10-25

Completion:

2026-08-10

Conditions

• Non-small Cell Lung Cancer

Interventions

• DRUG

No Results Yet

NCT03371719 | ACTIVE_NOT_RECRUITING | PHASE2

298 participants

Radiation Therapy With or Without Apalutamide in Treating Patients With Recurrent Prostate Cancer, the BALANCE Trial

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-28

Start Date:

2018-06-20

Completion:

2025-03-10

Conditions

• Recurrent Prostate Carcinoma
• Stage III Prostate Adenocarcinoma AJCC v7
• Stage IV Prostate Adenocarcinoma AJCC v7

Interventions

• DRUG
• RADIATION
• OTHER

Results Available

NCT03366155 | COMPLETED | PHASE2

24 participants

Hepatic Artery Infusion Pump Chemotherapy With Floxuridine and Dexamethasone in Combination With Systemic Chemotherapy for Patients With Colorectal Cancer Metastatic to the Liver

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-28

Start Date:

2019-06-24

Completion:

2025-11-13

Conditions

• Colorectal Cancer
• Liver Metastases
• Colorectal Adenocarcinoma
• Colorectal Cancer With Hepatic Metastases
• Colorectal Carcinoma

Interventions

• DEVICE
• DRUG
• PROCEDURE
• DIAGNOSTIC_TEST

Results Available

NCT03337360 | COMPLETED | NA

1200 participants

The Impact of a Nutritional Supplement (Impryl®) on Male Fertility

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-28

Start Date:

2018-04-23

Completion:

2024-12-01

Conditions

• Male Subfertility

Interventions

• DIETARY_SUPPLEMENT
• OTHER

No Results Yet

NCT03331250 | COMPLETED | PHASE2

13 participants

Eribulin in Angiosarcoma and Epithelioid Hemangioendothelioma (EHE)

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-28

Start Date:

2018-01-18

Completion:

2022-03-31

Conditions

• Angiosarcoma
• Epithelioid Hemangioendothelioma

Interventions

• DRUG

Results Available

NCT03328325 | TERMINATED | PHASE4

152 participants

Age and Response to Flu Vaccines

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-28

Start Date:

2017-12-14

Completion:

2020-02-09

Conditions

• Influenza
• Influenza Immunisation

Interventions

• BIOLOGICAL

Results Available

NCT03294460 | RECRUITING | PHASE1

128 participants

Nicotinic Receptor Genetic Variation and Alcohol Reward

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-28

Start Date:

2019-06-10

Completion:

2026-12-31

Conditions

• Alcohol Drinking

Interventions

• DRUG

No Results Yet

NCT03244384 | ACTIVE_NOT_RECRUITING | PHASE3

739 participants

Testing MK-3475 (Pembrolizumab) After Surgery for Localized Muscle-Invasive Bladder Cancer and Locally Advanced Urothelial Cancer

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-28

Start Date:

2017-11-03

Completion:

2026-10-31

Conditions

• Localized Renal Pelvis and Ureter Urothelial Carcinoma
• Locally Advanced Bladder Urothelial Carcinoma
• Locally Advanced Renal Pelvis and Ureter Urothelial Carcinoma
• Locally Advanced Ureter Urothelial Carcinoma
• Locally Advanced Urothelial Carcinoma
• Stage II Bladder Urothelial Carcinoma AJCC v6 and v7
• Stage II Renal Pelvis and Ureter Cancer AJCC v7
• Stage II Ureter Cancer AJCC v7
• Stage III Bladder Urothelial Carcinoma AJCC v6 and v7
• Stage III Renal Pelvis and Ureter Cancer AJCC v7
• Stage III Ureter Cancer AJCC v7

Interventions

• PROCEDURE
• OTHER
• BIOLOGICAL

No Results Yet

NCT03233711 | ACTIVE_NOT_RECRUITING | PHASE3

344 participants

Nivolumab After Combined Modality Therapy in Treating Patients With High Risk Stage II-IIIB Anal Cancer

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-28

Start Date:

2018-07-05

Completion:

2027-12-31

Conditions

• Anal Basaloid Carcinoma
• Anal Canal Cloacogenic Carcinoma
• Anal Margin Squamous Cell Carcinoma
• Stage IIB Anal Cancer AJCC v8
• Stage III Anal Cancer AJCC v8

Interventions

• PROCEDURE
• BIOLOGICAL
• OTHER

No Results Yet

NCT03218488 | ACTIVE_NOT_RECRUITING

135 participants

A Safety Study of Ustekinumab in the Treatment of Pediatric Participants Aged 6 Years and Older With Moderate to Severe Plaque Psoriasis

Study Type:

OBSERVATIONAL

Last Updated:

2026-08-28

Start Date:

2017-10-25

Completion:

2032-08-31

Conditions

• Psoriasis

Interventions

• DRUG

No Results Yet

NCT03162549 | ENROLLING_BY_INVITATION

2287 participants

CorEvitas Inflammatory Bowel Disease (IBD) Registry

Study Type:

OBSERVATIONAL

Last Updated:

2026-08-28

Start Date:

2017-03-27

Completion:

2100-12-31

Conditions

• Inflammatory Bowel Diseases

No Results Yet

NCT03153475 | ACTIVE_NOT_RECRUITING | NA

400 participants

ATTUNE Revision System in the Revision Total Knee Arthroplasty Population

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-28

Start Date:

2017-05-30

Completion:

2029-03-31

Conditions

• Revision Total Knee Arthroplasty

Interventions

• DEVICE

No Results Yet

NCT03153449 | ACTIVE_NOT_RECRUITING | NA

400 participants

ATTUNE® Revision- Complex Primary in Total Knee Arthroplasty Population

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-28

Start Date:

2017-09-19

Completion:

2028-04-17

Conditions

• Primary Knee Arthroplasty

Interventions

• DEVICE

No Results Yet

NCT03145181 | ACTIVE_NOT_RECRUITING | PHASE1

302 participants

Dose Escalation Study of Teclistamab, a Humanized BCMA*CD3 Bispecific Antibody, in Participants With Relapsed or Refractory Multiple Myeloma

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-28

Start Date:

2017-05-16

Completion:

2025-09-25

Conditions

• Hematological Malignancies

Interventions

• DRUG

No Results Yet

NCT03109197 | RECRUITING

1600 participants

Sudden Unexplained Death in Childhood (SUDC) Registry

Study Type:

OBSERVATIONAL

Last Updated:

2026-08-28

Start Date:

2014-10-01

Completion:

2028-11-30

Conditions

• Sudden Unexplained Death Syndrome
• Sudden Unexplained Death in Childhood

Interventions

• OTHER

No Results Yet

NCT03076554 | ACTIVE_NOT_RECRUITING | PHASE2

56 participants

A Pilot Study to Investigate the Safety and Clinical Activity of Avelumab (MSB0010718C) in Thymoma and Thymic Carcinoma After Progression on Platinum-Based Chemotherapy

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-28

Start Date:

2017-04-19

Completion:

2027-03-30

Conditions

• Thymoma
• Thymic Carcinoma

Interventions

• DRUG

No Results Yet