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Clinical Trials

Showing trials with last updates posted in 2026.

NCT02465060 | ACTIVE_NOT_RECRUITING | PHASE2
6452 participants

Targeted Therapy Directed by Genetic Testing in Treating Patients With Advanced Refractory Solid Tumors, Lymphomas, or Multiple Myeloma (The MATCH Screening Trial)

Study Type:
INTERVENTIONAL
Last Updated:
2026-08-28
Start Date:
2015-08-17
Completion:
2026-12-31
Conditions
  • Advanced Lymphoma
  • Advanced Malignant Solid Neoplasm
  • Bladder Carcinoma
  • Breast Carcinoma
  • Cervical Carcinoma
  • Colon Carcinoma
  • Colorectal Carcinoma
  • Endometrial Carcinoma
  • Esophageal Carcinoma
  • Exocrine Pancreas Carcinoma
  • Gastric Carcinoma
  • Glioma
  • Head and Neck Carcinoma
  • Hematopoietic and Lymphoid Cell Neoplasm
  • Kidney Carcinoma
  • Liver Carcinoma
  • Lung Carcinoma
  • Lymphoma
  • Malignant Uterine Corpus Neoplasm
  • Malignant Uterine Neoplasm
  • Melanoma
  • Multiple Myeloma
  • Ovarian Carcinoma
  • Prostate Carcinoma
  • Rectal Carcinoma
  • Recurrent Bladder Carcinoma
  • Recurrent Breast Carcinoma
  • Recurrent Cervical Carcinoma
  • Recurrent Colon Carcinoma
  • Recurrent Colorectal Carcinoma
  • Recurrent Esophageal Carcinoma
  • Recurrent Gastric Carcinoma
  • Recurrent Glioma
  • Recurrent Head and Neck Carcinoma
  • Recurrent Liver Carcinoma
  • Recurrent Lung Carcinoma
  • Recurrent Lymphoma
  • Recurrent Malignant Solid Neoplasm
  • Recurrent Malignant Uterine Corpus Neoplasm
  • Recurrent Melanoma
  • Recurrent Multiple Myeloma
  • Recurrent Ovarian Carcinoma
  • Recurrent Pancreatic Carcinoma
  • Recurrent Prostate Carcinoma
  • Recurrent Rectal Carcinoma
  • Recurrent Skin Carcinoma
  • Recurrent Thyroid Gland Carcinoma
  • Refractory Lymphoma
  • Refractory Malignant Solid Neoplasm
  • Refractory Multiple Myeloma
  • Skin Carcinoma
  • Thyroid Gland Carcinoma
Interventions
  • DRUG
  • PROCEDURE
  • OTHER
  • BIOLOGICAL
No Results Yet
NCT02311933 | ACTIVE_NOT_RECRUITING | PHASE2
81 participants

Tamoxifen Citrate or Z-Endoxifen Hydrochloride in Treating Patients With Locally Advanced or Metastatic, Estrogen Receptor-Positive, HER2-Negative Breast Cancer

Study Type:
INTERVENTIONAL
Last Updated:
2026-08-28
Start Date:
2015-05-28
Completion:
2020-11-06
Conditions
  • Recurrent Breast Carcinoma
  • Stage III Breast Cancer AJCC v7
  • Stage IIIA Breast Cancer AJCC v7
  • Stage IIIB Breast Cancer AJCC v7
  • Stage IIIC Breast Cancer AJCC v7
  • Stage IV Breast Cancer AJCC v6 and v7
Interventions
  • DRUG
  • OTHER
Results Available
NCT02257528 | ACTIVE_NOT_RECRUITING | PHASE2
26 participants

Nivolumab in Treating Patients With Persistent, Recurrent, or Metastatic Cervical Cancer

Study Type:
INTERVENTIONAL
Last Updated:
2026-08-28
Start Date:
2015-05-18
Completion:
2019-03-05
Conditions
  • Cervical Adenocarcinoma
  • Cervical Adenosquamous Carcinoma
  • Recurrent Cervical Carcinoma
  • Stage IV Cervical Cancer AJCC v6 and v7
  • Stage IVA Cervical Cancer AJCC v6 and v7
  • Stage IVB Cervical Cancer AJCC v6 and v7
Interventions
  • OTHER
  • BIOLOGICAL
Results Available
NCT02224781 | ACTIVE_NOT_RECRUITING | PHASE3
267 participants

Dabrafenib and Trametinib Followed by Ipilimumab and Nivolumab or Ipilimumab and Nivolumab Followed by Dabrafenib and Trametinib in Treating Patients With Stage III-IV BRAFV600 Melanoma

Study Type:
INTERVENTIONAL
Last Updated:
2026-08-28
Start Date:
2015-09-08
Completion:
2023-09-30
Conditions
  • Clinical Stage III Cutaneous Melanoma AJCC v8
  • Clinical Stage IV Cutaneous Melanoma AJCC v8
  • Metastatic Melanoma
  • Recurrent Melanoma
  • Unresectable Melanoma
Interventions
  • PROCEDURE
  • DRUG
  • BIOLOGICAL
  • OTHER
Results Available
NCT02194738 | ACTIVE_NOT_RECRUITING | NA
8300 participants

Genetic Testing in Screening Patients With Stage IB-IIIA Non-small Cell Lung Cancer That Has Been or Will Be Removed by Surgery (The ALCHEMIST Screening Trial)

Study Type:
INTERVENTIONAL
Last Updated:
2026-08-28
Start Date:
2014-09-26
Completion:
2026-09-28
Conditions
  • Stage IB Lung Non-Small Cell Carcinoma AJCC v7
  • Stage II Lung Non-Small Cell Cancer AJCC v7
  • Stage IIA Lung Cancer AJCC v8
  • Stage IIB Lung Cancer AJCC v8
  • Stage IIIA Lung Cancer AJCC v8
  • Stage IIIA Lung Non-Small Cell Cancer AJCC v7
  • Stage IIIB Lung Cancer AJCC v8
Interventions
  • PROCEDURE
  • DRUG
  • OTHER
  • BIOLOGICAL
No Results Yet
NCT02152995 | ACTIVE_NOT_RECRUITING | PHASE2
34 participants

Trametinib in Increasing Tumoral Iodine Incorporation in Patients With Recurrent or Metastatic Thyroid Cancer

Study Type:
INTERVENTIONAL
Last Updated:
2026-08-28
Start Date:
2014-08-14
Completion:
2021-08-25
Conditions
  • Metastatic Thyroid Gland Carcinoma
  • Poorly Differentiated Thyroid Gland Carcinoma
  • Recurrent Thyroid Gland Carcinoma
  • Refractory Thyroid Gland Carcinoma
  • Stage IV Thyroid Gland Follicular Carcinoma AJCC v7
  • Stage IV Thyroid Gland Papillary Carcinoma AJCC v7
  • Stage IVA Thyroid Gland Follicular Carcinoma AJCC v7
  • Stage IVA Thyroid Gland Papillary Carcinoma AJCC v7
  • Stage IVB Thyroid Gland Follicular Carcinoma AJCC v7
  • Stage IVB Thyroid Gland Papillary Carcinoma AJCC v7
  • Stage IVC Thyroid Gland Follicular Carcinoma AJCC v7
  • Stage IVC Thyroid Gland Papillary Carcinoma AJCC v7
Interventions
  • PROCEDURE
  • OTHER
  • RADIATION
  • DRUG
Results Available
NCT02146170 | RECRUITING
2000 participants

Tissue Procurement and Natural History Study of People With Non-Small Cell Lung Cancer, Small Cell Lung Cancer, Extrapulmonary Small Cell Cancer, Pulmonary Neuroendocrine Tumors, and Thymic Epithelial Tumors

Study Type:
OBSERVATIONAL
Last Updated:
2026-08-28
Start Date:
2014-05-28
Completion:
2028-12-31
Conditions
  • Non-Small Cell Lung Cancer
  • Small Cell Lung Cancer
  • Extrapulmonary Small Cell Cancer
  • Pulmonary Neuroendocrine Tumors
  • Thymic Epithelial Tumors
No Results Yet
NCT02142803 | ACTIVE_NOT_RECRUITING | PHASE1
50 participants

TORC1/2 Inhibitor MLN0128 and Bevacizumab in Treating Patients With Recurrent Glioblastoma or Advanced Solid Tumors

Study Type:
INTERVENTIONAL
Last Updated:
2026-08-28
Start Date:
2014-05-20
Completion:
2020-12-31
Conditions
  • Adult Glioblastoma
  • Endometrial Clear Cell Adenocarcinoma
  • Endometrial Serous Adenocarcinoma
  • Ovarian Clear Cell Cystadenocarcinoma
  • Ovarian Endometrioid Adenocarcinoma
  • Ovarian Mucinous Cystadenocarcinoma
  • Ovarian Serous Cystadenocarcinoma
  • Recurrent Fallopian Tube Carcinoma
  • Recurrent Malignant Uterine Corpus Neoplasm
  • Recurrent Ovarian Carcinoma
  • Recurrent Primary Peritoneal Carcinoma
  • Solid Neoplasm
  • Stage IIIA Fallopian Tube Cancer AJCC v7
  • Stage IIIA Ovarian Cancer AJCC v6 and v7
  • Stage IIIA Primary Peritoneal Cancer AJCC v7
  • Stage IIIB Fallopian Tube Cancer AJCC v7
  • Stage IIIB Ovarian Cancer AJCC v6 and v7
  • Stage IIIB Primary Peritoneal Cancer AJCC v7
  • Stage IIIC Fallopian Tube Cancer AJCC v7
  • Stage IIIC Ovarian Cancer AJCC v6 and v7
  • Stage IIIC Primary Peritoneal Cancer AJCC v7
  • Stage IV Fallopian Tube Cancer AJCC v6 and v7
  • Stage IV Ovarian Cancer AJCC v6 and v7
  • Stage IV Primary Peritoneal Cancer AJCC v7
Interventions
  • BIOLOGICAL
  • OTHER
  • DRUG
Results Available
NCT02135042 | ACTIVE_NOT_RECRUITING | PHASE2/PHASE3
924 participants

Individualized Treatment in Treating Patients With Stage II-IVB Nasopharyngeal Cancer Based on EBV DNA

Study Type:
INTERVENTIONAL
Last Updated:
2026-08-28
Start Date:
2014-07-01
Completion:
2026-12-01
Conditions
  • EBV Infection
  • Stage II Nasopharyngeal Carcinoma AJCC v7
  • Stage III Nasopharyngeal Carcinoma AJCC v7
  • Stage IVA Nasopharyngeal Carcinoma AJCC v7
  • Stage IVB Nasopharyngeal Carcinoma AJCC v7
Interventions
  • PROCEDURE
  • DRUG
  • OTHER
  • RADIATION
No Results Yet
NCT01886872 | ACTIVE_NOT_RECRUITING | PHASE3
547 participants

Rituximab and Bendamustine Hydrochloride, Rituximab and Ibrutinib, or Ibrutinib Alone in Treating Older Patients With Previously Untreated Chronic Lymphocytic Leukemia

Study Type:
INTERVENTIONAL
Last Updated:
2026-08-28
Start Date:
2014-01-15
Completion:
2018-08-07
Conditions
  • Stage I Chronic Lymphocytic Leukemia
  • Stage II Chronic Lymphocytic Leukemia
  • Stage III Chronic Lymphocytic Leukemia
  • Stage IV Chronic Lymphocytic Leukemia
Interventions
  • DRUG
  • PROCEDURE
  • OTHER
  • BIOLOGICAL
Results Available
NCT01856192 | ACTIVE_NOT_RECRUITING | PHASE2
349 participants

Rituximab and Combination Chemotherapy With or Without Lenalidomide in Treating Patients With Newly Diagnosed Stage II-IV Diffuse Large B Cell Lymphoma

Study Type:
INTERVENTIONAL
Last Updated:
2026-08-28
Start Date:
2013-08-27
Completion:
2020-03-26
Conditions
  • Ann Arbor Stage II Diffuse Large B-Cell Lymphoma
  • Ann Arbor Stage III Diffuse Large B-Cell Lymphoma
  • Ann Arbor Stage IV Diffuse Large B-Cell Lymphoma
Interventions
  • DRUG
  • OTHER
  • BIOLOGICAL
Results Available
NCT01841736 | ACTIVE_NOT_RECRUITING | PHASE2
171 participants

Pazopanib Hydrochloride in Treating Patients With Progressive Carcinoid Tumors

Study Type:
INTERVENTIONAL
Last Updated:
2026-08-28
Start Date:
2013-09-20
Completion:
2019-03-05
Conditions
  • Foregut Neuroendocrine Tumor
  • Hindgut Neuroendocrine Tumor
  • Metastatic Digestive System Neuroendocrine Tumor G1
  • Metastatic Neuroendocrine Tumor
  • Midgut Neuroendocrine Tumor G1
  • Neuroendocrine Tumor G2
  • Recurrent Digestive System Neuroendocrine Tumor G1
  • Regional Digestive System Neuroendocrine Tumor G1
Interventions
  • PROCEDURE
  • OTHER
  • DRUG
Results Available
NCT01631617 | RECRUITING | PHASE2
130 participants

Effects of Treatments on Atopic Dermatitis

Study Type:
INTERVENTIONAL
Last Updated:
2026-08-28
Start Date:
2012-09-18
Completion:
2027-01-01
Conditions
  • Eczema
  • Dermatitis
  • Skin Diseases, Genetic
  • Dermatitis, Atopic
  • Skin Diseases
Interventions
  • DRUG
  • OTHER
No Results Yet
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