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Clinical Trials

Showing trials with last updates posted in 2026.

NCT04696315 | COMPLETED
800 participants

Early Diagnosis of SCD Based on Radiogenomics

Study Type:
OBSERVATIONAL
Last Updated:
2026-08-21
Start Date:
2021-01-01
Completion:
2024-12-31
Conditions
  • Alzheimer Disease
  • Subjective Cognitive Decline
  • Neuroimaging
  • Gene
Interventions
  • DIAGNOSTIC_TEST
No Results Yet
NCT04576091 | ACTIVE_NOT_RECRUITING | PHASE1
7 participants

Testing the Addition of an Anti-cancer Drug, BAY 1895344, With Radiation Therapy to the Usual Pembrolizumab Treatment for Recurrent Head and Neck Cancer

Study Type:
INTERVENTIONAL
Last Updated:
2026-08-21
Start Date:
2022-07-06
Completion:
2025-07-22
Conditions
  • Clinical Stage III HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8
  • Clinical Stage IV HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8
  • Recurrent Head and Neck Cutaneous Squamous Cell Carcinoma
  • Recurrent Head and Neck Squamous Cell Carcinoma
  • Recurrent Hypopharyngeal Squamous Cell Carcinoma
  • Recurrent Laryngeal Squamous Cell Carcinoma
  • Recurrent Oral Cavity Squamous Cell Carcinoma
  • Recurrent Oropharyngeal Squamous Cell Carcinoma
  • Recurrent Paranasal Sinus Squamous Cell Carcinoma
  • Recurrent Salivary Gland Carcinoma
  • Stage III Head and Neck Cutaneous Squamous Cell Carcinoma AJCC v8
  • Stage III Hypopharyngeal Carcinoma AJCC v8
  • Stage III Laryngeal Cancer AJCC v8
  • Stage III Lip and Oral Cavity Cancer AJCC v8
  • Stage III Major Salivary Gland Cancer AJCC v8
  • Stage III Oropharyngeal (p16-Negative) Carcinoma AJCC v8
  • Stage III Sinonasal Cancer AJCC v8
  • Stage IV Head and Neck Cutaneous Squamous Cell Carcinoma AJCC v8
  • Stage IV Hypopharyngeal Carcinoma AJCC v8
  • Stage IV Laryngeal Cancer AJCC v8
  • Stage IV Lip and Oral Cavity Cancer AJCC v8
  • Stage IV Major Salivary Gland Cancer AJCC v8
  • Stage IV Oropharyngeal (p16-Negative) Carcinoma AJCC v8
  • Stage IV Sinonasal Cancer AJCC v8
  • Unresectable Head and Neck Cutaneous Squamous Cell Carcinoma
  • Unresectable Head and Neck Squamous Cell Carcinoma
  • Unresectable Hypopharyngeal Squamous Cell Carcinoma
  • Unresectable Laryngeal Squamous Cell Carcinoma
  • Unresectable Oral Cavity Squamous Cell Carcinoma
  • Unresectable Oropharyngeal Squamous Cell Carcinoma
  • Unresectable Paranasal Sinus Squamous Cell Carcinoma
  • Unresectable Salivary Gland Squamous Cell Carcinoma
Interventions
  • PROCEDURE
  • DRUG
  • BIOLOGICAL
  • OTHER
  • RADIATION
Results Available
NCT04535401 | ACTIVE_NOT_RECRUITING | PHASE1
10 participants

Testing the Addition of an Anticancer Drug, BAY 1895344, to the Usual Chemotherapy With FOLFIRI in Advanced or Metastatic Cancers of the Stomach and Intestines

Study Type:
INTERVENTIONAL
Last Updated:
2026-08-21
Start Date:
2021-08-13
Completion:
2025-02-19
Conditions
  • Advanced Colorectal Carcinoma
  • Advanced Digestive System Carcinoma
  • Advanced Gastric Carcinoma
  • Advanced Gastroesophageal Junction Adenocarcinoma
  • Clinical Stage III Gastric Cancer AJCC v8
  • Clinical Stage III Gastroesophageal Junction Adenocarcinoma AJCC v8
  • Clinical Stage IV Gastric Cancer AJCC v8
  • Clinical Stage IV Gastroesophageal Junction Adenocarcinoma AJCC v8
  • Metastatic Colorectal Carcinoma
  • Metastatic Digestive System Carcinoma
  • Metastatic Gastric Carcinoma
  • Metastatic Gastroesophageal Junction Adenocarcinoma
  • Stage III Colorectal Cancer AJCC v8
  • Stage IV Colorectal Cancer AJCC v8
Interventions
  • PROCEDURE
  • DRUG
Results Available
NCT04438031 | ACTIVE_NOT_RECRUITING | NA
815 participants

Navigation Study: Durham

Study Type:
INTERVENTIONAL
Last Updated:
2026-08-21
Start Date:
2020-11-20
Completion:
2030-06-30
Conditions
  • Prenatal; Postnatal
Interventions
  • BEHAVIORAL
No Results Yet
NCT04376333 | ACTIVE_NOT_RECRUITING | NA
160 participants

Individualized Assessment and Treatment for TMD

Study Type:
INTERVENTIONAL
Last Updated:
2026-08-21
Start Date:
2021-02-03
Completion:
2027-03-31
Conditions
  • Temporomandibular Joint Disorders
  • Orofacial Pain
Interventions
  • BEHAVIORAL
  • OTHER
No Results Yet
NCT04278404 | RECRUITING
5000 participants

Pharmacokinetics, Pharmacodynamics, and Safety Profile of Understudied Drugs Administered to Children Per Standard of Care (POPS)

Study Type:
OBSERVATIONAL
Last Updated:
2026-08-21
Start Date:
2020-03-05
Completion:
2026-11-30
Conditions
  • Coronavirus Infection (COVID-19)
  • Pulmonary Arterial Hypertension
  • Urinary Tract Infections in Children
  • Hypertension
  • Pain
  • Hyperphosphatemia
  • Primary Hyperaldosteronism
  • Edema
  • Hypokalemia
  • Heart Failure
  • Hemophilia
  • Menorrhagia
  • Insomnia
  • Pneumonia
  • Skin Infection
  • Arrythmia
  • Asthma in Children
  • Bronchopulmonary Dysplasia
  • Adrenal Insufficiency
  • Fibrinolysis; Hemorrhage
  • Attention Deficit Hyperactivity Disorder
  • Multisystem Inflammatory Syndrome in Children (MIS-C)
  • Kawasaki Disease
  • Coagulation Disorder
  • Down Syndrome
Interventions
  • DRUG
No Results Yet
NCT04258670 | COMPLETED
86 participants

Spontaneous Antigenemia in Loiasis

Study Type:
OBSERVATIONAL
Last Updated:
2026-08-21
Start Date:
2020-01-23
Completion:
2021-05-31
Conditions
  • Loiasis
  • Lymphatic Filariasis
Interventions
  • OTHER
No Results Yet
NCT04231877 | ACTIVE_NOT_RECRUITING | PHASE1
56 participants

Polatuzumab Vedotin and Combination Chemotherapy With or Without Glofitamab for the Treatment of Untreated Aggressive Large B-cell Lymphoma

Study Type:
INTERVENTIONAL
Last Updated:
2026-08-21
Start Date:
2020-10-27
Completion:
2026-12-01
Conditions
  • Aggressive Non-Hodgkin Lymphoma
  • ALK-Positive Large B-Cell Lymphoma
  • Diffuse Large B-Cell Lymphoma, Not Otherwise Specified
  • EBV-Positive Diffuse Large B-Cell Lymphoma, Not Otherwise Specified
  • High Grade B-Cell Lymphoma With MYC and BCL2 and/or BCL6 Rearrangements
  • High Grade B-Cell Lymphoma, Not Otherwise Specified
  • Primary Mediastinal Large B-Cell Lymphoma
  • T-Cell/Histiocyte-Rich Large B-Cell Lymphoma
  • Gray-Zone Lymphoma
Interventions
  • DRUG
  • BIOLOGICAL
  • PROCEDURE
No Results Yet
NCT04189770 | ACTIVE_NOT_RECRUITING
200 participants

Lifestyle Behavior Influences Among African American Patients With Stage 0-III Prostate Cancer Survivors and Their Partners

Study Type:
OBSERVATIONAL
Last Updated:
2026-08-21
Start Date:
2020-02-26
Completion:
2028-02-28
Conditions
  • Cancer Survivor
  • Partner
  • Spouse
  • Stage I Prostate Cancer AJCC v8
  • Stage II Prostate Cancer AJCC v8
  • Stage IIA Prostate Cancer AJCC v8
  • Stage IIB Prostate Cancer AJCC v8
  • Stage IIC Prostate Cancer AJCC v8
  • Stage III Prostate Cancer AJCC v8
  • Stage IIIA Prostate Cancer AJCC v8
  • Stage IIIB Prostate Cancer AJCC v8
  • Stage IIIC Prostate Cancer AJCC v8
Interventions
  • DEVICE
  • OTHER
No Results Yet
NCT04147494 | ACTIVE_NOT_RECRUITING | EARLY_PHASE1
29 participants

Experimental PET Imaging Scans Before Cancer Surgery to Study the Amount of PET Tracer Accumulated in Normal and Cancer Tissues

Study Type:
INTERVENTIONAL
Last Updated:
2026-08-21
Start Date:
2019-11-05
Completion:
2030-06-01
Conditions
  • Breast Carcinoma
  • Colon Carcinoma
  • Esophageal Carcinoma
  • Gastric Carcinoma
  • Head and Neck Carcinoma
  • Kidney Carcinoma
  • Lung Carcinoma
  • Ovarian Carcinoma
  • Pancreatic Carcinoma
  • Solid Neoplasm
  • Uterine Corpus Cancer
Interventions
  • PROCEDURE
  • RADIATION
No Results Yet
NCT04102423 | RECRUITING
306 participants

CHIP/CCUS Natural History Protocol

Study Type:
OBSERVATIONAL
Last Updated:
2026-08-21
Start Date:
2020-03-03
Completion:
2033-09-15
Conditions
  • Clonal Hematopoiesis of Indeterminate Potential
  • Clonal Cytopenia of Undetermined Significance
No Results Yet
NCT04068194 | ACTIVE_NOT_RECRUITING | PHASE1/PHASE2
103 participants

Testing the Combination of New Anti-cancer Drug Peposertib With Avelumab and Radiation Therapy for Advanced/Metastatic Solid Tumors and Hepatobiliary Malignancies

Study Type:
INTERVENTIONAL
Last Updated:
2026-08-21
Start Date:
2020-04-07
Completion:
2027-07-01
Conditions
  • Locally Advanced Malignant Solid Neoplasm
  • Locally Advanced Unresectable Cholangiocarcinoma
  • Locally Advanced Unresectable Gallbladder Carcinoma
  • Locally Advanced Unresectable Malignant Solid Neoplasm
  • Metastatic Cholangiocarcinoma
  • Metastatic Gallbladder Carcinoma
  • Metastatic Malignant Solid Neoplasm
  • Stage III Gallbladder Cancer AJCC v8
  • Stage IV Gallbladder Cancer AJCC v8
  • Unresectable Malignant Solid Neoplasm
Interventions
  • DRUG
  • PROCEDURE
  • RADIATION
No Results Yet
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