Progressive Resistance Training Versus Total Hip Arthroplasty in Patients With Hip Osteoarthritis

Summary

Hip osteoarthritis is associated with joint pain, physical disability, decreased muscle strength and poor health status, and the most common cause for total hip arthroplasty. No studies have investigated the effect of total hip arthroplasty compared to non-surgical treatment in patients with end-stage hip osteoarthritis. This comparison is of upmost importance as it is unknown whether non-surgical treatment may be used as an alternate to surgery.

The purpose of this study is to investigate whether total hip arthroplasty followed by standard care is superior to progressive resistance training for improving hip function and pain in patients with end-stage hip osteoarthritis.

The hypothesis is that patients treated with total hip arthroplasty will improve more than patients treated with progressive resistance training.

Conditions

• Hip Osteoarthritis

Interventions

PROCEDURE

Total Hip Arthroplasty

Total hip arthroplasty following standard procedures.

OTHER

Progressive Resistance Training

Progressive resistance training based on available evidence on patients with hip osteoarthritis and designed in accordance with the "American College of Sports Medicine" (ACSM) recommendations for progression models in resistance training aiming at inducing muscle hypertrophy and increasing muscle strength and power.

Sponsors & Collaborators

• Odense University Hospital

  collaborator OTHER

• Naestved Hospital

  collaborator OTHER

• Aarhus University Hospital

  collaborator OTHER

• The Danish Rheumatism Association

  collaborator OTHER

• Region of Southern Denmark

  collaborator OTHER

• Association of Danish Physiotherapists

  collaborator OTHER

• The Research Council at Naestved-Slagelse-Ringsted Hospitals

  collaborator UNKNOWN

• Vejle Hospital

  lead OTHER

Principal Investigators

• Thomas Frydendal, PT, MSc · Vejle Hospital and University of Southern Denmark

• Søren Overgaard, Prof., MD · Odense University Hospital and University of Southern Denmark

• Inger Mechlenburg, Prof., DMSc · Aarhus University Hospital and Aarhus University

• Kim Gordon Ingwersen, PT, PhD · Vejle Hospital and University of Southern Denmark

• Lone Ramer Mikkelsen, PT, PhD · Silkeborg Regional Hospital

• Robin Christensen, Prof., PhD · The Parker Institute and Odense University Hospital

• Claus Varnum, PhD, MD · Vejle Hospital

• Henrik Morville Schrøder, PhD, MD · Naestved Hospital

Study Design

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

DOUBLE

Model

PARALLEL

Eligibility

Min Age

50 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2019-09-02

Primary Completion

2022-05-05

Completion

2026-06-30

Countries

• Denmark

Study Locations