Clinical Trials

NCT05545150 | COMPLETED | PHASE2

113 participants

Volumetric Specimen Imager Device for the Intraoperative Imaging of Patients With Breast Carcinoma and Breast Ductal Carcinoma In Situ, The VIVID Study

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-19

Start Date:

2022-11-28

Completion:

2024-07-26

Conditions

• Anatomic Stage 0 Breast Cancer AJCC v8
• Bilateral Breast Carcinoma
• Breast Ductal Carcinoma In Situ
• Invasive Breast Carcinoma
• Multicentric Breast Carcinoma
• Prognostic Stage 0 Breast Cancer AJCC v8

Interventions

• PROCEDURE
• DEVICE

Results Available

NCT05533372 | COMPLETED | PHASE1

78 participants

MAD Study of IA-14069

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-19

Start Date:

2022-10-10

Completion:

2025-10-15

Conditions

• Healthy
• Rheumatoid Arthritis

Interventions

• DRUG

No Results Yet

NCT05527652 | RECRUITING | NA

40 participants

Self-Supporting Nasopharyngeal Airway (ssNPA) Treating Upper Airway Obstruction in Hypotonia

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-19

Start Date:

2022-11-16

Completion:

2027-05-31

Conditions

• Obstructive Sleep Apnea
• Hypertonia, Muscle
• Nasal Airway Obstruction
• Tolerance
• Trisomy 21
• Down Syndrome

Interventions

• DEVICE

No Results Yet

NCT05525676 | ACTIVE_NOT_RECRUITING | NA

245 participants

Relationship Checkups to Reduce Veteran Suicide Risk

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-19

Start Date:

2023-01-03

Completion:

2027-04-30

Conditions

• Relationship Distress
• Mental Health

Interventions

• BEHAVIORAL

No Results Yet

NCT05524064 | ACTIVE_NOT_RECRUITING | NA

10 participants

FLASH Radiotherapy for the Treatment of Symptomatic Bone Metastases in the Thorax

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-19

Start Date:

2023-03-08

Completion:

2027-05-01

Conditions

• Bone Metastases in the Thorax

Interventions

• RADIATION

No Results Yet

NCT05514938 | COMPLETED | PHASE2

140 participants

Polypill in Acute Coronary Syndrome

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-19

Start Date:

2022-11-30

Completion:

2025-05-30

Conditions

• Acute Coronary Syndrome
• Lipid Disorder
• Coronary Artery Disease

Interventions

• DRUG

Results Available

NCT05501873 | ACTIVE_NOT_RECRUITING

1173 participants

Real World Data Collection in Subjects Treated With the FARAPULSE Pulsed Field Ablation System

Study Type:

OBSERVATIONAL

Last Updated:

2026-08-19

Start Date:

2023-03-24

Completion:

2025-10-21

Conditions

• Atrial Fibrillation

Interventions

• DEVICE

No Results Yet

NCT05497336 | TERMINATED | PHASE1

8 participants

A Study of IBI351 in Combination With Cetuximab in Subjects With KRAS G12C Mutated Metastatic Colorectal Cancer

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-19

Start Date:

2022-08-18

Completion:

2025-01-24

Conditions

• Colorectal Cancer

Interventions

• DRUG

No Results Yet

NCT05494697 | SUSPENDED | PHASE2

90 participants

Ampligen Combined With SOC Versus SOC Alone Following First-Line Therapy in Subjects With LAPC

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-19

Start Date:

2027-08-31

Completion:

2031-02-28

Conditions

• Pancreatic Cancer

Interventions

• DRUG

No Results Yet

NCT05489705 | RECRUITING

1700 participants

A Prospective Registry Study to Assess Real-world Patient Characteristics, Treatment Patterns, and Longitudinal Outcomes in Patients Receiving Mavacamten and Other Treatments for Symptomatic Obstructive Hypertrophic Cardiomyopathy (Obstructive-HCM)

Study Type:

OBSERVATIONAL

Last Updated:

2026-08-19

Start Date:

2022-08-16

Completion:

2029-08-17

Conditions

• Obstructive Hypertrophic Cardiomyopathy

Interventions

• DRUG

No Results Yet

NCT05487677 | RECRUITING | NA

100 participants

Subscapularis Repair Augmentation for Total Shoulder Arthroplasty

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-19

Start Date:

2023-12-01

Completion:

2028-09-01

Conditions

• Shoulder Injuries

Interventions

• DEVICE
• PROCEDURE

No Results Yet

NCT05480956 | COMPLETED | NA

60 participants

SIRI Checklist: An Integrated Hospital Model to Optimize HIV Prevention in Persons Who Inject Drugs

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-19

Start Date:

2022-10-11

Completion:

2025-07-01

Conditions

• HIV Infections
• Opioid-Related Disorders
• Pre-Exposure Prophylaxis (PrEP)

Interventions

• BEHAVIORAL

Results Available

NCT05480904 | ACTIVE_NOT_RECRUITING

199 participants

Characterizing Sleep Among Long-term Survivors of Childhood Cancer

Study Type:

OBSERVATIONAL

Last Updated:

2026-08-19

Start Date:

2023-04-17

Completion:

2026-04-29

Conditions

• ALL, Adult
• CNS Tumor
• Solid Tumor

Interventions

• OTHER
• DIAGNOSTIC_TEST
• DEVICE

No Results Yet

NCT05474534 | ACTIVE_NOT_RECRUITING | NA

40 participants

An Intervention to Enhance Well-Being in Trauma Exposed New Mothers

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-19

Start Date:

2023-02-13

Completion:

2025-09-01

Conditions

• Post-traumatic Stress Disorder
• Dissociation
• Maternal Care Patterns
• Infant Behavior
• Maternal Behavior
• Maternal Distress
• Mood Disturbance
• Emotional Regulation

Interventions

• DEVICE

No Results Yet

NCT05473013 | RECRUITING | NA

264 participants

Optimizing Digital Health Technology Interventions to Increase Skill Acquisition and Utilization

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-19

Start Date:

2023-01-06

Completion:

2027-01-31

Conditions

• Bulimia Nervosa
• Bulimia
• Binge Eating
• Binge-Eating Disorder

Interventions

• BEHAVIORAL

No Results Yet

NCT05471921 | COMPLETED | NA

400 participants

Effectiveness of an Evidence-based Stepped Care System for Alcohol and Other Drug Use Problems Among Congolese Refugees in Zambia

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-19

Start Date:

2023-04-26

Completion:

2025-02-24

Conditions

• Alcohol and Substance-Related Mental Disorders

Interventions

• BEHAVIORAL

Results Available

NCT05451589 | COMPLETED | NA

457 participants

A Trial of a Positive Psychology Intervention for Older Adults (RESET)

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-19

Start Date:

2023-07-14

Completion:

2026-05-28

Conditions

• Depressive Symptoms
• Anxiety
• Chronic Pain
• Fatigue
• Loneliness
• Stress, Psychological

Interventions

• BEHAVIORAL

No Results Yet

NCT05443438 | COMPLETED | NA

212 participants

Where's the Wif? Referent Selection and Retention

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-19

Start Date:

2022-04-07

Completion:

2025-03-29

Conditions

• Healthy

Interventions

• BEHAVIORAL

Results Available

NCT05443399 | COMPLETED | NA

212 participants

What Makes a Cup, a Cup? Generalizing Novel Words

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-19

Start Date:

2022-04-07

Completion:

2025-03-29

Conditions

• Healthy

Interventions

• BEHAVIORAL

Results Available

NCT05424783 | ACTIVE_NOT_RECRUITING

222 participants

MRI And GPS Informing Choices for Prostate Cancer Treatment (MAGIC)

Study Type:

OBSERVATIONAL

Last Updated:

2026-08-19

Start Date:

2022-10-15

Completion:

2027-02-01

Conditions

• Prostate Cancer

Interventions

• OTHER

No Results Yet

NCT05417555 | ACTIVE_NOT_RECRUITING | NA

120 participants

Low Intensity Focused Ultrasound for Mild Cognitive Impairment and Mild Alzheimer's Disease

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-19

Start Date:

2022-09-01

Completion:

2026-09-15

Conditions

• Mild Cognitive Impairment
• Amnestic Mild Cognitive Disorder
• Deep Brain Stimulation
• Mild Alzheimer's Disease

Interventions

• DEVICE

No Results Yet

NCT05415878 | RECRUITING | NA

40 participants

Impact of Removable Cast Walker Design on Usability for Patients With Diabetic Foot Ulcers

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-19

Start Date:

2023-08-02

Completion:

2027-04-30

Conditions

• Diabetes Mellitus
• Foot Ulcer

Interventions

• DEVICE

No Results Yet

NCT05398783 | RECRUITING

2000 participants

A Natural History Study of Metabolic Sizing in Health and Disease

Study Type:

OBSERVATIONAL

Last Updated:

2026-08-19

Start Date:

2022-10-25

Completion:

2031-07-01

Conditions

• Metabolic Disorders
• Cancer
• Chronic Kidney Disease
• Diabetes
• Normal Physiology

No Results Yet

NCT05377255 | COMPLETED | PHASE1

24 participants

Pharmacokinetics (PK) and Safety of Multiple Doses of Intranasal Naloxone in Healthy Adults

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-19

Start Date:

2022-03-28

Completion:

2022-05-10

Conditions

• Opioid Overdose

Interventions

• COMBINATION_PRODUCT

No Results Yet

NCT05372029 | RECRUITING | NA

176 participants

AAT for Alcohol Use Disorder in Veterans

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-19

Start Date:

2023-02-03

Completion:

2026-09-30

Conditions

• Alcohol Use Disorder

Interventions

• BEHAVIORAL

No Results Yet

NCT05361720 | RECRUITING | PHASE2

54 participants

Genetic Testing to Select Therapy for the Treatment of Advanced or Metastatic Kidney Cancer, OPTIC RCC Study

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-19

Start Date:

2022-12-06

Completion:

2027-10-01

Conditions

• Advanced Clear Cell Renal Cell Carcinoma
• Metastatic Clear Cell Renal Cell Carcinoma
• Stage III Renal Cell Cancer AJCC v8
• Stage IV Renal Cell Cancer AJCC v8

Interventions

• DRUG
• BIOLOGICAL

No Results Yet

NCT05361122 | RECRUITING | NA

1000 participants

Prevention of Developmental Delay and Xylitol (PDDaX) Study

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-19

Start Date:

2023-04-04

Completion:

2027-09-30

Conditions

• Prematurity
• Neurodevelopmental Disorders

Interventions

• DIETARY_SUPPLEMENT

No Results Yet

NCT05356741 | RECRUITING | PHASE1/PHASE2

645 participants

To Access the Safety and Effects of Intravenous Administration of VIR-5818 Alone and in Combination With Pembrolizumab in Adult Participants With Locally Advanced or Metastatic HER2-Expressing Cancers

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-19

Start Date:

2022-04-13

Completion:

2028-04-30

Conditions

• Locally Advanced or Metastatic HER2-Expressing Cancers

Interventions

• DRUG

No Results Yet

NCT05317858 | RECRUITING | PHASE3

30 participants

Blood-brain Barrier (BBB) Opening Using Exablate Focused Ultrasound With Standard of Care Treatment of NSCLC Brain Mets

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-19

Start Date:

2022-08-12

Completion:

2027-06-01

Conditions

• Brain Tumor
• Non Small Cell Lung Cancer

Interventions

• DEVICE
• DRUG

No Results Yet

NCT05309902 | WITHDRAWN | PHASE1

0 participants

A Study of Soticlestat in Healthy Adults To Evaluate the Effect on QTc Interval

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-19

Start Date:

2022-10-11

Completion:

2022-12-06

Conditions

• Healthy Volunteers

Interventions

• DRUG

No Results Yet

NCT05306665 | COMPLETED | NA

125 participants

PREventing Pain After Surgery

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-19

Start Date:

2023-01-13

Completion:

2026-03-31

Conditions

• Pain, Back
• Spinal Stenosis
• Disc Herniation
• Spondylosis
• Spondylolisthesis
• Back Injuries

Interventions

• BEHAVIORAL

No Results Yet

NCT05297786 | COMPLETED | PHASE2

28 participants

Hemodialysis.-Induced Hypotension Therapy for End Stage Kidney Disease

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-19

Start Date:

2022-07-27

Completion:

2024-09-26

Conditions

• Hemodialysis Complication
• Hypotension of Hemodialysis

Interventions

• DRUG

Results Available

NCT05283018 | WITHDRAWN

0 participants

Relationship Between the Depth of Anesthesia and Auditory Evoked Potentials (P3a)

Study Type:

OBSERVATIONAL

Last Updated:

2026-08-19

Start Date:

2023-12-31

Completion:

2024-12-31

Conditions

• General Anesthesia

Interventions

• DEVICE
• OTHER

No Results Yet

NCT05278234 | COMPLETED | NA

414 participants

STEPS: An Efficacy Trial of a Chronic Pain Self-Management Program for Older Adults

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-19

Start Date:

2022-12-06

Completion:

2026-04-24

Conditions

• Chronic Pain

Interventions

• BEHAVIORAL

No Results Yet

NCT05277025 | RECRUITING

150 participants

Pain Processing in Inflammatory and Non-Inflammatory Chronic Pain Syndromes

Study Type:

OBSERVATIONAL

Last Updated:

2026-08-19

Start Date:

2022-03-22

Completion:

2027-07-28

Conditions

• Fibromyalgia
• Rheumatoid Arthritis

No Results Yet

NCT05261256 | COMPLETED

40 participants

Cardiac Impairments Following Pediatric Cardiotoxic Anti-cancer Treatment

Study Type:

OBSERVATIONAL

Last Updated:

2026-08-19

Start Date:

2022-02-01

Completion:

2025-06-30

Conditions

• Cardiovascular Diseases
• Pediatric Cancer

Interventions

• DIAGNOSTIC_TEST

No Results Yet

NCT05261204 | ACTIVE_NOT_RECRUITING

4000 participants

Transcatheter Aortic Valve Implantation Versus Standard Surgical Aortic Valve Replacement

Study Type:

OBSERVATIONAL

Last Updated:

2026-08-19

Start Date:

2013-01-01

Completion:

2026-12-01

Conditions

• Prosthesis Survival
• Prosthesis; Cardiac, Heart, Functional Disturbance as Result

Interventions

• DEVICE
• PROCEDURE

No Results Yet

NCT05253469 | ACTIVE_NOT_RECRUITING

760 participants

Infective Endocarditis Surgery Using Conventional Prosthetic Valves Versus Cryopreserved Aortic Homograft

Study Type:

OBSERVATIONAL

Last Updated:

2026-08-19

Start Date:

2005-01-01

Completion:

2027-03-30

Conditions

• Infective Endocarditis
• Heart Failure

Interventions

• PROCEDURE

No Results Yet

NCT05235633 | ENROLLING_BY_INVITATION

20 participants

ADLs at the End of Acute Treatment for Childhood Leukemia and Non-Hodgkin Lymphoma

Study Type:

OBSERVATIONAL

Last Updated:

2026-08-19

Start Date:

2022-04-19

Completion:

2027-07-31

Conditions

• Childhood Cancer

Interventions

• DIAGNOSTIC_TEST

No Results Yet

NCT05234463 | RECRUITING

400 participants

Study of the Link Between Complement Activation and IgA Nephropathy Severity

Study Type:

OBSERVATIONAL

Last Updated:

2026-08-19

Start Date:

2022-05-09

Completion:

2027-05-01

Conditions

• IgA Nephropathy Severity in Kidney Transplantation

Interventions

• OTHER

No Results Yet