Clinical Trials

NCT04752722 | RECRUITING | PHASE1/PHASE2

350 participants

LEGEND Study: EG-70 in NMIBC Patients BCG-Unresponsive and High-Risk NMIBC Incompletely Treated With BCG or BCG-Naïve

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-07
Start Date:: 2021-04-22
Completion:: 2028-04-30

Conditions

Superficial Bladder Cancer
Non-muscle Invasive Bladder Cancer With Carcinoma in Situ
Non-muscle Invasive Bladder Cancer

Interventions

DRUG

No Results Yet

NCT04748913 | COMPLETED | NA

153 participants

Diagnostic Accuracy of Near Infrared Transillumination in Combination With a Dye in the Cavitation Detection

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-07
Start Date:: 2020-11-09
Completion:: 2023-11-09

Conditions

Initial Proximal Caries

Interventions

DEVICE
DIAGNOSTIC_TEST

No Results Yet

NCT04747613 | ACTIVE_NOT_RECRUITING | PHASE3

208 participants

Long-term Safety and Tolerability of Iptacopan in Patients With Paroxysmal Nocturnal Hemoglobinuria

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-07
Start Date:: 2021-07-27
Completion:: 2027-10-18

Conditions

Paroxysmal Nocturnal Hemoglobinuria

Interventions

DRUG

No Results Yet

NCT04746911 | COMPLETED | PHASE2

10 participants

Maximal Usage Pharmacokinetics and Safety of ARQ-151 in Children With Plaque Psoriasis (ARQ-151-216)

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-07
Start Date:: 2021-03-01
Completion:: 2022-05-11

Conditions

Psoriasis
Plaque Psoriasis

Interventions

DRUG

Results Available

NCT04734639 | COMPLETED | NA

17 participants

Appetite Response to Exercise- Versus Mixed (Exercise + Dietary Restriction)-Induced Energy Deficit in Adolescents With Obesity

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-07
Start Date:: 2021-04-24
Completion:: 2021-06-30

Conditions

Pediatric Obesity

Interventions

BEHAVIORAL

No Results Yet

NCT04729959 | ACTIVE_NOT_RECRUITING | PHASE2

61 participants

Testing the Addition of the Immune Therapy Drugs, Tocilizumab and Atezolizumab, to Radiation Therapy for Recurrent Glioblastoma

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-07
Start Date:: 2022-03-11
Completion:: 2025-06-15

Conditions

Diffuse Astrocytoma, IDH-Wildtype
Recurrent Glioblastoma

Interventions

BIOLOGICAL
PROCEDURE
RADIATION

Results Available

NCT04728893 | RECRUITING | PHASE2

490 participants

Efficacy and Safety of Nemtabrutinib (MK-1026) in Participants With Hematologic Malignancies (MK-1026-003)

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-07
Start Date:: 2021-04-05
Completion:: 2029-01-04

Conditions

Hematologic Malignancies
Waldenstroms Macroglobulinaemia
Non-Hodgkins Lymphoma
Chronic Lymphocytic Leukaemia

Interventions

DRUG

No Results Yet

NCT04706663 | RECRUITING

2000 participants

Precision-Based Genomics in Prostate Cancer

Study Type:: OBSERVATIONAL
Last Updated:: 2026-08-07
Start Date:: 2021-09-14
Completion:: 2029-06-30

Conditions

Prostate Cancer

No Results Yet

NCT04700150 | COMPLETED | NA

40 participants

Tai Chi in Spondyloarthritis

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-07
Start Date:: 2019-01-07
Completion:: 2021-07-22

Conditions

Spondyloarthritis

Interventions

OTHER

No Results Yet

NCT04689828 | ACTIVE_NOT_RECRUITING | PHASE3

469 participants

177Lu-PSMA-617 vs. Androgen Receptor-Directed Therapy in the Treatment of Progressive Metastatic Castrate Resistant Prostate Cancer

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-07
Start Date:: 2021-06-15
Completion:: 2022-10-02

Conditions

Prostatic Neoplasms

Interventions

DRUG

Results Available

NCT04685408 | COMPLETED | NA

276 participants

A TargEted MAnageMent Intervention for Reducing Stroke Risk Factors in High Risk Ugandans

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-07
Start Date:: 2022-05-13
Completion:: 2024-03-06

Conditions

Stroke

Interventions

BEHAVIORAL

Results Available

NCT04664478 | COMPLETED

32 participants

Gene First Approach to Connective Tissue Disease

Study Type:: OBSERVATIONAL
Last Updated:: 2026-08-07
Start Date:: 2021-04-22
Completion:: 2025-08-29

Conditions

Abnormal Elastogenesis
Vascular Diseases
Connective Tissue Diseases

No Results Yet

NCT04641026 | ACTIVE_NOT_RECRUITING | NA

83 participants

Discovery of Biological Signatures for Cruciferous Vegetable Intake (Single Serving)

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-07
Start Date:: 2021-02-22
Completion:: 2025-12-15

Conditions

Diet, Healthy

Interventions

OTHER

No Results Yet

NCT04633252 | RECRUITING | PHASE1/PHASE2

86 participants

A Phase I/II Study of PDS01ADC With Docetaxel and Abiraterone in Adults With Metastatic Castration Sensitive and PDS01ADC With Docetaxel in Castration Resistant Prostate Cancer

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-07
Start Date:: 2021-02-23
Completion:: 2026-12-31

Conditions

Cancer Of Prostate
Prostate Neoplasms

Interventions

DRUG

No Results Yet

NCT04620382 | COMPLETED | EARLY_PHASE1

31 participants

Effect of Midodrine vs Abdominal Compression on Cardiovascular Risk Markers in Autonomic Failure Patients

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-07
Start Date:: 2020-11-09
Completion:: 2025-07-01

Conditions

Neurogenic Orthostatic Hypotension
Autonomic Failure
Pure Autonomic Failure
Multiple System Atrophy
Parkinson Disease

Interventions

DRUG
DEVICE

Results Available

NCT04573231 | RECRUITING | PHASE2

13 participants

Evaluation of PSMA in HER2- AR+ Metastatic Breast Cancer

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-07
Start Date:: 2021-05-24
Completion:: 2026-08-31

Conditions

Breast Cancer
HER2-negative Breast Cancer
Metastatic Breast Cancer

Interventions

DRUG

No Results Yet

NCT04569708 | WITHDRAWN | NA

0 participants

Sleep Spindles and Memory in Rolandic Epilepsy

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-07
Start Date:: 2021-01-16
Completion:: 2025-06-30

Conditions

Rolandic Epilepsy
Rolandic Epilepsy, Benign
Centrotemporal Epilepsy
Centrotemporal; EEG Spikes, Epilepsy of Childhood
Epilepsy; Seizure
Epilepsy

Interventions

OTHER

No Results Yet

NCT04569162 | RECRUITING

100 participants

Rhizomelic Chondrodysplasia Punctata Registry

Study Type:: OBSERVATIONAL
Last Updated:: 2026-08-07
Start Date:: 2013-05-17
Completion:: 2030-01-01

Conditions

RCDP - Rhizomelic Chondrodysplasia Punctata
RCDP1
RCDP2
RCDP3
RCDP4
RCDP5

No Results Yet

NCT04541030 | ACTIVE_NOT_RECRUITING

241 participants

Integrated Genomic Prostate Score With MRI Targeted Prostate Biopsies

Study Type:: OBSERVATIONAL
Last Updated:: 2026-08-07
Start Date:: 2020-09-02
Completion:: 2027-07-01

Conditions

Prostate Cancer

No Results Yet

NCT04536480 | COMPLETED | NA

87 participants

Time Limited Eating in Adolescents With Type 2 Diabetes (KT2D)

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-07
Start Date:: 2023-04-15
Completion:: 2026-07-01

Conditions

Pediatric Obesity
Type 2 Diabetes
Time Restricted Eating

Interventions

BEHAVIORAL
DEVICE

No Results Yet

NCT04535882 | COMPLETED

673 participants

Effectiveness of Serum Leucine-rich Alpha-2 Glycoprotein Levels on IBD

Study Type:: OBSERVATIONAL
Last Updated:: 2026-08-07
Start Date:: 2020-10-01
Completion:: 2026-07-31

Conditions

LRG Levels

Interventions

DIAGNOSTIC_TEST

No Results Yet

NCT04507308 | COMPLETED | NA

57 participants

Real-time Experiences With Sleep Training Study

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-07
Start Date:: 2024-06-01
Completion:: 2026-06-21

Conditions

Borderline Personality Disorder
Sleep Disturbance

Interventions

BEHAVIORAL

No Results Yet

NCT04495504 | COMPLETED | PHASE2

32 participants

Administration of Ropivacaine by Bi-laterosternal Multiperforated Catheters Placed Before a Sternotomy for Cardiac Surgery

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-07
Start Date:: 2020-07-22
Completion:: 2021-01-12

Conditions

Scheduled Cardiac Surgery
Age Under 85 Years

Interventions

DRUG

No Results Yet

NCT04441307 | COMPLETED | NA

368 participants

Promoting Co-Parenting and Reducing Hazardous Drinking in New Families

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-07
Start Date:: 2021-01-25
Completion:: 2026-01-19

Conditions

Parenting
Parent-Child Relations
Drinking, Alcohol
Adjustment

Interventions

BEHAVIORAL

No Results Yet

NCT04438382 | TERMINATED | PHASE2

1 participants

Infliximab and Intravenous Immunoglobulin Therapy in Treating Patients With Steroid-Refractory Pneumonitis

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-07
Start Date:: 2021-01-07
Completion:: 2023-12-21

Conditions

Hematopoietic and Lymphoid Cell Neoplasm
Malignant Solid Neoplasm
Steroid-Refractory Pneumonitis

Interventions

BIOLOGICAL
DRUG

Results Available

NCT04433065 | ACTIVE_NOT_RECRUITING | NA

150 participants

TTVR Early Feasibility Study

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-07
Start Date:: 2020-10-20
Completion:: 2026-09-10

Conditions

Tricuspid Regurgitation

Interventions

DEVICE

No Results Yet

NCT04431011 | COMPLETED

40 participants

Layer-specific Contribution to Consolidation of Skill Learning in the Primary Motor Cortex

Study Type:: OBSERVATIONAL
Last Updated:: 2026-08-07
Start Date:: 2021-04-21
Completion:: 2024-12-09

Conditions

Normal Physiology

No Results Yet

NCT04403633 | RECRUITING | NA

25 participants

A Study of Facilitators and Barriers to Improve Acute Kidney Injury in Children Through Mobile Health Intervention

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-07
Start Date:: 2020-06-01
Completion:: 2026-12-31

Conditions

Acute Kidney Injury

Interventions

OTHER

No Results Yet

NCT04371016 | COMPLETED | NA

30 participants

Pulmonary and Ventilatory Effects of Bed Verticalization in Patients With Acute Respiratory Distress Syndrome

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-07
Start Date:: 2020-03-30
Completion:: 2021-01-14

Conditions

Acute Respiratory Distress Syndrome

Interventions

OTHER

No Results Yet

NCT04360018 | COMPLETED | PHASE1

20 participants

Effect of Acute Alcohol Intoxication on Neural Processes During Decisions to Engage in HIV Risk Behaviors

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-07
Start Date:: 2021-03-18
Completion:: 2025-04-02

Conditions

Alcohol Consumption

Interventions

OTHER

No Results Yet

NCT04355312 | COMPLETED | NA

51 participants

Using INDOcyanine Green to Analyse Ovarian Vascularization After Ovarian Laparoscopic CYStectomy

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-07
Start Date:: 2020-06-15
Completion:: 2022-12-12

Conditions

Ovarian Cysts
Endometriosis
Fertility

Interventions

DIAGNOSTIC_TEST

No Results Yet

NCT04334083 | COMPLETED | NA

48 participants

Biomarkes Of Job STRess In Emergency Senior Physicians - Detection of Stressful Events

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-07
Start Date:: 2022-02-17
Completion:: 2023-12-21

Conditions

Heart Rate Variability

Interventions

BEHAVIORAL

No Results Yet

NCT04326478 | COMPLETED | PHASE2

2475 participants

Single Dose Azithromycin to Prevent Cholera in Children

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-07
Start Date:: 2021-10-31
Completion:: 2025-05-31

Conditions

Cholera

Interventions

DRUG
BIOLOGICAL

Results Available

NCT04305431 | ACTIVE_NOT_RECRUITING | NA

43 participants

Dietary Behavior Intervention in African Americans at Risk for Cardiovascular Disease

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-07
Start Date:: 2021-02-25
Completion:: 2027-12-19

Conditions

Diet
Cooking

Interventions

BEHAVIORAL

No Results Yet

NCT04291612 | RECRUITING

1715 participants

Observational Study of Women With Endometrial Cancer Who Receive the Standard Treatment for Their Disease

Study Type:: OBSERVATIONAL
Last Updated:: 2026-08-07
Start Date:: 2020-02-26
Completion:: 2027-02-26

Conditions

Endometrial Cancer
Endometrioid Adenocarcinoma
Endometrial Cancer Stage I

Interventions

OTHER

No Results Yet

NCT04284943 | RECRUITING | NA

120 participants

Surgical TreAtment for Obesity Related Disease and Onco-Metabolic Surgery

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-07
Start Date:: 2020-12-01
Completion:: 2027-12-31

Conditions

Gastric Cancer
Diabetes Mellitus, Type 2

Interventions

PROCEDURE

No Results Yet

NCT04280081 | ACTIVE_NOT_RECRUITING | PHASE2

77 participants

A Study of Selpercatinib (LY3527723) in Participants With Advanced Solid Tumors Including RET Fusion-positive Solid Tumors, Medullary Thyroid Cancer and Other Tumors With RET Activation

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-07
Start Date:: 2020-03-16
Completion:: 2021-03-25

Conditions

Solid Tumor
Medullary Thyroid Cancer

Interventions

DRUG

Results Available

NCT04269200 | ACTIVE_NOT_RECRUITING | PHASE3

805 participants

Durvalumab With or Without Olaparib as Maintenance Therapy After First-Line Treatment of Advanced and Recurrent Endometrial Cancer

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-07
Start Date:: 2020-05-05
Completion:: 2024-07-08

Conditions

Endometrial Neoplasms

Interventions

DRUG
BIOLOGICAL

Results Available

NCT04251052 | RECRUITING | NA

1956 participants

A Study to Compare Two Surgical Procedures in Individuals With BRCA1 Mutations to Assess Reduced Risk of Ovarian Cancer

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-07
Start Date:: 2020-09-01
Completion:: 2047-06-30

Conditions

Ovarian Carcinoma

Interventions

PROCEDURE
OTHER

No Results Yet

NCT04236518 | COMPLETED | NA

53 participants

Nutritional Transitions to More Plant Proteins and Less Animal Proteins: Understanding the Induced Metabolic Reorientations and Searching for Their Biomarkers (ProVegOmics)

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-07
Start Date:: 2020-08-27
Completion:: 2022-08-05

Conditions

Metabolic Syndrome
Hypertriglyceridemia
Fasting Blood Sugar Above Normal
Lower Than Standard HDL-cholesterol Level
Slightly Elevated Blood Pressure

Interventions

BEHAVIORAL

No Results Yet