Clinical Trials

NCT06351722 | COMPLETED

100 participants

Non-surgical Periodontal Treatment in Smokers on SIRT-1, NLRP3 Inflammasome and LncRNAs

Study Type:: OBSERVATIONAL
Last Updated:: 2026-08-06
Start Date:: 2024-06-25
Completion:: 2025-12-15

Conditions

Periodontitis, Adult

Interventions

DIAGNOSTIC_TEST
PROCEDURE

No Results Yet

NCT06347016 | ACTIVE_NOT_RECRUITING | PHASE3

311 participants

Study of Plozasiran in Adults With Severe Hypertriglyceridemia

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-06
Start Date:: 2024-07-23
Completion:: 2026-06-17

Conditions

Severe Hypertriglyceridemia

Interventions

DRUG

No Results Yet

NCT06340659 | ACTIVE_NOT_RECRUITING | NA

104 participants

Concurrent Aerobic Exercise and Cognitive Training to Prevent Alzheimer's in At-risk Older Adults (The Exergames Telerehabilitation Study)

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-06
Start Date:: 2024-08-14
Completion:: 2026-11-30

Conditions

At Risk for AD-dementia, With Subjective Cognitive Decline

Interventions

BEHAVIORAL

No Results Yet

NCT06338995 | RECRUITING | PHASE3

510 participants

A Study of Lebrikizumab (LY3650150) in Participants With Chronic Rhinosinusitis and Nasal Polyps Treated With Intranasal Corticosteroids (CONTRAST-NP)

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-06
Start Date:: 2024-04-29
Completion:: 2027-05-31

Conditions

Chronic Rhinosinusitis With Nasal Polyps (CRSwNP)

Interventions

DRUG

No Results Yet

NCT06335953 | COMPLETED | NA

474 participants

ALIGN: Aligning Medications With What Matters Most (Demonstration)

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-06
Start Date:: 2024-05-07
Completion:: 2025-09-16

Conditions

Polypharmacy
Alzheimer's Disease and Related Dementias
Mild Cognitive Impairment

Interventions

BEHAVIORAL

Results Available

NCT06335771 | RECRUITING | NA

60 participants

Harnessing Macrophage Lysosomal Lipid Metabolism in Obesity

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-06
Start Date:: 2024-08-01
Completion:: 2028-03-31

Conditions

Obesity
Nonalcoholic Fatty Liver
Diabetes Type 2
Healthy

Interventions

OTHER

No Results Yet

NCT06324357 | RECRUITING | PHASE1/PHASE2

768 participants

Beamion BCGC-1: A Study to Find a Suitable Dose of Zongertinib Used Alone and in Combination With Other Treatments to Test Whether it Helps People With Different Types of HER2+ Cancer That Has Spread

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-06
Start Date:: 2024-06-28
Completion:: 2029-01-08

Conditions

Metastatic Breast Cancer
Metastatic Gastric Adenocarcinoma
Gastroesophageal Junction Adenocarcinoma
Esophageal Adenocarcinoma
Colorectal Cancer

Interventions

DRUG

No Results Yet

NCT06305338 | COMPLETED

110 participants

Predicting Intraocular Lens Tilt Using OCT Measurements and Partial Least Squares Regression Modelling

Study Type:: OBSERVATIONAL
Last Updated:: 2026-08-06
Start Date:: 2022-04-12
Completion:: 2023-04-01

Conditions

Intraocular Lens
Cataract

Interventions

OTHER

No Results Yet

NCT06300892 | COMPLETED

71 participants

Surgical Site Infections and the Microbiome: Understanding the Pathogenesis of Surgical Site Infections

Study Type:: OBSERVATIONAL
Last Updated:: 2026-08-06
Start Date:: 2024-04-01
Completion:: 2026-05-15

Conditions

Open GI Surgery

Interventions

OTHER

No Results Yet

NCT06290687 | RECRUITING | PHASE2

40 participants

Partial Cystectomy & Extended Pelvic Lymph Node Dissection With SOC Perioperative Systemic Therapy

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-06
Start Date:: 2026-09-30
Completion:: 2026-12-29

Conditions

Malignant Neoplasm of Bladder
Muscle Invasive Bladder Carcinoma

Interventions

DRUG
PROCEDURE

No Results Yet

NCT06287775 | RECRUITING | PHASE1/PHASE2

45 participants

Testing the Combination of an Anti-cancer Drug, Iadademstat, With Other Anti-cancer Drugs (Atezolizumab or Durvalumab) at Improving Outcomes for Small Cell Lung Cancer

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-06
Start Date:: 2025-04-08
Completion:: 2029-07-25

Conditions

Extensive Stage Lung Small Cell Carcinoma
Stage IV Lung Cancer AJCC v8

Interventions

BIOLOGICAL
PROCEDURE
DRUG

No Results Yet

NCT06287151 | COMPLETED | NA

80 participants

Regional Anesthesia EMG Study

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-06
Start Date:: 2023-08-09
Completion:: 2025-02-28

Conditions

Surgery

Interventions

DEVICE
DRUG

No Results Yet

NCT06276764 | ENROLLING_BY_INVITATION

500 participants

The LINFU® U.S. Registry in Patients With IPMN (Intraductal Papillary Mucinous Neoplasm of the Pancreas)

Study Type:: OBSERVATIONAL
Last Updated:: 2026-08-06
Start Date:: 2024-10-15
Completion:: 2034-09-30

Conditions

IPMN, Pancreatic
Pancreas Cancer
Pancreatic Cyst

Interventions

DIAGNOSTIC_TEST

No Results Yet

NCT06275724 | ACTIVE_NOT_RECRUITING

585 participants

Specified Drug-use Survey of Leqvio for s.c. Injection.

Study Type:: OBSERVATIONAL
Last Updated:: 2026-08-06
Start Date:: 2024-03-04
Completion:: 2026-12-17

Conditions

Familial Hypercholesterolaemia
Hypercholesterolaemia

Interventions

OTHER

No Results Yet

NCT06274515 | RECRUITING | PHASE4

320 participants

A Study to Investigate Mechanisms of Resistance to Breast Cancer Therapies

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-06
Start Date:: 2024-04-02
Completion:: 2026-09-30

Conditions

Breast Cancer

Interventions

PROCEDURE

No Results Yet

NCT06263244 | ACTIVE_NOT_RECRUITING | PHASE3

40 participants

Specifying the Anti-inflammatory Effects of Ziltivekimab

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-06
Start Date:: 2024-05-03
Completion:: 2026-09-04

Conditions

Atherosclerosis
Inflammation

Interventions

DRUG

No Results Yet

NCT06259500 | ACTIVE_NOT_RECRUITING

20 participants

Patient-derived Stem Cell Models of Anorexia Nervosa

Study Type:: OBSERVATIONAL
Last Updated:: 2026-08-06
Start Date:: 2022-08-25
Completion:: 2026-12-31

Conditions

Anorexia Nervosa

Interventions

OTHER

No Results Yet

NCT06237582 | COMPLETED | NA

20 participants

Inferior Epigastric Lymp Node (IELN) Basin as a Possible Systemic Metastatic Pathway of Ovarian Peritoneal Metastases

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-06
Start Date:: 2022-06-16
Completion:: 2023-01-01

Conditions

Carcinomatosis, Peritoneal

Interventions

PROCEDURE

No Results Yet

NCT06233370 | ACTIVE_NOT_RECRUITING | EARLY_PHASE1

24 participants

Acute Effects of Walking Exercise on Brain Functioning in Multiple Sclerosis

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-06
Start Date:: 2024-03-01
Completion:: 2025-02-28

Conditions

Multiple Sclerosis

Interventions

BEHAVIORAL

No Results Yet

NCT06233344 | RECRUITING | PHASE2

40 participants

Mindfulness-Assisted Psychedelic Therapy

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-06
Start Date:: 2025-07-30
Completion:: 2027-08-31

Conditions

Mental Health

Interventions

DRUG

No Results Yet

NCT06223789 | COMPLETED | NA

392 participants

VOLT-AF IDE Clinical Study

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-06
Start Date:: 2024-04-03
Completion:: 2025-10-03

Conditions

Atrial Arrhythmia
Atrial Fibrillation
Paroxysmal Atrial Fibrillation
Persistent Atrial Fibrillation

Interventions

DEVICE

No Results Yet

NCT06214156 | RECRUITING | PHASE1/PHASE2

42 participants

A Clinical Study of T3011 in Subjects With Advanced Melanoma

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-06
Start Date:: 2024-01-26
Completion:: 2026-09-30

Conditions

Advanced Melanoma

Interventions

BIOLOGICAL

No Results Yet

NCT06212570 | NOT_YET_RECRUITING | NA

12 participants

KeyScope Study in Uganda

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-06
Start Date:: 2026-09-01
Completion:: 2027-06-30

Conditions

Abdominal Neoplasm

Interventions

DEVICE

No Results Yet

NCT06206954 | ENROLLING_BY_INVITATION | NA

864 participants

Supporting Decisions on Lifestyle Change

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-06
Start Date:: 2024-01-24
Completion:: 2028-04-30

Conditions

Obesity

Interventions

BEHAVIORAL

No Results Yet

NCT06203210 | RECRUITING | PHASE3

540 participants

A Study of Ifinatamab Deruxtecan Versus Treatment of Physician's Choice in Subjects With Relapsed Small Cell Lung Cancer

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-06
Start Date:: 2024-05-21
Completion:: 2028-01-30

Conditions

Small Cell Lung Cancer

Interventions

DRUG

No Results Yet

NCT06201936 | COMPLETED

1346 participants

EPIDURAL- Evaluation of Preexisting Information Regarding Neuroaxial Procedures for Labour Analgesia

Study Type:: OBSERVATIONAL
Last Updated:: 2026-08-06
Start Date:: 2025-03-01
Completion:: 2026-08-01

Conditions

Neuroaxial Analgesia Procedures

Interventions

BEHAVIORAL

No Results Yet

NCT06188520 | RECRUITING | PHASE1/PHASE2

564 participants

A First-in-human Dose Escalation and Expansion Study to Evaluate the Safety, and Tolerability of AZD8421 Alone or in Combination in Participants With Selected Advanced or Metastatic Solid Tumors

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-06
Start Date:: 2023-12-05
Completion:: 2027-08-04

Conditions

ER+ HER2- Advanced Breast Cancer
High-grade Serous Ovarian Cancer (HGSOC)

Interventions

DRUG

No Results Yet

NCT06176261 | RECRUITING | PHASE2

58 participants

DATO-BASE: DATOpotamab-deruxtecan for Breast Cancer Brain metAstaSEs

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-06
Start Date:: 2024-01-08
Completion:: 2028-01-01

Conditions

Breast Cancer
Breast Cancer Female
Metastatic Triple-Negative Breast Carcinoma
ER Positive Breast Cancer
HER2-negative Breast Cancer
HER2 Negative Breast Carcinoma
ER-negative Breast Cancer

Interventions

DRUG

No Results Yet

NCT06168812 | ACTIVE_NOT_RECRUITING | PHASE2

29 participants

A Study of Glipizide to Treat High Blood Sugar in People With Pancreatic Cancer

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-06
Start Date:: 2023-12-05
Completion:: 2026-12-05

Conditions

Pancreatic Cancer
Pancreatic Carcinoma
Pancreatic Ductal Adenocarcinoma
Pancreatic Cancer Metastatic
Metastatic Pancreatic Cancer
Metastatic Pancreatic Ductal Adenocarcinoma

Interventions

DRUG

No Results Yet

NCT06168409 | COMPLETED | PHASE3

218 participants

A Study to Investigate the Effect of Baxdrostat on Ambulatory Blood Pressure in Participants With Resistant Hypertension

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-06
Start Date:: 2024-03-01
Completion:: 2025-08-17

Conditions

Resistant Hypertension

Interventions

DRUG

Results Available

NCT06162728 | COMPLETED | PHASE1/PHASE2

87 participants

Dose Escalation Trial Of Safety, Pharmacokinetic/Pharmacodynamic And Preliminary Clinical Activity of Briquilimab In Adult Patients With Chronic Spontaneous Urticaria (CSU)

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-06
Start Date:: 2023-11-29
Completion:: 2026-07-08

Conditions

Chronic Spontaneous Urticaria

Interventions

DRUG
OTHER

No Results Yet

NCT06157671 | ENROLLING_BY_INVITATION

1000 participants

The LINFU® U.S. Registry for the Detection of Asymptomatic Pancreatic Ductal Adenocarcinoma

Study Type:: OBSERVATIONAL
Last Updated:: 2026-08-06
Start Date:: 2024-01-31
Completion:: 2030-01-01

Conditions

Pancreatic Adenocarcinoma
Pancreatic Intraepithelial Neoplasia

No Results Yet

NCT06150729 | COMPLETED

107 participants

Study of Intramuscular Injections of OnabotulinumtoxinA to Assess Change in Disease Activity in Pediatric Participants With Spasticity Associated With Cerebral Palsy

Study Type:: OBSERVATIONAL
Last Updated:: 2026-08-06
Start Date:: 2023-09-08
Completion:: 2025-05-30

Conditions

Spasticity

No Results Yet

NCT06147843 | RECRUITING | NA

1000 participants

French-German Cohort Study to Determine Factors Associated With Weight Loss in Amyotrophic Lateral Sclerosis

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-06
Start Date:: 2024-09-17
Completion:: 2027-09-30

Conditions

Amyotrophic Lateral Sclerosis

Interventions

OTHER

No Results Yet

NCT06145633 | RECRUITING | PHASE2

15 participants

Vorinostat and 177Lu-PSMA-617 for the Treatment of PSMA-Low Metastatic Castration-Resistant Prostate Cancer

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-06
Start Date:: 2024-09-18
Completion:: 2026-12-30

Conditions

Castration-Resistant Prostate Carcinoma
Metastatic Prostate Adenocarcinoma
Stage IVB Prostate Cancer AJCC v8

Interventions

PROCEDURE
OTHER
DRUG

No Results Yet

NCT06144749 | COMPLETED | PHASE2

13 participants

A Safety, Efficacy, and Pharmacokinetic (PK) Study of HBI-002, an Oral Carbon Monoxide (CO) Therapeutic, in Subjects With Sickle Cell Disease (SCD)

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-06
Start Date:: 2025-02-15
Completion:: 2026-06-30

Conditions

Anemia, Sickle Cell

Interventions

DRUG

No Results Yet

NCT06143956 | RECRUITING | PHASE2

1481 participants

A Master Protocol Study (LY900038) of Multiple Intervention-Specific-Appendices (ISAs) in Adult Participants With Obesity or Overweight

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-06
Start Date:: 2023-11-17
Completion:: 2027-09-30

Conditions

Obesity
Overweight

Interventions

DRUG

No Results Yet

NCT06131554 | COMPLETED | PHASE3

1480 participants

A Clinical Trial to Evaluate the Immunogenicity and Safety of Group ACYW135 Meningococcal Conjugate Vaccine (CRM197) in Adults Aged 18 to 55 Years

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-06
Start Date:: 2024-03-20
Completion:: 2024-07-12

Conditions

Meningococcal Meningitis

Interventions

BIOLOGICAL

No Results Yet

NCT06129864 | RECRUITING | PHASE3

1145 participants

A Global Study of Volrustomig (MEDI5752) for Participants With Unresected Locally Advanced Head and Neck Squamous Cell Carcinoma Following Definitive Concurrent Chemoradiotherapy

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-06
Start Date:: 2023-12-14
Completion:: 2030-04-17

Conditions

Locally Advanced Head and Neck Squamous Cell Carcinoma

Interventions

DRUG

No Results Yet

NCT06129747 | RECRUITING | PHASE2

55 participants

Repeat Breast Conserving Surgery Followed by Daily Partial Breast Irradiation in Ipsilateral Breast

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-06
Start Date:: 2023-11-30
Completion:: 2029-08-09

Conditions

Breast Cancer
Tumor, Breast

Interventions

RADIATION

No Results Yet