Clinical Trials

NCT05386108 | RECRUITING | PHASE1/PHASE2

73 participants

Study of Abemaciclib and Elacestrant in Participants With Brain Metastasis Due to ER+/HER-2- Breast Cancer

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-06

Start Date:

2022-08-31

Completion:

2026-12-31

Conditions

• Breast Neoplasms
• Brain Neoplasms
• Neoplasms by Site
• Neoplasms
• Breast Diseases
• Central Nervous System Neoplasms
• Brain Diseases
• Central Nervous System Diseases

Interventions

• DRUG

No Results Yet

NCT05375812 | RECRUITING

85 participants

NIH Investigative Deep Phenotyping Study of Gulf War Veteran Health (Project NIH IN-DEPTH)

Study Type:

OBSERVATIONAL

Last Updated:

2026-08-06

Start Date:

2023-04-16

Completion:

2030-12-31

Conditions

• Gulf War Illness

No Results Yet

NCT05374824 | RECRUITING

4680 participants

Comparative Effectiveness of Palliative Surgery Versus Additional Anti-Seizure Medications for Lennox-Gastaut Syndrome

Study Type:

OBSERVATIONAL

Last Updated:

2026-08-06

Start Date:

2022-04-01

Completion:

2026-12-31

Conditions

• Lennox Gastaut Syndrome

No Results Yet

NCT05372614 | RECRUITING | PHASE1

58 participants

Testing the Safety and Tolerability of the Anti-cancer Drugs Trastuzumab Deruxtecan and Neratinib for Cancers With Changes in the HER2 Gene

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-06

Start Date:

2022-10-05

Completion:

2028-07-17

Conditions

• Metastatic Malignant Solid Neoplasm
• Metastatic Pancreatic Adenocarcinoma
• Stage III Pancreatic Cancer AJCC v8
• Stage IV Pancreatic Cancer AJCC v8
• Unresectable Malignant Solid Neoplasm
• Unresectable Pancreatic Adenocarcinoma

Interventions

• PROCEDURE
• DRUG
• BIOLOGICAL

No Results Yet

NCT05368493 | ENROLLING_BY_INVITATION | NA

182 participants

Air Pollution and Development in the Boricua Youth Study

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-06

Start Date:

2023-01-23

Completion:

2028-06-01

Conditions

• Pollution; Exposure
• Neurodevelopmental Disorders

Interventions

• OTHER

No Results Yet

NCT05353192 | COMPLETED | PHASE4

39 participants

A Study to Evaluate the Efficacy and Safety of Recombinant Human Growth Hormone in Children With Achondroplasia

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-06

Start Date:

2022-08-20

Completion:

2025-08-25

Conditions

• Achondroplasia

Interventions

• DRUG

No Results Yet

NCT05325931 | COMPLETED | NA

30 participants

1-Week Dispensing Evaluation of Kalifilcon A Daily Disposable Multifocal Compared to Ultra for Presbyopia

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-06

Start Date:

2022-02-25

Completion:

2022-03-28

Conditions

• Presbyopia

Interventions

• DEVICE

Results Available

NCT05313529 | COMPLETED | NA

396 participants

LIGHT-MCI Trial: GLP-1 Agonist, SGLT2 Inhibitor, and DPP-4 Inhibitor for MCI Remission in Type 2 Diabetes

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-06

Start Date:

2022-10-08

Completion:

2025-12-31

Conditions

• Type 2 Diabetes Mellitus
• Mild Cognitive Impairment

Interventions

• DRUG

No Results Yet

NCT05304416 | ACTIVE_NOT_RECRUITING

347 participants

Clinical Markers of Dysphagia in Cardiac Surgical Patients

Study Type:

OBSERVATIONAL

Last Updated:

2026-08-06

Start Date:

2022-06-07

Completion:

2026-07-31

Conditions

• Cardiovascular Diseases
• Dysphagia

Interventions

• DIAGNOSTIC_TEST
• OTHER

No Results Yet

NCT05276739 | COMPLETED | NA

47 participants

Role of Photic and Non-photic Time Cues in Resetting Circadian Rhythms

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-06

Start Date:

2022-07-29

Completion:

2026-07-31

Conditions

• Light Exposure
• Meal Timing

Interventions

• BEHAVIORAL

No Results Yet

NCT05261399 | ACTIVE_NOT_RECRUITING | PHASE3

341 participants

Savolitinib Plus Osimertinib Versus Platinum-based Doublet Chemotherapy in Participants With Non-Small Cell Lung Cancer Who Have Progressed on Osimertinib Treatment

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-06

Start Date:

2022-08-03

Completion:

2026-07-06

Conditions

• Carcinoma
• Non-Small-Cell Lung

Interventions

• DRUG

No Results Yet

NCT05232916 | RECRUITING | PHASE3

2250 participants

Phase 3 Study to Evaluate the Efficacy and Safety of HER2/Neu Peptide GLSI-100 (GP2 + GM-CSF) in HER2/Neu Positive Subjects

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-06

Start Date:

2022-12-16

Completion:

2031-12-31

Conditions

• Breast Cancer

Interventions

• BIOLOGICAL

No Results Yet

NCT05226507 | TERMINATED | PHASE1

45 participants

A Phase 1 Clinical Study of NXP800 in Subjects With Advanced Cancers and Expansion in Subjects With Ovarian Cancer

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-06

Start Date:

2021-12-31

Completion:

2025-01-01

Conditions

• Advanced Solid Tumor
• Ovarian Cancer
• Ovarian Clear Cell Carcinoma
• Ovarian Clear Cell Tumor
• Ovarian Clear Cell Adenocarcinoma
• Ovarian Endometrioid Adenocarcinoma
• Ovarian Endometrioid Tumor
• ARID1A Gene Mutation

Interventions

• DRUG

No Results Yet

NCT05210374 | RECRUITING | PHASE1

24 participants

Disulfiram With Copper Gluconate and Liposomal Doxorubicin in Treatment-Refractory Sarcomas

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-06

Start Date:

2023-03-09

Completion:

2026-09-01

Conditions

• Relapsed Sarcomas

Interventions

• DRUG

No Results Yet

NCT05207059 | ACTIVE_NOT_RECRUITING | NA

500 participants

Healthy Early Life Moments in Singapore

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-06

Start Date:

2022-03-18

Completion:

2027-12-31

Conditions

• Metabolic Disease
• Mental Health Wellness 1
• Lifestyle Risk Reduction
• Maternal Obesity

Interventions

• BEHAVIORAL

No Results Yet

NCT05176808 | COMPLETED | NA

117 participants

Telehealth Parent-Implemented Intervention for Young Children With Autism Spectrum Disorder (ASD)

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-06

Start Date:

2022-02-07

Completion:

2026-04-10

Conditions

• Autism Spectrum Disorder
• Autistic Disorder
• Active Autistic Disorder
• Autism
• Asperger Syndrome
• PDD-NOS
• Social Communication Delay
• Mixed Expressive Receptive Language Disorder
• Other Symbolic Dysfunctions

Interventions

• BEHAVIORAL

No Results Yet

NCT05172934 | COMPLETED | PHASE2

20 participants

Adjunctive Intra-arterial Tenecteplase Following Mechanical Thrombectomy Pilot Trial

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-06

Start Date:

2022-04-11

Completion:

2023-09-12

Conditions

• Ischemic Stroke

Interventions

• DRUG

Results Available

NCT05107115 | COMPLETED | PHASE2

160 participants

Rilzabrutinib for the Treatment of Chronic Spontaneous Urticaria in Patients Who Remain Symptomatic Despite the Use of H1 Antihistamine

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-06

Start Date:

2021-11-24

Completion:

2023-07-19

Conditions

• Chronic Spontaneous Urticaria

Interventions

• DRUG

Results Available

NCT05100862 | ACTIVE_NOT_RECRUITING | PHASE3

799 participants

A Study of Zanubrutinib Plus Anti-CD20 Versus Lenalidomide Plus Rituximab in Participants With Relapsed/Refractory Follicular or Marginal Zone Lymphoma

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-06

Start Date:

2022-03-10

Completion:

2028-07-31

Conditions

• Relapsed/Refractory Follicular Lymphoma
• Marginal Zone Lymphoma

Interventions

• DRUG

No Results Yet

NCT05093634 | COMPLETED | PHASE3

296 participants

EMANATE: A Study of Setmelanotide in Patients With Specific Gene Variants in the MC4R Pathway

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-06

Start Date:

2021-12-10

Completion:

2025-12-22

Conditions

• Obesity
• Genetic Obesity

Interventions

• DRUG

No Results Yet

NCT05090267 | RECRUITING | NA

80 participants

The Path Study: Cognitive and Inflammation Targeted Gut-brain Interventions in Alcohol; Probiotics, Alcohol, Transcutaneous Vagus Nerve Stimulation, and HIV Study

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-06

Start Date:

2022-06-01

Completion:

2026-12-30

Conditions

• Cognition
• Gut Microbiome

Interventions

• DIETARY_SUPPLEMENT
• DEVICE

No Results Yet

NCT05086497 | RECRUITING | NA

155 participants

WBSI Guided Personalized Delivery of TTFields

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-06

Start Date:

2023-01-15

Completion:

2027-06-30

Conditions

• GBM
• Glioma Glioblastoma Multiforme
• Tumor, Brain

Interventions

• DIAGNOSTIC_TEST

No Results Yet

NCT05081037 | ACTIVE_NOT_RECRUITING | NA

208 participants

Integrated Hyperglycaemia Incentivised Postnatal Surveillance Study (I-HIPS)

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-06

Start Date:

2021-09-06

Completion:

2028-07-15

Conditions

• Gestational Diabetes
• Glucose Metabolism Disorders
• Metabolic Disease

Interventions

• DEVICE

No Results Yet

NCT05066542 | ACTIVE_NOT_RECRUITING | NA

60 participants

Recreational Basketball to Increase Participation in Diabetes Prevention

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-06

Start Date:

2021-06-11

Completion:

2023-11-30

Conditions

• Type 2 Diabetes
• PreDiabetes

Interventions

• BEHAVIORAL

No Results Yet

NCT05064709 | RECRUITING | NA

1500 participants

Assessment of CCM in HF With Higher Ejection Fraction

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-06

Start Date:

2022-02-03

Completion:

2029-02-01

Conditions

• Heart Failure
• Heart Failure With Preserved Ejection Fraction
• Heart Failure With Mid Range Ejection Fraction
• Heart Failure With Moderately Reduced Ejection Fraction
• Diastolic Heart Failure

Interventions

• DEVICE

No Results Yet

NCT05055050 | ACTIVE_NOT_RECRUITING | PHASE1

10 participants

A Window of Opportunity Phase I Study of UGN-201 in Patients With Bladder Cancer Undergoing Radical Cystectomy Protocol #: 2021-0630

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-06

Start Date:

2022-01-24

Completion:

2026-08-31

Conditions

• Bladder Cancer
• Bladder

Interventions

• DRUG

No Results Yet

NCT05039840 | ACTIVE_NOT_RECRUITING | PHASE2

109 participants

Efficacy and Safety of Frexalimab (SAR441344) in the Treatment of Systemic Lupus Erythematosus

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-06

Start Date:

2021-11-10

Completion:

2026-09-03

Conditions

• Systemic Lupus Erythematosus

Interventions

• DRUG

No Results Yet

NCT05028621 | SUSPENDED | NA

135 participants

Molecular Basis of Langerhans and Non-Langerhans Cell Histiocytic Neoplasms and Castleman Disease

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-06

Start Date:

2021-06-18

Completion:

2026-09-30

Conditions

• Castleman's Disease (CD)
• Langerhans Cell Histiocytosis (LCH)
• Non-Langerhans-Cell Histiocytosis

Interventions

• DIAGNOSTIC_TEST

No Results Yet

NCT05017740 | ACTIVE_NOT_RECRUITING | NA

47 participants

PICSI RCT in Couples With a Previous Poor Fertilisation Cycle in IVF

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-06

Start Date:

2022-03-15

Completion:

2026-12-31

Conditions

• Infertility
• IVF

Interventions

• PROCEDURE

No Results Yet

NCT05006716 | RECRUITING | PHASE1/PHASE2

645 participants

A Dose-Escalation and Expansion Study of BGB-16673 in Participants With B-Cell Malignancies

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-06

Start Date:

2021-09-13

Completion:

2026-11-30

Conditions

• B-cell Malignancy
• Marginal Zone Lymphoma
• Follicular Lymphoma
• Non-Hodgkin Lymphoma
• Waldenström Macroglobulinemia
• Chronic Lymphocytic Leukemia
• Small Lymphocytic Lymphoma
• Mantle Cell Lymphoma
• Diffuse Large B Cell Lymphoma

Interventions

• DRUG

No Results Yet

NCT05002478 | RECRUITING | NA

14 participants

Infants With Severe Acute Respiratory Distress Syndrome: The Prone Trial

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-06

Start Date:

2022-07-30

Completion:

2027-07-31

Conditions

• Acute Lung Injury/Acute Respiratory Distress Syndrome (ARDS)
• Surfactant Dysfunction
• Infant

Interventions

• OTHER

No Results Yet

NCT04994808 | TERMINATED | PHASE2

23 participants

Treosulfan-Based Versus Clofarabine-Based Conditioning Before Donor Hematopoietic Stem Cell Transplant for the Treatment of Myelodysplastic Syndromes or Acute Myeloid Leukemia

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-06

Start Date:

2023-08-11

Completion:

2026-01-22

Conditions

• Acute Myeloid Leukemia
• Myelodysplastic Syndrome

Interventions

• DRUG
• PROCEDURE
• RADIATION

No Results Yet

NCT04969094 | ACTIVE_NOT_RECRUITING | NA

81 participants

Reducing Fall Risk With NMES

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-06

Start Date:

2022-01-04

Completion:

2026-12-20

Conditions

• Falls

Interventions

• OTHER

No Results Yet

NCT04967365 | COMPLETED

755 participants

Post-Intensive Care Syndrome - Pediatrics (PICS-p): Longitudinal Cohort Study

Study Type:

OBSERVATIONAL

Last Updated:

2026-08-06

Start Date:

2021-07-27

Completion:

2026-01-31

Conditions

• Critical Illness
• Post Intensive Care Unit Syndrome

No Results Yet

NCT04930744 | COMPLETED | PHASE2

112 participants

Safety and Tolerability of Metformin in People With Tuberculosis (TB) and Human Immunodeficiency Virus (HIV)

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-06

Start Date:

2022-03-04

Completion:

2025-04-29

Conditions

• Tuberculosis
• Pulmonary Tuberculosis
• HIV Coinfection

Interventions

• DRUG

Results Available

NCT04876248 | ACTIVE_NOT_RECRUITING | PHASE2

4 participants

Belantamab Mafodotin and Lenalidomide for the Treatment of Multiple Myeloma in Patients With Minimal Residual Disease Positive After Stem Cell Transplant

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-06

Start Date:

2024-08-19

Completion:

2026-12-01

Conditions

• Plasma Cell Myeloma

Interventions

• BIOLOGICAL
• DRUG

No Results Yet

NCT04862325 | COMPLETED | NA

158 participants

SOPHIE Trial: Surgery in Ovarian Cancer With PreHabilitation In ERAS

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-06

Start Date:

2021-04-20

Completion:

2026-04-28

Conditions

• Advanced Ovarian Cancer

Interventions

• OTHER

No Results Yet

NCT04826237 | TERMINATED | PHASE4

3 participants

Oral Statins and Protection From Hearing Loss

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-06

Start Date:

2023-02-09

Completion:

2025-10-30

Conditions

• Sudden Sensorineural Hearing Loss

Interventions

• DRUG

No Results Yet

NCT04804553 | RECRUITING | PHASE3

60 participants

Apremilast Pediatric Study in Children With Active Juvenile Psoriatic Arthritis

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-06

Start Date:

2022-03-17

Completion:

2028-03-21

Conditions

• Active Juvenile Psoriatic Arthritis

Interventions

• DRUG

No Results Yet

NCT04766190 | ACTIVE_NOT_RECRUITING | NA

254 participants

DISCO: A Patient Intervention to Reduce the Financial Burden of Cancer

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-06

Start Date:

2021-02-10

Completion:

2027-08-31

Conditions

• Financial Toxicity
• Cancer
• Question Prompt List
• Breast Cancer
• Prostate Cancer

Interventions

• BEHAVIORAL

No Results Yet