Clinical Trials

NCT05579366 | RECRUITING | PHASE1/PHASE2

884 participants

Rinatabart Sesutecan (Rina-S, PRO1184, GEN1184) for Advanced Solid Tumors (GCT1184-01/ PRO1184-001)

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-04
Start Date:: 2022-12-07
Completion:: 2027-07-31

Conditions

High Grade Epithelial Ovarian Cancer
High Grade Serous Ovarian Cancer
Primary Peritoneal Carcinoma
Fallopian Tube Cancer
Endometrial Cancer
Non-small Cell Lung Cancer
Epidermal Growth Factor Receptor (EGFR)-Mutated Non-Small Cell Lung Cancer (NSCLC)
Mesothelioma
Breast Adenocarcinoma
Triple Negative Breast Cancer
Hormone Receptor-positive/Her2 Negative Breast Cancer
Platinum-resistant Ovarian Cancer (PROC)
Platinum Sensitive Ovarian Cancer (PSOC)
Primary Refractory Ovarian Cancer
Uterine Cancer

Interventions

DRUG

No Results Yet

NCT05567198 | RECRUITING

100 participants

Gonadotropin-releasing Hormone Agonist (GnRHa) in Ovarian Preservation in SLE Subjects Receiving Cyclophosphamide as Determined by Questionnaires

Study Type:: OBSERVATIONAL
Last Updated:: 2026-08-04
Start Date:: 2023-03-03
Completion:: 2027-05-31

Conditions

Systemic Lupus Erythematosus (Sle)
Primary Ovarian Insufficiency (Poi)

No Results Yet

NCT05564403 | ACTIVE_NOT_RECRUITING | PHASE2

66 participants

Study of Chemotherapy, With or Without Binimetinib in Advanced Biliary Tract Cancers in 2nd Line Setting (A ComboMATCH Treatment Trial)

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-04
Start Date:: 2024-02-09
Completion:: 2026-10-01

Conditions

Advanced Biliary Tract Carcinoma
Advanced Gallbladder Carcinoma
Advanced Intrahepatic Cholangiocarcinoma
Recurrent Biliary Tract Carcinoma
Recurrent Gallbladder Carcinoma
Recurrent Intrahepatic Cholangiocarcinoma
Stage III Distal Bile Duct Cancer AJCC v8
Stage III Gallbladder Cancer AJCC v8
Stage III Hilar Cholangiocarcinoma AJCC v8
Stage III Intrahepatic Cholangiocarcinoma AJCC v8
Stage IV Distal Bile Duct Cancer AJCC v8
Stage IV Gallbladder Cancer AJCC v8
Stage IV Hilar Cholangiocarcinoma AJCC v8
Stage IV Intrahepatic Cholangiocarcinoma AJCC v8
Unresectable Biliary Tract Carcinoma
Unresectable Gallbladder Carcinoma
Unresectable Intrahepatic Cholangiocarcinoma

Interventions

DRUG
PROCEDURE

No Results Yet

NCT05562947 | RECRUITING | PHASE3

68 participants

A Study of the Efficacy, Safety, and Pharmacokinetics (PK) of the Port Delivery System With Ranibizumab (PDS) in Chinese Participants With Neovascular Age-related Macular Degeneration (nAMD)

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-04
Start Date:: 2024-06-17
Completion:: 2027-07-27

Conditions

Neovascular Age-related Macular Degeneration
nAMD

Interventions

DEVICE
DRUG

No Results Yet

NCT05554367 | ACTIVE_NOT_RECRUITING | PHASE2

199 participants

Palbociclib and Binimetinib in RAS-Mutant Cancers, A ComboMATCH Treatment Trial

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-04
Start Date:: 2023-12-13
Completion:: 2026-08-26

Conditions

Exocrine Pancreas Carcinoma
Malignant Solid Neoplasm
Ovarian Low Grade Serous Adenocarcinoma
Stage IV Ovarian Cancer AJCC v8
Stage IV Pancreatic Cancer AJCC v8

Interventions

DRUG
PROCEDURE

No Results Yet

NCT05554341 | ACTIVE_NOT_RECRUITING | PHASE2

40 participants

Testing the Use of Nilotinib and Paclitaxel as a Treatment for Patients With Prior Taxane Treatment, A ComboMATCH Treatment Trial

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-04
Start Date:: 2023-07-14
Completion:: 2027-06-30

Conditions

Metastatic Malignant Solid Neoplasm
Refractory Malignant Solid Neoplasm

Interventions

PROCEDURE
DRUG

No Results Yet

NCT05554328 | ACTIVE_NOT_RECRUITING | PHASE2

165 participants

Testing the Use of the Combination of Selumetinib and Olaparib or Selumetinib Alone Targeted Treatment for RAS Pathway Mutant Recurrent or Persistent Ovarian and Endometrial Cancers, A ComboMATCH Treatment Trial

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-04
Start Date:: 2023-04-25
Completion:: 2028-10-01

Conditions

Recurrent Endometrial Carcinoma
Recurrent Fallopian Tube Carcinoma
Recurrent Ovarian Carcinoma
Recurrent Primary Peritoneal Carcinoma

Interventions

PROCEDURE
DRUG

No Results Yet

NCT05471856 | RECRUITING | PHASE1

66 participants

A Study to Test How Different Doses of BI 1703880 in Combination With Ezabenlimab Are Tolerated in People With Different Types of Advanced Cancer (Solid Tumours)

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-04
Start Date:: 2023-02-24
Completion:: 2028-09-13

Conditions

Solid Tumors

Interventions

DRUG

No Results Yet

NCT05422573 | COMPLETED | NA

393 participants

Clinical Trial of the Sequence of Cardiovascular Genetic Counseling and Testing

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-04
Start Date:: 2022-12-20
Completion:: 2026-05-21

Conditions

Genetic Counseling
Inherited Cardiac Disease

Interventions

BEHAVIORAL

No Results Yet

NCT05411081 | ACTIVE_NOT_RECRUITING | PHASE2

200 participants

Testing Cabozantinib With or Without Atezolizumab in Patients With Advanced Papillary Kidney Cancer, PAPMET2 Trial

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-04
Start Date:: 2023-03-24
Completion:: 2027-07-01

Conditions

Metastatic Papillary Renal Cell Carcinoma
Stage IV Renal Cell Cancer AJCC v8

Interventions

BIOLOGICAL
PROCEDURE
DRUG

No Results Yet

NCT05397431 | ACTIVE_NOT_RECRUITING

155 participants

A Survey of Lanadelumab in Participants With Hereditary Angioedema

Study Type:: OBSERVATIONAL
Last Updated:: 2026-08-04
Start Date:: 2022-05-30
Completion:: 2026-10-27

Conditions

Hereditary Angioedema (HAE)

Interventions

DRUG

No Results Yet

NCT05384847 | COMPLETED | PHASE1

14 participants

Effects of Triiodothyronine (T3) in Ischemic Heart Failure

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-04
Start Date:: 2022-12-02
Completion:: 2025-10-01

Conditions

Heart Failure

Interventions

DRUG
OTHER

No Results Yet

NCT05375682 | COMPLETED | NA

30 participants

Integrating Care for Patients With Alcohol Liver Disease and Alcohol Use Disorders

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-04
Start Date:: 2024-04-01
Completion:: 2026-04-15

Conditions

Alcohol; Liver

Interventions

OTHER

No Results Yet

NCT05363813 | COMPLETED | NA

245 participants

Post-market Clinical Follow-up Study of Reusable Clip Applier Cartridge Devices for LAParoscopic Surgery

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-04
Start Date:: 2022-10-17
Completion:: 2024-08-19

Conditions

Minimally Invasive Surgical Procedures
Laparoscopy
Leakage of Cardiac Device

Interventions

DEVICE

Results Available

NCT05348005 | COMPLETED | NA

40 participants

Use of TENS Unit in the Management of Endometriosis Pain

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-04
Start Date:: 2022-07-28
Completion:: 2025-07-16

Conditions

Endometriosis
Pelvic Pain

Interventions

DEVICE

Results Available

NCT05341115 | COMPLETED | PHASE4

79 participants

A Study of Leuprolide Acetate Depot in Children With Central Precocious Puberty

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-04
Start Date:: 2023-03-12
Completion:: 2024-12-19

Conditions

Central Precocious Puberty

Interventions

DRUG

Results Available

NCT05312879 | RECRUITING | PHASE2/PHASE3

466 participants

Phase 2/3 Adaptive Study of VX-147 in Adult and Pediatric Participants With APOL1-Mediated Proteinuric Kidney Disease

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-04
Start Date:: 2022-03-30
Completion:: 2028-06-02

Conditions

Proteinuric Kidney Disease

Interventions

DRUG

No Results Yet

NCT05272423 | COMPLETED

58 participants

Studying Pathways of Resistance in KRAS-driven Cancers

Study Type:: OBSERVATIONAL
Last Updated:: 2026-08-04
Start Date:: 2022-09-08
Completion:: 2025-12-10

Conditions

KRAS P.G12C

Interventions

DIAGNOSTIC_TEST

No Results Yet

NCT05258357 | COMPLETED | NA

100 participants

Landmark vs. Ultrasound-Assisted Bone Marrow Biopsy Procedure Study

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-04
Start Date:: 2022-05-18
Completion:: 2026-05-12

Conditions

Bone Marrow Biopsy Procedure

Interventions

DEVICE
PROCEDURE

No Results Yet

NCT05250050 | WITHDRAWN | PHASE4

0 participants

Susceptibility-Guided Therapy for Helicobacter Pylori Infection Treatment

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-04
Start Date:: 2022-03-25
Completion:: 2022-12-30

Conditions

Helicobacter Pylori Infection

Interventions

DRUG

No Results Yet

NCT05246579 | RECRUITING

240 participants

Prospective Evaluation of Pathways for Preterm Birth

Study Type:: OBSERVATIONAL
Last Updated:: 2026-08-04
Start Date:: 2022-02-04
Completion:: 2027-07-01

Conditions

Preterm Birth
Cervix; Pregnancy

No Results Yet

NCT05238792 | RECRUITING | PHASE1

24 participants

Multi Tumor-Associated Antigen-Specific T Lymphocytes to Treat Patients With High Risk Solid Tumors

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-04
Start Date:: 2021-11-17
Completion:: 2028-10-31

Conditions

Solid Tumor

Interventions

BIOLOGICAL

No Results Yet

NCT05224557 | WITHDRAWN

0 participants

Analysis of Cardiac Biomarker Racial Discrepancies

Study Type:: OBSERVATIONAL
Last Updated:: 2026-08-04
Start Date:: 2021-09-15
Completion:: 2027-08-15

Conditions

Heart Failure

Interventions

OTHER

No Results Yet

NCT05202353 | ACTIVE_NOT_RECRUITING | PHASE1

29 participants

A Study in People With Obesity to Test the Effects of BI 456906 Compared With Semaglutide on Glucagon Receptor Activity in the Liver

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-04
Start Date:: 2024-10-01
Completion:: 2026-12-18

Conditions

Obesity

Interventions

DRUG

No Results Yet

NCT05199285 | TERMINATED | PHASE2

15 participants

A Phase II Study of Nivolumab + Ipilimumab in Advanced HCC Patients Who Have Progressed on First Line Atezolizumab + Bevacizumab

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-04
Start Date:: 2023-01-19
Completion:: 2026-02-01

Conditions

BCLC Stage B Hepatocellular Carcinoma
BCLC Stage C Hepatocellular Carcinoma
Locally Advanced Hepatocellular Carcinoma
Metastatic Hepatocellular Carcinoma
Stage III Hepatocellular Carcinoma AJCC v8
Stage IIIA Hepatocellular Carcinoma AJCC v8
Stage IIIB Hepatocellular Carcinoma AJCC v8
Stage IV Hepatocellular Carcinoma AJCC v8
Stage IVA Hepatocellular Carcinoma AJCC v8
Stage IVB Hepatocellular Carcinoma AJCC v8
Unresectable Hepatocellular Carcinoma

Interventions

BIOLOGICAL

No Results Yet

NCT05174169 | RECRUITING | PHASE2/PHASE3

1912 participants

Colon Adjuvant Chemotherapy Based on Evaluation of Residual Disease

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-04
Start Date:: 2022-07-08
Completion:: 2029-03-10

Conditions

Stage III Colon Cancer

Interventions

DEVICE
DRUG

No Results Yet

NCT05170399 | RECRUITING | PHASE4

350 participants

Vaccine Responses in Patients With B Cell Malignancies

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-04
Start Date:: 2022-09-14
Completion:: 2036-11-15

Conditions

Lymphoma

Interventions

DRUG
BIOLOGICAL

No Results Yet

NCT05168163 | RECRUITING | PHASE2

122 participants

Atezolizumab in Combination With a Multi-Kinase Inhibitor for the Treatment of Unresectable, Locally Advanced, or Metastatic Liver Cancer

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-04
Start Date:: 2022-05-27
Completion:: 2026-06-30

Conditions

Locally Advanced Hepatocellular Carcinoma
Metastatic Hepatocellular Carcinoma
Stage III Hepatocellular Carcinoma AJCC v8
Stage IIIA Hepatocellular Carcinoma AJCC v8
Stage IIIB Hepatocellular Carcinoma AJCC v8
Stage IV Hepatocellular Carcinoma AJCC v8
Stage IVA Hepatocellular Carcinoma AJCC v8
Stage IVB Hepatocellular Carcinoma AJCC v8
Unresectable Hepatocellular Carcinoma

Interventions

BIOLOGICAL
DRUG

No Results Yet

NCT05132504 | RECRUITING | PHASE2

30 participants

Neoadjuvant Folfirinox Combined With Pembrolizumab Followed by Surgery for Patients With Resectable Pancreatic Cancer

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-04
Start Date:: 2022-08-31
Completion:: 2027-05-21

Conditions

Pancreatic Ductal Adenocarcinoma

Interventions

DRUG

No Results Yet

NCT05111574 | ACTIVE_NOT_RECRUITING | PHASE2

101 participants

Using Nivolumab Alone or With Cabozantinib to Prevent Mucosal Melanoma Return After Surgery

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-04
Start Date:: 2022-08-11
Completion:: 2027-07-15

Conditions

Anal Melanoma
Bladder Melanoma
Cervical Melanoma
Esophageal Melanoma
Gallbladder Melanoma
Head and Neck Mucosal Melanoma
Mucosal Melanoma
Nasopharyngeal Mucosal Melanoma
Oral Cavity Mucosal Melanoma
Penile Mucosal Melanoma
Rectal Melanoma
Recurrent Mucosal Melanoma
Sinonasal Mucosal Melanoma
Urethral Melanoma
Urinary System Mucosal Melanoma
Vaginal Melanoma
Vulvar Melanoma

Interventions

PROCEDURE
BIOLOGICAL
DRUG

No Results Yet

NCT05080673 | RECRUITING | NA

9500 participants

Five or Ten Year Colonoscopy for 1-2 Non-Advanced Adenomatous Polyps

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-04
Start Date:: 2022-02-09
Completion:: 2035-11-01

Conditions

Adenocarcinoma of the Colon
Adenocarcinoma of the Rectum

Interventions

PROCEDURE

No Results Yet

NCT05080166 | COMPLETED | NA

74 participants

UPLYFT For Lymphoma Survivors

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-04
Start Date:: 2022-02-08
Completion:: 2026-07-17

Conditions

Lymphoma
Survivorship

Interventions

OTHER
BEHAVIORAL

No Results Yet

NCT05068102 | ACTIVE_NOT_RECRUITING | PHASE1

14 participants

A Study to Test How BI 765063 and BI 770371 Are Taken up in Tumours of People With Different Types of Advanced Cancer Who Are Also Taking Ezabenlimab

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-04
Start Date:: 2022-03-03
Completion:: 2026-01-22

Conditions

Carcinoma, Squamous Cell of Head and Neck (HNSCC)
Melanoma
Non-small Cell Lung Cancer (NSCLC)

Interventions

DRUG

No Results Yet

NCT05050916 | COMPLETED | PHASE2

998 participants

The Investigation of Vitamin D and Menstrual Cycles Trial, the inVitD Trial: A Phase II Clinical Trial

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-04
Start Date:: 2023-03-17
Completion:: 2024-06-07

Conditions

Reproductive Issues

Interventions

DIETARY_SUPPLEMENT
OTHER

No Results Yet

NCT05016700 | COMPLETED

100 participants

Neuropathological Changes of the Intestinal Wall in Patients With Bowel Evacuation Disorders

Study Type:: OBSERVATIONAL
Last Updated:: 2026-08-04
Start Date:: 2019-03-20
Completion:: 2025-04-01

Conditions

Defecation Disorder
Neuropathology
Autoimmune Diseases

Interventions

DIAGNOSTIC_TEST

No Results Yet

NCT05006833 | COMPLETED | NA

8043 participants

Text and Talk: A Multi-level Intervention to Increase Provider HPV Vaccine Recommendation Effectiveness

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-04
Start Date:: 2021-11-18
Completion:: 2025-02-25

Conditions

HPV

Interventions

BEHAVIORAL

Results Available

NCT05004662 | COMPLETED | NA

502 participants

Partnering With Food Bank to Provide Tobacco Treatment to Underserved Smokers

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-04
Start Date:: 2021-12-01
Completion:: 2025-06-05

Conditions

Smoking Cessation

Interventions

BEHAVIORAL
DRUG

Results Available

NCT04969926 | RECRUITING

3000 participants

Natural History Study of Parathyroid Disorders

Study Type:: OBSERVATIONAL
Last Updated:: 2026-08-04
Start Date:: 2021-11-30
Completion:: 2031-01-22

Conditions

Parathyroid Cancer
Primary Hyperparathyroidism
Pseudohypoparathyroidism
Inheritable Bone Diseases
Multiple Endocrine Neoplasia, Type 1

No Results Yet

NCT04949100 | ACTIVE_NOT_RECRUITING | NA

50 participants

Microcurrent for Fibromyalgia

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-04
Start Date:: 2021-10-25
Completion:: 2026-12-31

Conditions

Fibromyalgia

Interventions

DEVICE

No Results Yet

NCT04943861 | RECRUITING | NA

200 participants

Human Immunodeficiency Virus (HIV) Food Insecurities

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-04
Start Date:: 2023-12-01
Completion:: 2027-02-28

Conditions

Food Insecurities
Cardiometabolic Comorbidities
HIV
PreDiabetes
Type 2 Diabetes Mellitus (T2DM)

Interventions

BEHAVIORAL
OTHER

No Results Yet