Clinical Trials

NCT04666610 | COMPLETED | PHASE3

153 participants

A Study to Evaluate the Efficacy, Safety, and Tolerability of Brivaracetam as Monotherapy in Patients 2 to 25 Years of Age With Childhood Absence Epilepsy or Juvenile Absence Epilepsy

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-04

Start Date:

2021-07-29

Completion:

2026-07-07

Conditions

• Childhood Absence Epilepsy
• Juvenile Absence Epilepsy

Interventions

• DRUG
• OTHER

No Results Yet

NCT04663347 | ACTIVE_NOT_RECRUITING | PHASE1/PHASE2

543 participants

Safety and Efficacy Trial of Epcoritamab Combinations in Subjects With B-cell Non-Hodgkin Lymphoma (B-NHL)

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-04

Start Date:

2020-11-03

Completion:

2027-09-30

Conditions

• Diffuse Large B-Cell Lymphoma
• Follicular Lymphoma

Interventions

• DRUG
• BIOLOGICAL

No Results Yet

NCT04640259 | COMPLETED

187 participants

Epidemiology of Young Lung Cancer - Survey

Study Type:

OBSERVATIONAL

Last Updated:

2026-08-04

Start Date:

2021-02-01

Completion:

2025-12-10

Conditions

• NSCLC

Interventions

• OTHER

No Results Yet

NCT04628767 | RECRUITING | PHASE2/PHASE3

131 participants

Testing the Addition of MEDI4736 (Durvalumab) to Chemotherapy Before Surgery for Patients With High-Grade Upper Urinary Tract Cancer

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-04

Start Date:

2021-11-12

Completion:

2027-09-30

Conditions

• Renal Pelvis and Ureter Urothelial Carcinoma

Interventions

• PROCEDURE
• DRUG
• BIOLOGICAL

No Results Yet

NCT04623541 | ACTIVE_NOT_RECRUITING | PHASE1/PHASE2

194 participants

Safety and Efficacy Study of Epcoritamab in Subjects With Relapsed/Refractory Chronic Lymphocytic Leukemia and Richter's Syndrome

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-04

Start Date:

2020-11-25

Completion:

2027-12-31

Conditions

• Relapsed/Refractory Chronic Lymphocytic Leukemia
• Small Lymphocytic Lymphoma
• Richter's Syndrome
• Treatment-naïve High Risk Chronic Lymphocytic Leukemia

Interventions

• BIOLOGICAL
• DRUG

No Results Yet

NCT04579224 | ACTIVE_NOT_RECRUITING | PHASE3

184 participants

Comparing the New Anti-cancer Drug Eribulin With Chemotherapy Against the Usual Chemotherapy Alone in Metastatic Urothelial Cancer

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-04

Start Date:

2021-06-28

Completion:

2030-08-15

Conditions

• Metastatic Bladder Urothelial Carcinoma
• Metastatic Urothelial Carcinoma
• Refractory Bladder Urothelial Carcinoma
• Refractory Urothelial Carcinoma
• Stage IV Bladder Cancer AJCC v8

Interventions

• PROCEDURE
• DRUG
• BIOLOGICAL

No Results Yet

NCT04573062 | RECRUITING

1590 participants

Natural History of Post-Coronavirus Disease 19 Convalescence at the National Institutes of Health

Study Type:

OBSERVATIONAL

Last Updated:

2026-08-04

Start Date:

2022-01-02

Completion:

2027-12-31

Conditions

• Post-Coronavirus Disease 19

No Results Yet

NCT04548752 | ACTIVE_NOT_RECRUITING | PHASE2

88 participants

Testing the Addition of Pembrolizumab, an Immunotherapy Cancer Drug to Olaparib Alone as Therapy for Patients With Pancreatic Cancer That Has Spread With Inherited BRCA Mutations

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-04

Start Date:

2021-02-22

Completion:

2026-10-01

Conditions

• Metastatic Pancreatic Adenocarcinoma
• Stage IV Pancreatic Cancer AJCC v8

Interventions

• PROCEDURE
• DRUG
• BIOLOGICAL

No Results Yet

NCT04543773 | ACTIVE_NOT_RECRUITING | NA

24 participants

Individualized Targeting and Neuromodulation of Late-Life Depression

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-04

Start Date:

2024-10-01

Completion:

2026-09-01

Conditions

• Major Depressive Disorder

Interventions

• DEVICE

No Results Yet

NCT04542824 | ACTIVE_NOT_RECRUITING | PHASE1/PHASE2

78 participants

Trial of the Safety and Efficacy of Epcoritamab in Japanese Subjects With Relapsed or Refractory (R/R) B-Cell Non-Hodgkin Lymphoma (R/R B-NHL)

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-04

Start Date:

2020-08-20

Completion:

2027-09-30

Conditions

• Diffuse Large B Cell Lymphoma
• High-grade B-cell Lymphoma
• Primary Mediastinal Large B Cell Lymphoma
• Follicular Lymphoma
• Marginal Zone Lymphoma
• Small Lymphocytic Lymphoma

Interventions

• BIOLOGICAL
• DRUG

No Results Yet

NCT04526665 | ACTIVE_NOT_RECRUITING | PHASE3

161 participants

Study of Elafibranor in Patients With Primary Biliary Cholangitis (PBC)

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-04

Start Date:

2020-09-24

Completion:

2023-06-01

Conditions

• Primary Biliary Cirrhosis

Interventions

• DRUG

Results Available

NCT04451798 | COMPLETED | NA

20 participants

Acute Impact of the Impella CP Assist Device in Pts. With Cardiogenic Shock on the Patients Hemodynamic

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-04

Start Date:

2016-12-31

Completion:

2026-08-31

Conditions

• Cardiogenic Shock

Interventions

• DEVICE

No Results Yet

NCT04444921 | ACTIVE_NOT_RECRUITING | PHASE3

205 participants

EA2176: Phase 3 Clinical Trial of Carboplatin and Paclitaxel +/- Nivolumab in Metastatic Anal Cancer Patients

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-04

Start Date:

2020-11-17

Completion:

2027-03-31

Conditions

• Anal Basaloid Carcinoma
• Anal Canal Cloacogenic Carcinoma
• Metastatic Anal Squamous Cell Carcinoma
• Recurrent Anal Squamous Cell Carcinoma
• Stage III Anal Cancer AJCC v8
• Stage IV Anal Cancer AJCC v8
• Unresectable Anal Squamous Cell Carcinoma

Interventions

• DRUG
• BIOLOGICAL

No Results Yet

NCT04387656 | ACTIVE_NOT_RECRUITING

1877 participants

NCI COVID-19 in Cancer Patients, NCCAPS Study

Study Type:

OBSERVATIONAL

Last Updated:

2026-08-04

Start Date:

2020-06-05

Completion:

2024-03-20

Conditions

• COVID-19 Infection
• Hematopoietic and Lymphatic System Neoplasm
• Malignant Solid Neoplasm
• Metastatic Malignant Solid Neoplasm

Interventions

• PROCEDURE
• OTHER

No Results Yet

NCT04310007 | ACTIVE_NOT_RECRUITING | PHASE2

117 participants

Testing the Addition of the Pill Chemotherapy, Cabozantinib, to the Standard Immune Therapy Nivolumab Compared to Standard Chemotherapy for Non-small Cell Lung Cancer

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-04

Start Date:

2020-07-13

Completion:

2026-12-31

Conditions

• Metastatic Lung Non-Squamous Non-Small Cell Carcinoma
• Recurrent Lung Non-Squamous Non-Small Cell Carcinoma
• Stage IV Lung Cancer AJCC v8

Interventions

• PROCEDURE
• DRUG
• BIOLOGICAL

No Results Yet

NCT04239079 | RECRUITING

120 participants

Autoimmune Features of Neurodegenerative Disorders

Study Type:

OBSERVATIONAL

Last Updated:

2026-08-04

Start Date:

2019-05-01

Completion:

2028-07-31

Conditions

• Parkinson Disease
• Alzheimer Disease
• Mild Cognitive Impairment

No Results Yet

NCT04145115 | ACTIVE_NOT_RECRUITING | PHASE2

37 participants

A Study Testing the Effect of Immunotherapy (Ipilimumab and Nivolumab) in Patients With Recurrent Glioma With Elevated Mutational Burden

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-04

Start Date:

2020-12-24

Completion:

2026-12-31

Conditions

• Astrocytoma, IDH-Mutant, Grade 4
• Diffuse Glioma
• Glioblastoma, IDH-Wildtype
• Secondary Glioblastoma

Interventions

• BIOLOGICAL
• PROCEDURE

No Results Yet

NCT04123795 | COMPLETED | PHASE3

49 participants

A Study to Evaluate the Pharmacokinetics, Safety, and Effectiveness of Certolizumab Pegol in Children With Moderate to Severe Chronic Plaque Psoriasis

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-04

Start Date:

2020-01-21

Completion:

2026-04-09

Conditions

• Moderate Chronic Plaque Psoriasis
• Severe Chronic Plaque Psoriasis
• Mixed Guttate/Plaque Psoriasis

Interventions

• DRUG

No Results Yet

NCT04111939 | COMPLETED | NA

67 participants

HEALing Communities Study

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-04

Start Date:

2019-10-23

Completion:

2023-12-31

Conditions

• Opioid Use Disorder (OUD)

Interventions

• OTHER

Results Available

NCT04111458 | ACTIVE_NOT_RECRUITING | PHASE1

71 participants

A Study to Test Different Doses of BI 1701963 Alone and Combined With Trametinib in Patients With Different Types of Advanced Cancer (Solid Tumours With KRAS Mutation)

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-04

Start Date:

2019-11-04

Completion:

2028-03-31

Conditions

• Solid Tumors, KRAS Mutation; SOS1

Interventions

• DRUG

No Results Yet

NCT04083599 | ACTIVE_NOT_RECRUITING | PHASE1/PHASE2

350 participants

GEN1042 Safety Trial and Anti-tumor Activity in Participants With Malignant Solid Tumors

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-04

Start Date:

2019-09-17

Completion:

2025-12-30

Conditions

• Malignant Solid Tumor
• Non-Small Cell Lung Cancer (NSCLC)
• Colorectal Cancer (CRC)
• Melanoma
• Head and Neck Squamous Cell Carcinoma (HNSCC)
• Pancreatic Ductal Adenocarcinoma (PDAC)

Interventions

• BIOLOGICAL
• DRUG

No Results Yet

NCT04058652 | ACTIVE_NOT_RECRUITING | NA

20 participants

Use of Transcutaneous Electrical Nerve Stimulation for Reducing Biologic Injection Site Pain(TENS Study)

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-04

Start Date:

2019-08-07

Completion:

2027-01-31

Conditions

• Psoriasis

Interventions

• DEVICE

No Results Yet

NCT04040634 | COMPLETED | NA

9476 participants

Optimal Blood Pressure for the prevenTIon of Major vAscuLar Events in Patients With DIABETES Mellitus (OPTIMAL-DIABETES)

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-04

Start Date:

2019-08-08

Completion:

2026-07-08

Conditions

• Diabetes Mellitus
• High Blood Pressure
• Cardiovascular Diseases
• Cognitive Impairment

Interventions

• DRUG

No Results Yet

NCT04032470 | RECRUITING

500 participants

Boston Scientific Registry of Deep Brain Stimulation for Treatment of Essential Tremor (ET)

Study Type:

OBSERVATIONAL

Last Updated:

2026-08-04

Start Date:

2019-10-23

Completion:

2029-12-31

Conditions

• Essential Tremor

Interventions

• DEVICE

No Results Yet

NCT03984448 | ACTIVE_NOT_RECRUITING | PHASE2/PHASE3

363 participants

Testing the Addition of a New Anti-cancer Drug, Venetoclax, to Usual Chemotherapy for High Grade B-cell Lymphomas

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-04

Start Date:

2019-10-22

Completion:

2028-04-01

Conditions

• Diffuse Large B-Cell Lymphoma
• Diffuse Large B-Cell Lymphoma, Not Otherwise Specified
• Double-Expressor Lymphoma
• EBV-Positive Diffuse Large B-Cell Lymphoma, Not Otherwise Specified
• High Grade B-Cell Lymphoma With MYC and BCL2 or BCL6 Rearrangements
• High Grade B-Cell Lymphoma, Not Otherwise Specified
• Neoplastic Cells With Double Expression of MYC and BCL2 Proteins Present
• Transformed Indolent B-Cell Non-Hodgkin Lymphoma to Diffuse Large B-Cell Lymphoma

Interventions

• PROCEDURE
• DRUG
• BIOLOGICAL

No Results Yet

NCT03917381 | ACTIVE_NOT_RECRUITING | PHASE1/PHASE2

429 participants

GEN1046 Safety Trial in Patients With Malignant Solid Tumors

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-04

Start Date:

2019-05-14

Completion:

2025-04-01

Conditions

• Solid Tumors

Interventions

• BIOLOGICAL

Results Available

NCT03907488 | ACTIVE_NOT_RECRUITING | PHASE3

994 participants

Immunotherapy (Nivolumab or Brentuximab Vedotin) Plus Combination Chemotherapy in Treating Patients With Newly Diagnosed Stage III-IV Classic Hodgkin Lymphoma

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-04

Start Date:

2019-08-29

Completion:

2024-03-31

Conditions

• Ann Arbor Stage III Hodgkin Lymphoma
• Ann Arbor Stage III Lymphocyte-Depleted Classic Hodgkin Lymphoma
• Ann Arbor Stage III Mixed Cellularity Classic Hodgkin Lymphoma
• Ann Arbor Stage III Nodular Sclerosis Classic Hodgkin Lymphoma
• Ann Arbor Stage IV Hodgkin Lymphoma
• Ann Arbor Stage IV Lymphocyte-Depleted Classic Hodgkin Lymphoma
• Ann Arbor Stage IV Mixed Cellularity Classic Hodgkin Lymphoma
• Ann Arbor Stage IV Nodular Sclerosis Classic Hodgkin Lymphoma
• Classic Hodgkin Lymphoma
• Lymphocyte-Rich Classic Hodgkin Lymphoma

Interventions

• PROCEDURE
• DRUG
• BIOLOGICAL
• OTHER
• RADIATION

Results Available

NCT03906721 | COMPLETED | PHASE2

20 participants

Reduction of Opioid Dose Using Conditioning & Open-Label Placebo (COLP) in Intensive Rehabilitation

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-04

Start Date:

2019-02-20

Completion:

2021-11-01

Conditions

• Spinal Cord Injuries
• Polytrauma
• Burn Injury
• Pain Management

Interventions

• DRUG
• OTHER

Results Available

NCT03811561 | ACTIVE_NOT_RECRUITING | PHASE3

1500 participants

A Research Study to Look at How Semaglutide Compared to Placebo Affects Diabetic Eye Disease in People With Type 2 Diabetes

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-04

Start Date:

2019-05-08

Completion:

2027-11-07

Conditions

• Diabetes Mellitus, Type 2

Interventions

• DRUG

No Results Yet

NCT03811015 | ACTIVE_NOT_RECRUITING | PHASE3

636 participants

Testing Immunotherapy Versus Observation in Patients With HPV Throat Cancer

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-04

Start Date:

2019-08-16

Completion:

2027-01-01

Conditions

• Clinical Stage II HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8
• Clinical Stage III HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8

Interventions

• PROCEDURE
• DRUG
• OTHER
• RADIATION
• BIOLOGICAL

No Results Yet

NCT03811002 | ACTIVE_NOT_RECRUITING | PHASE3

544 participants

Testing the Addition of a New Immunotherapy Drug, Atezolizumab (MPDL3280A), to the Usual Chemoradiation (CRT) Therapy Treatment for Limited Stage Small Cell Lung Cancer (LS-SCLC)

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-04

Start Date:

2019-07-26

Completion:

2024-04-21

Conditions

• Limited Stage Lung Small Cell Carcinoma
• Stage I Lung Cancer AJCC v8
• Stage II Lung Cancer AJCC v8
• Stage III Lung Cancer AJCC v8

Interventions

• RADIATION
• DRUG
• PROCEDURE
• OTHER

Results Available

NCT03793179 | ACTIVE_NOT_RECRUITING | PHASE3

600 participants

Testing the Timing of Pembrolizumab Alone or With Chemotherapy as First Line Treatment and Maintenance in Non-small Cell Lung Cancer

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-04

Start Date:

2019-04-05

Completion:

2027-09-30

Conditions

• Lung Non-Squamous Non-Small Cell Carcinoma
• Stage IIIB Lung Cancer AJCC v8
• Stage IIIC Lung Cancer AJCC v8
• Stage IV Lung Cancer AJCC v8

Interventions

• PROCEDURE
• DRUG
• BIOLOGICAL

No Results Yet

NCT03793166 | ACTIVE_NOT_RECRUITING | PHASE3

1175 participants

Immunotherapy With Nivolumab and Ipilimumab Followed by Nivolumab or Nivolumab With Cabozantinib for Patients With Advanced Kidney Cancer, The PDIGREE Study

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-04

Start Date:

2019-06-07

Completion:

2028-01-25

Conditions

• Clear Cell Renal Cell Carcinoma
• Metastatic Malignant Neoplasm in the Bone
• Metastatic Malignant Neoplasm in the Lymph Nodes
• Metastatic Malignant Neoplasm in the Soft Tissue
• Metastatic Malignant Neoplasm in the Viscera
• Rhabdoid Tumor of the Kidney
• Sarcomatoid Renal Cell Carcinoma
• Stage III Renal Cell Cancer AJCC v8
• Stage IV Renal Cell Cancer AJCC v8

Interventions

• PROCEDURE
• DRUG
• BIOLOGICAL
• OTHER

No Results Yet

NCT03775265 | ACTIVE_NOT_RECRUITING | PHASE3

475 participants

Chemoradiotherapy With or Without Atezolizumab in Treating Patients With Localized Muscle Invasive Bladder Cancer

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-04

Start Date:

2019-06-03

Completion:

2027-06-01

Conditions

• Bladder Urothelial Carcinoma
• Muscle Invasive Bladder Carcinoma
• Stage II Bladder Cancer AJCC v8
• Stage IIIA Bladder Cancer AJCC v8

Interventions

• PROCEDURE
• DRUG
• OTHER
• RADIATION

No Results Yet

NCT03772990 | COMPLETED | PHASE4

820 participants

Calcium Administration in Cardiac Surgery

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-04

Start Date:

2019-01-14

Completion:

2025-07-13

Conditions

• Cardiac Surgery
• Cardiopulmonary Bypass

Interventions

• DRUG

No Results Yet

NCT03745339 | RECRUITING

150 participants

Outcome Inference in the Sensory Preconditioning Task in Opioid-Use Disorder

Study Type:

OBSERVATIONAL

Last Updated:

2026-08-04

Start Date:

2019-06-07

Completion:

2026-10-01

Conditions

• Opioid-Related Disorders
• Drug Addiction

No Results Yet

NCT03742102 | ACTIVE_NOT_RECRUITING | PHASE1/PHASE2

243 participants

A Study of Novel Anti-cancer Agents in Patients With Metastatic Triple Negative Breast Cancer

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-04

Start Date:

2018-12-21

Completion:

2024-11-29

Conditions

• Triple Negative Breast Neoplasms

Interventions

• DRUG

Results Available

NCT03737981 | ACTIVE_NOT_RECRUITING | PHASE3

465 participants

Testing the Addition of a New Anti-cancer Drug, Venetoclax, to the Usual Treatment (Ibrutinib and Obinutuzumab) in Untreated, Older Patients With Chronic Lymphocytic Leukemia

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-04

Start Date:

2019-01-31

Completion:

2025-01-17

Conditions

• Chronic Lymphocytic Leukemia
• Small Lymphocytic Lymphoma

Interventions

• DRUG
• BIOLOGICAL
• OTHER

Results Available

NCT03712605 | ACTIVE_NOT_RECRUITING | PHASE3

280 participants

Testing Pembrolizumab Versus Observation in Patients With Merkel Cell Carcinoma After Surgery, STAMP Trial

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-04

Start Date:

2018-11-15

Completion:

2026-12-31

Conditions

• Pathologic Stage I Cutaneous Merkel Cell Carcinoma AJCC v8
• Pathologic Stage II Cutaneous Merkel Cell Carcinoma AJCC v8
• Pathologic Stage III Cutaneous Merkel Cell Carcinoma AJCC v8

Interventions

• OTHER
• PROCEDURE
• BIOLOGICAL
• RADIATION

No Results Yet

NCT03701282 | ACTIVE_NOT_RECRUITING | PHASE3

720 participants

Assessing the Ability of Combination Treatment With Venetoclax to Permit Time Limited Therapy in Chronic Lymphocytic Leukemia

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-04

Start Date:

2019-02-12

Completion:

2028-05-07

Conditions

• Chronic Lymphocytic Leukemia
• Small Lymphocytic Lymphoma

Interventions

• PROCEDURE
• DRUG
• BIOLOGICAL
• OTHER

No Results Yet