Clinical Trials

NCT04816006 | RECRUITING | NA
160 participants

Breast Cancer, Reasoning, and Activity Intervention

Study Type:
INTERVENTIONAL
Last Updated:
2026-07-31
Start Date:
2024-02-22
Completion:
2028-07-31
Conditions
  • Breast Cancer
  • Breast Neoplasms
  • Anatomic Stage I Breast Cancer AJCC v8
  • Anatomic Stage II Breast Cancer AJCC v8
  • Anatomic Stage IIIA Breast Cancer AJCC v8
  • Cancer-related Cognitive Dysfunction
Interventions
  • BEHAVIORAL
  • OTHER
No Results Yet
NCT04763681 | COMPLETED | NA
54 participants

Couple HOPES and COVID-19

Study Type:
INTERVENTIONAL
Last Updated:
2026-07-31
Start Date:
2021-01-01
Completion:
2024-01-31
Conditions
  • Posttraumatic Stress Disorder
Interventions
  • BEHAVIORAL
No Results Yet
NCT04671667 | RECRUITING | PHASE2
188 participants

Testing What Happens When an Immunotherapy Drug (Pembrolizumab) is Given by Itself Compared to the Usual Treatment of Chemotherapy With Radiation After Surgery for Recurrent Head and Neck Squamous Cell Carcinoma

Study Type:
INTERVENTIONAL
Last Updated:
2026-07-31
Start Date:
2021-04-27
Completion:
2029-06-30
Conditions
  • Recurrent Head and Neck Squamous Cell Carcinoma
  • Recurrent Hypopharyngeal Squamous Cell Carcinoma
  • Recurrent Laryngeal Squamous Cell Carcinoma
  • Recurrent Oral Cavity Squamous Cell Carcinoma
  • Recurrent Oropharyngeal Squamous Cell Carcinoma
Interventions
  • DRUG
  • PROCEDURE
  • RADIATION
  • BIOLOGICAL
No Results Yet
NCT04640623 | ACTIVE_NOT_RECRUITING | PHASE2
220 participants
NCT04616534 | ACTIVE_NOT_RECRUITING | PHASE1
14 participants

Testing the Addition of an Anti-cancer Drug, Elimusertib (BAY 1895344) ATR Inhibitor, to the Chemotherapy Treatment (Gemcitabine) for Advanced Pancreatic and Ovarian Cancer, and Advanced Solid Tumors

Study Type:
INTERVENTIONAL
Last Updated:
2026-07-31
Start Date:
2021-06-01
Completion:
2025-04-01
Conditions
  • Advanced Fallopian Tube Carcinoma
  • Advanced Malignant Solid Neoplasm
  • Advanced Ovarian Carcinoma
  • Advanced Pancreatic Adenocarcinoma
  • Advanced Primary Peritoneal Carcinoma
  • Fallopian Tube High Grade Serous Adenocarcinoma
  • Metastatic Pancreatic Adenocarcinoma
  • Ovarian High Grade Serous Adenocarcinoma
  • Platinum-Resistant Fallopian Tube Carcinoma
  • Platinum-Resistant Ovarian Carcinoma
  • Platinum-Resistant Primary Peritoneal Carcinoma
  • Primary Peritoneal High Grade Serous Adenocarcinoma
  • Stage II Pancreatic Cancer AJCC v8
  • Stage III Fallopian Tube Cancer AJCC v8
  • Stage III Ovarian Cancer AJCC v8
  • Stage III Pancreatic Cancer AJCC v8
  • Stage III Primary Peritoneal Cancer AJCC v8
  • Stage IV Fallopian Tube Cancer AJCC v8
  • Stage IV Ovarian Cancer AJCC v8
  • Stage IV Pancreatic Cancer AJCC v8
  • Stage IV Primary Peritoneal Cancer AJCC v8
  • Unresectable Pancreatic Adenocarcinoma
Interventions
  • PROCEDURE
  • DRUG
NCT04595747 | ACTIVE_NOT_RECRUITING | PHASE2
48 participants

Testing the Anti-cancer Drug, Rogaratinib (BAY 1163877), for Treatment of Advanced Sarcoma With Alteration in Fibroblast Growth Factor Receptor (FGFR 1-4), and in Patients With SDH-deficient Gastrointestinal Stromal Tumor (GIST)

Study Type:
INTERVENTIONAL
Last Updated:
2026-07-31
Start Date:
2021-05-03
Completion:
2027-07-31
Conditions
  • Locally Advanced Gastrointestinal Stromal Tumor
  • Locally Advanced Sarcoma
  • Metastatic Gastrointestinal Stromal Tumor
  • Metastatic Sarcoma
  • Stage III Gastric and Omental Gastrointestinal Stromal Tumor AJCC v8
  • Stage III Small Intestinal, Esophageal, Colorectal, Mesenteric, and Peritoneal Gastrointestinal Stromal Tumor AJCC v8
  • Stage IV Gastric and Omental Gastrointestinal Stromal Tumor AJCC v8
  • Stage IV Small Intestinal, Esophageal, Colorectal, Mesenteric, and Peritoneal Gastrointestinal Stromal Tumor AJCC v8
Interventions
  • PROCEDURE
  • DRUG
No Results Yet
NCT04554914 | ACTIVE_NOT_RECRUITING | PHASE2
190 participants

A Study to Evaluate Tabelecleucel in Participants With Epstein Barr Virus (EBV) Associated Diseases

Study Type:
INTERVENTIONAL
Last Updated:
2026-07-31
Start Date:
2021-07-14
Completion:
2027-06-30
Conditions
  • Epstein-Barr Virus (EBV)-Associated Diseases
  • EBV+ Lymphoproliferative Disease With Primary Immunodeficiency (EBV+ PID LPD)
  • EBV+ Lymphoproliferative Disease With Acquired (Non-congenital) Immunodeficiency (EBV+ AID LPD)
  • EBV+ Posttransplant Lymphoproliferative Disease in Central Nervous System (EBV+ CNS PTLD)
  • EBV+ Post-transplant Lymphoproliferative Disease (EBV+ PTLD)
  • Solid Organ Transplant Complications
  • Lymphoproliferative Disorders
  • Allogeneic Hematopoietic Cell Transplant
  • Stem Cell Transplant Complications
  • EBV+ Sarcomas
  • Leiomyosarcoma
Interventions
  • BIOLOGICAL
No Results Yet
NCT04514497 | ACTIVE_NOT_RECRUITING | PHASE1
29 participants

Testing the Addition of an Anti-cancer Drug, BAY 1895344, to Usual Chemotherapy for Advanced Stage Solid Tumors, With a Specific Focus on Patients With Small Cell Lung Cancer, Poorly Differentiated Neuroendocrine Cancer, and Pancreatic Cancer

Study Type:
INTERVENTIONAL
Last Updated:
2026-07-31
Start Date:
2021-10-20
Completion:
2025-02-15
Conditions
  • Metastatic Lung Small Cell Carcinoma
  • Metastatic Malignant Solid Neoplasm
  • Metastatic Neuroendocrine Carcinoma
  • Metastatic Pancreatic Adenocarcinoma
  • Stage III Lung Cancer AJCC v8
  • Stage III Pancreatic Cancer AJCC v8
  • Stage IV Lung Cancer AJCC v8
  • Stage IV Pancreatic Cancer AJCC v8
  • Unresectable Lung Small Cell Carcinoma
  • Unresectable Malignant Solid Neoplasm
  • Unresectable Neuroendocrine Carcinoma
  • Unresectable Pancreatic Adenocarcinoma
Interventions
  • PROCEDURE
  • DRUG
NCT04491942 | ACTIVE_NOT_RECRUITING | PHASE1
74 participants

Testing the Addition of an Anti-cancer Drug, BAY 1895344, to the Usual Chemotherapy Treatment (Cisplatin, or Cisplatin and Gemcitabine) for Advanced Solid Tumors With Emphasis on Urothelial Cancer

Study Type:
INTERVENTIONAL
Last Updated:
2026-07-31
Start Date:
2021-08-25
Completion:
2027-06-30
Conditions
  • Advanced Bile Duct Carcinoma
  • Advanced Breast Carcinoma
  • Advanced Cervical Carcinoma
  • Advanced Endometrial Carcinoma
  • Advanced Esophageal Carcinoma
  • Advanced Gastric Carcinoma
  • Advanced Head and Neck Carcinoma
  • Advanced Lung Non-Small Cell Carcinoma
  • Advanced Lung Small Cell Carcinoma
  • Advanced Malignant Solid Neoplasm
  • Advanced Ovarian Carcinoma
  • Advanced Penile Carcinoma
  • Advanced Pleural Malignant Mesothelioma
  • Advanced Urothelial Carcinoma
  • Anatomic Stage III Breast Cancer AJCC v8
  • Anatomic Stage IV Breast Cancer AJCC v8
  • Clinical Stage III Gastric Cancer AJCC v8
  • Clinical Stage IV Gastric Cancer AJCC v8
  • Stage III Cervical Cancer AJCC v8
  • Stage III Distal Bile Duct Cancer AJCC v8
  • Stage III Intrahepatic Bile Duct Cancer AJCC v8
  • Stage III Lung Cancer AJCC v8
  • Stage III Ovarian Cancer AJCC v8
  • Stage III Penile Cancer AJCC v8
  • Stage III Pleural Diffuse Malignant Mesothelioma AJCC v8
  • Stage IV Cervical Cancer AJCC v8
  • Stage IV Distal Bile Duct Cancer AJCC v8
  • Stage IV Intrahepatic Bile Duct Cancer AJCC v8
  • Stage IV Lung Cancer AJCC v8
  • Stage IV Ovarian Cancer AJCC v8
  • Stage IV Penile Cancer AJCC v8
  • Stage IV Pleural Diffuse Malignant Mesothelioma AJCC v8
  • Triple-Negative Breast Carcinoma
  • Unresectable Urothelial Carcinoma
Interventions
  • DRUG
No Results Yet
NCT04460937 | ACTIVE_NOT_RECRUITING | PHASE1
4 participants

Testing the Addition of an Anti-cancer Drug, Adavosertib, to Radiation Therapy for Patients With Incurable Esophageal and Gastroesophageal Junction Cancers

Study Type:
INTERVENTIONAL
Last Updated:
2026-07-31
Start Date:
2021-04-09
Completion:
2024-03-29
Conditions
  • Clinical Stage III Esophageal Adenocarcinoma AJCC v8
  • Clinical Stage III Esophageal Squamous Cell Carcinoma AJCC v8
  • Clinical Stage III Gastroesophageal Junction Adenocarcinoma AJCC v8
  • Clinical Stage IV Esophageal Adenocarcinoma AJCC v8
  • Clinical Stage IV Esophageal Squamous Cell Carcinoma AJCC v8
  • Clinical Stage IV Gastroesophageal Junction Adenocarcinoma AJCC v8
  • Clinical Stage IVA Esophageal Adenocarcinoma AJCC v8
  • Clinical Stage IVA Esophageal Squamous Cell Carcinoma AJCC v8
  • Clinical Stage IVA Gastroesophageal Junction Adenocarcinoma AJCC v8
  • Clinical Stage IVB Esophageal Adenocarcinoma AJCC v8
  • Clinical Stage IVB Esophageal Squamous Cell Carcinoma AJCC v8
  • Clinical Stage IVB Gastroesophageal Junction Adenocarcinoma AJCC v8
  • Distal Esophagus Adenocarcinoma
  • Gastric Cardia Adenocarcinoma
  • Metastatic Esophageal Adenocarcinoma
  • Metastatic Esophageal Squamous Cell Carcinoma
  • Metastatic Gastroesophageal Junction Adenocarcinoma
  • Metastatic Malignant Neoplasm in the Brain
  • Metastatic Malignant Neoplasm in the Leptomeninges
  • Pathologic Stage III Esophageal Adenocarcinoma AJCC v8
  • Pathologic Stage III Esophageal Squamous Cell Carcinoma AJCC v8
  • Pathologic Stage III Gastroesophageal Junction Adenocarcinoma AJCC v8
  • Pathologic Stage IIIA Esophageal Adenocarcinoma AJCC v8
  • Pathologic Stage IIIA Esophageal Squamous Cell Carcinoma AJCC v8
  • Pathologic Stage IIIA Gastroesophageal Junction Adenocarcinoma AJCC v8
  • Pathologic Stage IIIB Esophageal Adenocarcinoma AJCC v8
  • Pathologic Stage IIIB Esophageal Squamous Cell Carcinoma AJCC v8
  • Pathologic Stage IIIB Gastroesophageal Junction Adenocarcinoma AJCC v8
  • Pathologic Stage IV Esophageal Adenocarcinoma AJCC v8
  • Pathologic Stage IV Esophageal Squamous Cell Carcinoma AJCC v8
  • Pathologic Stage IV Gastroesophageal Junction Adenocarcinoma AJCC v8
  • Pathologic Stage IVA Esophageal Adenocarcinoma AJCC v8
  • Pathologic Stage IVA Esophageal Squamous Cell Carcinoma AJCC v8
  • Pathologic Stage IVA Gastroesophageal Junction Adenocarcinoma AJCC v8
  • Pathologic Stage IVB Esophageal Adenocarcinoma AJCC v8
  • Pathologic Stage IVB Esophageal Squamous Cell Carcinoma AJCC v8
  • Pathologic Stage IVB Gastroesophageal Junction Adenocarcinoma AJCC v8
  • Postneoadjuvant Therapy Stage III Esophageal Adenocarcinoma AJCC v8
  • Postneoadjuvant Therapy Stage III Esophageal Squamous Cell Carcinoma AJCC v8
  • Postneoadjuvant Therapy Stage III Gastroesophageal Junction Adenocarcinoma AJCC v8
  • Postneoadjuvant Therapy Stage IIIA Esophageal Adenocarcinoma AJCC v8
  • Postneoadjuvant Therapy Stage IIIA Esophageal Squamous Cell Carcinoma AJCC v8
  • Postneoadjuvant Therapy Stage IIIA Gastroesophageal Junction Adenocarcinoma AJCC v8
  • Postneoadjuvant Therapy Stage IIIB Esophageal Adenocarcinoma AJCC v8
  • Postneoadjuvant Therapy Stage IIIB Esophageal Squamous Cell Carcinoma AJCC v8
  • Postneoadjuvant Therapy Stage IIIB Gastroesophageal Junction Adenocarcinoma AJCC v8
  • Postneoadjuvant Therapy Stage IV Esophageal Adenocarcinoma AJCC v8
  • Postneoadjuvant Therapy Stage IV Esophageal Squamous Cell Carcinoma AJCC v8
  • Postneoadjuvant Therapy Stage IV Gastroesophageal Junction Adenocarcinoma AJCC v8
  • Postneoadjuvant Therapy Stage IVA Esophageal Adenocarcinoma AJCC v8
  • Postneoadjuvant Therapy Stage IVA Esophageal Squamous Cell Carcinoma AJCC v8
  • Postneoadjuvant Therapy Stage IVA Gastroesophageal Junction Adenocarcinoma AJCC v8
  • Postneoadjuvant Therapy Stage IVB Esophageal Adenocarcinoma AJCC v8
  • Postneoadjuvant Therapy Stage IVB Esophageal Squamous Cell Carcinoma AJCC v8
  • Postneoadjuvant Therapy Stage IVB Gastroesophageal Junction Adenocarcinoma AJCC v8
  • Unresectable Esophageal Adenocarcinoma
  • Unresectable Esophageal Carcinoma
  • Unresectable Esophageal Squamous Cell Carcinoma
  • Unresectable Gastroesophageal Junction Adenocarcinoma
Interventions
  • DRUG
  • RADIATION
NCT04458922 | ACTIVE_NOT_RECRUITING | PHASE2
27 participants

Testing Atezolizumab in People 2-17 Years Old With Clear Cell Sarcoma or Advanced Chondrosarcoma

Study Type:
INTERVENTIONAL
Last Updated:
2026-07-31
Start Date:
2020-10-05
Completion:
2022-11-28
Conditions
  • Central Chondrosarcoma, Grade 2
  • Central Chondrosarcoma, Grade 3
  • Dedifferentiated Chondrosarcoma
  • Metastatic Clear Cell Sarcoma of Soft Tissue
  • Metastatic Primary Central Chondrosarcoma
  • Unresectable Primary Central Chondrosarcoma
Interventions
  • DRUG
  • PROCEDURE
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