Trial Outcomes & Findings for Adapt2Quit - An Adaptive Motivational System for Socio-Economically Disadvantaged Smokers (NCT NCT04720625)
NCT ID: NCT04720625
Last Updated: 2026-07-31
Results Overview
Participants who self-reported no tobacco use in the past 7 days at the 6-month follow-up underwent biochemical verification using the CoVita Smokerlyzer breath carbon monoxide (CO) monitor. Participants with a CO measurement of ≤6 ppm were classified as abstinent; those with a CO measurement of \>6 ppm were classified as tobacco users.
COMPLETED
NA
757 participants
6-months post-randomization
2026-07-31
Participant Flow
Participant milestones
| Measure |
Adapt2Quit
These participants will receive Adapt2Quit motivational messaging and Quitline facilitation messaging for 6 months.
Adapt2Quit: Motivational text messages and Quitline facilitation text messages will be sent to participants; these participants will receive Adapt2Quit (experimental) messages as well as Quitline facilitation messages.
|
Control
These participants will receive Quitline facilitation-only messaging for 6 months.
Control: Quitline facilitation text messages will be sent to participants; these participants will receive quitline facilitation-only messages.
|
|---|---|---|
|
Overall Study
STARTED
|
378
|
379
|
|
Overall Study
COMPLETED
|
315
|
324
|
|
Overall Study
NOT COMPLETED
|
63
|
55
|
Reasons for withdrawal
Withdrawal data not reported
Baseline Characteristics
Adapt2Quit - An Adaptive Motivational System for Socio-Economically Disadvantaged Smokers
Baseline characteristics by cohort
| Measure |
Adapt2Quit
n=378 Participants
These participants will receive Adapt2Quit motivational messaging and Quitline facilitation messaging for 6 months.
Adapt2Quit: Motivational text messages and Quitline facilitation text messages will be sent to participants; these participants will receive Adapt2Quit (experimental) messages as well as Quitline facilitation messages.
|
Control
n=379 Participants
These participants will receive Quitline facilitation-only messaging for 6 months.
Control: Quitline facilitation text messages will be sent to participants; these participants will receive quitline facilitation-only messages.
|
Total
n=757 Participants
Total of all reporting groups
|
|---|---|---|---|
|
Age, Categorical
<=18 years
|
0 Participants
n=9 Participants
|
0 Participants
n=27 Participants
|
0 Participants
n=267 Participants
|
|
Age, Categorical
Between 18 and 65 years
|
332 Participants
n=9 Participants
|
353 Participants
n=27 Participants
|
685 Participants
n=267 Participants
|
|
Age, Categorical
>=65 years
|
46 Participants
n=9 Participants
|
26 Participants
n=27 Participants
|
72 Participants
n=267 Participants
|
|
Sex: Female, Male
Female
|
253 Participants
n=9 Participants
|
234 Participants
n=27 Participants
|
487 Participants
n=267 Participants
|
|
Sex: Female, Male
Male
|
125 Participants
n=9 Participants
|
145 Participants
n=27 Participants
|
270 Participants
n=267 Participants
|
|
Ethnicity (NIH/OMB)
Hispanic or Latino
|
55 Participants
n=9 Participants
|
50 Participants
n=27 Participants
|
105 Participants
n=267 Participants
|
|
Ethnicity (NIH/OMB)
Not Hispanic or Latino
|
297 Participants
n=9 Participants
|
316 Participants
n=27 Participants
|
613 Participants
n=267 Participants
|
|
Ethnicity (NIH/OMB)
Unknown or Not Reported
|
26 Participants
n=9 Participants
|
13 Participants
n=27 Participants
|
39 Participants
n=267 Participants
|
|
Race (NIH/OMB)
American Indian or Alaska Native
|
3 Participants
n=9 Participants
|
3 Participants
n=27 Participants
|
6 Participants
n=267 Participants
|
|
Race (NIH/OMB)
Asian
|
3 Participants
n=9 Participants
|
2 Participants
n=27 Participants
|
5 Participants
n=267 Participants
|
|
Race (NIH/OMB)
Native Hawaiian or Other Pacific Islander
|
0 Participants
n=9 Participants
|
0 Participants
n=27 Participants
|
0 Participants
n=267 Participants
|
|
Race (NIH/OMB)
Black or African American
|
128 Participants
n=9 Participants
|
132 Participants
n=27 Participants
|
260 Participants
n=267 Participants
|
|
Race (NIH/OMB)
White
|
197 Participants
n=9 Participants
|
195 Participants
n=27 Participants
|
392 Participants
n=267 Participants
|
|
Race (NIH/OMB)
More than one race
|
1 Participants
n=9 Participants
|
1 Participants
n=27 Participants
|
2 Participants
n=267 Participants
|
|
Race (NIH/OMB)
Unknown or Not Reported
|
46 Participants
n=9 Participants
|
46 Participants
n=27 Participants
|
92 Participants
n=267 Participants
|
|
Region of Enrollment
United States
|
378 participants
n=9 Participants
|
379 participants
n=27 Participants
|
757 participants
n=267 Participants
|
PRIMARY outcome
Timeframe: 6-months post-randomizationParticipants who self-reported no tobacco use in the past 7 days at the 6-month follow-up underwent biochemical verification using the CoVita Smokerlyzer breath carbon monoxide (CO) monitor. Participants with a CO measurement of ≤6 ppm were classified as abstinent; those with a CO measurement of \>6 ppm were classified as tobacco users.
Outcome measures
| Measure |
Adapt2Quit
n=280 Participants
These participants will receive Adapt2Quit motivational messaging and Quitline facilitation messaging for 6 months.
Adapt2Quit: Motivational text messages and Quitline facilitation text messages will be sent to participants; these participants will receive Adapt2Quit (experimental) messages as well as Quitline facilitation messages.
|
Control
n=293 Participants
These participants will receive Quitline facilitation-only messaging for 6 months.
Control: Quitline facilitation text messages will be sent to participants; these participants will receive quitline facilitation-only messages.
|
|---|---|---|
|
Number of Participants With Biochemically Verified 7-Day Point Prevalence Tobacco Abstinence at 6 Months
|
21 Participants
|
18 Participants
|
SECONDARY outcome
Timeframe: 6-months post-randomizationPopulation: The analysis included participants with complete 6-month self-reported smoking status data. One participant who completed the 6-month follow-up did not answer the smoking status question and was excluded from the complete-case analysis.
Self-reported cigarette abstinence was assessed at the 6-month follow-up using the question: "Do you currently smoke cigarettes, even one puff in the last 7 days?" Participants who answered "No" were classified as self-reported abstinent.
Outcome measures
| Measure |
Adapt2Quit
n=314 Participants
These participants will receive Adapt2Quit motivational messaging and Quitline facilitation messaging for 6 months.
Adapt2Quit: Motivational text messages and Quitline facilitation text messages will be sent to participants; these participants will receive Adapt2Quit (experimental) messages as well as Quitline facilitation messages.
|
Control
n=324 Participants
These participants will receive Quitline facilitation-only messaging for 6 months.
Control: Quitline facilitation text messages will be sent to participants; these participants will receive quitline facilitation-only messages.
|
|---|---|---|
|
Number of Participants With Self-Reported 7-Day Point Prevalence Cigarette Abstinence at 6 Months
|
58 Participants
|
58 Participants
|
Adverse Events
Control
Adapt2Quit
Serious adverse events
Adverse event data not reported
Other adverse events
Adverse event data not reported
Additional Information
Dr. Rajani Sadasivam, PhD, Professor
UMass Chan Medical School
Results disclosure agreements
- Principal investigator is a sponsor employee
- Publication restrictions are in place