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Clinical Trials

Showing trials with last updates posted in 2026.

NCT03896503 | ACTIVE_NOT_RECRUITING | PHASE2
104 participants

Randomized Trial of Topotecan With M6620, an ATR Kinase Inhibitor, in Small Cell Lung Cancers and Small Cell Cancers Outside of the Lungs

Study Type:
INTERVENTIONAL
Last Updated:
2026-07-31
Start Date:
2019-12-30
Completion:
2022-12-19
Conditions
  • Extensive Stage Lung Small Cell Carcinoma
  • Extrapulmonary Small Cell Neuroendocrine Carcinoma
  • Limited Stage Lung Small Cell Carcinoma
  • Platinum-Resistant Lung Small Cell Carcinoma
  • Platinum-Sensitive Lung Small Cell Carcinoma
  • Recurrent Lung Small Cell Carcinoma
Interventions
  • DRUG
  • PROCEDURE
Results Available
NCT03872427 | ACTIVE_NOT_RECRUITING | PHASE2
54 participants

Testing Whether Cancers With Specific Mutations Respond Better to Glutaminase Inhibitor, Telaglenastat Hydrochloride, Anti-Cancer Treatment, BeGIN Study

Study Type:
INTERVENTIONAL
Last Updated:
2026-07-31
Start Date:
2019-12-14
Completion:
2023-10-30
Conditions
  • Advanced Malignant Solid Neoplasm
  • Metastatic Malignant Solid Neoplasm
  • NF1 Mutation Positive Malignant Peripheral Nerve Sheath Tumor
  • Unresectable Malignant Solid Neoplasm
Interventions
  • PROCEDURE
  • OTHER
  • DRUG
Results Available
NCT03816345 | RECRUITING | PHASE1
300 participants

Testing an Immunotherapy Anti-cancer Drug, Nivolumab, for Advanced Cancers in Patients With Autoimmune Disorders, AIM-NIVO

Study Type:
INTERVENTIONAL
Last Updated:
2026-07-31
Start Date:
2019-07-16
Completion:
2028-03-30
Conditions
  • Autoimmune Disease
  • Crohn Disease
  • Dermatomyositis
  • Hematopoietic and Lymphoid Cell Neoplasm
  • Inflammatory Bowel Disease
  • Malignant Solid Neoplasm
  • Multiple Sclerosis
  • Psoriasis
  • Psoriatic Arthritis
  • Rheumatoid Arthritis
  • Sjogren Syndrome
  • Systemic Lupus Erythematosus
  • Systemic Scleroderma
  • Ulcerative Colitis
Interventions
  • PROCEDURE
  • DRUG
  • BIOLOGICAL
No Results Yet
NCT03816332 | ACTIVE_NOT_RECRUITING | PHASE1
12 participants

Tacrolimus, Nivolumab, and Ipilimumab in Treating Kidney Transplant Recipients With Selected Unresectable or Metastatic Cancers

Study Type:
INTERVENTIONAL
Last Updated:
2026-07-31
Start Date:
2019-11-08
Completion:
2022-10-11
Conditions
  • Clinical Stage III Cutaneous Melanoma AJCC v8
  • Clinical Stage III Cutaneous Merkel Cell Carcinoma AJCC v8
  • Clinical Stage IV Cutaneous Melanoma AJCC v8
  • Clinical Stage IV Cutaneous Merkel Cell Carcinoma AJCC v8
  • Metastatic Basal Cell Carcinoma
  • Metastatic Melanoma
  • Metastatic Merkel Cell Carcinoma
  • Metastatic Skin Squamous Cell Carcinoma
  • Pathologic Stage III Cutaneous Melanoma AJCC v8
  • Pathologic Stage III Cutaneous Merkel Cell Carcinoma AJCC v8
  • Pathologic Stage IIIA Cutaneous Melanoma AJCC v8
  • Pathologic Stage IIIA Cutaneous Merkel Cell Carcinoma AJCC v8
  • Pathologic Stage IIIB Cutaneous Melanoma AJCC v8
  • Pathologic Stage IIIB Cutaneous Merkel Cell Carcinoma AJCC v8
  • Pathologic Stage IIIC Cutaneous Melanoma AJCC v8
  • Pathologic Stage IIID Cutaneous Melanoma AJCC v8
  • Pathologic Stage IV Cutaneous Melanoma AJCC v8
  • Pathologic Stage IV Cutaneous Merkel Cell Carcinoma AJCC v8
  • Unresectable Basal Cell Carcinoma
  • Unresectable Melanoma
  • Unresectable Merkel Cell Carcinoma
Interventions
  • BIOLOGICAL
  • DRUG
Results Available
NCT03796273 | TERMINATED | EARLY_PHASE1
15 participants

Ketoconazole Before Surgery in Treating Patients With Recurrent Glioma or Breast Cancer Brain Metastases

Study Type:
INTERVENTIONAL
Last Updated:
2026-07-31
Start Date:
2019-03-13
Completion:
2022-10-23
Conditions
  • Anatomic Stage IV Breast Cancer AJCC v8
  • Astrocytoma
  • Breast Carcinoma Metastatic in the Brain
  • Glioma
  • Invasive Breast Carcinoma
  • Oligodendroglioma
  • Prognostic Stage IV Breast Cancer AJCC v8
  • Recurrent Glioma
Interventions
  • OTHER
  • DRUG
No Results Yet
NCT03386539 | COMPLETED | PHASE3
211 participants

Tacrolimus/Everolimus vs. Tacrolimus/MMF in Pediatric Heart Transplant Recipients Using the MATE Score

Study Type:
INTERVENTIONAL
Last Updated:
2026-07-31
Start Date:
2018-01-29
Completion:
2023-04-17
Conditions
  • Pediatric Heart Transplantation
  • Immunosuppression
  • Chronic Kidney Diseases
  • Cardiac Allograft Vasculopathy
  • Heart Transplant Failure and Rejection
  • Post-transplant Lymphoproliferative Disorder
  • Heart Transplant Infection
Interventions
  • DRUG
Results Available
NCT03284385 | ACTIVE_NOT_RECRUITING | PHASE2
18 participants

Testing AZD1775 in Advanced Solid Tumors That Have a Mutation Called SETD2

Study Type:
INTERVENTIONAL
Last Updated:
2026-07-31
Start Date:
2019-01-29
Completion:
2026-03-01
Conditions
  • Clear Cell Renal Cell Carcinoma
  • Locally Advanced Clear Cell Renal Cell Carcinoma
  • Locally Advanced Malignant Solid Neoplasm
  • Metastatic Malignant Solid Neoplasm
  • Metastatic Renal Cell Carcinoma
  • Stage III Renal Cell Cancer AJCC v8
  • Stage IV Renal Cell Cancer AJCC v8
Interventions
  • DRUG
No Results Yet
NCT03237780 | ACTIVE_NOT_RECRUITING | PHASE2
72 participants

Atezolizumab With or Without Eribulin Mesylate in Treating Patients With Recurrent Locally Advanced or Metastatic Urothelial Cancer

Study Type:
INTERVENTIONAL
Last Updated:
2026-07-31
Start Date:
2018-07-20
Completion:
2027-06-30
Conditions
  • Locally Advanced Bladder Urothelial Carcinoma
  • Locally Advanced Renal Pelvis Urothelial Carcinoma
  • Locally Advanced Ureter Urothelial Carcinoma
  • Locally Advanced Urethral Urothelial Carcinoma
  • Metastatic Bladder Urothelial Carcinoma
  • Metastatic Renal Pelvis Urothelial Carcinoma
  • Metastatic Ureter Urothelial Carcinoma
  • Metastatic Urethral Urothelial Carcinoma
  • Recurrent Bladder Urothelial Carcinoma
  • Recurrent Renal Pelvis Urothelial Carcinoma
  • Recurrent Ureter Urothelial Carcinoma
  • Recurrent Urethral Urothelial Carcinoma
  • Stage III Bladder Cancer AJCC v8
  • Stage III Renal Pelvis Cancer AJCC v8
  • Stage III Ureter Cancer AJCC v8
  • Stage III Urethral Cancer AJCC v8
  • Stage IV Bladder Cancer AJCC v8
  • Stage IV Renal Pelvis Cancer AJCC v8
  • Stage IV Ureter Cancer AJCC v8
  • Stage IV Urethral Cancer AJCC v8
  • Unresectable Bladder Urothelial Carcinoma
  • Unresectable Renal Pelvis Urothelial Carcinoma
  • Unresectable Ureter Urothelial Carcinoma
  • Unresectable Urethral Urothelial Carcinoma
Interventions
  • DRUG
  • PROCEDURE
No Results Yet
NCT03188705 | COMPLETED | PHASE4
6 participants

CES1 Carriers in the PAPI Study

Study Type:
INTERVENTIONAL
Last Updated:
2026-07-31
Start Date:
2019-10-14
Completion:
2020-01-17
Conditions
  • Heart Diseases
  • Coronary Disease
  • Coronary Artery Disease
  • Cardiovascular Diseases
  • Myocardial Ischemia
  • Artery Occlusion
  • Aspirin Sensitivity
  • Clopidogrel, Poor Metabolism of
  • Platelet Dysfunction
  • Platelet Thrombus
Interventions
  • DRUG
Results Available
NCT03047213 | ACTIVE_NOT_RECRUITING | PHASE2
17 participants

Sapanisertib in Treating Patients With Locally Advanced or Metastatic Bladder Cancer With TSC1 and/or TSC2 Mutations

Study Type:
INTERVENTIONAL
Last Updated:
2026-07-31
Start Date:
2017-08-24
Completion:
2020-10-06
Conditions
  • Locally Advanced Bladder Urothelial Carcinoma
  • Metastatic Transitional Cell Carcinoma
  • Metastatic Urothelial Carcinoma
  • Recurrent Bladder Carcinoma
  • Stage III Bladder Urothelial Carcinoma AJCC v6 and v7
  • Stage IV Bladder Urothelial Carcinoma AJCC v7
Interventions
  • DRUG
Results Available
NCT03011814 | RECRUITING | PHASE1/PHASE2
78 participants

Durvalumab With or Without Lenalidomide in Treating Patients With Relapsed or Refractory Cutaneous or Peripheral T Cell Lymphoma

Study Type:
INTERVENTIONAL
Last Updated:
2026-07-31
Start Date:
2017-03-08
Completion:
2030-04-14
Conditions
  • Folliculotropic Mycosis Fungoides
  • Recurrent Cutaneous T-Cell Non-Hodgkin Lymphoma
  • Recurrent Mycosis Fungoides
  • Refractory Cutaneous T-Cell Non-Hodgkin Lymphoma
  • Refractory Mycosis Fungoides
  • Refractory Peripheral T-Cell Lymphoma, Not Otherwise Specified
  • Sezary Syndrome
  • Recurrent Mature T- and NK-Cell Non-Hodgkin Lymphoma
Interventions
  • BIOLOGICAL
  • OTHER
  • DRUG
No Results Yet
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