Clinical Trials

NCT03872427 | ACTIVE_NOT_RECRUITING | PHASE2

54 participants

Testing Whether Cancers With Specific Mutations Respond Better to Glutaminase Inhibitor, Telaglenastat Hydrochloride, Anti-Cancer Treatment, BeGIN Study

Study Type:: INTERVENTIONAL
Last Updated:: 2026-07-31
Start Date:: 2019-12-14
Completion:: 2023-10-30

Conditions

Advanced Malignant Solid Neoplasm
Metastatic Malignant Solid Neoplasm
NF1 Mutation Positive Malignant Peripheral Nerve Sheath Tumor
Unresectable Malignant Solid Neoplasm

Interventions

PROCEDURE
OTHER
DRUG

Results Available

NCT03854474 | ACTIVE_NOT_RECRUITING | PHASE1/PHASE2

30 participants

Testing the Addition of Tazemetostat to the Immunotherapy Drug, Pembrolizumab (MK-3475), in Advanced Urothelial Carcinoma

Study Type:: INTERVENTIONAL
Last Updated:: 2026-07-31
Start Date:: 2019-11-18
Completion:: 2027-06-30

Conditions

Locally Advanced Urothelial Carcinoma
Metastatic Urothelial Carcinoma
Stage III Bladder Cancer AJCC v8
Stage IV Bladder Cancer AJCC v8

Interventions

PROCEDURE
BIOLOGICAL
DRUG

No Results Yet

NCT03842228 | ACTIVE_NOT_RECRUITING | PHASE1

39 participants

Testing the Combination of the Anti-cancer Drugs Copanlisib, Olaparib, and MEDI4736 (Durvalumab) in Patients With Advanced Solid Tumors With Selected Mutations

Study Type:: INTERVENTIONAL
Last Updated:: 2026-07-31
Start Date:: 2019-11-21
Completion:: 2024-07-29

Conditions

Advanced Malignant Solid Neoplasm
Metastatic Malignant Solid Neoplasm
Unresectable Malignant Solid Neoplasm

Interventions

PROCEDURE
DRUG
BIOLOGICAL

Results Available

NCT03839212 | COMPLETED | NA

18 participants

The Happy Older Latinos Are Active (HOLA) Health Promotion Study in HIV-Infected Latino Men

Study Type:: INTERVENTIONAL
Last Updated:: 2026-07-31
Start Date:: 2019-10-01
Completion:: 2020-07-27

Conditions

Human Immunodeficiency Virus
Cardiometabolic Risk

Interventions

BEHAVIORAL

Results Available

NCT03831932 | ACTIVE_NOT_RECRUITING | PHASE1/PHASE2

22 participants

Telaglenastat Hydrochloride and Osimertinib in Treating Patients With EGFR-Mutated Stage IV Non-small Cell Lung Cancer

Study Type:: INTERVENTIONAL
Last Updated:: 2026-07-31
Start Date:: 2020-03-16
Completion:: 2024-06-12

Conditions

Advanced Lung Non-Small Cell Carcinoma
Metastatic Lung Non-Small Cell Carcinoma
Stage IV Lung Cancer AJCC v8

Interventions

PROCEDURE
DRUG

Results Available

NCT03816345 | RECRUITING | PHASE1

300 participants

Testing an Immunotherapy Anti-cancer Drug, Nivolumab, for Advanced Cancers in Patients With Autoimmune Disorders, AIM-NIVO

Study Type:: INTERVENTIONAL
Last Updated:: 2026-07-31
Start Date:: 2019-07-16
Completion:: 2028-03-30

Conditions

Autoimmune Disease
Crohn Disease
Dermatomyositis
Hematopoietic and Lymphoid Cell Neoplasm
Inflammatory Bowel Disease
Malignant Solid Neoplasm
Multiple Sclerosis
Psoriasis
Psoriatic Arthritis
Rheumatoid Arthritis
Sjogren Syndrome
Systemic Lupus Erythematosus
Systemic Scleroderma
Ulcerative Colitis

Interventions

PROCEDURE
DRUG
BIOLOGICAL

No Results Yet

NCT03816332 | ACTIVE_NOT_RECRUITING | PHASE1

12 participants

Tacrolimus, Nivolumab, and Ipilimumab in Treating Kidney Transplant Recipients With Selected Unresectable or Metastatic Cancers

Study Type:: INTERVENTIONAL
Last Updated:: 2026-07-31
Start Date:: 2019-11-08
Completion:: 2022-10-11

Conditions

Clinical Stage III Cutaneous Melanoma AJCC v8
Clinical Stage III Cutaneous Merkel Cell Carcinoma AJCC v8
Clinical Stage IV Cutaneous Melanoma AJCC v8
Clinical Stage IV Cutaneous Merkel Cell Carcinoma AJCC v8
Metastatic Basal Cell Carcinoma
Metastatic Melanoma
Metastatic Merkel Cell Carcinoma
Metastatic Skin Squamous Cell Carcinoma
Pathologic Stage III Cutaneous Melanoma AJCC v8
Pathologic Stage III Cutaneous Merkel Cell Carcinoma AJCC v8
Pathologic Stage IIIA Cutaneous Melanoma AJCC v8
Pathologic Stage IIIA Cutaneous Merkel Cell Carcinoma AJCC v8
Pathologic Stage IIIB Cutaneous Melanoma AJCC v8
Pathologic Stage IIIB Cutaneous Merkel Cell Carcinoma AJCC v8
Pathologic Stage IIIC Cutaneous Melanoma AJCC v8
Pathologic Stage IIID Cutaneous Melanoma AJCC v8
Pathologic Stage IV Cutaneous Melanoma AJCC v8
Pathologic Stage IV Cutaneous Merkel Cell Carcinoma AJCC v8
Unresectable Basal Cell Carcinoma
Unresectable Melanoma
Unresectable Merkel Cell Carcinoma

Interventions

BIOLOGICAL
DRUG

Results Available

NCT03796273 | TERMINATED | EARLY_PHASE1

15 participants

Ketoconazole Before Surgery in Treating Patients With Recurrent Glioma or Breast Cancer Brain Metastases

Study Type:: INTERVENTIONAL
Last Updated:: 2026-07-31
Start Date:: 2019-03-13
Completion:: 2022-10-23

Conditions

Anatomic Stage IV Breast Cancer AJCC v8
Astrocytoma
Breast Carcinoma Metastatic in the Brain
Glioma
Invasive Breast Carcinoma
Oligodendroglioma
Prognostic Stage IV Breast Cancer AJCC v8
Recurrent Glioma

Interventions

OTHER
DRUG

No Results Yet

NCT03773770 | AVAILABLE

Expanded Access to Triheptanoin

Study Type:: EXPANDED_ACCESS
Last Updated:: 2026-07-31

Conditions

Long Chain Fatty Acid Oxidation Disorders

Interventions

DRUG

No Results Yet

NCT03767244 | ACTIVE_NOT_RECRUITING | PHASE3

2517 participants

A Study of Apalutamide in Participants With High-Risk, Localized or Locally Advanced Prostate Cancer Who Are Candidates for Radical Prostatectomy

Study Type:: INTERVENTIONAL
Last Updated:: 2026-07-31
Start Date:: 2019-06-11
Completion:: 2026-12-01

Conditions

Prostatic Neoplasms

Interventions

DRUG

No Results Yet

NCT03765918 | ACTIVE_NOT_RECRUITING | PHASE3

714 participants

Study of Pembrolizumab Given Prior to Surgery and in Combination With Radiotherapy Given Post-surgery for Advanced Head and Neck Squamous Cell Carcinoma (MK-3475-689)

Study Type:: INTERVENTIONAL
Last Updated:: 2026-07-31
Start Date:: 2018-12-17
Completion:: 2024-07-25

Conditions

Head and Neck Neoplasms

Interventions

BIOLOGICAL
RADIATION
DRUG

Results Available

NCT03748641 | ACTIVE_NOT_RECRUITING | PHASE3

765 participants

A Study of Niraparib in Combination With Abiraterone Acetate and Prednisone Versus Abiraterone Acetate and Prednisone for Treatment of Participants With Metastatic Prostate Cancer

Study Type:: INTERVENTIONAL
Last Updated:: 2026-07-31
Start Date:: 2019-01-25
Completion:: 2021-10-08

Conditions

Castration-Resistant Prostatic Cancer

Interventions

DRUG

Results Available

NCT03696784 | ACTIVE_NOT_RECRUITING | PHASE1

12 participants

Anti-CD19 CAR-T Cells With Inducible Caspase 9 Safety Switch for B-cell Lymphoma

Study Type:: INTERVENTIONAL
Last Updated:: 2026-07-31
Start Date:: 2019-03-12
Completion:: 2025-08-31

Conditions

Lymphoma
Lymphoma, B-Cell
Immune System Diseases
Immunoproliferative Disorders
Lymphatic Diseases

Interventions

BIOLOGICAL
DRUG

Results Available

NCT03689595 | ENROLLING_BY_INVITATION

30000 participants

Predicting Progression of Developing Myeloma in a High-Risk Screened Population (PROMISE)

Study Type:: OBSERVATIONAL
Last Updated:: 2026-07-31
Start Date:: 2018-10-31
Completion:: 2033-10-31

Conditions

Multiple Myeloma

Interventions

OTHER

No Results Yet

NCT03683251 | RECRUITING | PHASE3

1000 participants

Extension Study for the Port Delivery System With Ranibizumab (Portal)

Study Type:: INTERVENTIONAL
Last Updated:: 2026-07-31
Start Date:: 2018-09-20
Completion:: 2029-12-31

Conditions

Neovascular Age-Related Macular Degeneration

Interventions

DRUG

No Results Yet

NCT03654079 | NOT_YET_RECRUITING | NA

50 participants

Patient Centered Simulation For Labor and Delivery

Study Type:: INTERVENTIONAL
Last Updated:: 2026-07-31
Start Date:: 2027-01-31
Completion:: 2027-11-30

Conditions

Pregnancy Related

Interventions

OTHER

No Results Yet

NCT03604978 | ACTIVE_NOT_RECRUITING | PHASE1/PHASE2

38 participants

Nivolumab and Multi-fraction Stereotactic Radiosurgery With or Without Ipilimumab in Treating Patients With Recurrent Grade II-III Meningioma

Study Type:: INTERVENTIONAL
Last Updated:: 2026-07-31
Start Date:: 2019-06-17
Completion:: 2027-03-19

Conditions

Grade 2 Meningioma
Grade 3 Meningioma
Recurrent Meningioma

Interventions

PROCEDURE
BIOLOGICAL
RADIATION

No Results Yet

NCT03528642 | ACTIVE_NOT_RECRUITING | PHASE1

40 participants

Telaglenastat With Radiation Therapy and Temozolomide in Treating Patients With IDH-Mutated Diffuse Astrocytoma or Anaplastic Astrocytoma

Study Type:: INTERVENTIONAL
Last Updated:: 2026-07-31
Start Date:: 2019-05-01
Completion:: 2026-09-11

Conditions

Astrocytoma, IDH-Mutant, Grade 2
Astrocytoma, IDH-Mutant, Grade 3

Interventions

OTHER
RADIATION
DRUG

No Results Yet

NCT03517969 | ACTIVE_NOT_RECRUITING | PHASE2

73 participants

M6620 and Carboplatin With or Without Docetaxel in Treating Patients With Metastatic Castration-Resistant Prostate Cancer

Study Type:: INTERVENTIONAL
Last Updated:: 2026-07-31
Start Date:: 2019-05-29
Completion:: 2021-08-10

Conditions

Castration-Resistant Prostate Carcinoma
Metastatic Prostate Carcinoma
Stage IV Prostate Cancer AJCC v8

Interventions

DRUG
OTHER

Results Available

NCT03446651 | COMPLETED | EARLY_PHASE1

50 participants

Mechanism and Effects of Manipulating Chloride Homeostasis in Acute Heart Failure

Study Type:: INTERVENTIONAL
Last Updated:: 2026-07-31
Start Date:: 2018-07-12
Completion:: 2022-09-07

Conditions

Heart Failure

Interventions

DRUG
OTHER

Results Available

NCT03394365 | RECRUITING | PHASE3

115 participants

A Phase 3 Study of Tabelecleucel for Participants With Epstein-Barr Virus-Associated Post-Transplant Lymphoproliferative Disease After Failure With Rituximab or Rituximab and Chemotherapy

Study Type:: INTERVENTIONAL
Last Updated:: 2026-07-31
Start Date:: 2017-12-29
Completion:: 2030-05-31

Conditions

Epstein-Barr Virus+ Associated Post-transplant Lymphoproliferative Disease (EBV+ PTLD)
Solid Organ Transplant Complications
Lymphoproliferative Disorders
Allogeneic Hematopoietic Cell Transplant
Stem Cell Transplant Complications

Interventions

BIOLOGICAL

No Results Yet

NCT03386539 | COMPLETED | PHASE3

211 participants

Tacrolimus/Everolimus vs. Tacrolimus/MMF in Pediatric Heart Transplant Recipients Using the MATE Score

Study Type:: INTERVENTIONAL
Last Updated:: 2026-07-31
Start Date:: 2018-01-29
Completion:: 2023-04-17

Conditions

Pediatric Heart Transplantation
Immunosuppression
Chronic Kidney Diseases
Cardiac Allograft Vasculopathy
Heart Transplant Failure and Rejection
Post-transplant Lymphoproliferative Disorder
Heart Transplant Infection

Interventions

DRUG

Results Available

NCT03383458 | ACTIVE_NOT_RECRUITING | PHASE3

545 participants

A Study of Nivolumab in Participants With Hepatocellular Carcinoma Who Are at High Risk of Recurrence After Curative Hepatic Resection or Ablation

Study Type:: INTERVENTIONAL
Last Updated:: 2026-07-31
Start Date:: 2018-04-18
Completion:: 2026-05-27

Conditions

Hepatocellular Carcinoma
Liver Cancer

Interventions

BIOLOGICAL
OTHER

No Results Yet

NCT03334253 | COMPLETED | PHASE3

200 participants

Low-Dose Atropine for Treatment of Myopia

Study Type:: INTERVENTIONAL
Last Updated:: 2026-07-31
Start Date:: 2018-06-01
Completion:: 2022-04-15

Conditions

Myopia

Interventions

DRUG
OTHER

Results Available

NCT03317392 | ACTIVE_NOT_RECRUITING | PHASE1/PHASE2

132 participants

Testing the Safety of Different Doses of Olaparib Given Radium-223 for Men With Advanced Prostate Cancer With Bone Metastasis

Study Type:: INTERVENTIONAL
Last Updated:: 2026-07-31
Start Date:: 2019-02-04
Completion:: 2025-03-31

Conditions

Castration-Resistant Prostate Carcinoma
Metastatic Prostate Adenocarcinoma
Stage IVB Prostate Cancer AJCC v8

Interventions

PROCEDURE
OTHER
DRUG
RADIATION

Results Available

NCT03300817 | ACTIVE_NOT_RECRUITING | PHASE1

50 participants

MUC1 Vaccine in Preventing Lung Cancer in Current and Former Smokers at High Risk for Lung Cancer

Study Type:: INTERVENTIONAL
Last Updated:: 2026-07-31
Start Date:: 2017-12-27
Completion:: 2021-09-23

Conditions

Lung Carcinoma

Interventions

OTHER
BIOLOGICAL

Results Available

NCT03287271 | TERMINATED | PHASE1/PHASE2

8 participants

ROCKIF Trial: Re-sensitization of Carboplatin-resistant Ovarian Cancer With Kinase Inhibition of FAK

Study Type:: INTERVENTIONAL
Last Updated:: 2026-07-31
Start Date:: 2018-02-06
Completion:: 2023-07-30

Conditions

Ovarian Cancer

Interventions

DRUG

Results Available

NCT03284385 | ACTIVE_NOT_RECRUITING | PHASE2

18 participants

Testing AZD1775 in Advanced Solid Tumors That Have a Mutation Called SETD2

Study Type:: INTERVENTIONAL
Last Updated:: 2026-07-31
Start Date:: 2019-01-29
Completion:: 2026-03-01

Conditions

Clear Cell Renal Cell Carcinoma
Locally Advanced Clear Cell Renal Cell Carcinoma
Locally Advanced Malignant Solid Neoplasm
Metastatic Malignant Solid Neoplasm
Metastatic Renal Cell Carcinoma
Stage III Renal Cell Cancer AJCC v8
Stage IV Renal Cell Cancer AJCC v8

Interventions

DRUG

No Results Yet

NCT03269422 | COMPLETED | PHASE1

35 participants

Radiotherapy to the Prostate and Dominant Intra-Prostatic Lesion (DIL)

Study Type:: INTERVENTIONAL
Last Updated:: 2026-07-31
Start Date:: 2017-08-28
Completion:: 2026-07-29

Conditions

Prostate Cancer

Interventions

RADIATION

No Results Yet

NCT03246841 | ACTIVE_NOT_RECRUITING | NA

7274 participants

Investigation of Tumour Spectrum of Germline Mutations in Breast and Ovarian Cancer Genes.

Study Type:: INTERVENTIONAL
Last Updated:: 2026-07-31
Start Date:: 2017-09-21
Completion:: 2026-12-30

Conditions

Hereditary Breast and Ovarian Cancer
Mutation

Interventions

OTHER

No Results Yet

NCT03237780 | ACTIVE_NOT_RECRUITING | PHASE2

72 participants

Atezolizumab With or Without Eribulin Mesylate in Treating Patients With Recurrent Locally Advanced or Metastatic Urothelial Cancer

Study Type:: INTERVENTIONAL
Last Updated:: 2026-07-31
Start Date:: 2018-07-20
Completion:: 2027-06-30

Conditions

Locally Advanced Bladder Urothelial Carcinoma
Locally Advanced Renal Pelvis Urothelial Carcinoma
Locally Advanced Ureter Urothelial Carcinoma
Locally Advanced Urethral Urothelial Carcinoma
Metastatic Bladder Urothelial Carcinoma
Metastatic Renal Pelvis Urothelial Carcinoma
Metastatic Ureter Urothelial Carcinoma
Metastatic Urethral Urothelial Carcinoma
Recurrent Bladder Urothelial Carcinoma
Recurrent Renal Pelvis Urothelial Carcinoma
Recurrent Ureter Urothelial Carcinoma
Recurrent Urethral Urothelial Carcinoma
Stage III Bladder Cancer AJCC v8
Stage III Renal Pelvis Cancer AJCC v8
Stage III Ureter Cancer AJCC v8
Stage III Urethral Cancer AJCC v8
Stage IV Bladder Cancer AJCC v8
Stage IV Renal Pelvis Cancer AJCC v8
Stage IV Ureter Cancer AJCC v8
Stage IV Urethral Cancer AJCC v8
Unresectable Bladder Urothelial Carcinoma
Unresectable Renal Pelvis Urothelial Carcinoma
Unresectable Ureter Urothelial Carcinoma
Unresectable Urethral Urothelial Carcinoma

Interventions

DRUG
PROCEDURE

No Results Yet

NCT03188705 | COMPLETED | PHASE4

6 participants

CES1 Carriers in the PAPI Study

Study Type:: INTERVENTIONAL
Last Updated:: 2026-07-31
Start Date:: 2019-10-14
Completion:: 2020-01-17

Conditions

Heart Diseases
Coronary Disease
Coronary Artery Disease
Cardiovascular Diseases
Myocardial Ischemia
Artery Occlusion
Aspirin Sensitivity
Clopidogrel, Poor Metabolism of
Platelet Dysfunction
Platelet Thrombus

Interventions

DRUG

Results Available

NCT03145181 | ACTIVE_NOT_RECRUITING | PHASE1

302 participants

Dose Escalation Study of Teclistamab, a Humanized BCMA*CD3 Bispecific Antibody, in Participants With Relapsed or Refractory Multiple Myeloma

Study Type:: INTERVENTIONAL
Last Updated:: 2026-07-31
Start Date:: 2017-05-16
Completion:: 2025-09-25

Conditions

Hematological Malignancies

Interventions

DRUG

No Results Yet

NCT03141684 | ACTIVE_NOT_RECRUITING | PHASE2

63 participants

Testing Atezolizumab Alone or Atezolizumab Plus Bevacizumab in People With Advanced Alveolar Soft Part Sarcoma

Study Type:: INTERVENTIONAL
Last Updated:: 2026-07-31
Start Date:: 2017-04-25
Completion:: 2026-10-31

Conditions

Metastatic Alveolar Soft Part Sarcoma
Unresectable Alveolar Soft Part Sarcoma

Interventions

DRUG
BIOLOGICAL
PROCEDURE

No Results Yet

NCT03115086 | ACTIVE_NOT_RECRUITING

55 participants

The REPLACE Registry for Cholbam® (Cholic Acid)

Study Type:: OBSERVATIONAL
Last Updated:: 2026-07-31
Start Date:: 2017-07-10
Completion:: 2038-07-31

Conditions

Bile Acid Synthesis Disorders

Interventions

DRUG

No Results Yet

NCT03108495 | TERMINATED | PHASE2

210 participants

Study of LN-145, Autologous Tumor Infiltrating Lymphocytes in the Treatment of Patients With Cervical Carcinoma

Study Type:: INTERVENTIONAL
Last Updated:: 2026-07-31
Start Date:: 2017-06-22
Completion:: 2025-08-22

Conditions

Cervical Carcinoma

Interventions

BIOLOGICAL

Results Available

NCT03099356 | RECRUITING | PHASE2

22 participants

Cyclophosphamide and Sirolimus for the Treatment of Metastatic, RAI-refractory, Differentiated Thyroid Cancer

Study Type:: INTERVENTIONAL
Last Updated:: 2026-07-31
Start Date:: 2017-04-27
Completion:: 2026-12-31

Conditions

Metastatic Thyroid Cancer

Interventions

DRUG

No Results Yet

NCT03091257 | ACTIVE_NOT_RECRUITING | PHASE1

30 participants

A Study of Dabrafenib and/or Trametinib in Patients With Relapsed and/or Refractory Multiple Myeloma

Study Type:: INTERVENTIONAL
Last Updated:: 2026-07-31
Start Date:: 2017-06-21
Completion:: 2026-07-15

Conditions

Multiple Myeloma

Interventions

DRUG

No Results Yet

NCT03055013 | ACTIVE_NOT_RECRUITING | PHASE3

819 participants

Nivolumab in Treating Patients With Localized Kidney Cancer Undergoing Nephrectomy

Study Type:: INTERVENTIONAL
Last Updated:: 2026-07-31
Start Date:: 2017-04-28
Completion:: 2023-05-24

Conditions

Metastatic Renal Cell Carcinoma
Sarcomatoid Renal Cell Carcinoma
Stage II Renal Cell Cancer AJCC v7
Stage III Renal Cell Cancer AJCC v7
Unclassified Renal Cell Carcinoma

Interventions

PROCEDURE
BIOLOGICAL
OTHER

Results Available

NCT03053141 | RECRUITING

100 participants

RHythmia mAPping and Signal acquisitiOn for Data analYsis (RHAPSODY)

Study Type:: OBSERVATIONAL
Last Updated:: 2026-07-31
Start Date:: 2016-05-31
Completion:: 2027-12-31

Conditions

Cardiac Arrythmias

Interventions

DEVICE

No Results Yet