Clinical Trials Updated in 2026

NCT05009069 | ACTIVE_NOT_RECRUITING | PHASE2

58 participants

A Study of Atezolizumab With or Without Tiragolumab Following Neoadjuvant Chemoradiotherapy in Participants With Locally Advanced Rectal Cancer

Study Type:: INTERVENTIONAL
Last Updated:: 2026-07-28
Start Date:: 2022-03-18
Completion:: 2023-11-21

Conditions

Rectal Neoplasms
Rectal Cancer

Interventions

DRUG
RADIATION

No Results Yet

NCT04968808 | RECRUITING | NA

1014 participants

Timing of FFR-guided PCI for Non-IRA in NSTEMI and MVD (OPTION-NSTEMI)

Study Type:: INTERVENTIONAL
Last Updated:: 2026-07-28
Start Date:: 2021-09-06
Completion:: 2028-08-31

Conditions

Myocardial Infarction, Acute
Multi-Vessel Coronary Artery Stenosis
Multi Vessel Coronary Artery Disease

Interventions

PROCEDURE

No Results Yet

NCT04855032 | COMPLETED | NA

86 participants

Post-stroke Perturbation Training

Study Type:: INTERVENTIONAL
Last Updated:: 2026-07-28
Start Date:: 2021-10-06
Completion:: 2025-11-21

Conditions

Stroke

Interventions

BEHAVIORAL

No Results Yet

NCT04798014 | COMPLETED

860 participants

HERO-2: Home-Reported Outcomes With CFTR Modulator Therapy

Study Type:: OBSERVATIONAL
Last Updated:: 2026-07-28
Start Date:: 2021-05-26
Completion:: 2023-08-15

Conditions

Cystic Fibrosis

No Results Yet

NCT04763200 | ACTIVE_NOT_RECRUITING | NA

1252 participants

Impella®-Supported PCI in High-Risk Patients With Complex Coronary Artery Disease and Reduced Left Ventricular Function

Study Type:: INTERVENTIONAL
Last Updated:: 2026-07-28
Start Date:: 2021-04-13
Completion:: 2026-10-31

Conditions

Left Ventricular Dysfunction
Coronary Artery Disease

Interventions

DEVICE

No Results Yet

NCT04752774 | RECRUITING | PHASE1/PHASE2

240 participants

A Study to Assess the Safety and Efficacy of IPN10200 in Adult Participants With Upper Limb Spasticity.

Study Type:: INTERVENTIONAL
Last Updated:: 2026-07-28
Start Date:: 2021-04-29
Completion:: 2029-03-30

Conditions

Spasticity

Interventions

BIOLOGICAL
DRUG

No Results Yet

NCT04743661 | ACTIVE_NOT_RECRUITING | PHASE2

62 participants

131I-Omburtamab, in Recurrent Medulloblastoma and Ependymoma

Study Type:: INTERVENTIONAL
Last Updated:: 2026-07-28
Start Date:: 2022-04-04
Completion:: 2026-04-01

Conditions

Recurrent Medulloblastoma
Recurrent Ependymoma

Interventions

DRUG

No Results Yet

NCT04742894 | RECRUITING | NA

100 participants

Neural Bases of Vocal Sensorimotor Impairment in Aphasia

Study Type:: INTERVENTIONAL
Last Updated:: 2026-07-28
Start Date:: 2021-07-11
Completion:: 2027-02-28

Conditions

Aphasia

Interventions

BEHAVIORAL

No Results Yet

NCT04734106 | RECRUITING | EARLY_PHASE1

30 participants

Safety and Efficacy of Aloe Vera in the Management of the Symptoms of Interstitial Cystitis

Study Type:: INTERVENTIONAL
Last Updated:: 2026-07-28
Start Date:: 2025-02-18
Completion:: 2027-04-30

Conditions

Interstitial Cystitis
Chronic Interstitial Cystitis
Bladder Pain Syndrome

Interventions

DRUG
OTHER

No Results Yet

NCT04713787 | RECRUITING | PHASE2

249 participants

A Safety and Efficacy Study of Different Doses of Oxfendazole Compared to a Single Dose of Albendazole to Treat Trichuris Trichiura Infection in Adults

Study Type:: INTERVENTIONAL
Last Updated:: 2026-07-28
Start Date:: 2024-09-07
Completion:: 2027-02-28

Conditions

Trichuriasis

Interventions

DRUG

No Results Yet

NCT04644575 | ACTIVE_NOT_RECRUITING | PHASE3

261 participants

Long-term Safety and Efficacy of Efanesoctocog Alfa (BIVV001) in Previously Treated Patients With Hemophilia A

Study Type:: INTERVENTIONAL
Last Updated:: 2026-07-28
Start Date:: 2021-02-23
Completion:: 2027-01-15

Conditions

Hemophilia A

Interventions

DRUG

No Results Yet

NCT04603040 | TERMINATED | PHASE2

17 participants

A Study to Evaluate the Efficacy and Safety of Toripalimab Injection in the Treatment of Recurrent or Metastatic Gastric or Gastroesophageal Junction Adenocarcinoma Who Have Failed at Least Two Prior Lines of Therapy and Are Positive Specific Markers

Study Type:: INTERVENTIONAL
Last Updated:: 2026-07-28
Start Date:: 2020-09-28
Completion:: 2023-03-27

Conditions

Recurrent or Metastatic Gastric or Gastroesophageal Junction Adenocarcinoma Who Have Failed at Least Two Prior Lines of Therapy

Interventions

DRUG

No Results Yet

NCT04563871 | COMPLETED | PHASE2

73 participants

Efficacy and Safety of 80mg Osimertinib in Patients With Non-small Cell Lung Cancer(NSCLC)

Study Type:: INTERVENTIONAL
Last Updated:: 2026-07-28
Start Date:: 2020-11-17
Completion:: 2023-10-25

Conditions

Non-small Cell Lung Cancer (NSCLC)

Interventions

DRUG

No Results Yet

NCT04552171 | COMPLETED | NA

314 participants

Game Plan: Efficacy of a Brief, Web-based Intervention on Alcohol Use and Sexually-transmitted Infections

Study Type:: INTERVENTIONAL
Last Updated:: 2026-07-28
Start Date:: 2021-08-13
Completion:: 2025-09-01

Conditions

Sexually Transmitted Diseases, Bacterial
Alcohol; Harmful Use

Interventions

BEHAVIORAL

No Results Yet

NCT04524767 | COMPLETED | NA

505 participants

Depression Screening in Black Churches

Study Type:: INTERVENTIONAL
Last Updated:: 2026-07-28
Start Date:: 2021-08-01
Completion:: 2025-07-18

Conditions

Depression

Interventions

BEHAVIORAL

Results Available

NCT04494412 | COMPLETED | PHASE2

8 participants

An Intravenous (IV) Zanamivir Pharmacokinetics (PK) Study in Hospitalized Neonates and Infants With Influenza Infection

Study Type:: INTERVENTIONAL
Last Updated:: 2026-07-28
Start Date:: 2022-11-21
Completion:: 2026-01-14

Conditions

Influenza, Human
Arthralgia

Interventions

DRUG

No Results Yet

NCT04484818 | ACTIVE_NOT_RECRUITING | PHASE3

27 participants

Testing the Addition of Darolutamide to Hormonal Therapy (Androgen Deprivation Therapy [ADT]) After Surgery for Men With High-Risk Prostate Cancer, The ERADICATE Study

Study Type:: INTERVENTIONAL
Last Updated:: 2026-07-28
Start Date:: 2021-03-01
Completion:: 2026-06-09

Conditions

Prostate Carcinoma

Interventions

DRUG
OTHER

No Results Yet

NCT04463407 | COMPLETED | NA

36 participants

Effect of a Single Nutritional Intervention Previous to a Critical Period of Fat Gain in University Students With Overweight and Obesity

Study Type:: INTERVENTIONAL
Last Updated:: 2026-07-28
Start Date:: 2017-08-28
Completion:: 2017-09-27

Conditions

Obesity

Interventions

OTHER

No Results Yet

NCT04436731 | COMPLETED | EARLY_PHASE1

73 participants

Sex Disparities in Hypoxic Sympatholysis and Impact of Obesity

Study Type:: INTERVENTIONAL
Last Updated:: 2026-07-28
Start Date:: 2020-12-09
Completion:: 2026-07-02

Conditions

Obesity
Healthy
Vasoconstriction
Vasodilation

Interventions

OTHER

No Results Yet

NCT04432584 | ACTIVE_NOT_RECRUITING | PHASE3

190 participants

A Study Evaluating the Safety, Pharmacokinetics, and Efficacy of Crovalimab Versus Eculizumab in Participants With Paroxysmal Nocturnal Hemoglobinuria (PNH) Currently Treated With Complement Inhibitors

Study Type:: INTERVENTIONAL
Last Updated:: 2026-07-28
Start Date:: 2020-09-30
Completion:: 2027-04-18

Conditions

Paroxysmal Nocturnal Hemoglobinuria

Interventions

DRUG

No Results Yet

NCT04392622 | RECRUITING | PHASE1

40 participants

d-Limonene +Radiation +PlatinumBasedChemo for Xerostomia Prevention in LocallyAdvanced HNSCC

Study Type:: INTERVENTIONAL
Last Updated:: 2026-07-28
Start Date:: 2021-02-15
Completion:: 2027-08-15

Conditions

Xerostomia

Interventions

DRUG
RADIATION
OTHER

No Results Yet

NCT04318886 | ACTIVE_NOT_RECRUITING | PHASE3

387 participants

Lay Coach-Led Early Palliative Care for Underserved Advanced Cancer Caregivers: The Project ENABLE Cornerstone RCT

Study Type:: INTERVENTIONAL
Last Updated:: 2026-07-28
Start Date:: 2021-01-07
Completion:: 2025-12-31

Conditions

Cancer Metastatic
Family Members

Interventions

BEHAVIORAL

No Results Yet

NCT04298255 | RECRUITING | NA

50 participants

Experimental Round Spermatid Injection (ROSI) to Treat Infertile Couples

Study Type:: INTERVENTIONAL
Last Updated:: 2026-07-28
Start Date:: 2020-08-24
Completion:: 2028-07-31

Conditions

Infertility, Male

Interventions

OTHER

No Results Yet

NCT04237545 | COMPLETED | NA

106 participants

A Clinical Study of the T3 Short Dental Implant System

Study Type:: INTERVENTIONAL
Last Updated:: 2026-07-28
Start Date:: 2019-10-01
Completion:: 2026-01-01

Conditions

Edentulous Jaw

Interventions

DEVICE

No Results Yet

NCT04171999 | COMPLETED | NA

660 participants

CommunityRx-Hunger

Study Type:: INTERVENTIONAL
Last Updated:: 2026-07-28
Start Date:: 2020-01-06
Completion:: 2023-09-30

Conditions

Food Insecurity

Interventions

OTHER

Results Available

NCT04167514 | COMPLETED | PHASE3

136 participants

Treatment of GVHD in Hematopoietic Stem Cell Transplant (HSCT) Recipients Using AAT Plus Corticosteroids (CS) Compared With Corticosteroids Alone

Study Type:: INTERVENTIONAL
Last Updated:: 2026-07-28
Start Date:: 2020-01-09
Completion:: 2023-09-11

Conditions

Graft Versus Host Disease (GVHD)

Interventions

BIOLOGICAL
DRUG

Results Available

NCT04162938 | RECRUITING | NA

308 participants

Use of a Patient-Centered Electronic App to Increase ED Patient's Knowledge on HCV to Improve the HCV Care Continuum

Study Type:: INTERVENTIONAL
Last Updated:: 2026-07-28
Start Date:: 2022-03-24
Completion:: 2026-09-30

Conditions

Hepatitis C

Interventions

OTHER

No Results Yet

NCT04160390 | ACTIVE_NOT_RECRUITING

72 participants

Blood Samples to Identify Biomarkers in Patients Treated With Cyclophosphamide After Donor Stem Cell Transplant

Study Type:: OBSERVATIONAL
Last Updated:: 2026-07-28
Start Date:: 2018-11-13
Completion:: 2027-04-24

Conditions

Allogeneic Hematopoietic Stem Cell Transplant Recipient
Donor
Malignant Neoplasm

Interventions

OTHER

No Results Yet

NCT04140162 | ACTIVE_NOT_RECRUITING | PHASE2

57 participants

Phase 2 Study With Minimal Residual Disease (MRD) Driven Adaptive Strategy in Treatment for Newly Diagnosed Multiple Myeloma (MM) With Upfront Daratumumab-based Therapy

Study Type:: INTERVENTIONAL
Last Updated:: 2026-07-28
Start Date:: 2020-10-05
Completion:: 2024-05-02

Conditions

Multiple Myeloma

Interventions

DRUG

Results Available

NCT04098471 | RECRUITING | NA

168 participants

Total Meso-rectal Excision Versus Transanal Local Excision Followed by Radiotherapy for T2N0M0 Distal Rectal Cancer

Study Type:: INTERVENTIONAL
Last Updated:: 2026-07-28
Start Date:: 2021-10-01
Completion:: 2027-06-01

Conditions

Rectal Cancer

Interventions

PROCEDURE

No Results Yet

NCT04093570 | ENROLLING_BY_INVITATION | PHASE2

332 participants

A Study for Participants Who Participated in Prior Clinical Studies of ASTX727 (Standard Dose)

Study Type:: INTERVENTIONAL
Last Updated:: 2026-07-28
Start Date:: 2019-09-30
Completion:: 2027-12-31

Conditions

Acute Myeloid Leukemia
Chronic Myelomonocytic Leukemia
Myelodysplastic Syndromes

Interventions

DRUG

No Results Yet

NCT04058756 | ACTIVE_NOT_RECRUITING | PHASE1

120 participants

Rollover Study for Continued Safety and Tolerability in Subjects Treated With Spartalizumab Alone or in Combination With Other Study Treatments

Study Type:: INTERVENTIONAL
Last Updated:: 2026-07-28
Start Date:: 2019-10-30
Completion:: 2030-04-30

Conditions

Advanced Solid Tumors

Interventions

DRUG

No Results Yet

NCT04055428 | RECRUITING | PHASE2

200 participants

NAUTICAL: Effect of Natriuretic Peptide Augmentation on Cardiometabolic Health in Black Individuals

Study Type:: INTERVENTIONAL
Last Updated:: 2026-07-28
Start Date:: 2020-08-15
Completion:: 2026-12-31

Conditions

Diabetes Mellitus
Cardiovascular Diseases
Insulin Sensitivity/Resistance
Metabolic Disease
Natriuretic Peptides
Metabolism
Energy Expenditure

Interventions

DRUG
OTHER
DIETARY_SUPPLEMENT

No Results Yet

NCT04040205 | RECRUITING | PHASE2

44 participants

Abemaciclib for Bone and Soft Tissue Sarcoma With Cyclin-Dependent Kinase (CDK) Pathway Alteration

Study Type:: INTERVENTIONAL
Last Updated:: 2026-07-28
Start Date:: 2019-10-07
Completion:: 2027-06-01

Conditions

Chondrosarcoma
Osteosarcoma
Soft Tissue Sarcoma

Interventions

DRUG

No Results Yet

NCT03963375 | COMPLETED | PHASE4

47 participants

Cladribine Tablets: Collaborative Study to Evaluate Impact On Central Nervous System Biomarkers in Multiple Sclerosis

Study Type:: INTERVENTIONAL
Last Updated:: 2026-07-28
Start Date:: 2019-10-28
Completion:: 2025-05-27

Conditions

Multiple Sclerosis
Multiple Sclerosis, Relapsing-Remitting

Interventions

DRUG

Results Available

NCT03945305 | RECRUITING | NA

500 participants

Safety and Efficacy of Remote Ischemic Conditioning Treatment for Community-based Essential Hypertension

Study Type:: INTERVENTIONAL
Last Updated:: 2026-07-28
Start Date:: 2023-11-25
Completion:: 2026-07-31

Conditions

Essential Hypertension

Interventions

DEVICE
OTHER

No Results Yet

NCT03899883 | COMPLETED | PHASE2

11 participants

Uric Acid Lowering Trial in Youth Onset T2D

Study Type:: INTERVENTIONAL
Last Updated:: 2026-07-28
Start Date:: 2020-01-01
Completion:: 2023-04-13

Conditions

Diabetic Kidney Disease
Hyperuricemia
Diabetes
Diabetes Mellitus, Type 2
Type2 Diabetes
Type 2 Diabetes Mellitus
Diabetic Nephropathies
Diabetes Complications

Interventions

DRUG

Results Available

NCT03893500 | COMPLETED | NA

63 participants

Utility of At-home Monitoring of Exercise Capacity by App-based 6-minute Walk Test

Study Type:: INTERVENTIONAL
Last Updated:: 2026-07-28
Start Date:: 2020-07-01
Completion:: 2024-06-01

Conditions

Pulmonary Arterial Hypertension

Interventions

DEVICE

Results Available

NCT03872778 | COMPLETED | PHASE1/PHASE2

35 participants

[177Lu]-NeoB in Patients With Advanced Solid Tumors and With [68Ga]-neoB Lesion Uptake

Study Type:: INTERVENTIONAL
Last Updated:: 2026-07-28
Start Date:: 2019-07-24
Completion:: 2025-01-07

Conditions

Neoplasms

Interventions

DRUG

No Results Yet

NCT03814304 | COMPLETED | NA

99 participants

tDCS in Elderly Fallers Study

Study Type:: INTERVENTIONAL
Last Updated:: 2026-07-28
Start Date:: 2019-07-08
Completion:: 2025-01-24

Conditions

Accidental Falls
Aging

Interventions

OTHER

Results Available