Clinical Trials

NCT04793958 | ACTIVE_NOT_RECRUITING | PHASE3

461 participants

Phase 3 Study of MRTX849 With Cetuximab vs Chemotherapy in Patients With Advanced Colorectal Cancer With KRAS G12C Mutation (KRYSTAL-10)

Study Type:

INTERVENTIONAL

Last Updated:

2026-07-23

Start Date:

2021-06-24

Completion:

2026-01-16

Conditions

• Advanced Colorectal Cancer
• Metastatic Colorectal Cancer

Interventions

• DRUG
• BIOLOGICAL

No Results Yet

NCT04789148 | RECRUITING | PHASE1

40 participants

Effects of Intranasal Oxytocin in Patients With Arginine-vasopressin Deficiency

Study Type:

INTERVENTIONAL

Last Updated:

2026-07-23

Start Date:

2025-09-10

Completion:

2027-06-30

Conditions

• Vasopressin Deficiency

Interventions

• DRUG

No Results Yet

NCT04749368 | COMPLETED | PHASE2

91 participants

Study to Investigate the Safety and Efficacy of BRII-835 and BRII-179 Combination Therapy Treating Chronic Hepatitis B Virus (HBV) Infection

Study Type:

INTERVENTIONAL

Last Updated:

2026-07-23

Start Date:

2021-04-12

Completion:

2023-07-04

Conditions

• Hepatitis B, Chronic

Interventions

• DRUG
• BIOLOGICAL

Results Available

NCT04702724 | COMPLETED | NA

26 participants

Reinstatement of Context During Sleep and Its Subsequent Effect on Memory: an fMRI Study

Study Type:

INTERVENTIONAL

Last Updated:

2026-07-23

Start Date:

2021-05-10

Completion:

2022-06-30

Conditions

• Sleep
• Consolidation

Interventions

• BEHAVIORAL

No Results Yet

NCT04677972 | COMPLETED | PHASE3

220 participants

SPI-1005 for the Treatment of Meniere's Disease

Study Type:

INTERVENTIONAL

Last Updated:

2026-07-23

Start Date:

2022-08-02

Completion:

2023-09-19

Conditions

• Meniere Disease
• Ménière

Interventions

• DRUG

Results Available

NCT04614558 | ACTIVE_NOT_RECRUITING | PHASE2

12 participants

Isatuximab in Patients With Monoclonal Gammopathy of Renal Significance

Study Type:

INTERVENTIONAL

Last Updated:

2026-07-23

Start Date:

2021-06-08

Completion:

2025-10-23

Conditions

• Monoclonal Gammopathy

Interventions

• DRUG

No Results Yet

NCT04595435 | ACTIVE_NOT_RECRUITING

94 participants

IORT-Breast at Medical Center Navicent Health

Study Type:

OBSERVATIONAL

Last Updated:

2026-07-23

Start Date:

2019-03-19

Completion:

2033-12-31

Conditions

• Breast Cancer Female
• Early-stage Breast Cancer

Interventions

• PROCEDURE
• RADIATION

No Results Yet

NCT04553926 | COMPLETED

661 participants

'OLAP' (OLAparib Regulatory Post-marketing Surveillance)

Study Type:

OBSERVATIONAL

Last Updated:

2026-07-23

Start Date:

2021-02-01

Completion:

2025-07-11

Conditions

• Ovarian Cancer
• Breast Cancer
• Prostate Cancer
• Pancreatic Cancer

No Results Yet

NCT04543617 | ACTIVE_NOT_RECRUITING | PHASE3

760 participants

A Study of Atezolizumab With or Without Tiragolumab in Participants With Unresectable Esophageal Squamous Cell Carcinoma Whose Cancers Have Not Progressed Following Definitive Concurrent Chemoradiotherapy

Study Type:

INTERVENTIONAL

Last Updated:

2026-07-23

Start Date:

2020-09-28

Completion:

2027-03-31

Conditions

• Esophageal Squamous Cell Carcinoma

Interventions

• DRUG

No Results Yet

NCT04501081 | RECRUITING

1100 participants

Natural History of Autosomal Dominant Hearing Loss

Study Type:

OBSERVATIONAL

Last Updated:

2026-07-23

Start Date:

2021-02-09

Completion:

2029-08-21

Conditions

• Hearing Loss

No Results Yet

NCT04483531 | NO_LONGER_AVAILABLE

Odevixibat for the Treatment of Progressive Familial Intrahepatic Cholestasis

Study Type:

EXPANDED_ACCESS

Last Updated:

2026-07-23

Conditions

• Progressive Familial Intrahepatic Cholestasis

Interventions

• DRUG

No Results Yet

NCT04471974 | ACTIVE_NOT_RECRUITING | PHASE2

61 participants

ZEN-3694, Enzalutamide, and Pembrolizumab for the Treatment of Metastatic Castration-Resistant Prostate Cancer

Study Type:

INTERVENTIONAL

Last Updated:

2026-07-23

Start Date:

2021-01-26

Completion:

2028-05-31

Conditions

• Castration-Resistant Prostate Carcinoma
• Metastatic Prostate Adenocarcinoma
• Metastatic Prostate Small Cell Carcinoma
• Stage IV Prostate Cancer AJCC v8
• Stage IVA Prostate Cancer AJCC v8
• Stage IVB Prostate Cancer AJCC v8

Interventions

• DRUG
• BIOLOGICAL

No Results Yet

NCT04413123 | ACTIVE_NOT_RECRUITING | PHASE2

60 participants

Cabozantinib In Combo With NIVO + IPI In Advanced NCCRCC

Study Type:

INTERVENTIONAL

Last Updated:

2026-07-23

Start Date:

2020-11-05

Completion:

2026-12-20

Conditions

• Papillary Renal Cell Carcinoma
• Unclassified Renal Cell Carcinoma
• Translocation Renal Cell Carcinoma
• Chromophobe Renal Cell Carcinoma
• Collecting Duct Renal Cell Carcinoma
• Renal Cell Carcinoma
• Unresectable Advanced Renal Cell Carcinoma
• Metastatic Ncc Renal Cell Carcinoma

Interventions

• DRUG

No Results Yet

NCT04362696 | COMPLETED | NA

964 participants

Improving Working Memory in Older Adults

Study Type:

INTERVENTIONAL

Last Updated:

2026-07-23

Start Date:

2019-09-01

Completion:

2026-04-30

Conditions

• Memory Disorders in Old Age

Interventions

• DEVICE

No Results Yet

NCT04362150 | RECRUITING

800 participants

Long-term Impact of Infection With Novel Coronavirus (COVID-19)

Study Type:

OBSERVATIONAL

Last Updated:

2026-07-23

Start Date:

2020-04-21

Completion:

2030-12-31

Conditions

• COVID

No Results Yet

NCT04281017 | COMPLETED | PHASE4

22 participants

Effect of Position and Anesthetic Choice in Intraocular Pressure in Robotic GYN (Gynecologic) Oncology Patients

Study Type:

INTERVENTIONAL

Last Updated:

2026-07-23

Start Date:

2020-11-10

Completion:

2025-11-20

Conditions

• Intraocular Pressure
• Oncology

Interventions

• DRUG

Results Available

NCT04218331 | ACTIVE_NOT_RECRUITING | NA

56 participants

Boosting Language Outcomes of Minimally Verbal Children With ASD (BLOOM)

Study Type:

INTERVENTIONAL

Last Updated:

2026-07-23

Start Date:

2021-04-29

Completion:

2026-06-12

Conditions

• Autism Spectrum Disorder

Interventions

• BEHAVIORAL

No Results Yet

NCT04212013 | ACTIVE_NOT_RECRUITING | PHASE3

23 participants

A Study of Ibrutinib With Rituximab in People With Untreated Marginal Zone Lymphoma

Study Type:

INTERVENTIONAL

Last Updated:

2026-07-23

Start Date:

2019-12-23

Completion:

2027-03-18

Conditions

• Marginal Zone Lymphoma

Interventions

• DRUG
• OTHER

No Results Yet

NCT04158440 | COMPLETED | PHASE3

501 participants

Phase III Study of Toripalimab Versus Placebo Plus Chemotherapy in Resectable NSCLC

Study Type:

INTERVENTIONAL

Last Updated:

2026-07-23

Start Date:

2020-04-07

Completion:

2026-04-18

Conditions

• Stage II-III Non-small Cell Lung Cancer

Interventions

• DRUG

No Results Yet

NCT04075591 | COMPLETED | NA

219 participants

Wavefront-guided LASIK for Monovision Treatment of Myopic Subjects With Presbyopia

Study Type:

INTERVENTIONAL

Last Updated:

2026-07-23

Start Date:

2019-09-24

Completion:

2025-06-25

Conditions

• Refractive Error

Interventions

• DEVICE

Results Available

NCT04060667 | COMPLETED | NA

3191 participants

Wireless Physiologic Monitoring in Postpartum Women

Study Type:

INTERVENTIONAL

Last Updated:

2026-07-23

Start Date:

2020-01-21

Completion:

2022-03-30

Conditions

• Maternal Death During Childbirth
• Pregnancy Complications

Interventions

• COMBINATION_PRODUCT

Results Available

NCT04058990 | COMPLETED | NA

180 participants

Safety and Effectiveness of Agent Paclitaxel-Coated PTCA Balloon Catheter. (AGENT Japan SV)

Study Type:

INTERVENTIONAL

Last Updated:

2026-07-23

Start Date:

2019-12-12

Completion:

2021-12-22

Conditions

• Coronary Artery Disease

Interventions

• DEVICE

Results Available

NCT04021615 | COMPLETED | NA

90 participants

Rehabilitation Program for Weaning From Mechanical Ventilator

Study Type:

INTERVENTIONAL

Last Updated:

2026-07-23

Start Date:

2019-07-21

Completion:

2020-01-05

Conditions

• Mechanical Ventilation Complication

Interventions

• OTHER

No Results Yet

NCT03975647 | ACTIVE_NOT_RECRUITING | PHASE3

466 participants

A Study of Tucatinib vs. Placebo in Combination With Ado-trastuzumab Emtansine (T-DM1) for Patients With Advanced or Metastatic HER2+ Breast Cancer

Study Type:

INTERVENTIONAL

Last Updated:

2026-07-23

Start Date:

2019-10-02

Completion:

2023-06-29

Conditions

• HER2-positive Breast Cancer

Interventions

• DRUG

Results Available

NCT03941366 | TERMINATED | NA

15 participants

Treatment of Adenocarcinoma of the Rectum With Transanal Local Excision for Complete Responders

Study Type:

INTERVENTIONAL

Last Updated:

2026-07-23

Start Date:

2016-02-26

Completion:

2023-03-01

Conditions

• Rectal Cancer

Interventions

• PROCEDURE

No Results Yet

NCT03934372 | RECRUITING | PHASE1/PHASE2

70 participants

Safety and Efficacy of Ponatinib for Treatment of Pediatric Recurrent or Refractory Leukemias, Lymphomas or Solid Tumors

Study Type:

INTERVENTIONAL

Last Updated:

2026-07-23

Start Date:

2020-01-29

Completion:

2028-02-01

Conditions

• Acute Myeloid Leukemia
• Accelerated Phase Chronic Myeloid Leukemia
• Blast Phase Chronic Myeloid Leukemia
• Chronic Phase Chronic Myeloid Leukemia
• Acute Lymphoblastic Leukemia
• Acute Lymphocytic Leukemia
• Leukemia
• Lymphoma
• Solid Tumors

Interventions

• DRUG

No Results Yet

NCT03917043 | RECRUITING | PHASE1

165 participants

APG-2449 in Patients With Advanced Solid Tumors

Study Type:

INTERVENTIONAL

Last Updated:

2026-07-23

Start Date:

2019-05-27

Completion:

2027-12-31

Conditions

• Advanced Solid Cancer
• Non Small Cell Lung Cancer
• Esophageal Cancer
• Ovarian Cancer
• Malignant Pleural Mesothelioma

Interventions

• DRUG

No Results Yet

NCT03854110 | RECRUITING | PHASE1

80 participants

A Trial to Evaluate Safety, Tolerability, and Preliminary Efficacy of Misetionamide (GP-2250) as Monotherapy or in Combination With Gemcitabine

Study Type:

INTERVENTIONAL

Last Updated:

2026-07-23

Start Date:

2019-01-14

Completion:

2027-07-31

Conditions

• Ovarian Cancer

Interventions

• DRUG

No Results Yet

NCT03851575 | ACTIVE_NOT_RECRUITING | NA

508 participants

Accelerated Treatment of Endocarditis

Study Type:

INTERVENTIONAL

Last Updated:

2026-07-23

Start Date:

2019-01-17

Completion:

2026-04-28

Conditions

• Infectious Endocarditis

Interventions

• OTHER

No Results Yet

NCT03836209 | COMPLETED | PHASE2

181 participants

Gilteritinib vs Midostaurin in FLT3 Mutated Acute Myeloid Leukemia

Study Type:

INTERVENTIONAL

Last Updated:

2026-07-23

Start Date:

2019-12-06

Completion:

2023-10-17

Conditions

• Acute Myeloid Leukemia

Interventions

• DRUG

Results Available

NCT03835273 | TERMINATED

73 participants

Oesophagectomy and Chest Wall and Respiratory Function

Study Type:

OBSERVATIONAL

Last Updated:

2026-07-23

Start Date:

2019-05-29

Completion:

2024-08-31

Conditions

• Esophageal Cancer
• Esophagectomy
• Respiratory Function Loss

Interventions

• OTHER

No Results Yet

NCT03833401 | WITHDRAWN | NA

0 participants

Dental Pulp Regeneration by Autologous Tissue Transplantation

Study Type:

INTERVENTIONAL

Last Updated:

2026-07-23

Start Date:

2019-02-14

Completion:

2021-06-30

Conditions

• Dental Pulp Regeneration

Interventions

• PROCEDURE

No Results Yet

NCT03712878 | COMPLETED | PHASE2

10 participants

2-Step Approach to Stem Cell Transplant in Treating Participants With Hematological Malignancies

Study Type:

INTERVENTIONAL

Last Updated:

2026-07-23

Start Date:

2018-09-19

Completion:

2025-03-19

Conditions

• Hematopoietic and Lymphoid Cell Neoplasm

Interventions

• RADIATION
• PROCEDURE
• DRUG

Results Available

NCT03610802 | RECRUITING

3000 participants

Send-In Sample Collection to Achieve Genetic and Immunologic Characterization of Primary Immunodeficiencies

Study Type:

OBSERVATIONAL

Last Updated:

2026-07-23

Start Date:

2019-07-22

Completion:

2038-03-31

Conditions

• Primary Immunodeficiency

No Results Yet

NCT03586661 | COMPLETED | PHASE1

31 participants

Niraparib and Copanlisib in Treating Patients With Recurrent Endometrial, Ovarian, Primary Peritoneal, or Fallopian Tube Cancer

Study Type:

INTERVENTIONAL

Last Updated:

2026-07-23

Start Date:

2019-04-29

Completion:

2026-06-16

Conditions

• Deleterious BRCA1 Gene Mutation
• Deleterious BRCA2 Gene Mutation
• Endometrial Adenocarcinoma
• High Grade Ovarian Serous Adenocarcinoma
• Platinum-Resistant Ovarian Carcinoma
• Primary Peritoneal High Grade Serous Adenocarcinoma
• Progressive Disease
• Recurrent Endometrial Carcinoma
• Recurrent Fallopian Tube Carcinoma
• Recurrent Ovarian Carcinoma
• Recurrent Primary Peritoneal Carcinoma

Interventions

• DRUG

No Results Yet

NCT03523858 | ACTIVE_NOT_RECRUITING | PHASE3

927 participants

A Study to Evaluate Ocrelizumab Treatment in Participants With Progressive Multiple Sclerosis

Study Type:

INTERVENTIONAL

Last Updated:

2026-07-23

Start Date:

2018-05-28

Completion:

2026-10-22

Conditions

• Progressive Multiple Sclerosis (PMS)

Interventions

• DRUG

No Results Yet

NCT03453008 | COMPLETED

14 participants

Spastic Cocontractions and Limitation of Active Movements Before and After Treatment During Injection of Botulinum Toxin

Study Type:

OBSERVATIONAL

Last Updated:

2026-07-23

Start Date:

2018-01-14

Completion:

2021-05-21

Conditions

• Cerebrovascular Accident
• Stroke

Interventions

• OTHER

No Results Yet

NCT03433274 | ACTIVE_NOT_RECRUITING | NA

103 participants

Clinical Trial to Evaluate the Safety and Effectiveness of Using the Tendyne Transcatheter Mitral Valve System for the Treatment of Symptomatic Mitral Regurgitation

Study Type:

INTERVENTIONAL

Last Updated:

2026-07-23

Start Date:

2018-06-15

Completion:

2024-04-29

Conditions

• Mitral Regurgitation
• Mitral Insufficiency
• Mitral Valve Insufficiency
• Cardiovascular Diseases
• Valve Disease, Heart
• Heart Valve Diseases
• Functional Mitral Regurgitation
• Degenerative Mitral Valve Disease

Interventions

• DEVICE

Results Available

NCT03415035 | COMPLETED

269 participants

Study Venetoclax Effectiveness and Real-Life Treatment Management in Participants With Chronic Lymphocytic Leukemia

Study Type:

OBSERVATIONAL

Last Updated:

2026-07-23

Start Date:

2018-03-09

Completion:

2026-06-17

Conditions

• Cancer - Chronic Lymphocytic Leukemia

No Results Yet

NCT03410030 | COMPLETED | PHASE1/PHASE2

17 participants

Trial of Ascorbic Acid (AA) + Nanoparticle Paclitaxel Protein Bound + Cisplatin + Gemcitabine (AA NABPLAGEM)

Study Type:

INTERVENTIONAL

Last Updated:

2026-07-23

Start Date:

2017-12-15

Completion:

2021-09-14

Conditions

• Pancreatic Cancer
• Pancreas Cancer
• Pancreatic Adenocarcinoma Resectable
• Pancreatic Ductal Adenocarcinoma
• Pancreas Metastases

Interventions

• DRUG

Results Available