Clinical Trials

NCT04861259 | ACTIVE_NOT_RECRUITING | PHASE3

83 participants

A Study Evaluating the Efficacy, Safety, Pharmacokinetics and Pharmacodynamics of Crovalimab in Adult and Adolescent Participants With Atypical Hemolytic Uremic Syndrome (aHUS)

Study Type:

INTERVENTIONAL

Last Updated:

2026-07-21

Start Date:

2021-10-22

Completion:

2025-10-09

Conditions

• Atypical Hemolytic Uremic Syndrome

Interventions

• DRUG

No Results Yet

NCT04826341 | COMPLETED | PHASE1/PHASE2

35 participants

A Phase I/II Study of Sacituzumab Govitecan Plus Berzosertib in Small Cell Lung Cancer, Extra-Pulmonary Small Cell Neuroendocrine Cancer and Homologous Recombination-Deficient Cancers Resistant to PARP Inhibitors

Study Type:

INTERVENTIONAL

Last Updated:

2026-07-21

Start Date:

2021-09-20

Completion:

2026-05-20

Conditions

• HRD Cancer
• SCLC
• Advanced Solid Tumors

Interventions

• DRUG

No Results Yet

NCT04818138 | TERMINATED | NA

69 participants

BROadband vs Narrowband photoTherapy for Eczema Trial Nested in the CACTI Cohort

Study Type:

INTERVENTIONAL

Last Updated:

2026-07-21

Start Date:

2021-09-27

Completion:

2025-06-05

Conditions

• Atopic Dermatitis
• Skin Diseases
• Eczema

Interventions

• DEVICE

Results Available

NCT04816955 | COMPLETED | NA

242 participants

Dietary Recommendations for Reducing Free Sugar Intakes

Study Type:

INTERVENTIONAL

Last Updated:

2026-07-21

Start Date:

2021-05-01

Completion:

2022-12-20

Conditions

• Dietary Recommendations

Interventions

• BEHAVIORAL

Results Available

NCT04800874 | ACTIVE_NOT_RECRUITING | PHASE2

14 participants

Study of BBP-418 in Patients With LGMD2I

Study Type:

INTERVENTIONAL

Last Updated:

2026-07-21

Start Date:

2021-02-18

Completion:

2026-11-01

Conditions

• LGMD2I

Interventions

• DRUG

No Results Yet

NCT04798690 | RECRUITING

5000 participants

Long-term Safety and Effectiveness of Growtropin®-II Treatment in Children With Short Stature

Study Type:

OBSERVATIONAL

Last Updated:

2026-07-21

Start Date:

2021-02-08

Completion:

2035-02-28

Conditions

• Growth Hormone Deficiency
• Idiopathic Short Stature
• Turner Syndrome
• Small for Gestational Age

No Results Yet

NCT04768972 | ACTIVE_NOT_RECRUITING | PHASE3

89 participants

FUSION: A Study to Evaluate the Efficacy, Safety, Pharmacokinetics and Pharmacodynamics of ION363 in Amyotrophic Lateral Sclerosis Participants With Fused in Sarcoma Mutations (FUS-ALS)

Study Type:

INTERVENTIONAL

Last Updated:

2026-07-21

Start Date:

2021-06-14

Completion:

2026-06-17

Conditions

• Amyotrophic Lateral Sclerosis

Interventions

• DRUG

No Results Yet

NCT04757181 | COMPLETED | NA

38 participants

The Inflammatory Bowel Disease - Anti-Inflammatory Diet (IBD-AID)

Study Type:

INTERVENTIONAL

Last Updated:

2026-07-21

Start Date:

2017-02-01

Completion:

2019-02-01

Conditions

• Inflammatory Bowel Diseases

Interventions

• OTHER

No Results Yet

NCT04751435 | RECRUITING | NA

445 participants

Developing New Educational Materials About Genetic Testing for a Diverse Group of Cancer Patients

Study Type:

INTERVENTIONAL

Last Updated:

2026-07-21

Start Date:

2021-11-16

Completion:

2027-08-31

Conditions

• Educational Materials for Genetic Testing
• Breast Cancer
• Ovarian Cancer
• Prostate Cancer
• Pancreatic Cancer
• Colorectal Cancer

Interventions

• OTHER
• BEHAVIORAL

No Results Yet

NCT04750902 | COMPLETED | PHASE2

2025 participants

A Clinical Trial to Assess the Safety and the Anti-caries Efficacy of COL 101 (Arginine) Non-fluoride Dentifrices in Comparison With 0.24% Sodium Fluoride (1100 Ppm F) Dentifrice Control in 10 to 14-year-old Children

Study Type:

INTERVENTIONAL

Last Updated:

2026-07-21

Start Date:

2021-01-21

Completion:

2024-02-28

Conditions

• Dental Caries

Interventions

• DRUG

Results Available

NCT04723264 | ACTIVE_NOT_RECRUITING | NA

400 participants

The Development of Eating Behavior in Infancy: Associations With Behavior, Diet, and Growth at School Age

Study Type:

INTERVENTIONAL

Last Updated:

2026-07-21

Start Date:

2021-04-28

Completion:

2026-10-31

Conditions

• Eating Behavior

Interventions

• BEHAVIORAL

No Results Yet

NCT04722523 | RECRUITING | PHASE1

40 participants

A Study of Cemiplimab With Chemotherapy and Immunotherapy in People With Head and Neck Cancer

Study Type:

INTERVENTIONAL

Last Updated:

2026-07-21

Start Date:

2021-01-20

Completion:

2027-06-20

Conditions

• Head and Neck Cancer
• Head Cancer
• Head Cancer Neck
• Neck Cancer
• Head and Neck Squamous Cell Carcinoma
• HNSCC

Interventions

• DRUG
• PROCEDURE
• RADIATION

No Results Yet

NCT04702009 | COMPLETED | PHASE2/PHASE3

33 participants

Efficacy and Safety of First-line Anti-PD-1/PD-L1 Monoclonal Antibody in Combination With Chemotherapy and Bronchoscopy-assisted Interventional Therapy in Patients With Advanced Central Non-small Cell Lung Cancer

Study Type:

INTERVENTIONAL

Last Updated:

2026-07-21

Start Date:

2021-01-20

Completion:

2025-10-17

Conditions

• Advanced Lung Carcinoma
• Non-small Cell Lung Cancer

Interventions

• DRUG
• PROCEDURE

No Results Yet

NCT04691986 | ACTIVE_NOT_RECRUITING | NA

74 participants

Impacts of Nicotinamide Riboside on Functional Capacity and Muscle Physiology in Older Veterans

Study Type:

INTERVENTIONAL

Last Updated:

2026-07-21

Start Date:

2023-09-01

Completion:

2026-03-31

Conditions

• Sarcopenia
• Nicotinamide Adenine Dinucleotide Concentration
• Muscle Quality and NAD+ Content

Interventions

• DIETARY_SUPPLEMENT
• OTHER

No Results Yet

NCT04690205 | COMPLETED | NA

72 participants

Hospital at Home at EOL in Heme Malignancies

Study Type:

INTERVENTIONAL

Last Updated:

2026-07-21

Start Date:

2021-02-26

Completion:

2024-07-01

Conditions

• Hematologic Malignancy

Interventions

• OTHER

No Results Yet

NCT04685317 | RECRUITING | NA

48 participants

Safety and Efficacy of the Sentinel Cerebral Protection Device in Atrial Fibrillation Ablation

Study Type:

INTERVENTIONAL

Last Updated:

2026-07-21

Start Date:

2023-03-07

Completion:

2027-06-30

Conditions

• Arrhythmia
• Atrial Fibrillation

Interventions

• DEVICE
• DIAGNOSTIC_TEST

No Results Yet

NCT04669197 | COMPLETED | PHASE2

19 participants

Study of Paclitaxel Protein Bound + Gemcitabine + Cisplatin + Hydroxychloroquine as Treatment in Untreated Pancreas Cancer

Study Type:

INTERVENTIONAL

Last Updated:

2026-07-21

Start Date:

2020-12-01

Completion:

2024-02-21

Conditions

• Untreated Resectable Pancreatic Adenocarcinoma
• Borderline Resectable Pancreatic Adenocarcinoma
• Locally Advanced Pancreatic Adenocarcinoma

Interventions

• DRUG

Results Available

NCT04632810 | COMPLETED | NA

70 participants

Effect of Ketosis on Pain and Quality of Life in Patients With Lipedema

Study Type:

INTERVENTIONAL

Last Updated:

2026-07-21

Start Date:

2021-03-22

Completion:

2023-07-01

Conditions

• Lipedema

Interventions

• OTHER

No Results Yet

NCT04629677 | RECRUITING

150 participants

Evaluation of Portal Vein Stenting in Patients With Portal Vein Stenosis and Gastrointestinal Cancers

Study Type:

OBSERVATIONAL

Last Updated:

2026-07-21

Start Date:

2019-04-02

Completion:

2028-04-30

Conditions

• Malignant Digestive System Neoplasm

Interventions

• OTHER

No Results Yet

NCT04620915 | COMPLETED | NA

300 participants

Construal Level as a Novel Pathway for Affect Regulation and Cancer Control

Study Type:

INTERVENTIONAL

Last Updated:

2026-07-21

Start Date:

2021-10-11

Completion:

2025-08-20

Conditions

• Smoking Cessation
• Smoking Reduction
• Cancer

Interventions

• BEHAVIORAL

No Results Yet

NCT04614922 | TERMINATED | NA

48 participants

Acceptance and Commitment Therapy-based Rehabilitation of Post-concussion Symptoms

Study Type:

INTERVENTIONAL

Last Updated:

2026-07-21

Start Date:

2020-10-29

Completion:

2025-09-09

Conditions

• Post-Concussion Syndrome
• Post-Traumatic Headache

Interventions

• BEHAVIORAL

No Results Yet

NCT04612348 | COMPLETED

45 participants

Gastric Ultrasound in Tube Fed Intubated Patients

Study Type:

OBSERVATIONAL

Last Updated:

2026-07-21

Start Date:

2021-02-26

Completion:

2026-03-17

Conditions

• Critical Illness

Interventions

• DIAGNOSTIC_TEST

Results Available

NCT04549207 | ACTIVE_NOT_RECRUITING | PHASE4

240 participants

Comparing Continuation or De-escalation of Bone Modifying Agents (BMA) in Patients Treated for Over 2 Years for Bone Metastases From Either Breast or Castration-resistant Prostate Cancer

Study Type:

INTERVENTIONAL

Last Updated:

2026-07-21

Start Date:

2020-10-09

Completion:

2025-04-17

Conditions

• Breast Cancer
• Castration-resistant Prostate Cancer

Interventions

• DRUG

No Results Yet

NCT04537286 | COMPLETED | PHASE2

90 participants

First-line Nab-paclitaxel Plus Cisplatin Plus Camrelizumab in mTNBC Patients

Study Type:

INTERVENTIONAL

Last Updated:

2026-07-21

Start Date:

2020-08-25

Completion:

2023-03-30

Conditions

• Breast Cancer
• TNBC - Triple-Negative Breast Cancer

Interventions

• DRUG

No Results Yet

NCT04534205 | RECRUITING | PHASE2/PHASE3

350 participants

A Clinical Trial Investigating the Safety, Tolerability, and Therapeutic Effects of BNT113 in Combination With Pembrolizumab Versus Pembrolizumab Alone for Patients With a Form of Head and Neck Cancer Positive for Human Papilloma Virus 16 and Expressing the Protein PD-L1

Study Type:

INTERVENTIONAL

Last Updated:

2026-07-21

Start Date:

2021-01-07

Completion:

2029-04-30

Conditions

• Unresectable Head and Neck Squamous Cell Carcinoma
• Metastatic Head and Neck Cancer
• Recurrent Head and Neck Cancer

Interventions

• BIOLOGICAL

No Results Yet

NCT04528758 | COMPLETED | EARLY_PHASE1

15 participants

F-18 Rhodamine 6G PET Imaging for Myocardial Blood Flow

Study Type:

INTERVENTIONAL

Last Updated:

2026-07-21

Start Date:

2018-10-16

Completion:

2024-06-24

Conditions

• Coronary Artery Disease

Interventions

• DRUG

No Results Yet

NCT04504526 | RECRUITING | EARLY_PHASE1

50 participants

Value of Chemokine Receptor CXCR4 Imaging for Diagnosis and Prognostic Evaluation in Lymphoproliferative Diseases

Study Type:

INTERVENTIONAL

Last Updated:

2026-07-21

Start Date:

2020-08-07

Completion:

2027-12-31

Conditions

• Lymphoma
• Multiple Myeloma
• Leukemia

Interventions

• DRUG

No Results Yet

NCT04499365 | RECRUITING | EARLY_PHASE1

500 participants

68Ga-FAPI PET/CT in Patients With Various Types of Cancer

Study Type:

INTERVENTIONAL

Last Updated:

2026-07-21

Start Date:

2020-08-15

Completion:

2027-12-30

Conditions

• Tumor
• Positron-Emission Tomography
• Metastasis

Interventions

• DRUG
• DIAGNOSTIC_TEST

No Results Yet

NCT04464980 | ACTIVE_NOT_RECRUITING | PHASE2

1516 participants

Optimizing Retention, Duration and Discontinuation Strategies for Opioid Use Disorder Pharmacotherapy (RDD)

Study Type:

INTERVENTIONAL

Last Updated:

2026-07-21

Start Date:

2021-06-08

Completion:

2026-12-31

Conditions

• Opioid Use Disorder (OUD)

Interventions

• DRUG
• BEHAVIORAL

No Results Yet

NCT04458974 | COMPLETED | NA

20 participants

tDCS in Post-stroke Neglect Rehabilitation

Study Type:

INTERVENTIONAL

Last Updated:

2026-07-21

Start Date:

2019-11-08

Completion:

2025-11-03

Conditions

• Stroke
• Neglect, Hemispatial

Interventions

• DEVICE
• PROCEDURE

No Results Yet

NCT04447651 | ACTIVE_NOT_RECRUITING

6 participants

Patient Response to Immunotherapy Using Spliceosome Mutational Markers (PRISMM)

Study Type:

OBSERVATIONAL

Last Updated:

2026-07-21

Start Date:

2020-09-17

Completion:

2023-05-15

Conditions

• Metastatic Solid Tumor
• SF3B1 Gene Mutation
• Spliceosome Mutation
• U2AF1 Gene Mutation
• SRSF2 Gene Mutation

Interventions

• OTHER

No Results Yet

NCT04409639 | ACTIVE_NOT_RECRUITING | PHASE2

14 participants

Cobimetinib in Newly Diagnosed or HMA-treated CMML Patients With RAS Pathway Mutations

Study Type:

INTERVENTIONAL

Last Updated:

2026-07-21

Start Date:

2021-01-12

Completion:

2026-01-02

Conditions

• Chronic Myelomonocytic Leukemia (CMML)

Interventions

• DRUG

Results Available

NCT04394338 | COMPLETED | NA

60 participants

The Plastic Covering Method for Self-gripping Mesh Placement in Laparoscopic Inguinal Hernia Repair

Study Type:

INTERVENTIONAL

Last Updated:

2026-07-21

Start Date:

2020-02-01

Completion:

2021-12-31

Conditions

• Laparoscopic Inguinal Hernia Repair

Interventions

• OTHER

No Results Yet

NCT04364503 | ENROLLING_BY_INVITATION

2000 participants

Compliant Analysis of Patient Samples and Data

Study Type:

OBSERVATIONAL

Last Updated:

2026-07-21

Start Date:

2018-03-17

Completion:

2030-03-17

Conditions

• Pregnancy Related
• Cancer
• Infectious Disease

Interventions

• DEVICE

No Results Yet

NCT04348747 | RECRUITING | PHASE2

23 participants

Dendritic Cell Vaccines Against Her2/Her3 and Pembrolizumab for the Treatment of Brain Metastasis From Triple Negative Breast Cancer or HER2+ Breast Cancer

Study Type:

INTERVENTIONAL

Last Updated:

2026-07-21

Start Date:

2022-12-19

Completion:

2028-05-15

Conditions

• Anatomic Stage IV Breast Cancer AJCC v8
• Metastatic Malignant Neoplasm in the Brain
• Metastatic Triple-Negative Breast Carcinoma
• Prognostic Stage IV Breast Cancer AJCC v8

Interventions

• BIOLOGICAL

No Results Yet

NCT04297683 | ACTIVE_NOT_RECRUITING | PHASE2/PHASE3

1500 participants

HEALEY ALS Platform Trial - Master Protocol

Study Type:

INTERVENTIONAL

Last Updated:

2026-07-21

Start Date:

2020-06-14

Completion:

2027-07-31

Conditions

• Amyotrophic Lateral Sclerosis

Interventions

• DRUG

No Results Yet

NCT04287166 | ACTIVE_NOT_RECRUITING

100 participants

Early Remote At-risk Diagnosis for Cerebral Palsy in Follow-up Clinics for High-risk Infants

Study Type:

OBSERVATIONAL

Last Updated:

2026-07-21

Start Date:

2020-08-03

Completion:

2027-06-01

Conditions

• Cerebral Palsy

No Results Yet

NCT04254133 | ENROLLING_BY_INVITATION

1360 participants

Genetic Information to Inform Treatment and Screening for Prostate Cancer, GIFTS Study

Study Type:

OBSERVATIONAL

Last Updated:

2026-07-21

Start Date:

2018-11-30

Completion:

2028-08-31

Conditions

• Prostate Carcinoma

Interventions

• BEHAVIORAL
• PROCEDURE
• DIAGNOSTIC_TEST
• OTHER

No Results Yet

NCT04221477 | ACTIVE_NOT_RECRUITING | PHASE3

271 participants

A Study to Evaluate the Efficacy and Safety of Obinutuzumab in Participants With ISN/RPS 2003 Class III or IV Lupus Nephritis

Study Type:

INTERVENTIONAL

Last Updated:

2026-07-21

Start Date:

2020-08-10

Completion:

2024-08-15

Conditions

• Lupus Nephritis

Interventions

• DRUG

Results Available

NCT04204915 | RECRUITING | NA

2104 participants

The Early Valve Replacement in Severe ASYmptomatic Aortic Stenosis Study

Study Type:

INTERVENTIONAL

Last Updated:

2026-07-21

Start Date:

2020-03-10

Completion:

2031-04-01

Conditions

• Aortic Stenosis

Interventions

• PROCEDURE

No Results Yet