Clinical Trials

NCT05006794 | TERMINATED | PHASE1

37 participants

Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of GS-9716 as Monotherapy and in Combination With Anticancer Therapies in Adults With Solid Malignancies

Study Type:: INTERVENTIONAL
Last Updated:: 2026-07-17
Start Date:: 2021-09-15
Completion:: 2025-06-16

Conditions

Solid Malignancies

Interventions

DRUG

No Results Yet

NCT05006404 | ACTIVE_NOT_RECRUITING | NA

51 participants

Autus Valve Pivotal Study

Study Type:: INTERVENTIONAL
Last Updated:: 2026-07-17
Start Date:: 2024-02-05
Completion:: 2026-08-01

Conditions

Congenital Heart Disease

Interventions

DEVICE

No Results Yet

NCT04984473 | RECRUITING | NA

42 participants

A Study to Evaluate Breathing Muscle Training in Cardiac Rehab

Study Type:: INTERVENTIONAL
Last Updated:: 2026-07-17
Start Date:: 2021-06-01
Completion:: 2027-08-31

Conditions

Healthy
Heart Failure

Interventions

DEVICE

No Results Yet

NCT04970901 | ACTIVE_NOT_RECRUITING | PHASE1

154 participants

A Study to Evaluate the Safety and Anti-cancer Activity of Loncastuximab Tesirine in Combination With Other Anti-cancer Agents in Participants With Relapsed or Refractory B-cell Non-Hodgkin Lymphoma (LOTIS-7)

Study Type:: INTERVENTIONAL
Last Updated:: 2026-07-17
Start Date:: 2022-06-17
Completion:: 2027-03-31

Conditions

B-Cell Non-Hodgkin Lymphoma
Relapsed B-Cell Non-Hodgkin Lymphoma
Refractory B-Cell Non-Hodgkin Lymphoma

Interventions

DRUG

No Results Yet

NCT04965259 | ACTIVE_NOT_RECRUITING

2002 participants

Early Detection of Hepatocellular Carcinoma in a High-risk Prospective Cohort (ELEGANCE)

Study Type:: OBSERVATIONAL
Last Updated:: 2026-07-17
Start Date:: 2021-04-15
Completion:: 2025-03-11

Conditions

Liver Diseases

No Results Yet

NCT04950894 | COMPLETED | NA

107 participants

Treating Obstructive Sleep Apnea Using Targeted Hypoglossal Neurostimulation

Study Type:: INTERVENTIONAL
Last Updated:: 2026-07-17
Start Date:: 2022-02-24
Completion:: 2024-10-17

Conditions

Obstructive Sleep Apnea
OSA
Apnea
Apnea, Obstructive
Apnea, Obstructive Sleep
Apnea+Hypopnea
Hypopnea, Sleep

Interventions

DEVICE

No Results Yet

NCT04943588 | COMPLETED

25000 participants

Treating Hepatitis C in Pakistan. Strategies to Avoid Resistance to Antiviral Drugs

Study Type:: OBSERVATIONAL
Last Updated:: 2026-07-17
Start Date:: 2021-11-01
Completion:: 2026-01-30

Conditions

Hepatitis C, Chronic

Interventions

DIAGNOSTIC_TEST

No Results Yet

NCT04915508 | ACTIVE_NOT_RECRUITING | PHASE2

165 participants

Extremely Hypofractionated Intensity Modulated Stereotactic Body Radiotherapy for the Treatment of Prostate Cancer With Rising PSA After Radical Prostatectomy

Study Type:: INTERVENTIONAL
Last Updated:: 2026-07-17
Start Date:: 2021-06-23
Completion:: 2026-12-31

Conditions

Prostate Adenocarcinoma
Stage IIIB Prostate Cancer American Joint Committee on Cancer (AJCC) v8
Stage IIIC Prostate Cancer AJCC v8
Stage IV Prostate Cancer AJCC v8
Stage IVA Prostate Cancer AJCC v8
Stage IVB Prostate Cancer AJCC v8

Interventions

DRUG
RADIATION

No Results Yet

NCT04903132 | ACTIVE_NOT_RECRUITING

200 participants

Cellular Senescence and COVID-19 Long-Hauler Syndrome

Study Type:: OBSERVATIONAL
Last Updated:: 2026-07-17
Start Date:: 2021-03-01
Completion:: 2026-12-31

Conditions

SARS-CoV2 Infection

No Results Yet

NCT04879043 | RECRUITING | PHASE1/PHASE2

78 participants

Study to Assess Safety of HDP-101 in Patients With Relapsed Refractory Multiple Myeloma

Study Type:: INTERVENTIONAL
Last Updated:: 2026-07-17
Start Date:: 2022-02-07
Completion:: 2028-03-31

Conditions

Multiple Myeloma
Plasma Cell Disorder

Interventions

DRUG

No Results Yet

NCT04857502 | RECRUITING | EARLY_PHASE1

30 participants

99mTc-PSMA-I&S Biodistribution in Patients With Prostate Cancer

Study Type:: INTERVENTIONAL
Last Updated:: 2026-07-17
Start Date:: 2021-04-27
Completion:: 2027-06-01

Conditions

Prostate Carcinoma
Recurrent Prostate Carcinoma

Interventions

DRUG
PROCEDURE

No Results Yet

NCT04855799 | COMPLETED | PHASE2

35 participants

GI Permeability Change in Response to Aquamin®

Study Type:: INTERVENTIONAL
Last Updated:: 2026-07-17
Start Date:: 2021-11-02
Completion:: 2024-03-11

Conditions

Ulcerative Colitis
Healthy
Irritable Bowel Syndrome With Diarrhea

Interventions

DRUG

Results Available

NCT04792801 | ACTIVE_NOT_RECRUITING

108 participants

PET TDM FDG-Choline as a Decision-making Tool for Routine Care on the Liver Transplant List for HCC

Study Type:: OBSERVATIONAL
Last Updated:: 2026-07-17
Start Date:: 2021-06-22
Completion:: 2028-06-05

Conditions

Hepatocellular Carcinoma
Liver Transplant

Interventions

RADIATION

No Results Yet

NCT04785300 | ACTIVE_NOT_RECRUITING | PHASE1/PHASE2

20 participants

ALSENLITE: Senolytics for Alzheimer's Disease

Study Type:: INTERVENTIONAL
Last Updated:: 2026-07-17
Start Date:: 2022-07-06
Completion:: 2026-12-31

Conditions

Mild Cognitive Impairment
Alzheimer Disease

Interventions

DRUG

No Results Yet

NCT04783415 | ACTIVE_NOT_RECRUITING | PHASE2

12 participants

Acalabrutinib, Umbralisib, and Ublituximab for the Treatment of Previously Untreated Mantle Cell Lymphoma

Study Type:: INTERVENTIONAL
Last Updated:: 2026-07-17
Start Date:: 2021-03-26
Completion:: 2022-07-31

Conditions

Mantle Cell Lymphoma

Interventions

DRUG
BIOLOGICAL

Results Available

NCT04746950 | COMPLETED

90 participants

ALICIA (Acalabrutinib in CLL Therapy)

Study Type:: OBSERVATIONAL
Last Updated:: 2026-07-17
Start Date:: 2021-02-03
Completion:: 2026-02-28

Conditions

Chronic Lymphocytic Leukemia

No Results Yet

NCT04737720 | COMPLETED

1 participants

Intravenous ACP-501 for Familial LCAT Deficiency (rhLCAT)

Study Type:: OBSERVATIONAL
Last Updated:: 2026-07-17
Start Date:: 2013-01-24
Completion:: 2013-12-12

Conditions

Familial LCAT Deficiency

Interventions

DRUG

No Results Yet

NCT04719273 | COMPLETED | PHASE2

14 participants

Onapristone and Anastrozole for the Treatment of Refractory Hormone Receptor Positive Endometrial Cancer

Study Type:: INTERVENTIONAL
Last Updated:: 2026-07-17
Start Date:: 2021-01-28
Completion:: 2025-03-01

Conditions

Refractory Endometrial Adenocarcinoma
Refractory Endometrial Carcinoma
Refractory Endometrial Clear Cell Adenocarcinoma
Refractory Endometrial Endometrioid Adenocarcinoma
Refractory Endometrial Mixed Cell Adenocarcinoma
Refractory Endometrial Serous Adenocarcinoma
Refractory Endometrial Undifferentiated Carcinoma

Interventions

DRUG
OTHER
DIAGNOSTIC_TEST

Results Available

NCT04705116 | COMPLETED

1184 participants

COVID-19 Vaccines International Pregnancy Exposure Registry

Study Type:: OBSERVATIONAL
Last Updated:: 2026-07-17
Start Date:: 2021-06-01
Completion:: 2026-04-26

Conditions

Covid19

Interventions

BIOLOGICAL

No Results Yet

NCT04692493 | RECRUITING | PHASE3

924 participants

RA-PRO PRAGMATIC TRIAL

Study Type:: INTERVENTIONAL
Last Updated:: 2026-07-17
Start Date:: 2021-09-22
Completion:: 2029-05-31

Conditions

Rheumatoid Arthritis

Interventions

DRUG

No Results Yet

NCT04674306 | COMPLETED | EARLY_PHASE1

35 participants

Adjuvant Therapy With an Alpha-lactalbumin Vaccine in Triple-Negative Breast Cancer

Study Type:: INTERVENTIONAL
Last Updated:: 2026-07-17
Start Date:: 2021-10-01
Completion:: 2025-12-15

Conditions

Pathologic Stage IIA-IIIC Triple-Negative Breast Cancer
TNBC - Triple-Negative Breast Cancer
Residual Disease

Interventions

BIOLOGICAL

Results Available

NCT04624178 | ACTIVE_NOT_RECRUITING | PHASE2

20 participants

A Study of Rucaparib and Nivolumab in People With Leiomyosarcoma

Study Type:: INTERVENTIONAL
Last Updated:: 2026-07-17
Start Date:: 2020-11-05
Completion:: 2025-11-17

Conditions

Leiomyosarcoma

Interventions

DRUG

Results Available

NCT04619004 | ACTIVE_NOT_RECRUITING | PHASE2

277 participants

HERTHENA-Lung01: Patritumab Deruxtecan in Subjects With Metastatic or Locally Advanced EGFR-mutated Non-Small Cell Lung Cancer

Study Type:: INTERVENTIONAL
Last Updated:: 2026-07-17
Start Date:: 2021-02-02
Completion:: 2022-11-21

Conditions

Non-Small Cell Lung Cancer Metastatic
Non-Small Cell Lung Cancer With Mutation in Epidermal Growth Factor Receptor

Interventions

DRUG

Results Available

NCT04603495 | ACTIVE_NOT_RECRUITING | PHASE3

430 participants

Phase 3 Study of Pelabresib (CPI-0610) in Myelofibrosis (MF) (MANIFEST-2)

Study Type:: INTERVENTIONAL
Last Updated:: 2026-07-17
Start Date:: 2021-04-09
Completion:: 2023-08-23

Conditions

Myelofibrosis
Primary Myelofibrosis
Post-polycythemia Vera Myelofibrosis
Post-essential Thrombocythemia Myelofibrosis

Interventions

DRUG

Results Available

NCT04597359 | ACTIVE_NOT_RECRUITING | PHASE2

360 participants

To Evaluate if Green Tea Can be Effective in Reducing the Progression of Prostate Cancer in Men on Close Monitoring

Study Type:: INTERVENTIONAL
Last Updated:: 2026-07-17
Start Date:: 2021-10-05
Completion:: 2032-12-31

Conditions

Prostate Carcinoma

Interventions

DRUG
OTHER

No Results Yet

NCT04596514 | ACTIVE_NOT_RECRUITING | NA

200 participants

Resuscitative Endovascular Balloon Occlusion of the Aorta in Non-traumatic Out of Hospital Cardiac Arrest

Study Type:: INTERVENTIONAL
Last Updated:: 2026-07-17
Start Date:: 2021-06-07
Completion:: 2025-06-28

Conditions

Cardiac Arrest

Interventions

PROCEDURE

No Results Yet

NCT04572295 | COMPLETED | PHASE1

51 participants

A Study of E7090 as Monotherapy and in Combination With Other Anticancer Agents in Participants With Estrogen Receptor Positive (ER+) and Human Epidermal Growth Receptor 2 Negative (HER2-) Recurrent/Metastatic Breast Cancer

Study Type:: INTERVENTIONAL
Last Updated:: 2026-07-17
Start Date:: 2020-10-09
Completion:: 2026-06-18

Conditions

Breast Neoplasms

Interventions

DRUG

No Results Yet

NCT04567108 | COMPLETED | NA

461 participants

Health Effects of Substituting Sugary Beverages With Artificially-sweetened Beverages or Water

Study Type:: INTERVENTIONAL
Last Updated:: 2026-07-17
Start Date:: 2021-04-22
Completion:: 2026-05-21

Conditions

Body Weight

Interventions

BEHAVIORAL

No Results Yet

NCT04542135 | COMPLETED | PHASE2

61 participants

Sulindac and Breast Density in Women at Risk of Developing Breast Cancer

Study Type:: INTERVENTIONAL
Last Updated:: 2026-07-17
Start Date:: 2020-11-20
Completion:: 2025-04-22

Conditions

Breast Cancer

Interventions

DRUG

Results Available

NCT04539236 | SUSPENDED | PHASE1/PHASE2

50 participants

Luspatercept and Lenalidomide (L2) in Lower-risk, Non-del(5q) MDS Patients

Study Type:: INTERVENTIONAL
Last Updated:: 2026-07-17
Start Date:: 2021-11-09
Completion:: 2029-08-01

Conditions

Myelodysplastic Syndromes

Interventions

DRUG

No Results Yet

NCT04520139 | RECRUITING | PHASE1/PHASE2

102 participants

Effect of NAC on Preventing Chemo-Related Cognitive Impairments in Ovarian Ca Pts Treated W/ PBT

Study Type:: INTERVENTIONAL
Last Updated:: 2026-07-17
Start Date:: 2026-05-21
Completion:: 2026-12-31

Conditions

Ovarian Cancer
Cognitive Impairment

Interventions

DRUG
OTHER

No Results Yet

NCT04516278 | COMPLETED | PHASE3

197 participants

A 3-month Study to Assess the Safety of ONS-5010 in Subjects With Visual Impairment Due to Retinal Disorders

Study Type:: INTERVENTIONAL
Last Updated:: 2026-07-17
Start Date:: 2020-10-01
Completion:: 2021-02-10

Conditions

Age-related Macular Degeneration
Neovascular Age-related Macular Degeneration
Wet Macular Degeneration
BRVO - Branch Retinal Vein Occlusion
Diabetic Macular Edema

Interventions

BIOLOGICAL

Results Available

NCT04497922 | COMPLETED | NA

100 participants

Virtual White Boards for Patient Satisfaction

Study Type:: INTERVENTIONAL
Last Updated:: 2026-07-17
Start Date:: 2021-01-25
Completion:: 2021-07-01

Conditions

Satisfaction, Patient
Covid19
Emergencies
Satisfaction
Information Disclosure

Interventions

DEVICE
BEHAVIORAL

No Results Yet

NCT04487041 | ACTIVE_NOT_RECRUITING | PHASE4

400 participants

Tfh Dysfunction in HIV and Aging

Study Type:: INTERVENTIONAL
Last Updated:: 2026-07-17
Start Date:: 2020-10-30
Completion:: 2027-04-30

Conditions

Human Influenza

Interventions

BIOLOGICAL

No Results Yet

NCT04469764 | RECRUITING | PHASE2

32 participants

Abemaciclib for the Treatment of Recurrent Ovarian or Endometrial Cancer

Study Type:: INTERVENTIONAL
Last Updated:: 2026-07-17
Start Date:: 2020-10-16
Completion:: 2027-07-01

Conditions

Recurrent Endometrial Carcinoma
Recurrent Fallopian Tube Carcinoma
Recurrent Ovarian Carcinoma
Recurrent Primary Peritoneal Carcinoma

Interventions

DRUG

No Results Yet

NCT04467021 | ACTIVE_NOT_RECRUITING | NA

61 participants

Cancer and Blood Pressure Management, CARISMA Study

Study Type:: INTERVENTIONAL
Last Updated:: 2026-07-17
Start Date:: 2020-10-29
Completion:: 2026-08-31

Conditions

Cardiovascular Disorder
Chronic Kidney Disease
Metastatic Renal Cell Carcinoma
Metastatic Thyroid Gland Medullary Carcinoma
Stage IV Renal Cell Cancer AJCC v8
Stage IV Thyroid Gland Medullary Carcinoma AJCC v8
Stage IVA Thyroid Gland Medullary Carcinoma AJCC v8
Stage IVB Thyroid Gland Medullary Carcinoma AJCC v8
Stage IVC Thyroid Gland Medullary Carcinoma AJCC v8

Interventions

OTHER

No Results Yet

NCT04462406 | ACTIVE_NOT_RECRUITING | PHASE2

150 participants

Using Biomarkers to Help Guide Safe Immunotherapy Discontinuation in Patients With Unresectable Stage IIIB-IV Melanoma, The PET-Stop Trial

Study Type:: INTERVENTIONAL
Last Updated:: 2026-07-17
Start Date:: 2021-02-09
Completion:: 2027-01-31

Conditions

Advanced Melanoma
Clinical Stage III Cutaneous Melanoma AJCC v8
Clinical Stage IV Cutaneous Melanoma AJCC v8
Melanoma of Unknown Primary
Pathologic Stage IIIB Cutaneous Melanoma AJCC v8
Pathologic Stage IIIC Cutaneous Melanoma AJCC v8
Pathologic Stage IIID Cutaneous Melanoma AJCC v8
Pathologic Stage IV Cutaneous Melanoma AJCC v8
Unresectable Acral Lentiginous Melanoma
Unresectable Melanoma
Unresectable Mucosal Melanoma

Interventions

BIOLOGICAL
OTHER

No Results Yet

NCT04458090 | COMPLETED | NA

144 participants

Underutilization of Hospice in Older African Americans

Study Type:: INTERVENTIONAL
Last Updated:: 2026-07-17
Start Date:: 2019-03-01
Completion:: 2021-04-30

Conditions

Hospice Decision Making

Interventions

BEHAVIORAL

Results Available

NCT04457258 | ACTIVE_NOT_RECRUITING | EARLY_PHASE1

18 participants

68Ga-FAPi-46 PET/CT Scan in Imaging Patients With Sarcoma

Study Type:: INTERVENTIONAL
Last Updated:: 2026-07-17
Start Date:: 2020-09-08
Completion:: 2026-12-02

Conditions

Metastatic Sarcoma
Recurrent Sarcoma
Sarcoma

Interventions

PROCEDURE
DRUG
RADIATION

No Results Yet

NCT04446611 | COMPLETED | NA

2247 participants

Clinical Study of STI Screening to Prevent Adverse Birth and New-born Outcomes (Philani Ndiphile)

Study Type:: INTERVENTIONAL
Last Updated:: 2026-07-17
Start Date:: 2021-03-29
Completion:: 2024-12-31

Conditions

Sexually Transmitted Infection
HIV/AIDS
Cost-effectiveness
Birth Outcomes
Vaginal Microbiome
Neisseria Gonorrhoeae
Chlamydia Trachomatis
Trichomonas Vaginalis
Antenatal Care
Pregnancy

Interventions

DIAGNOSTIC_TEST

Results Available