Clinical Trials

NCT05037968 | RECRUITING | NA

100 participants

MagnetOs Flex Matrix Compared to Trinity Elite Mixed With Local Autograft in Patients Undergoing up to Four-level Instrumented Posterolateral Fusion

Study Type:: INTERVENTIONAL
Last Updated:: 2026-07-07
Start Date:: 2024-06-10
Completion:: 2026-12-31

Conditions

Degenerative Disc Disease
Spine Fusion
Leg Pain and/or Back Pain

Interventions

DEVICE

No Results Yet

NCT05036473 | COMPLETED | PHASE2

40 participants

A Study of the Efficacy and Safety of Carbidopa-Levodopa Extended-Release Tablets in Patients With Parkinson's Disease

Study Type:: INTERVENTIONAL
Last Updated:: 2026-07-07
Start Date:: 2021-11-11
Completion:: 2022-12-28

Conditions

Parkinson Disease

Interventions

DRUG

No Results Yet

NCT04984720 | COMPLETED | NA

403 participants

Efficacy of Smartphone Based Digital Application in Improving Headache Related Parameters in Patients With Migraine

Study Type:: INTERVENTIONAL
Last Updated:: 2026-07-07
Start Date:: 2021-07-25
Completion:: 2025-08-31

Conditions

Migraine

Interventions

BEHAVIORAL

No Results Yet

NCT04945330 | RECRUITING

100 participants

NTRK Gene Fusion - Positive Advanced or Recurrent Solid Tumors, a Rare Cancer Caused by Specific Changes in the Genes

Study Type:: OBSERVATIONAL
Last Updated:: 2026-07-07
Start Date:: 2021-11-05
Completion:: 2029-06-30

Conditions

Advanced or Recurrent Solid Tumor Harboring an NTRK Gene Fusion

Interventions

DRUG

No Results Yet

NCT04919408 | COMPLETED | NA

283 participants

Evaluation of the Incidence of Chronic Post-cesarean Pain as Part of an Enhanced Recovery After Surgery (ERAS) Protocol.

Study Type:: INTERVENTIONAL
Last Updated:: 2026-07-07
Start Date:: 2021-07-12
Completion:: 2024-04-17

Conditions

Chronic Post-cesarean Pain

Interventions

OTHER

No Results Yet

NCT04915261 | RECRUITING | PHASE4

6300 participants

A Randomized Trial of Lenient Versus Strict Arm Instruction Post Cardiac Device Surgery

Study Type:: INTERVENTIONAL
Last Updated:: 2026-07-07
Start Date:: 2021-08-19
Completion:: 2029-08-01

Conditions

Post-Op Complication

Interventions

BEHAVIORAL

No Results Yet

NCT04908579 | RECRUITING | PHASE4

90 participants

Efficacy of Preventive Ketamine on Postoperative Pain

Study Type:: INTERVENTIONAL
Last Updated:: 2026-07-07
Start Date:: 2021-06-15
Completion:: 2026-09-30

Conditions

Postoperative Pain

Interventions

DRUG

No Results Yet

NCT04906746 | ACTIVE_NOT_RECRUITING | EARLY_PHASE1

10 participants

Ruxolitinib for Cancer Cachexia

Study Type:: INTERVENTIONAL
Last Updated:: 2026-07-07
Start Date:: 2022-02-23
Completion:: 2024-09-27

Conditions

Stage IV Non-small Cell Lung Cancer
Cachexia

Interventions

DRUG

Results Available

NCT04903522 | COMPLETED | NA

18 participants

Can the Affects Conveyed by Baroque Music Reduce Anxiety in Patients With Major Depressive Disorder ?

Study Type:: INTERVENTIONAL
Last Updated:: 2026-07-07
Start Date:: 2021-05-28
Completion:: 2022-02-17

Conditions

Major Depressive Disorder

Interventions

BEHAVIORAL

No Results Yet

NCT04887792 | RECRUITING | PHASE1/PHASE2

60 participants

Acetazolamide for Treatment Resistant Schizophrenia

Study Type:: INTERVENTIONAL
Last Updated:: 2026-07-07
Start Date:: 2022-02-01
Completion:: 2027-12-30

Conditions

Schizophrenia
Schizo Affective Disorder

Interventions

DRUG

No Results Yet

NCT04878263 | COMPLETED | NA

361 participants

Evaluation and Support Care Process Within the Care Pathway of Heart Failure Patients

Study Type:: INTERVENTIONAL
Last Updated:: 2026-07-07
Start Date:: 2021-06-28
Completion:: 2023-12-14

Conditions

Heart Failure Acute

Interventions

OTHER

No Results Yet

NCT04837222 | COMPLETED

1000 participants

A Study of Brentuximab Vedotin in Adults With CD30-positive Lymphoma

Study Type:: OBSERVATIONAL
Last Updated:: 2026-07-07
Start Date:: 2021-06-07
Completion:: 2026-06-26

Conditions

Lymphoma

Interventions

OTHER

No Results Yet

NCT04824859 | TERMINATED | NA

21 participants

A Geriatric Assessment Electronic Platform for Older Patients With Cancer (eGAP - Electronic Geriatric Assessment Platform)

Study Type:: INTERVENTIONAL
Last Updated:: 2026-07-07
Start Date:: 2021-12-07
Completion:: 2023-04-30

Conditions

Cancer

Interventions

BEHAVIORAL

No Results Yet

NCT04809987 | COMPLETED | NA

38 participants

Effectiveness of Virtual Gait System Intervention in Motor Function in People With Incomplete Spinal Cord Injury.

Study Type:: INTERVENTIONAL
Last Updated:: 2026-07-07
Start Date:: 2021-01-30
Completion:: 2025-12-31

Conditions

Incomplete Spinal Cord Injury

Interventions

OTHER

No Results Yet

NCT04808479 | COMPLETED | NA

210 participants

Effectiveness of a CBT-based mHealth Intervention Targeting MOUD Retention, Adherence, and Opioid Use

Study Type:: INTERVENTIONAL
Last Updated:: 2026-07-07
Start Date:: 2019-12-10
Completion:: 2026-06-15

Conditions

Opioid-use Disorder

Interventions

BEHAVIORAL

No Results Yet

NCT04777396 | COMPLETED | PHASE3

1840 participants

A Research Study Investigating Semaglutide in People With Early Alzheimer's Disease (EVOKE)

Study Type:: INTERVENTIONAL
Last Updated:: 2026-07-07
Start Date:: 2021-05-18
Completion:: 2025-09-16

Conditions

Early Alzheimer's Disease

Interventions

DRUG

No Results Yet

NCT04774354 | COMPLETED

350 participants

POSSUM, P-POSSUM, Clinical Frailty Scale, Clinical Frailty Scale and Charlson's Comorbidity Index in Abdominal Surgery.

Study Type:: OBSERVATIONAL
Last Updated:: 2026-07-07
Start Date:: 2021-03-01
Completion:: 2025-03-30

Conditions

Postoperative Complications

Interventions

DIAGNOSTIC_TEST

No Results Yet

NCT04765150 | RECRUITING

275 participants

Integrating Quantitative MRI and Artificial Intelligence to Improve Prostate Cancer Classification

Study Type:: OBSERVATIONAL
Last Updated:: 2026-07-07
Start Date:: 2021-04-01
Completion:: 2027-06-01

Conditions

Prostate Carcinoma

Interventions

PROCEDURE
OTHER

No Results Yet

NCT04765059 | ACTIVE_NOT_RECRUITING | PHASE3

98 participants

A Study to Evaluate Chemotherapy Plus Osimertinib Against Chemotherapy Plus Placebo in Patients With Non-small Cell Lung Cancer (NSCLC)

Study Type:: INTERVENTIONAL
Last Updated:: 2026-07-07
Start Date:: 2021-09-12
Completion:: 2024-10-28

Conditions

Non-small Cell Lung Cancer

Interventions

DRUG

Results Available

NCT04717427 | COMPLETED

161 participants

Longitudinal Studies to Identify Biomarkers for Sturge-Weber Syndrome

Study Type:: OBSERVATIONAL
Last Updated:: 2026-07-07
Start Date:: 2021-09-08
Completion:: 2025-06-30

Conditions

Sturge-Weber Syndrome

No Results Yet

NCT04701203 | COMPLETED | PHASE3

84 participants

A Trial Investigating the Safety, Tolerability and Efficacy of TransCon PTH Administered Daily in Adults With Hypoparathyroidism

Study Type:: INTERVENTIONAL
Last Updated:: 2026-07-07
Start Date:: 2021-02-16
Completion:: 2022-01-12

Conditions

Hypoparathyroidism
Endocrine System Diseases
Parathyroid Diseases

Interventions

COMBINATION_PRODUCT

Results Available

NCT04695600 | RECRUITING | PHASE2/PHASE3

100 participants

Onabotulinum Toxin A (Botox) in the Treatment of Pharyngo-esophageal Dysphagia

Study Type:: INTERVENTIONAL
Last Updated:: 2026-07-07
Start Date:: 2023-08-11
Completion:: 2027-08-31

Conditions

Transfer Dysphagia
Oropharyngeal Dysphagia
Cricopharyngeus Muscle Dysfunction

Interventions

DRUG

No Results Yet

NCT04693988 | COMPLETED | NA

114 participants

Early Case Management on Recovery From a Cardiac Event in Women

Study Type:: INTERVENTIONAL
Last Updated:: 2026-07-07
Start Date:: 2021-01-18
Completion:: 2023-12-01

Conditions

Cardiac Rehabilitation

Interventions

BEHAVIORAL

Results Available

NCT04666636 | RECRUITING | PHASE2

65 participants

Mechanisms for Activation of Beige Adipose Tissue in Humans

Study Type:: INTERVENTIONAL
Last Updated:: 2026-07-07
Start Date:: 2020-12-07
Completion:: 2027-06-30

Conditions

PreDiabetes

Interventions

DRUG

No Results Yet

NCT04660552 | COMPLETED | NA

34 participants

Transcranial Photobiomodulation for Reducing Autism Symptoms in Children

Study Type:: INTERVENTIONAL
Last Updated:: 2026-07-07
Start Date:: 2020-11-15
Completion:: 2022-12-31

Conditions

Autism Spectrum Disorder

Interventions

DEVICE

Results Available

NCT04638478 | ACTIVE_NOT_RECRUITING

67 participants

PREselection of Patients at Risk for COgnitive DEcline After Radiotherapy Using Advanced MRI

Study Type:: OBSERVATIONAL
Last Updated:: 2026-07-07
Start Date:: 2021-04-08
Completion:: 2028-12-31

Conditions

Meningioma

Interventions

OTHER

No Results Yet

NCT04629248 | ACTIVE_NOT_RECRUITING | PHASE3

142 participants

A Study Evaluating the Efficacy and Safety of Obinutuzumab in Participants With Primary Membranous Nephropathy

Study Type:: INTERVENTIONAL
Last Updated:: 2026-07-07
Start Date:: 2021-06-25
Completion:: 2025-12-22

Conditions

Primary Membranous Nephropathy

Interventions

DRUG

No Results Yet

NCT04626882 | ACTIVE_NOT_RECRUITING | NA

994 participants

Timing of FFR-guided PCI for Non-IRA in STEMI and MVD (OPTION-STEMI)

Study Type:: INTERVENTIONAL
Last Updated:: 2026-07-07
Start Date:: 2019-12-30
Completion:: 2025-01-15

Conditions

Myocardial Infarction, Acute
Multi-Vessel Coronary Artery Stenosis

Interventions

PROCEDURE

No Results Yet

NCT04624256 | ACTIVE_NOT_RECRUITING | NA

208 participants

Germline DNA-Based Radiosensitivity Biomarker Influence on Toxicity Following Prostate Radiotherapy, GARUDA Trial

Study Type:: INTERVENTIONAL
Last Updated:: 2026-07-07
Start Date:: 2020-11-10
Completion:: 2027-12-31

Conditions

Prostate Adenocarcinoma
Stage I Prostate Cancer American Joint Committee on Cancer (AJCC) v8
Stage II Prostate Cancer AJCC v8
Stage IIA Prostate Cancer AJCC v8
Stage IIB Prostate Cancer AJCC v8
Stage IIC Prostate Cancer AJCC v8

Interventions

PROCEDURE
RADIATION
OTHER

No Results Yet

NCT04615273 | COMPLETED | PHASE3

264 participants

A Trial to Compare the Efficacy and Safety of Once-weekly Lonapegsomatropin With Placebo and a Daily Somatropin Product in Adults With Growth Hormone Deficiency

Study Type:: INTERVENTIONAL
Last Updated:: 2026-07-07
Start Date:: 2020-12-03
Completion:: 2023-11-02

Conditions

Growth Hormone Deficiency
Endocrine System Diseases
Hormone Deficiency

Interventions

DRUG
OTHER

Results Available

NCT04610866 | ACTIVE_NOT_RECRUITING | PHASE1/PHASE2

15 participants

Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Long-term Mitapivat Dosing in Subjects With Stable Sickle Cell Disease: An Extension of a Phase I Pilot Study of Mitapivat

Study Type:: INTERVENTIONAL
Last Updated:: 2026-07-07
Start Date:: 2020-12-09
Completion:: 2028-02-28

Conditions

Sickle Cell Disease
Hemolytic Anemia

Interventions

DRUG

No Results Yet

NCT04600115 | RECRUITING | EARLY_PHASE1

100 participants

New MRI Methods Applied to Heart Failure With Preserved Ejection Fraction (HFpEF)

Study Type:: INTERVENTIONAL
Last Updated:: 2026-07-07
Start Date:: 2017-03-03
Completion:: 2027-03-03

Conditions

MRI Scans

Interventions

DRUG
DEVICE

No Results Yet

NCT04585477 | SUSPENDED | PHASE2

80 participants

Adjuvant ctDNA-Adapted Personalized Treatment in Early Stage NSCLC (ADAPT-E)

Study Type:: INTERVENTIONAL
Last Updated:: 2026-07-07
Start Date:: 2021-04-08
Completion:: 2026-12-30

Conditions

Non-small Cell Lung Cancer
Non-small Cell Lung Cancer Stage I
Non-small Cell Lung Cancer Stage II
Non-small Cell Lung Cancer Stage III

Interventions

DEVICE
DRUG

No Results Yet

NCT04580017 | COMPLETED

4267 participants

Prognostic Accuracy of the HEART Score in Undifferentiated Chest Pain: A Multicenter Validation Study

Study Type:: OBSERVATIONAL
Last Updated:: 2026-07-07
Start Date:: 2015-01-31
Completion:: 2017-04-30

Conditions

Coronary Disease
Coronary Syndrome
Risk Factor, Cardiovascular
Major Adverse Cardiovascular Events

No Results Yet

NCT04524000 | ACTIVE_NOT_RECRUITING | PHASE2

24 participants

Study Assessing the Efficacy and Safety of Treatment With Alpelisib Plus Fulvestrant in Japanese Men and Postmenopausal Women With Advanced Breast Cancer

Study Type:: INTERVENTIONAL
Last Updated:: 2026-07-07
Start Date:: 2021-01-08
Completion:: 2027-02-26

Conditions

Advanced Breast Cancer

Interventions

DRUG

No Results Yet

NCT04515901 | WITHDRAWN | NA

0 participants

Spenopalatine Ganglion Block for Treatment of Post-dural Puncture Headaches

Study Type:: INTERVENTIONAL
Last Updated:: 2026-07-07
Start Date:: 2021-12-01
Completion:: 2022-11-11

Conditions

Postdural Puncture Headache

Interventions

DRUG
OTHER

No Results Yet

NCT04464226 | ACTIVE_NOT_RECRUITING | PHASE3

402 participants

Study to Continue Treatment With Darolutamide in Patients Who Have Been Participating in Previous Darolutamide Studies Supported by Bayer

Study Type:: INTERVENTIONAL
Last Updated:: 2026-07-07
Start Date:: 2020-10-20
Completion:: 2028-06-26

Conditions

Cancer

Interventions

DRUG

No Results Yet

NCT04447768 | ACTIVE_NOT_RECRUITING | PHASE2

100 participants

The Combination of Venetoclax and Obinutuzumab in People With Chronic Lymphocytic Leukemia (CLL)

Study Type:: INTERVENTIONAL
Last Updated:: 2026-07-07
Start Date:: 2020-12-03
Completion:: 2027-07-31

Conditions

Chronic Lymphocytic Leukemia (CLL)

Interventions

DRUG

No Results Yet

NCT04439708 | RECRUITING

250 participants

Biomarkers and Choroidal Neovascularization

Study Type:: OBSERVATIONAL
Last Updated:: 2026-07-07
Start Date:: 2020-07-06
Completion:: 2027-01-06

Conditions

Choroidal Neovascularization
Mineralocorticoid Excess

Interventions

OTHER

No Results Yet

NCT04437654 | COMPLETED | PHASE4

1803 participants

The Efficacy and Safety of Non-vItamiN K antaGonist oraL Anticoagulants for intermEdiate Stroke Risk in Patients With Atrial Fibrillation (SINGLE-AF)

Study Type:: INTERVENTIONAL
Last Updated:: 2026-07-07
Start Date:: 2020-07-28
Completion:: 2025-08-21

Conditions

Atrial Fibrillation Patients With Intermediate Stroke Risk

Interventions

DRUG

No Results Yet