Clinical Trials

NCT05008926 | SUSPENDED | PHASE3

370 participants

The NIPA Study Naloxegol Administration to Prevent Opioids Induced Gastrointestinal Motility Disturbance in Brain Injured PAtients

Study Type:: INTERVENTIONAL
Last Updated:: 2026-06-16
Start Date:: 2022-03-15
Completion:: 2027-10-26

Conditions

Brain Injuries

Interventions

DRUG

No Results Yet

NCT04965649 | COMPLETED

30 participants

Is There an Association Between Innate CD8+ T Cells and the Evolution of Tyrosine Kinase Inhibitor Resistance Mutations in Phi+ Hematological Malignancies.

Study Type:: OBSERVATIONAL
Last Updated:: 2026-06-16
Start Date:: 2021-01-01
Completion:: 2026-05-26

Conditions

Leukemia
Myelogenous Leukemia
Chronic Leukemia
BCR-ABL Positive Acute Myeloid Leukemia

Interventions

GENETIC

No Results Yet

NCT04959838 | RECRUITING | NA

30 participants

JOB STRESS in OPHthalmology Physicians and Residents

Study Type:: INTERVENTIONAL
Last Updated:: 2026-06-16
Start Date:: 2021-07-06
Completion:: 2027-07-31

Conditions

Stress
Heart Rate Variability

Interventions

BEHAVIORAL

No Results Yet

NCT04944550 | COMPLETED

20 participants

New Models for the Evaluation of Preclinical Treatment for Urothelial Carcinomas of the Upper Excretory Tract.

Study Type:: OBSERVATIONAL
Last Updated:: 2026-06-16
Start Date:: 2021-03-01
Completion:: 2023-03-31

Conditions

Upper Urinary Tract Urothelial Carcinoma
Nephroureterectomy
Tumor
Xenograft Model

No Results Yet

NCT04941768 | COMPLETED

105 participants

An Observational Study to Evaluate the Efficacy and Safety of Avelumab + Axitinib Combination in Participants With aRCC (AVION)

Study Type:: OBSERVATIONAL
Last Updated:: 2026-06-16
Start Date:: 2021-08-09
Completion:: 2024-08-08

Conditions

Carcinoma, Renal Cell

Results Available

NCT04928261 | ACTIVE_NOT_RECRUITING | PHASE4

52 participants

Evaluating 6-months of HER2-targeted Therapy in Patients With HER2 Positive Early-stage Breast Cancer That Achieve a Pathological Complete Response to Neoadjuvant Systemic Therapy

Study Type:: INTERVENTIONAL
Last Updated:: 2026-06-16
Start Date:: 2021-12-13
Completion:: 2025-12-15

Conditions

Breast Cancer

Interventions

DRUG

No Results Yet

NCT04905901 | COMPLETED | PHASE3

90 participants

Nebulized Tranexamic Acid in Sinus Surgery

Study Type:: INTERVENTIONAL
Last Updated:: 2026-06-16
Start Date:: 2021-05-06
Completion:: 2026-06-05

Conditions

Bleeding Nose

Interventions

DRUG
OTHER

No Results Yet

NCT04899063 | COMPLETED | NA

318 participants

Excimer Laser Trabeculostomy Glaucoma Treatment Study

Study Type:: INTERVENTIONAL
Last Updated:: 2026-06-16
Start Date:: 2021-05-10
Completion:: 2025-07-29

Conditions

Glaucoma, Primary Open Angle

Interventions

DEVICE

No Results Yet

NCT04896697 | COMPLETED | PHASE1/PHASE2

125 participants

Vilastobart (XTX101) Monotherapy and Vilastobart and Atezolizumab Combination Therapy in Advanced Solid Tumors

Study Type:: INTERVENTIONAL
Last Updated:: 2026-06-16
Start Date:: 2021-09-13
Completion:: 2026-05-18

Conditions

Advanced Solid Tumor

Interventions

DRUG

No Results Yet

NCT04894864 | RECRUITING | PHASE4

40 participants

Opioid Free Anesthesia-Analgesia Strategy and Surgical Stress in Elective Open Abdominal Aortic Aneurysm Repair

Study Type:: INTERVENTIONAL
Last Updated:: 2026-06-16
Start Date:: 2020-10-08
Completion:: 2026-09-01

Conditions

Elective Surgical Procedures
Postoperative Pain
Anesthesia
Opioid Use
Abdominal Aortic Aneurysm Without Rupture
Vascular Surgical Procedure
Interleukin 6
Immunomodulators

Interventions

DRUG

No Results Yet

NCT04829383 | COMPLETED | PHASE2

6 participants

A Study of Atezolizumab and Bevacizumab in Hepatocellular Carcinoma

Study Type:: INTERVENTIONAL
Last Updated:: 2026-06-16
Start Date:: 2021-03-22
Completion:: 2024-06-19

Conditions

Unresectable Hepatocellular Carcinoma

Interventions

DRUG

Results Available

NCT04826991 | ACTIVE_NOT_RECRUITING | NA

908 participants

Wells and Enteric Disease Transmission

Study Type:: INTERVENTIONAL
Last Updated:: 2026-06-16
Start Date:: 2021-07-01
Completion:: 2027-03-31

Conditions

Diarrhea
Gastrointestinal Infection
Respiratory Viral Infection
Waterborne Diseases

Interventions

DEVICE

No Results Yet

NCT04809740 | ACTIVE_NOT_RECRUITING | NA

3090 participants

Evaluating the Implementation and Impact of Navigator-delivered ePRO System

Study Type:: INTERVENTIONAL
Last Updated:: 2026-06-16
Start Date:: 2021-05-04
Completion:: 2025-12-31

Conditions

Cancer

Interventions

OTHER

Results Available

NCT04796220 | ACTIVE_NOT_RECRUITING | PHASE1

32 participants

Focused Ultrasound and Gemcitabine in Breast Cancer

Study Type:: INTERVENTIONAL
Last Updated:: 2026-06-16
Start Date:: 2022-01-27
Completion:: 2029-09-30

Conditions

Breast Cancer
Breast Neoplasms

Interventions

DEVICE
OTHER

No Results Yet

NCT04776239 | COMPLETED | PHASE1/PHASE2

26 participants

Allogeneic Mesenchymal Human Stem Cell Infusion Therapy for Endothelial DySfunctiOn in Diabetic Subjects With Symptomatic Ischemic Heart Disease. (ACESO-IHD)

Study Type:: INTERVENTIONAL
Last Updated:: 2026-06-16
Start Date:: 2021-08-16
Completion:: 2025-03-30

Conditions

Diabetes Mellitus
Ischemic Heart Disease

Interventions

DRUG
OTHER

Results Available

NCT04734015 | COMPLETED | NA

162 participants

Together Overcoming Diabetes

Study Type:: INTERVENTIONAL
Last Updated:: 2026-06-16
Start Date:: 2021-06-18
Completion:: 2025-04-30

Conditions

Type 2 Diabetes

Interventions

BEHAVIORAL

Results Available

NCT04715685 | RECRUITING | NA

260 participants

Mind Body Balance for Pediatric Migraine

Study Type:: INTERVENTIONAL
Last Updated:: 2026-06-16
Start Date:: 2021-03-09
Completion:: 2026-11-01

Conditions

Headache
Headache Disorders
Headache, Migraine
Migraine
Migraine Disorders
Migraine With Aura
Migraine Without Aura
Chronic Migraine

Interventions

BEHAVIORAL

No Results Yet

NCT04714749 | COMPLETED | NA

38 participants

Feasibility and Tolerance Study for the Treatment of Varicose Ulcers by Cyanoacrylate Glue (ETUVVE)

Study Type:: INTERVENTIONAL
Last Updated:: 2026-06-16
Start Date:: 2021-01-21
Completion:: 2024-01-30

Conditions

Venous Leg Ulcer

Interventions

PROCEDURE
DEVICE

No Results Yet

NCT04710576 | RECRUITING | PHASE2

296 participants

A Study of Axatilimab at 3 Different Doses in Participants With Chronic Graft Versus Host Disease (cGVHD)

Study Type:: INTERVENTIONAL
Last Updated:: 2026-06-16
Start Date:: 2021-03-04
Completion:: 2023-04-07

Conditions

Chronic Graft-versus-host-disease

Interventions

DRUG

Results Available

NCT04695106 | RECRUITING | PHASE4

1194 participants

Dual Antithrombotic Therapy With Dabigatran and Ticagrelor in Patients With ACS and Non-valvular AF Undergoing PCI

Study Type:: INTERVENTIONAL
Last Updated:: 2026-06-16
Start Date:: 2021-10-25
Completion:: 2026-07-11

Conditions

Atrial Fibrillation
Antithrombotic Therapy
Acute Coronary Syndrome
Percutaneous Coronary Interventions

Interventions

DRUG

No Results Yet

NCT04675554 | WITHDRAWN

0 participants

Role of Psychological Factors and Acceptability of New Technology in Engaging Seniors in Physical Activity

Study Type:: OBSERVATIONAL
Last Updated:: 2026-06-16
Start Date:: 2021-01-12
Completion:: 2021-01-12

Conditions

Motivation

Interventions

OTHER

No Results Yet

NCT04643002 | RECRUITING | PHASE1/PHASE2

258 participants

Isatuximab in Combination With Novel Agents in RRMM - Master Protocol

Study Type:: INTERVENTIONAL
Last Updated:: 2026-06-16
Start Date:: 2021-01-25
Completion:: 2027-09-13

Conditions

Plasma Cell Myeloma Refractory

Interventions

DRUG

No Results Yet

NCT04639050 | ACTIVE_NOT_RECRUITING | PHASE1/PHASE2

241 participants

Brainshuttle AD: A Multiple Ascending Dose Study to Investigate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of RO7126209 Following Intravenous Infusion in Participants With Prodromal or Mild to Moderate Alzheimer's Disease

Study Type:: INTERVENTIONAL
Last Updated:: 2026-06-16
Start Date:: 2021-03-15
Completion:: 2027-07-31

Conditions

Alzheimers Disease

Interventions

DRUG

No Results Yet

NCT04613791 | RECRUITING

800 participants

Situation and Evolution of the Misuse of Alcohol and Other Addictive Behaviors in Obese Patients Being Managed at Nîmes University Hospital

Study Type:: OBSERVATIONAL
Last Updated:: 2026-06-16
Start Date:: 2021-02-16
Completion:: 2026-12-15

Conditions

Obesity

Interventions

BIOLOGICAL

No Results Yet

NCT04534127 | RECRUITING | NA

56 participants

Alpha Radiation Emitters Device (DaRT) for the Treatment of Cutaneous, Mucosal or Superficial Soft Tissue Neoplasia

Study Type:: INTERVENTIONAL
Last Updated:: 2026-06-16
Start Date:: 2020-12-22
Completion:: 2027-01-01

Conditions

Skin Cancer
Mucosal Neoplasm of Oral Cavity
Soft Tissue Neoplasm

Interventions

DEVICE

No Results Yet

NCT04521647 | COMPLETED | PHASE1

14 participants

Effects of Menthol in E-cigarettes on Smoking Behaviors

Study Type:: INTERVENTIONAL
Last Updated:: 2026-06-16
Start Date:: 2022-05-10
Completion:: 2023-07-25

Conditions

Nicotine Dependence

Interventions

DRUG

Results Available

NCT04517838 | RECRUITING

230 participants

Immune Response to Anti-HER2 Therapies in Patients With HER2-Positive Stage I-IV Breast Cancer

Study Type:: OBSERVATIONAL
Last Updated:: 2026-06-16
Start Date:: 2020-07-31
Completion:: 2028-07-27

Conditions

Breast Adenocarcinoma
HER2-Positive Breast Carcinoma
Anatomic Stage I Breast Cancer AJCC v8
Anatomic Stage II Breast Cancer AJCC v8
Anatomic Stage III Breast Cancer AJCC v8
Anatomic Stage IV Breast Cancer AJCC v8

Interventions

PROCEDURE

No Results Yet

NCT04506593 | RECRUITING

5000 participants

Indiana University Gastrointestinal Motility Diagnosis Registry

Study Type:: OBSERVATIONAL
Last Updated:: 2026-06-16
Start Date:: 2014-11-01
Completion:: 2026-11-30

Conditions

Eosinophilic Esophagitis
Gastroesophageal Reflux Disease (GERD)
Gastroparesis
Functional Vomiting
Irritable Bowel Syndrome (IBS)
Constipation
Chronic Intestinal Pseudo-obstruction
Fecal Incontinence
Small Intestinal Bacterial Overgrowth

Interventions

OTHER

No Results Yet

NCT04503785 | RECRUITING

1000 participants

Esophageal Impedance and Manometry Measurements and Dysphagia Symptom Scoring

Study Type:: OBSERVATIONAL
Last Updated:: 2026-06-16
Start Date:: 2017-01-17
Completion:: 2026-12-31

Conditions

Dysphagia, Esophageal

Interventions

DIAGNOSTIC_TEST

No Results Yet

NCT04503083 | COMPLETED

243 participants

BIOmarkers of MIGraine: a Proof of Concept Study Based on the Stratification of Responders to CGRP Monoclonal Antibodies

Study Type:: OBSERVATIONAL
Last Updated:: 2026-06-16
Start Date:: 2021-01-15
Completion:: 2024-01-31

Conditions

Migraine

No Results Yet

NCT04474392 | COMPLETED

340 participants

Sputum Studies of Anti-Citrullinated Protein Antibodies (ACPA) and Rheumatoid Arthritis (RA) Origins

Study Type:: OBSERVATIONAL
Last Updated:: 2026-06-16
Start Date:: 2020-08-01
Completion:: 2026-01-14

Conditions

Rheumatoid Arthritis

Interventions

OTHER

No Results Yet

NCT04472702 | RECRUITING | NA

90 participants

Fluoroscopic Versus Ultrasound Guidance for Cooled Radiofrequency Ablation of Geniculate Nerves in Knee Osteoarthritis: A Randomized Control Trial

Study Type:: INTERVENTIONAL
Last Updated:: 2026-06-16
Start Date:: 2022-02-02
Completion:: 2027-05-01

Conditions

Knee Osteoarthritis

Interventions

PROCEDURE

No Results Yet

NCT04464759 | ACTIVE_NOT_RECRUITING | PHASE1/PHASE2

41 participants

A Study of Nivolumab and Hydroxychloroquine or Nivolumab/Ipilimumab and Hydroxychloroquine in Advanced Melanoma

Study Type:: INTERVENTIONAL
Last Updated:: 2026-06-16
Start Date:: 2020-10-21
Completion:: 2026-07-31

Conditions

Melanoma

Interventions

DRUG

No Results Yet

NCT04444154 | COMPLETED | NA

90 participants

Comparison of the Effectiveness of Three Teaching Methods in Oral Hygiene in Adolescent Orthodontic Patients

Study Type:: INTERVENTIONAL
Last Updated:: 2026-06-16
Start Date:: 2022-01-29
Completion:: 2025-02-21

Conditions

Orthodontic Appliance

Interventions

BEHAVIORAL

No Results Yet

NCT04367987 | RECRUITING

117 participants

Variability of Heart Rate as a Marker of Complication of Colorectal Surgery

Study Type:: OBSERVATIONAL
Last Updated:: 2026-06-16
Start Date:: 2020-06-17
Completion:: 2027-06-30

Conditions

Surgery--Complications

Interventions

DIAGNOSTIC_TEST

No Results Yet

NCT04363697 | COMPLETED | PHASE4

2401 participants

Dapagliflozin and Effect on Cardiovascular Events in Acute Heart Failure -Thrombolysis in Myocardial Infarction 68 (DAPA ACT HF-TIMI 68)

Study Type:: INTERVENTIONAL
Last Updated:: 2026-06-16
Start Date:: 2020-09-24
Completion:: 2025-06-02

Conditions

Acute Heart Failure
Heart Failure

Interventions

DRUG

Results Available

NCT04341350 | ACTIVE_NOT_RECRUITING | PHASE3

250 participants

Comparison of an Inhaled Sedation Strategy to an Intravenous Sedation Strategy in Intensive Care Unit Patients Treated With Invasive Mechanical Ventilation

Study Type:: INTERVENTIONAL
Last Updated:: 2026-06-16
Start Date:: 2020-08-06
Completion:: 2025-09-14

Conditions

Prevention of Delirium

Interventions

DRUG

No Results Yet

NCT04328532 | RECRUITING | NA

71 participants

MRI Screening of Placenta Adhesion Abnormalities

Study Type:: INTERVENTIONAL
Last Updated:: 2026-06-16
Start Date:: 2020-10-21
Completion:: 2026-10-21

Conditions

Placenta; Implantation

Interventions

DEVICE

No Results Yet

NCT04326218 | RECRUITING | NA

400 participants

Immunopathological Analysis in a French National Cohort of Membranous Nephropathy

Study Type:: INTERVENTIONAL
Last Updated:: 2026-06-16
Start Date:: 2020-07-04
Completion:: 2031-06-03

Conditions

Membranous Nephropathy

Interventions

OTHER

No Results Yet

NCT04310046 | ACTIVE_NOT_RECRUITING | NA

986 participants

Optimal Timing of Transcatheter Aortic Valve Implantation and Percutaneous Coronary Intervention - The TAVI PCI Trial

Study Type:: INTERVENTIONAL
Last Updated:: 2026-06-16
Start Date:: 2020-09-30
Completion:: 2026-07-31

Conditions

Aortic Stenosis
Coronary Artery Disease
TAVI
PCI

Interventions

PROCEDURE

No Results Yet