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Clinical Trials

NCT02595944 | ACTIVE_NOT_RECRUITING | PHASE3
903 participants

Nivolumab After Surgery and Chemotherapy in Treating Patients With Stage IB-IIIA Non-small Cell Lung Cancer (An ALCHEMIST Treatment Trial)

Study Type:
INTERVENTIONAL
Last Updated:
2026-05-29
Start Date:
2016-07-22
Completion:
2026-12-31
Conditions
  • Stage IB Lung Non-Small Cell Carcinoma AJCC v7
  • Stage II Lung Non-Small Cell Cancer AJCC v7
  • Stage IIIA Lung Non-Small Cell Cancer AJCC v7
Interventions
  • PROCEDURE
  • BIOLOGICAL
  • OTHER
No Results Yet
NCT02595879 | ACTIVE_NOT_RECRUITING | PHASE1
21 participants

Triapine With Chemotherapy and Radiation Therapy in Treating Patients With IB2-IVA Cervical or Vaginal Cancer

Study Type:
INTERVENTIONAL
Last Updated:
2026-05-29
Start Date:
2019-09-18
Completion:
2023-06-04
Conditions
  • Advanced Cervical Adenocarcinoma
  • Advanced Cervical Adenosquamous Carcinoma
  • Advanced Cervical Squamous Cell Carcinoma
  • Advanced Vaginal Adenocarcinoma
  • Advanced Vaginal Adenosquamous Carcinoma
  • Advanced Vaginal Squamous Cell Carcinoma
  • Stage IB2 Cervical Cancer AJCC v6 and v7
  • Stage II Cervical Cancer AJCC v7
  • Stage II Vaginal Cancer AJCC v6 and v7
  • Stage III Vaginal Cancer AJCC v6 and v7
  • Stage IIIB Cervical Cancer AJCC v6 and v7
  • Stage IVA Cervical Cancer AJCC v6 and v7
  • Stage IVA Vaginal Cancer AJCC v6 and v7
Interventions
  • PROCEDURE
  • RADIATION
  • DRUG
  • OTHER
Results Available
NCT02466971 | ACTIVE_NOT_RECRUITING | PHASE3
450 participants

Testing the Addition of a New Anti-Cancer Drug, Triapine, to the Usual Chemotherapy Treatment (Cisplatin) During Radiation Therapy for Advanced-stage Cervical and Vaginal Cancers

Study Type:
INTERVENTIONAL
Last Updated:
2026-05-29
Start Date:
2016-05-10
Completion:
2023-01-26
Conditions
  • Advanced Vaginal Adenocarcinoma
  • Advanced Vaginal Adenosquamous Carcinoma
  • Advanced Vaginal Squamous Cell Carcinoma
  • Cervical Adenocarcinoma
  • Cervical Adenosquamous Carcinoma
  • Cervical Squamous Cell Carcinoma
  • Stage IB2 Cervical Cancer AJCC v6 and v7
  • Stage II Cervical Cancer AJCC v7
  • Stage II Vaginal Cancer AJCC v6 and v7
  • Stage IIA Cervical Cancer AJCC v7
  • Stage IIB Cervical Cancer AJCC v6 and v7
  • Stage III Vaginal Cancer AJCC v6 and v7
  • Stage IIIB Cervical Cancer AJCC v6 and v7
  • Stage IV Vaginal Cancer AJCC v6 and v7
  • Stage IVA Cervical Cancer AJCC v6 and v7
  • Stage IVA Vaginal Cancer AJCC v6 and v7
  • Unresectable Vaginal Carcinoma
  • Vaginal Adenocarcinoma
  • Vaginal Adenosquamous Carcinoma
  • Vaginal Carcinoma
  • Vaginal Squamous Cell Carcinoma, Not Otherwise Specified
Interventions
  • RADIATION
  • DRUG
  • OTHER
Results Available
NCT02465060 | ACTIVE_NOT_RECRUITING | PHASE2
6452 participants

Targeted Therapy Directed by Genetic Testing in Treating Patients With Advanced Refractory Solid Tumors, Lymphomas, or Multiple Myeloma (The MATCH Screening Trial)

Study Type:
INTERVENTIONAL
Last Updated:
2026-05-29
Start Date:
2015-08-17
Completion:
2026-12-31
Conditions
  • Advanced Lymphoma
  • Advanced Malignant Solid Neoplasm
  • Bladder Carcinoma
  • Breast Carcinoma
  • Cervical Carcinoma
  • Colon Carcinoma
  • Colorectal Carcinoma
  • Endometrial Carcinoma
  • Esophageal Carcinoma
  • Exocrine Pancreas Carcinoma
  • Gastric Carcinoma
  • Glioma
  • Head and Neck Carcinoma
  • Hematopoietic and Lymphoid Cell Neoplasm
  • Kidney Carcinoma
  • Liver Carcinoma
  • Lung Carcinoma
  • Lymphoma
  • Malignant Uterine Corpus Neoplasm
  • Malignant Uterine Neoplasm
  • Melanoma
  • Multiple Myeloma
  • Ovarian Carcinoma
  • Prostate Carcinoma
  • Rectal Carcinoma
  • Recurrent Bladder Carcinoma
  • Recurrent Breast Carcinoma
  • Recurrent Cervical Carcinoma
  • Recurrent Colon Carcinoma
  • Recurrent Colorectal Carcinoma
  • Recurrent Esophageal Carcinoma
  • Recurrent Gastric Carcinoma
  • Recurrent Glioma
  • Recurrent Head and Neck Carcinoma
  • Recurrent Liver Carcinoma
  • Recurrent Lung Carcinoma
  • Recurrent Lymphoma
  • Recurrent Malignant Solid Neoplasm
  • Recurrent Malignant Uterine Corpus Neoplasm
  • Recurrent Melanoma
  • Recurrent Multiple Myeloma
  • Recurrent Ovarian Carcinoma
  • Recurrent Pancreatic Carcinoma
  • Recurrent Prostate Carcinoma
  • Recurrent Rectal Carcinoma
  • Recurrent Skin Carcinoma
  • Recurrent Thyroid Gland Carcinoma
  • Refractory Lymphoma
  • Refractory Malignant Solid Neoplasm
  • Refractory Multiple Myeloma
  • Skin Carcinoma
  • Thyroid Gland Carcinoma
Interventions
  • DRUG
  • PROCEDURE
  • OTHER
  • BIOLOGICAL
No Results Yet
NCT02446600 | ACTIVE_NOT_RECRUITING | PHASE3
579 participants

Testing the Use of A Single Drug (Olaparib) or the Combination of Two Drugs (Cediranib and Olaparib) Compared to the Usual Chemotherapy for Women With Platinum Sensitive Ovarian, Fallopian Tube, or Primary Peritoneal Cancer

Study Type:
INTERVENTIONAL
Last Updated:
2026-05-29
Start Date:
2016-03-28
Completion:
2020-02-23
Conditions
  • Fallopian Tube Clear Cell Adenocarcinoma
  • Fallopian Tube Transitional Cell Carcinoma
  • Fallopian Tube Undifferentiated Carcinoma
  • Ovarian Clear Cell Adenocarcinoma
  • Ovarian Endometrioid Tumor
  • Ovarian Seromucinous Carcinoma
  • Ovarian Serous Tumor
  • Ovarian Transitional Cell Carcinoma
  • Ovarian Undifferentiated Carcinoma
  • Recurrent Fallopian Tube Carcinoma
  • Recurrent Ovarian Carcinoma
  • Recurrent Ovarian Endometrioid Adenocarcinoma
  • Recurrent Primary Peritoneal Carcinoma
Interventions
  • PROCEDURE
  • DRUG
  • OTHER
Results Available
NCT02311933 | ACTIVE_NOT_RECRUITING | PHASE2
81 participants

Tamoxifen Citrate or Z-Endoxifen Hydrochloride in Treating Patients With Locally Advanced or Metastatic, Estrogen Receptor-Positive, HER2-Negative Breast Cancer

Study Type:
INTERVENTIONAL
Last Updated:
2026-05-29
Start Date:
2015-05-28
Completion:
2020-11-06
Conditions
  • Recurrent Breast Carcinoma
  • Stage III Breast Cancer AJCC v7
  • Stage IIIA Breast Cancer AJCC v7
  • Stage IIIB Breast Cancer AJCC v7
  • Stage IIIC Breast Cancer AJCC v7
  • Stage IV Breast Cancer AJCC v6 and v7
Interventions
  • OTHER
  • DRUG
Results Available
NCT02306161 | ACTIVE_NOT_RECRUITING | PHASE3
312 participants

Combination Chemotherapy With or Without Ganitumab in Treating Patients With Newly Diagnosed Metastatic Ewing Sarcoma

Study Type:
INTERVENTIONAL
Last Updated:
2026-05-29
Start Date:
2014-12-12
Completion:
2021-03-31
Conditions
  • Metastatic Ewing Sarcoma
  • Metastatic Malignant Neoplasm in the Bone
  • Metastatic Malignant Neoplasm in the Bone Marrow
  • Metastatic Malignant Neoplasm in the Lung
  • Metastatic Peripheral Primitive Neuroectodermal Tumor of Bone
  • Peripheral Primitive Neuroectodermal Tumor of Soft Tissues
Interventions
  • DRUG
  • RADIATION
  • BIOLOGICAL
  • PROCEDURE
Results Available
NCT02257528 | ACTIVE_NOT_RECRUITING | PHASE2
26 participants

Nivolumab in Treating Patients With Persistent, Recurrent, or Metastatic Cervical Cancer

Study Type:
INTERVENTIONAL
Last Updated:
2026-05-29
Start Date:
2015-05-18
Completion:
2019-03-05
Conditions
  • Cervical Adenocarcinoma
  • Cervical Adenosquamous Carcinoma
  • Recurrent Cervical Carcinoma
  • Stage IV Cervical Cancer AJCC v6 and v7
  • Stage IVA Cervical Cancer AJCC v6 and v7
  • Stage IVB Cervical Cancer AJCC v6 and v7
Interventions
  • OTHER
  • BIOLOGICAL
Results Available
NCT02224781 | ACTIVE_NOT_RECRUITING | PHASE3
267 participants

Dabrafenib and Trametinib Followed by Ipilimumab and Nivolumab or Ipilimumab and Nivolumab Followed by Dabrafenib and Trametinib in Treating Patients With Stage III-IV BRAFV600 Melanoma

Study Type:
INTERVENTIONAL
Last Updated:
2026-05-29
Start Date:
2015-09-08
Completion:
2023-09-30
Conditions
  • Clinical Stage III Cutaneous Melanoma AJCC v8
  • Clinical Stage IV Cutaneous Melanoma AJCC v8
  • Metastatic Melanoma
  • Recurrent Melanoma
  • Unresectable Melanoma
Interventions
  • PROCEDURE
  • DRUG
  • BIOLOGICAL
  • OTHER
Results Available
NCT02194738 | ACTIVE_NOT_RECRUITING | NA
8300 participants

Genetic Testing in Screening Patients With Stage IB-IIIA Non-small Cell Lung Cancer That Has Been or Will Be Removed by Surgery (The ALCHEMIST Screening Trial)

Study Type:
INTERVENTIONAL
Last Updated:
2026-05-29
Start Date:
2014-09-26
Completion:
2026-09-28
Conditions
  • Stage IB Lung Non-Small Cell Carcinoma AJCC v7
  • Stage II Lung Non-Small Cell Cancer AJCC v7
  • Stage IIA Lung Cancer AJCC v8
  • Stage IIB Lung Cancer AJCC v8
  • Stage IIIA Lung Cancer AJCC v8
  • Stage IIIA Lung Non-Small Cell Cancer AJCC v7
  • Stage IIIB Lung Cancer AJCC v8
Interventions
  • PROCEDURE
  • DRUG
  • OTHER
  • BIOLOGICAL
No Results Yet
NCT02193282 | ACTIVE_NOT_RECRUITING | PHASE3
390 participants

Erlotinib Hydrochloride in Treating Patients With Stage IB-IIIA Non-small Cell Lung Cancer That Has Been Completely Removed by Surgery (An ALCHEMIST Treatment Trial)

Study Type:
INTERVENTIONAL
Last Updated:
2026-05-29
Start Date:
2015-02-11
Completion:
2025-12-06
Conditions
  • Lung Non-Squamous Non-Small Cell Carcinoma
  • Stage IB Lung Non-Small Cell Carcinoma AJCC v7
  • Stage II Lung Non-Small Cell Cancer AJCC v7
  • Stage IIA Lung Non-Small Cell Carcinoma AJCC v7
  • Stage IIB Lung Non-Small Cell Carcinoma AJCC v7
  • Stage IIIA Lung Non-Small Cell Cancer AJCC v7
Interventions
  • OTHER
  • DRUG
No Results Yet
NCT02146170 | RECRUITING
2000 participants

Tissue Procurement and Natural History Study of People With Non-Small Cell Lung Cancer, Small Cell Lung Cancer, Extrapulmonary Small Cell Cancer, Pulmonary Neuroendocrine Tumors, and Thymic Epithelial Tumors

Study Type:
OBSERVATIONAL
Last Updated:
2026-05-29
Start Date:
2014-05-28
Completion:
2028-12-31
Conditions
  • Non-Small Cell Lung Cancer
  • Small Cell Lung Cancer
  • Extrapulmonary Small Cell Cancer
  • Pulmonary Neuroendocrine Tumors
  • Thymic Epithelial Tumors
No Results Yet
NCT02115282 | ACTIVE_NOT_RECRUITING | PHASE3
608 participants

Exemestane With or Without Entinostat in Treating Patients With Recurrent Hormone Receptor-Positive Breast Cancer That is Locally Advanced or Metastatic

Study Type:
INTERVENTIONAL
Last Updated:
2026-05-29
Start Date:
2014-03-29
Completion:
2020-05-05
Conditions
  • Anatomic Stage III Breast Cancer AJCC v8
  • Anatomic Stage IV Breast Cancer AJCC v8
  • Breast Adenocarcinoma
  • HER2/Neu Negative
  • Locally Advanced Breast Carcinoma
  • Metastatic Breast Carcinoma
  • Recurrent Breast Carcinoma
Interventions
  • PROCEDURE
  • DRUG
  • OTHER
Results Available
NCT02091245 | ACTIVE_NOT_RECRUITING | PHASE1
16 participants

Phase I Trial of the Selective Inhibitor of Nuclear Export, KPT-330, in Relapsed Childhood ALL and AML

Study Type:
INTERVENTIONAL
Last Updated:
2026-05-29
Start Date:
2014-03-31
Completion:
2018-02-28
Conditions
  • Relapsed Acute Lymphoblastic Leukemia (ALL)
  • Refractory Acute Lymphoblastic Leukemia (ALL)
  • Relapsed Acute Myelogenous Leukemia (AML)
  • Refractory Acute Myelogenous Leukemia (AML)
  • Relapsed Mixed Lineage Leukemia
  • Refractory Mixed Lineage Leukemia
  • Relapsed Biphenotypic Leukemia
  • Refractory Biphenotypic Leukemia
  • Chronic Myelogenous Leukemia (CML) in Blast Crisis
Interventions
  • DRUG
No Results Yet
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