Clinical Trials

NCT05630976 | COMPLETED | PHASE4

70 participants

Cresemba® in Treating Chinese Patients With IFD Caused by Aspergillus Species or Other Filamentous Fungi

Study Type:

INTERVENTIONAL

Last Updated:

2026-05-27

Start Date:

2023-02-07

Completion:

2025-04-11

Conditions

• Invasive Fungal Disease

Interventions

• DRUG

Results Available

NCT05626452 | COMPLETED | NA

724 participants

PrEP Optimization Among Women to Enhance Retention and Uptake

Study Type:

INTERVENTIONAL

Last Updated:

2026-05-27

Start Date:

2023-08-10

Completion:

2026-04-30

Conditions

• PrEP Uptake

Interventions

• BEHAVIORAL
• OTHER

No Results Yet

NCT05616676 | COMPLETED | NA

122 participants

A Brief Cognitive Task Intervention for NHS Staff Affected by COVID-19 Trauma (GAINS-2 Study)

Study Type:

INTERVENTIONAL

Last Updated:

2026-05-27

Start Date:

2022-12-08

Completion:

2023-10-30

Conditions

• Intrusive Memories of Traumatic Event(s)

Interventions

• BEHAVIORAL
• OTHER

Results Available

NCT05601427 | COMPLETED | NA

200 participants

Intra-Operative Adductor Canal Blocks

Study Type:

INTERVENTIONAL

Last Updated:

2026-05-27

Start Date:

2023-03-22

Completion:

2025-10-13

Conditions

• Knee Osteoarthritis
• Knee Arthritis
• Knee Pain Chronic
• Anesthesia

Interventions

• PROCEDURE

No Results Yet

NCT05599048 | RECRUITING | PHASE1/PHASE2

65 participants

Hyperpolarized 13C MRI as a Biomarker in Advanced Solid Tumors

Study Type:

INTERVENTIONAL

Last Updated:

2026-05-27

Start Date:

2022-12-15

Completion:

2027-01-31

Conditions

• Advanced Solid Tumor

Interventions

• DRUG
• PROCEDURE

No Results Yet

NCT05590585 | COMPLETED | PHASE4

124 participants

Dupilumab in Adolescent and Adult Skin of Color Participants: Open-label Moderate-to-severe Eczema Trial

Study Type:

INTERVENTIONAL

Last Updated:

2026-05-27

Start Date:

2023-01-11

Completion:

2024-11-14

Conditions

• Moderate-to-Severe Atopic Dermatitis
• Atopic Eczema

Interventions

• DRUG
• OTHER

Results Available

NCT05582993 | RECRUITING | PHASE3

24 participants

A Study of Vonicog Alfa (rVWF) in Children With Severe Von Willebrand Disease (vWD)

Study Type:

INTERVENTIONAL

Last Updated:

2026-05-27

Start Date:

2024-11-06

Completion:

2030-04-11

Conditions

• Von Willebrand Disease (VWD)

Interventions

• BIOLOGICAL

No Results Yet

NCT05568719 | RECRUITING | PHASE3

173 participants

Safety and Effectiveness of Giroctocogene Fitelparvovec or Fidanacogene Elaparvovec in Patients With Hemophilia A or B Respectively

Study Type:

INTERVENTIONAL

Last Updated:

2026-05-27

Start Date:

2022-12-28

Completion:

2040-02-25

Conditions

• Hemophilia A
• Hemophilia B

Interventions

• DIAGNOSTIC_TEST

No Results Yet

NCT05562830 | RECRUITING | PHASE1/PHASE2

48 participants

A Substudy of Investigational Agents in Programmed Cell Death-1/Ligand 1 (PD-1/L1) Refractory Locally Advanced or Metastatic Urothelial Carcinoma (mUC) (MK-3475-04A)

Study Type:

INTERVENTIONAL

Last Updated:

2026-05-27

Start Date:

2022-11-16

Completion:

2029-02-26

Conditions

• Urothelial Carcinoma

Interventions

• BIOLOGICAL

No Results Yet

NCT05554406 | RECRUITING | PHASE2

335 participants

Testing the Effects of Novel Therapeutics for Newly Diagnosed, Untreated Patients With High-Risk Acute Myeloid Leukemia (A MyeloMATCH Treatment Trial)

Study Type:

INTERVENTIONAL

Last Updated:

2026-05-27

Start Date:

2024-09-25

Completion:

2027-03-31

Conditions

• Acute Myeloid Leukemia
• Acute Myeloid Leukemia Arising From Previous Myelodysplastic/Myeloproliferative Neoplasm
• Acute Myeloid Leukemia Post Cytotoxic Therapy
• Acute Myeloid Leukemia, Myelodysplasia-Related

Interventions

• DRUG
• PROCEDURE

No Results Yet

NCT05550194 | RECRUITING | PHASE4

40 participants

VZV in the Enteric Nervous System: Pathogenesis and Consequences

Study Type:

INTERVENTIONAL

Last Updated:

2026-05-27

Start Date:

2023-03-27

Completion:

2026-08-31

Conditions

• Achalasia

Interventions

• DRUG
• BIOLOGICAL

No Results Yet

NCT05519085 | RECRUITING | PHASE3

810 participants

A Study to Evaluate Mezigdomide, Bortezomib and Dexamethasone (MEZIVd) Versus Pomalidomide, Bortezomib and Dexamethasone (PVd) in Participants With Relapsed or Refractory Multiple Myeloma (RRMM)

Study Type:

INTERVENTIONAL

Last Updated:

2026-05-27

Start Date:

2022-09-20

Completion:

2027-01-10

Conditions

• Relapsed or Refractory Multiple Myeloma

Interventions

• DRUG

No Results Yet

NCT05508789 | ACTIVE_NOT_RECRUITING | PHASE3

1500 participants

A Study of Donanemab (LY3002813) in Participants With Early Symptomatic Alzheimer's Disease (TRAILBLAZER-ALZ 5)

Study Type:

INTERVENTIONAL

Last Updated:

2026-05-27

Start Date:

2022-10-10

Completion:

2028-05-31

Conditions

• Alzheimer Disease
• Dementia
• Brain Diseases
• Central Nervous System Diseases
• Nervous System Diseases
• Tauopathies
• Neurodegenerative Diseases
• Neurocognitive Disorders
• Mental Disorders

Interventions

• DRUG

No Results Yet

NCT05508360 | RECRUITING | NA

72 participants

"Lumbar Operatively Inserted PerQdisc Artificial Implant Following Nulcectomy" (LOPAIN2)

Study Type:

INTERVENTIONAL

Last Updated:

2026-05-27

Start Date:

2022-08-22

Completion:

2027-08-22

Conditions

• Degenerative Disc Disease
• Chronic Low-back Pain

Interventions

• DEVICE

No Results Yet

NCT05493982 | COMPLETED | NA

2779 participants

Evaluation of the Be Vape Free Curriculum of the Tobacco Prevention Toolkit

Study Type:

INTERVENTIONAL

Last Updated:

2026-05-27

Start Date:

2022-10-19

Completion:

2026-05-08

Conditions

• E-cigarette Use

Interventions

• BEHAVIORAL

No Results Yet

NCT05492344 | RECRUITING | NA

538 participants

Personalized Mechanical Ventilation Guided by UltraSound in Patients With Acute Respiratory Distress Syndrome

Study Type:

INTERVENTIONAL

Last Updated:

2026-05-27

Start Date:

2022-08-09

Completion:

2027-08-01

Conditions

• ARDS, Human
• Lung Ultrasound
• Mechanical Ventilation

Interventions

• OTHER

No Results Yet

NCT05484570 | RECRUITING

40 participants

Natural History Study for DNA Repair Disorders

Study Type:

OBSERVATIONAL

Last Updated:

2026-05-27

Start Date:

2022-10-01

Completion:

2026-12-31

Conditions

• DNA Repair Disorder
• Cockayne Syndrome
• Xeroderma Pigmentosum
• Trichothiodystrophy

Interventions

• OTHER

No Results Yet

NCT05476640 | TERMINATED

3348 participants

Newborn Sequencing Screening in China

Study Type:

OBSERVATIONAL

Last Updated:

2026-05-27

Start Date:

2022-09-20

Completion:

2024-01-31

Conditions

• Newborns

Interventions

• GENETIC

No Results Yet

NCT05476601 | COMPLETED | NA

80 participants

CMAP Plus Intervention for Self-harm in Individuals With Substance Use Disorder in Pakistan

Study Type:

INTERVENTIONAL

Last Updated:

2026-05-27

Start Date:

2023-12-01

Completion:

2026-01-30

Conditions

• Self Harm
• Substance-Related Disorders

Interventions

• BEHAVIORAL

No Results Yet

NCT05474027 | COMPLETED | PHASE4

115 participants

Reducing Hypotensive Anesthesia Use With TXA During Orthognathic Surgery

Study Type:

INTERVENTIONAL

Last Updated:

2026-05-27

Start Date:

2022-11-11

Completion:

2025-11-11

Conditions

• Hypotension During Surgery
• Blood Loss, Surgical

Interventions

• OTHER
• DRUG

Results Available

NCT05469126 | COMPLETED | PHASE1

26 participants

A Drug Interaction Study of Clarithromycin and LY3502970 in Healthy Participants

Study Type:

INTERVENTIONAL

Last Updated:

2026-05-27

Start Date:

2022-08-01

Completion:

2022-11-03

Conditions

• Healthy

Interventions

• DRUG

Results Available

NCT05456191 | ACTIVE_NOT_RECRUITING | PHASE3

568 participants

A Study to Investigate Tolerability and Efficacy of Asciminib (Oral) Versus Nilotinib (Oral) in Adult Participants (≥18 Years of Age) With Newly Diagnosed Philadelphia Chromosome Positive Chronic Myelogenous Leukemia in Chronic Phase (Ph+ CML-CP)

Study Type:

INTERVENTIONAL

Last Updated:

2026-05-27

Start Date:

2022-11-21

Completion:

2025-05-15

Conditions

• Philadelphia Chromosome-Positive Chronic Myeloid Leukemia

Interventions

• DRUG

Results Available

NCT05454787 | RECRUITING

300 participants

Ondexxya for Intravenous Injection 200mg Drug Use Result Investigation (All Case Investigation)

Study Type:

OBSERVATIONAL

Last Updated:

2026-05-27

Start Date:

2022-06-02

Completion:

2026-08-31

Conditions

• Life Threatening Bleeding
• Factor Xa Inhibitor

No Results Yet

NCT05428176 | ACTIVE_NOT_RECRUITING | NA

342 participants

A High Intensity Electronic Health Intervention for the Reduction of Learning Disparities in Childhood Cancer Survivors

Study Type:

INTERVENTIONAL

Last Updated:

2026-05-27

Start Date:

2023-02-16

Completion:

2027-06-30

Conditions

• Acute Leukemia
• Acute Lymphoblastic Leukemia
• Acute Myeloid Leukemia
• Lymphoblastic Lymphoma

Interventions

• OTHER

No Results Yet

NCT05427695 | RECRUITING | PHASE2

60 participants

Topical Probiotic Sinus Irrigations for Treating Chronic Sinusitis

Study Type:

INTERVENTIONAL

Last Updated:

2026-05-27

Start Date:

2025-02-05

Completion:

2028-03-31

Conditions

• Chronic Rhinosinusitis (Diagnosis)

Interventions

• DRUG
• OTHER

No Results Yet

NCT05419011 | ACTIVE_NOT_RECRUITING | PHASE2

186 participants

Testing a Combination of Vaccines for Cancer Prevention in Lynch Syndrome

Study Type:

INTERVENTIONAL

Last Updated:

2026-05-27

Start Date:

2023-05-08

Completion:

2027-07-01

Conditions

• Colorectal Carcinoma
• Colorectal Neoplasm
• Lynch Syndrome

Interventions

• BIOLOGICAL
• PROCEDURE
• DRUG
• OTHER

No Results Yet

NCT05410977 | RECRUITING

950 participants

Collecting Blood and Stool Samples to Detect Colorectal Cancer or Advanced Neoplasia in Lynch Syndrome Patients

Study Type:

OBSERVATIONAL

Last Updated:

2026-05-27

Start Date:

2022-03-30

Completion:

2027-12-31

Conditions

• Colorectal Carcinoma
• Lynch Syndrome

Interventions

• PROCEDURE
• OTHER

No Results Yet

NCT05408091 | COMPLETED | PHASE1

16 participants

Study to Evaluate Safety and Activity of TRL345 in Healthy Volunteers

Study Type:

INTERVENTIONAL

Last Updated:

2026-05-27

Start Date:

2023-09-14

Completion:

2024-12-23

Conditions

• Healthy Volunteers

Interventions

• DRUG

Results Available

NCT05384626 | RECRUITING | PHASE1/PHASE2

840 participants

A Study of Neladalkib (NVL-655) in Patients With Advanced NSCLC and Other Solid Tumors Harboring ALK Rearrangement or Activating ALK Mutation (ALKOVE-1)

Study Type:

INTERVENTIONAL

Last Updated:

2026-05-27

Start Date:

2022-06-09

Completion:

2027-12-31

Conditions

• Locally Advanced Solid Tumor
• Metastatic Solid Tumor

Interventions

• DRUG

No Results Yet

NCT05353530 | RECRUITING | PHASE1

39 participants

IL-8 Receptor-modified CD70 CAR T Cell Therapy in CD70+ Adult Glioblastoma

Study Type:

INTERVENTIONAL

Last Updated:

2026-05-27

Start Date:

2023-07-25

Completion:

2027-12-31

Conditions

• Glioblastoma Multiforme
• Glioblastoma

Interventions

• BIOLOGICAL

No Results Yet

NCT05341089 | COMPLETED | PHASE1

39 participants

A Study of Two Different Formulations of LY3502970 in Healthy Participants

Study Type:

INTERVENTIONAL

Last Updated:

2026-05-27

Start Date:

2022-05-17

Completion:

2022-09-01

Conditions

• Healthy

Interventions

• DRUG

Results Available

NCT05336864 | ACTIVE_NOT_RECRUITING

650 participants

Association of Intraoperative Blood Pressure Excursions Below Cerebral Autoregulatory Boundaries With Organ Injury Following Major Noncardiac Surgery

Study Type:

OBSERVATIONAL

Last Updated:

2026-05-27

Start Date:

2022-05-20

Completion:

2026-01-29

Conditions

• Intraoperative Arterial Hypotension

Interventions

• OTHER

No Results Yet

NCT05335252 | ACTIVE_NOT_RECRUITING | PHASE3

30 participants

Dronabinol After Arthroscopic Surgery

Study Type:

INTERVENTIONAL

Last Updated:

2026-05-27

Start Date:

2022-06-28

Completion:

2026-12-31

Conditions

• Knee Osteoarthritis
• Knee Injuries
• Meniscus Tear
• Synovitis of Knee
• Knee Ligament Injury
• Chondral Injury of Left Knee
• Chondral Injury of Right Knee
• Loose Body Knee

Interventions

• DRUG

No Results Yet

NCT05333003 | ACTIVE_NOT_RECRUITING | NA

92 participants

Semaglutide in Comorbid Schizophrenia Spectrum Disorder and Obesity

Study Type:

INTERVENTIONAL

Last Updated:

2026-05-27

Start Date:

2022-05-25

Completion:

2026-08-31

Conditions

• Schizophrenia Spectrum Disorders

Interventions

• DRUG
• OTHER

No Results Yet

NCT05288452 | ACTIVE_NOT_RECRUITING | NA

304 participants

Food Delivery, Remote Monitoring, and Coaching-Enhanced Education for Optimized Diabetes Management (FREEDOM)

Study Type:

INTERVENTIONAL

Last Updated:

2026-05-27

Start Date:

2023-01-01

Completion:

2026-06-30

Conditions

• Diabetes Mellitus, Type 2

Interventions

• BEHAVIORAL
• DIETARY_SUPPLEMENT

No Results Yet

NCT05264974 | SUSPENDED | PHASE1

18 participants

Novel RNA-lipid Particle (RNA-LP) Vaccine for Anti-PD-1 Antibody Therapy Sensitization

Study Type:

INTERVENTIONAL

Last Updated:

2026-05-27

Start Date:

2026-03-17

Completion:

2026-12-31

Conditions

• Melanoma
• Soft Tissue Sarcoma

Interventions

• BIOLOGICAL

No Results Yet

NCT05256225 | RECRUITING | PHASE3

360 participants

Testing the Addition of Herceptin Hylecta or Phesgo to the Usual Chemotherapy for HER2 Positive Endometrial Serous Carcinoma or Carcinosarcoma

Study Type:

INTERVENTIONAL

Last Updated:

2026-05-27

Start Date:

2022-11-16

Completion:

2027-10-31

Conditions

• Endometrial Carcinoma
• Endometrial Clear Cell Adenocarcinoma
• Endometrial Dedifferentiated Carcinoma
• Endometrial Endometrioid Adenocarcinoma
• Endometrial Mixed Cell Adenocarcinoma
• Endometrial Serous Adenocarcinoma
• Endometrial Undifferentiated Carcinoma
• Uterine Corpus Malignant Mixed Mesodermal (Mullerian) Tumor

Interventions

• PROCEDURE
• DRUG
• RADIATION
• OTHER

No Results Yet

NCT05252702 | COMPLETED | NA

464 participants

Aveir DR i2i Study

Study Type:

INTERVENTIONAL

Last Updated:

2026-05-27

Start Date:

2022-02-02

Completion:

2023-08-02

Conditions

• Cardiac Pacemaker, Artificial
• Cardiac Rhythm Disorder
• Bradycardia

Interventions

• DEVICE

Results Available

NCT05249426 | ACTIVE_NOT_RECRUITING | PHASE1

48 participants

A Study to Test Whether Different Combinations of BI 765063, Ezabenlimab, Chemotherapy, Cetuximab, and BI 836880 Help People With Head and Neck Cancer or Liver Cancer

Study Type:

INTERVENTIONAL

Last Updated:

2026-05-27

Start Date:

2022-04-12

Completion:

2024-07-15

Conditions

• Head and Neck Squamous Cell Carcinoma (HNSCC)

Interventions

• DRUG
• OTHER

No Results Yet

NCT05242471 | ACTIVE_NOT_RECRUITING | PHASE2

703 participants

A Study of Combination Therapy With Guselkumab and Golimumab in Participants With Moderately to Severely Active Crohn's Disease

Study Type:

INTERVENTIONAL

Last Updated:

2026-05-27

Start Date:

2022-07-22

Completion:

2025-05-23

Conditions

• Crohn's Disease

Interventions

• BIOLOGICAL
• DRUG

No Results Yet