Clinical Trials

NCT03047213 | ACTIVE_NOT_RECRUITING | PHASE2
17 participants

Sapanisertib in Treating Patients With Locally Advanced or Metastatic Bladder Cancer With TSC1 and/or TSC2 Mutations

Study Type:
INTERVENTIONAL
Last Updated:
2026-05-13
Start Date:
2017-08-24
Completion:
2020-10-06
Conditions
  • Locally Advanced Bladder Urothelial Carcinoma
  • Metastatic Transitional Cell Carcinoma
  • Metastatic Urothelial Carcinoma
  • Recurrent Bladder Carcinoma
  • Stage III Bladder Urothelial Carcinoma AJCC v6 and v7
  • Stage IV Bladder Urothelial Carcinoma AJCC v7
Interventions
  • DRUG
NCT02978625 | ACTIVE_NOT_RECRUITING | PHASE2
68 participants

Talimogene Laherparepvec and Nivolumab in Treating Patients With Refractory Lymphomas or Advanced or Refractory Non-melanoma Skin Cancers

Study Type:
INTERVENTIONAL
Last Updated:
2026-05-13
Start Date:
2017-09-27
Completion:
2027-09-01
Conditions
  • Anaplastic Large Cell Lymphoma, ALK-Negative
  • Anaplastic Large Cell Lymphoma, ALK-Positive
  • Apocrine Carcinoma
  • Carcinoma Arising From Cylindroma
  • Carcinoma Arising From Spiradenoma
  • Digital Papillary Adenocarcinoma
  • Endocrine Mucin-Producing Sweat Gland Carcinoma
  • Extramammary Paget Disease
  • Extraocular Sebaceous Carcinoma
  • Hidradenocarcinoma
  • Malignant Sweat Gland Neoplasm
  • Merkel Cell Carcinoma
  • Microcystic Adnexal Carcinoma
  • NK-Cell Lymphoma, Unclassifiable
  • Papillary Adenocarcinoma
  • Porocarcinoma
  • Primary Cutaneous Mucinous Carcinoma
  • Recurrent Mature T-Cell and NK-Cell Non-Hodgkin Lymphoma
  • Recurrent T-Cell Non-Hodgkin Lymphoma
  • Refractory Anaplastic Large Cell Lymphoma
  • Refractory Mature T-Cell and NK-Cell Non-Hodgkin Lymphoma
  • Refractory Merkel Cell Carcinoma
  • Refractory Mycosis Fungoides
  • Refractory Primary Cutaneous T-Cell Non-Hodgkin Lymphoma
  • Refractory Skin Squamous Cell Carcinoma
  • Refractory T-Cell Non-Hodgkin Lymphoma
  • Sezary Syndrome
  • Signet Ring Cell Adenocarcinoma
  • Skin Adenoid Cystic Carcinoma
  • Skin Adnexal Carcinoma
  • Skin Basal Cell Carcinoma
  • Skin Basosquamous Cell Carcinoma
  • Skin Keratoacanthoma
  • Skin Squamous Cell Carcinoma
  • Squamoid Eccrine Ductal Carcinoma
  • Squamous Cell Carcinoma of Unknown Primary
  • Sweat Gland Carcinoma
  • Trichilemmal Carcinoma
  • Vulvar Squamous Cell Carcinoma
Interventions
  • PROCEDURE
  • OTHER
  • BIOLOGICAL
No Results Yet
NCT02923778 | ACTIVE_NOT_RECRUITING | PHASE2
40 participants

Talimogene Laherparepvec and Radiation Therapy in Treating Patients With Newly Diagnosed Soft Tissue Sarcoma That Can Be Removed by Surgery

Study Type:
INTERVENTIONAL
Last Updated:
2026-05-13
Start Date:
2019-12-31
Completion:
2026-12-29
Conditions
  • Leiomyosarcoma
  • Liposarcoma
  • Sarcoma G2
  • Sarcoma G3
  • Soft Tissue Sarcoma
  • Soft Tissue Sarcoma of the Trunk and Extremities
  • Stage I Soft Tissue Sarcoma AJCC v7
  • Stage II Soft Tissue Sarcoma AJCC v7
  • Undifferentiated Pleomorphic Sarcoma
Interventions
  • PROCEDURE
  • RADIATION
  • BIOLOGICAL
No Results Yet
NCT02595931 | ACTIVE_NOT_RECRUITING | PHASE1
66 participants

M6620 and Irinotecan Hydrochloride in Treating Patients With Solid Tumors That Are Metastatic or Cannot Be Removed by Surgery

Study Type:
INTERVENTIONAL
Last Updated:
2026-05-13
Start Date:
2016-07-22
Completion:
2023-03-07
Conditions
  • Metastatic Colorectal Carcinoma
  • Metastatic Lung Small Cell Carcinoma
  • Metastatic Malignant Solid Neoplasm
  • Metastatic Pancreatic Carcinoma
  • Refractory Colorectal Carcinoma
  • Refractory Lung Small Cell Carcinoma
  • Refractory Malignant Solid Neoplasm
  • Refractory Pancreatic Carcinoma
  • Stage III Colorectal Cancer AJCC v8
  • Stage III Lung Cancer AJCC v8
  • Stage III Pancreatic Cancer AJCC v8
  • Stage IV Colorectal Cancer AJCC v8
  • Stage IV Lung Cancer AJCC v8
  • Stage IV Pancreatic Cancer AJCC v8
  • Unresectable Colorectal Carcinoma
  • Unresectable Lung Small Cell Carcinoma
  • Unresectable Malignant Solid Neoplasm
  • Unresectable Pancreatic Carcinoma
Interventions
  • DRUG
  • PROCEDURE
No Results Yet
NCT02496663 | ACTIVE_NOT_RECRUITING | PHASE1
138 participants

Osimertinib and Necitumumab in Treating Patients With EGFR-Mutant Stage IV or Recurrent Non-small Cell Lung Cancer Who Have Progressed on a Previous EGFR Tyrosine Kinase Inhibitor

Study Type:
INTERVENTIONAL
Last Updated:
2026-05-13
Start Date:
2016-05-11
Completion:
2027-06-30
Conditions
  • Metastatic Lung Non-Small Cell Carcinoma
  • Recurrent Lung Non-Small Cell Carcinoma
  • Stage IV Lung Cancer AJCC v8
Interventions
  • PROCEDURE
  • BIOLOGICAL
  • DRUG
No Results Yet
NCT02496208 | ACTIVE_NOT_RECRUITING | PHASE1
152 participants

Cabozantinib S-malate and Nivolumab With or Without Ipilimumab in Treating Patients With Metastatic Genitourinary Tumors

Study Type:
INTERVENTIONAL
Last Updated:
2026-05-13
Start Date:
2015-07-22
Completion:
2026-09-30
Conditions
  • Bladder Small Cell Neuroendocrine Carcinoma
  • Bladder Squamous Cell Carcinoma
  • Bladder Urothelial Carcinoma
  • Clear Cell Renal Cell Carcinoma
  • Invasive Bladder Plasmacytoid Urothelial Carcinoma
  • Invasive Bladder Sarcomatoid Urothelial Carcinoma
  • Invasive Sarcomatoid Urothelial Carcinoma
  • Kidney Medullary Carcinoma
  • Malignant Genitourinary System Neoplasm
  • Malignant Solid Neoplasm
  • Penile Carcinoma
  • Penile Squamous Cell Carcinoma
  • Renal Cell Carcinoma
  • Renal Pelvis Urothelial Carcinoma
  • Sarcomatoid Renal Cell Carcinoma
  • Stage III Bladder Cancer AJCC v8
  • Stage III Penile Cancer AJCC v8
  • Stage III Renal Cell Cancer AJCC v8
  • Stage III Renal Pelvis and Ureter Cancer AJCC v8
  • Stage III Renal Pelvis Cancer AJCC v8
  • Stage III Ureter Cancer AJCC v8
  • Stage III Urethral Cancer AJCC v8
  • Stage IV Bladder Cancer AJCC v8
  • Stage IV Penile Cancer AJCC v8
  • Stage IV Renal Cell Cancer AJCC v8
  • Stage IV Renal Pelvis and Ureter Cancer AJCC v8
  • Stage IV Ureter Cancer AJCC v8
  • Stage IV Urethral Cancer AJCC v8
  • Ureter Urothelial Carcinoma
  • Urethral Urothelial Carcinoma
Interventions
  • PROCEDURE
  • DRUG
  • BIOLOGICAL
No Results Yet
NCT02425345 | COMPLETED | NA
49331 participants

Women's Health Initiative Strong and Healthy Study

Study Type:
INTERVENTIONAL
Last Updated:
2026-05-13
Start Date:
2015-04-02
Completion:
2024-12-31
Conditions
  • Myocardial Infarction
  • Stroke
  • Cardiovascular Mortality
  • Hip Fractures
  • Falls
  • Mortality
  • Venous Thromboembolic Event
  • Peripheral Artery Disease
  • Physical Function
  • Coronary Revascularization
  • Mobility and Independence
  • Clinical (Non-hip) Fractures
  • Sleep
  • Depressive Symptoms
Interventions
  • BEHAVIORAL
NCT02362035 | COMPLETED | PHASE1/PHASE2
161 participants

ACP-196 (Acalabrutinib) in Combination With Pembrolizumab, for Treatment of Hematologic Malignancies

Study Type:
INTERVENTIONAL
Last Updated:
2026-05-13
Start Date:
2015-02-20
Completion:
2020-07-14
Conditions
  • Follicular Lymphoma (FL)
  • CLL
  • Small Lymphocytic Lymphoma (SLL)
  • Richter's Syndrome
  • Mantle Cell Lymphoma (MCL)
  • Indolent Non Hodgkin Lymphoma
  • Waldenström Macroglobulinemia
  • Multiple Myeloma
  • Hodgkin Lymphoma
  • Burkitt Lymphoma
  • Marginal Zone Lymphomas
  • Mediastinal Large B Cell Lymphoma
  • Hairy Cell Leukemia
Interventions
  • DRUG
NCT02359565 | ACTIVE_NOT_RECRUITING | PHASE1
71 participants

Pembrolizumab in Treating Younger Patients With Recurrent, Progressive, or Refractory High-Grade Gliomas, Diffuse Intrinsic Pontine Gliomas, Hypermutated Brain Tumors, Ependymoma or Medulloblastoma

Study Type:
INTERVENTIONAL
Last Updated:
2026-05-13
Start Date:
2015-06-03
Completion:
2026-01-05
Conditions
  • Constitutional Mismatch Repair Deficiency Syndrome
  • Lynch Syndrome
  • Malignant Glioma
  • Recurrent Brain Neoplasm
  • Recurrent Childhood Ependymoma
  • Recurrent Diffuse Intrinsic Pontine Glioma
  • Recurrent Medulloblastoma
  • Refractory Brain Neoplasm
  • Refractory Diffuse Intrinsic Pontine Glioma
  • Refractory Ependymoma
  • Refractory Medulloblastoma
Interventions
  • PROCEDURE
  • BIOLOGICAL
No Results Yet
NCT02298959 | ACTIVE_NOT_RECRUITING | PHASE1
59 participants

Testing the PD-1 Antibody, MK3475, Given With Ziv-aflibercept in Patients With Advanced Cancer

Study Type:
INTERVENTIONAL
Last Updated:
2026-05-13
Start Date:
2015-04-08
Completion:
2025-05-21
Conditions
  • Clinical Stage IV Cutaneous Melanoma AJCC v8
  • Metastatic Colorectal Carcinoma
  • Metastatic Malignant Solid Neoplasm
  • Metastatic Melanoma
  • Metastatic Ovarian Carcinoma
  • Metastatic Renal Cell Carcinoma
  • Platinum-Resistant Ovarian Carcinoma
  • Recurrent Melanoma
  • Recurrent Renal Cell Carcinoma
  • Refractory Melanoma
  • Refractory Renal Cell Carcinoma
  • Sarcoma
  • Stage IV Colorectal Cancer AJCC v8
  • Stage IV Ovarian Cancer AJCC v8
  • Stage IV Renal Cell Cancer AJCC v8
Interventions
  • PROCEDURE
  • BIOLOGICAL
No Results Yet
NCT02160015 | ACTIVE_NOT_RECRUITING | PHASE1
12 participants

Lenalidomide, Ibrutinib, and Rituximab in Treating Patients With Relapsed or Refractory Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma That Is Metastatic or Cannot Be Removed by Surgery

Study Type:
INTERVENTIONAL
Last Updated:
2026-05-13
Start Date:
2014-05-20
Completion:
2017-03-27
Conditions
  • Recurrent Chronic Lymphocytic Leukemia
  • Recurrent Small Lymphocytic Lymphoma
  • Refractory Chronic Lymphocytic Leukemia
  • Refractory Small Lymphocytic Lymphoma
Interventions
  • PROCEDURE
  • DRUG
  • BIOLOGICAL
No Results Yet
NCT01989585 | ACTIVE_NOT_RECRUITING | PHASE1/PHASE2
75 participants

Testing the Addition of Navitoclax to the Combination of Dabrafenib and Trametinib in People Who Have BRAF Mutant Melanoma

Study Type:
INTERVENTIONAL
Last Updated:
2026-05-13
Start Date:
2014-03-24
Completion:
2027-12-31
Conditions
  • Clinical Stage III Cutaneous Melanoma AJCC v8
  • Clinical Stage IV Cutaneous Melanoma AJCC v8
  • Malignant Solid Neoplasm
  • Metastatic Melanoma
  • Unresectable Melanoma
Interventions
  • PROCEDURE
  • DRUG
  • OTHER
  • BIOLOGICAL
No Results Yet
NCT01955499 | ACTIVE_NOT_RECRUITING | PHASE1
39 participants

Lenalidomide and Ibrutinib in Treating Patients With Relapsed or Refractory B-Cell Non-Hodgkin Lymphoma

Study Type:
INTERVENTIONAL
Last Updated:
2026-05-13
Start Date:
2013-09-24
Completion:
2024-11-06
Conditions
  • Recurrent Diffuse Large B-Cell Lymphoma
  • Recurrent Follicular Lymphoma
  • Recurrent Lymphoplasmacytic Lymphoma
  • Recurrent Mantle Cell Lymphoma
  • Recurrent Marginal Zone Lymphoma
  • Refractory Diffuse Large B-Cell Lymphoma
  • Refractory Follicular Lymphoma
  • Refractory Lymphoplasmacytic Lymphoma
  • Refractory Mantle Cell Lymphoma
  • Refractory Marginal Zone Lymphoma
Interventions
  • PROCEDURE
  • DRUG
No Results Yet
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