Clinical Trials

NCT04230304 | TERMINATED | PHASE2

8 participants

Daratumumab and Ibrutinib for the Treatment of Relapsed or Refractory Chronic Lymphocytic Leukemia, DIRECT Study

Study Type:

INTERVENTIONAL

Last Updated:

2025-12-30

Start Date:

2020-11-11

Completion:

2023-05-01

Conditions

• Recurrent Chronic Lymphocytic Leukemia
• Recurrent Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma
• Recurrent Small Lymphocytic Lymphoma
• Refractory Chronic Lymphocytic Leukemia
• Refractory Small Lymphocytic Lymphoma

Interventions

• BIOLOGICAL
• DRUG

Results Available

NCT04230174 | COMPLETED | PHASE4

22 participants

Effect of Ocrelizumab on Neuroinflammation in Multiple Sclerosis as Measured by 11C-PBR28 MR-PET Imaging of Microglia Activation

Study Type:

INTERVENTIONAL

Last Updated:

2025-12-30

Start Date:

2020-12-29

Completion:

2024-10-09

Conditions

• Multiple Sclerosis

Interventions

• DRUG

Results Available

NCT04227899 | ACTIVE_NOT_RECRUITING | NA

261 participants

LIFE-BTK Randomized Controlled Trial

Study Type:

INTERVENTIONAL

Last Updated:

2025-12-30

Start Date:

2020-08-18

Completion:

2023-08-17

Conditions

• Critical Limb Ischemia (CLI)

Interventions

• DEVICE

Results Available

NCT04188457 | COMPLETED

859 participants

Medical-economic Evaluation Comparing Intensive Outpatient Monitoring of Neuro-cardiovascular Diseases by Nurses, Doctors and Hospital and Private-sector Pharmacists, Compared to Usual Monitoring.

Study Type:

OBSERVATIONAL

Last Updated:

2025-12-30

Start Date:

2020-10-15

Completion:

2025-10-09

Conditions

• Cerebrovascular Accidents
• Myocardial Infarction

Interventions

• OTHER

No Results Yet

NCT04160455 | RECRUITING

180 participants

Study of Autophagy and the Effects of GALIG Gene Products in HIV-1 Infected Patients Who Are Under Antiretroviral Therapy Since Primary-infection, Chronic Phase, or Never Treated.

Study Type:

OBSERVATIONAL

Last Updated:

2025-12-30

Start Date:

2019-11-07

Completion:

2029-11-07

Conditions

• Autophagy
• Galectins
• HIV Infections
• Highly Active Antiretroviral Therapy

Interventions

• BIOLOGICAL

No Results Yet

NCT04041583 | RECRUITING

45 participants

Clinical and Radiological Outcomes of Posterior Cervical Fusion Supplemented With Interfacet Spacers

Study Type:

OBSERVATIONAL

Last Updated:

2025-12-30

Start Date:

2019-09-01

Completion:

2026-08-31

Conditions

• Cervical Fusion

Interventions

• DEVICE

No Results Yet

NCT04022980 | COMPLETED | PHASE1

14 participants

Nivolumab Consolidation in Older (≥ 65) Patients With Primary CNS Lymphoma

Study Type:

INTERVENTIONAL

Last Updated:

2025-12-30

Start Date:

2020-03-31

Completion:

2025-01-21

Conditions

• Brain and Nervous System
• Eye and Orbit

Interventions

• DRUG

No Results Yet

NCT03993678 | COMPLETED | PHASE1/PHASE2

28 participants

Intratumoral Injection of IP-001 Following Thermal Ablation in Patients With Advanced Solid Tumors.

Study Type:

INTERVENTIONAL

Last Updated:

2025-12-30

Start Date:

2020-10-12

Completion:

2025-07-15

Conditions

• Advanced Solid Tumors

Interventions

• DRUG
• DEVICE

No Results Yet

NCT03988608 | COMPLETED | PHASE2

20 participants

Study Assessed the Safety and Efficacy of Eltrombopag in Chinese Refractory or Relapsed Severe Aplastic Anemia (SAA) Subjects.

Study Type:

INTERVENTIONAL

Last Updated:

2025-12-30

Start Date:

2019-12-09

Completion:

2021-07-16

Conditions

• Aplastic Anemia

Interventions

• DRUG

Results Available

NCT03984708 | COMPLETED | NA

9 participants

New Therapeutic Strategy in ALS Based on Metabolic Status and Associated Metabolic Pathways.

Study Type:

INTERVENTIONAL

Last Updated:

2025-12-30

Start Date:

2020-01-27

Completion:

2023-01-10

Conditions

• Amyotrophic Lateral Sclerosis

Interventions

• OTHER

No Results Yet

NCT03956095 | COMPLETED

23 participants

Study of Nutritional Supplement Shakes in People About to Receive Their Debulking Surgery for Ovarian Cancer

Study Type:

OBSERVATIONAL

Last Updated:

2025-12-30

Start Date:

2019-05-16

Completion:

2025-12-19

Conditions

• Debulking Surgery for Ovarian Cancer

Interventions

• DIETARY_SUPPLEMENT
• OTHER

No Results Yet

NCT03921554 | COMPLETED | PHASE2

54 participants

JAK Inhibitor Treatment in AGS

Study Type:

INTERVENTIONAL

Last Updated:

2025-12-30

Start Date:

2019-06-03

Completion:

2024-01-04

Conditions

• Aicardi Goutieres Syndrome

Interventions

• DRUG

Results Available

NCT03884998 | ACTIVE_NOT_RECRUITING | PHASE1

27 participants

Copanlisib and Nivolumab in Treating Patients With Richter's Transformation or Transformed Indolent Non-Hodgkin Lymphoma

Study Type:

INTERVENTIONAL

Last Updated:

2025-12-30

Start Date:

2019-02-26

Completion:

2026-11-04

Conditions

• Chronic Lymphocytic Leukemia
• Diffuse Large B-Cell Lymphoma
• Follicular Lymphoma
• Indolent Non-Hodgkin Lymphoma
• Lymphoplasmacytic Lymphoma
• Marginal Zone Lymphoma
• Richter Syndrome

Interventions

• DRUG
• BIOLOGICAL

No Results Yet

NCT03879252 | COMPLETED | PHASE3

76 participants

Tolerance of Teeth Brushing During Prolonged Aplasia

Study Type:

INTERVENTIONAL

Last Updated:

2025-12-30

Start Date:

2019-07-22

Completion:

2023-02-01

Conditions

• Aplasia

Interventions

• DEVICE
• DRUG

No Results Yet

NCT03837626 | COMPLETED | PHASE2/PHASE3

137 participants

ENAC Blockade and Arterial Stiffness

Study Type:

INTERVENTIONAL

Last Updated:

2025-12-30

Start Date:

2019-07-15

Completion:

2024-10-05

Conditions

• Overweight and Obesity
• Insulin Resistance

Interventions

• DRUG

Results Available

NCT03820947 | TERMINATED | NA

506 participants

VenaSeal Spectrum: Global Post-Market Randomized Controlled Trial

Study Type:

INTERVENTIONAL

Last Updated:

2025-12-30

Start Date:

2020-02-05

Completion:

2024-06-12

Conditions

• Venous Reflux

Interventions

• DEVICE
• PROCEDURE

Results Available

NCT03809000 | ACTIVE_NOT_RECRUITING | PHASE2

188 participants

A Study of Salvage Radiotherapy With or Without Enzalutamide in Recurrent Prostate Cancer Following Surgery

Study Type:

INTERVENTIONAL

Last Updated:

2025-12-30

Start Date:

2019-04-15

Completion:

2023-04-07

Conditions

• Prostate Cancer

Interventions

• RADIATION
• DRUG

Results Available

NCT03708003 | TERMINATED | PHASE2

30 participants

Ibrutinib lead-in Followed by Venetoclax Plus Ibrutinib in Patients With RR CLL

Study Type:

INTERVENTIONAL

Last Updated:

2025-12-30

Start Date:

2019-03-11

Completion:

2025-11-30

Conditions

• Relapsed/Refractory Chronic Lymphocytic Leukemia
• Chronic Lymphocytic Leukemia
• Leukemia

Interventions

• DRUG

No Results Yet

NCT03696017 | RECRUITING

120 participants

Opioid/Benzodiazepine Polydrug Abuse

Study Type:

OBSERVATIONAL

Last Updated:

2025-12-30

Start Date:

2019-02-08

Completion:

2026-12-31

Conditions

• Polysubstance Abuse

Interventions

• OTHER

No Results Yet

NCT03694457 | COMPLETED | NA

90 participants

Comparison Between Anterior Approach (Deltopectoral) and Lateral Approach (Deltoid Splitting) in Shoulder Reverse Arthroplasty for Proximal Humerus Fracture

Study Type:

INTERVENTIONAL

Last Updated:

2025-12-30

Start Date:

2018-11-26

Completion:

2023-12-31

Conditions

• Humeral Fracture
• Aged Patient
• Reversed Total Shoulder Arthroplasty
• Surgical Approach

Interventions

• PROCEDURE

No Results Yet

NCT03663348 | RECRUITING

500 participants

Registry of Patients With Takotsubo Syndrome

Study Type:

OBSERVATIONAL

Last Updated:

2025-12-30

Start Date:

2009-09-11

Completion:

2028-09-01

Conditions

• Takotsubo Cardiomyopathy
• Broken Heart Syndrome
• Tako-tsubo Cardiomyopathy

No Results Yet

NCT03630536 | ACTIVE_NOT_RECRUITING

28 participants

TFE Renal Cell Carcinoma: A Prospective Registry and Translational Research Initiative

Study Type:

OBSERVATIONAL

Last Updated:

2025-12-30

Start Date:

2018-08-12

Completion:

2026-06-30

Conditions

• Renal Cell Carcinoma

No Results Yet

NCT03615794 | COMPLETED

300 participants

A Study of Pregnant and Postpartum Women With and Without Mood Disorders

Study Type:

OBSERVATIONAL

Last Updated:

2025-12-30

Start Date:

2017-10-01

Completion:

2024-01-31

Conditions

• Bipolar Disorder
• Major Depressive Disorder
• Postpartum Depression
• Postpartum Psychosis

No Results Yet

NCT03609944 | COMPLETED | NA

181 participants

SpHincterotomy for Acute Recurrent Pancreatitis

Study Type:

INTERVENTIONAL

Last Updated:

2025-12-30

Start Date:

2018-09-27

Completion:

2025-02-28

Conditions

• Pancreatitis
• Pancreas Divisum
• Pancreatitis, Acute
• Pancreatitis Idiopathic
• Pancreas Inflamed

Interventions

• PROCEDURE

Results Available

NCT03605524 | COMPLETED | NA

150 participants

Olfactory Training and Emotional State

Study Type:

INTERVENTIONAL

Last Updated:

2025-12-30

Start Date:

2018-08-28

Completion:

2023-06-27

Conditions

• Depressive Symptoms
• Depressive Disorder, Major

Interventions

• OTHER

No Results Yet

NCT03574363 | COMPLETED | PHASE2

162 participants

Phase 2b Study of KBP-5074 in Subjects With Uncontrolled Hypertension and Advanced Chronic Kidney Disease

Study Type:

INTERVENTIONAL

Last Updated:

2025-12-30

Start Date:

2018-04-25

Completion:

2020-08-05

Conditions

• Chronic Kidney Diseases
• Hypertension

Interventions

• DRUG

Results Available

NCT03481010 | RECRUITING | NA

204 participants

Periacetabular Osteotomy With and Without Arthroscopic Management of Central Compartment Pathology

Study Type:

INTERVENTIONAL

Last Updated:

2025-12-30

Start Date:

2018-04-04

Completion:

2030-07-31

Conditions

• Hip Dysplasia

Interventions

• PROCEDURE

No Results Yet

NCT03443492 | COMPLETED | PHASE2

130 participants

SLOG vs mFOLFIRINOX as the First-line Treatment in Locally Advanced Uncresectable or Metastatic Pancreatic Cancer

Study Type:

INTERVENTIONAL

Last Updated:

2025-12-30

Start Date:

2018-03-26

Completion:

2019-11-30

Conditions

• Locally Advanced or Metastatic Pancreatic Cancer

Interventions

• DRUG

No Results Yet

NCT03383016 | ACTIVE_NOT_RECRUITING

2053 participants

Diet, Physical Activity and Related Candidate Biomarkers in Relation to Prostate Cancer Risk (BIOCaPPE)

Study Type:

OBSERVATIONAL

Last Updated:

2025-12-30

Start Date:

2013-06-20

Completion:

2022-09-23

Conditions

• Epidemiology
• Prostate Cancer

Interventions

• OTHER
• DIAGNOSTIC_TEST

No Results Yet

NCT03345420 | COMPLETED | PHASE2

102 participants

Hypofractionated Radiation Therapy in Treating Patients With Stage 0-IIB Breast Cancer

Study Type:

INTERVENTIONAL

Last Updated:

2025-12-30

Start Date:

2017-12-12

Completion:

2022-08-30

Conditions

• Ductal Breast Carcinoma In Situ
• Invasive Breast Carcinoma
• Stage 0 Breast Cancer
• Stage I Breast Cancer
• Stage IA Breast Cancer
• Stage IB Breast Cancer
• Stage II Breast Cancer
• Stage IIA Breast Cancer
• Stage IIB Breast Cancer

Interventions

• RADIATION

Results Available

NCT03292458 | COMPLETED | PHASE2/PHASE3

117 participants

Sodium Oxybate in Spasmodic Dysphonia and Voice Tremor

Study Type:

INTERVENTIONAL

Last Updated:

2025-12-30

Start Date:

2018-01-22

Completion:

2021-12-29

Conditions

• Spasmodic Dysphonia
• Voice Tremor

Interventions

• DRUG

Results Available

NCT03203330 | ACTIVE_NOT_RECRUITING | PHASE3

535 participants

A Study to Determine the Safety and Efficacy of TG-C in Subjects With Kellgren and Lawrence Grade 2 or 3 OA of the Knee

Study Type:

INTERVENTIONAL

Last Updated:

2025-12-30

Start Date:

2018-10-30

Completion:

2024-07-10

Conditions

• Degenerative Osteoarthritis

Interventions

• BIOLOGICAL

No Results Yet

NCT03199885 | COMPLETED | PHASE3

190 participants

Testing the Drug Atezolizumab or Placebo With Usual Therapy in First-Line HER2-Positive Metastatic Breast Cancer

Study Type:

INTERVENTIONAL

Last Updated:

2025-12-30

Start Date:

2019-04-05

Completion:

2024-04-30

Conditions

• Metastatic Breast Adenocarcinoma
• Metastatic HER2-Positive Breast Carcinoma
• Recurrent Breast Adenocarcinoma
• Recurrent HER2-Positive Breast Carcinoma
• Stage III Breast Cancer AJCC v7
• Stage IV Breast Cancer AJCC v6 and v7
• Unresectable Breast Carcinoma
• Unresectable HER2-Positive Breast Carcinoma

Interventions

• DRUG
• PROCEDURE
• BIOLOGICAL
• OTHER

Results Available

NCT03192891 | COMPLETED

2349 participants

Stress CMR Perfusion Imaging in the United States (SPINS) Study

Study Type:

OBSERVATIONAL

Last Updated:

2025-12-30

Start Date:

2016-12-01

Completion:

2019-11-30

Conditions

• Myocardial Ischemia

Interventions

• DIAGNOSTIC_TEST

Results Available

NCT02990286 | COMPLETED | PHASE3

122 participants

Evaluation of Efficacy and Safety of Rituximab With Mycophenolate Mofetil in Patients With Interstitial Lung Diseases

Study Type:

INTERVENTIONAL

Last Updated:

2025-12-30

Start Date:

2017-01-20

Completion:

2019-07-24

Conditions

• Lung Disease, Interstitial

Interventions

• DRUG

No Results Yet

NCT02975310 | RECRUITING | NA

140 participants

In-clinic Endoscopic Polypectomy for Chronic Sinusitis With Nasal Polyps

Study Type:

INTERVENTIONAL

Last Updated:

2025-12-30

Start Date:

2017-04-11

Completion:

2025-12-31

Conditions

• Sinusitis
• Nasal Polyps

Interventions

• PROCEDURE
• OTHER

No Results Yet

NCT02917473 | COMPLETED | NA

420 participants

Comparison of Two Strategies for Counseling Skin Examination and Sun Protection in First-degree Relatives of Patients With Melanoma

Study Type:

INTERVENTIONAL

Last Updated:

2025-12-30

Start Date:

2017-12-13

Completion:

2019-04-26

Conditions

• Melanoma
• Screening

Interventions

• BEHAVIORAL

No Results Yet

NCT02837237 | COMPLETED | PHASE1

11 participants

Safety, Tolerability, and Pharmacokinetics of KBP-5074 Following Oral Administration in Chronic Kidney Disease

Study Type:

INTERVENTIONAL

Last Updated:

2025-12-30

Start Date:

2016-07-13

Completion:

2016-12-20

Conditions

• Chronic Kidney Disease

Interventions

• DRUG

Results Available

NCT02789839 | COMPLETED | NA

102 participants

Analyses of Bone Marrow and Blood Samples From Healthy Volunteers: Focus on the redOx Metabolism

Study Type:

INTERVENTIONAL

Last Updated:

2025-12-30

Start Date:

2016-08-31

Completion:

2017-08-31

Conditions

• redOx Metabolism

Interventions

• PROCEDURE

No Results Yet

NCT02730039 | ACTIVE_NOT_RECRUITING

350 participants

Meaning-Centered Psychotherapy Training for Cancer Care Providers

Study Type:

OBSERVATIONAL

Last Updated:

2025-12-30

Start Date:

2015-12-11

Completion:

2026-12-11

Conditions

• Cancer Care Providers

Interventions

• BEHAVIORAL

No Results Yet