Clinical Trials Updated in 2025

NCT06506084 | ACTIVE_NOT_RECRUITING

319 participants

Observational Study on the Use of Ropeginterferon Alfa-2b in Polycythemia Vera (ROPEG-PV)

Study Type:: OBSERVATIONAL
Last Updated:: 2025-12-26
Start Date:: 2022-09-08
Completion:: 2026-09-30

Conditions

Polycythemia Vera

Interventions

DRUG

No Results Yet

NCT06502964 | RECRUITING | PHASE2

82 participants

Study of ALTO-101 in Patients With Schizophrenia

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-26
Start Date:: 2024-06-11
Completion:: 2026-02-28

Conditions

Schizophrenia
Cognitive Impairment

Interventions

DRUG
DEVICE

No Results Yet

NCT06490757 | RECRUITING | PHASE2

25 participants

A Phase 2 Open-label Single-arm Trial of JAK1 Inhibitor for the Treatment of Large Inflammatory Hepatocellular Adenomas

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-26
Start Date:: 2024-10-02
Completion:: 2028-09-02

Conditions

Inflammatory Hepatocellular Adenoma

Interventions

DRUG

No Results Yet

NCT06487338 | COMPLETED | NA

40 participants

Effect of Low-level Laser Therapy Versus Shock Wave Therapy on Pain and Function in Patients With Chronic Non-specific Low Back Pain

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-26
Start Date:: 2024-08-25
Completion:: 2024-10-20

Conditions

Low Back Pain

Interventions

OTHER

No Results Yet

NCT06480006 | COMPLETED

100 participants

Validity and Reliability of the BETY-Biopsychosocial Questionnaire in Individuals With Coronary Artery Disease

Study Type:: OBSERVATIONAL
Last Updated:: 2025-12-26
Start Date:: 2024-06-10
Completion:: 2025-05-08

Conditions

Validity
Reliability

No Results Yet

NCT06479512 | COMPLETED

200 participants

Caval-aorta Index and Perfusion Index on Predict Hypotension After Spinal Anaesthesia in Elderly

Study Type:: OBSERVATIONAL
Last Updated:: 2025-12-26
Start Date:: 2024-07-01
Completion:: 2025-04-15

Conditions

Anesthesia, Spinal

Interventions

DEVICE

No Results Yet

NCT06438133 | COMPLETED

52 participants

Digital Supported Compression Bandaging in Patients With Chronic Edema in the Lower Limbs

Study Type:: OBSERVATIONAL
Last Updated:: 2025-12-26
Start Date:: 2024-06-10
Completion:: 2025-12-18

Conditions

Compression; Vein
Venous Insufficiency
Lymphedema of Leg
Digital Technology

Interventions

OTHER

No Results Yet

NCT06438107 | NOT_YET_RECRUITING

24 participants

Deep Phenotyping of the Renal Allograft to Prognosticate Clinical Outcomes

Study Type:: OBSERVATIONAL
Last Updated:: 2025-12-26
Start Date:: 2026-04-30
Completion:: 2027-12-31

Conditions

Renal Transplant Rejection

No Results Yet

NCT06429033 | COMPLETED | PHASE1

8 participants

Purified Exosome Product (PEP) Injected Into the Hypodermis

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-26
Start Date:: 2025-04-14
Completion:: 2025-12-17

Conditions

Safety

Interventions

DRUG

No Results Yet

NCT06414889 | RECRUITING | PHASE1

4 participants

Protocol Title: Safety and Feasibility of Autologous CD34+ Hematopoietic Stem Cells Mobilization and Apheresis in Participants With RUNX1 Familial Platelet Disorder

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-26
Start Date:: 2024-05-20
Completion:: 2027-06-30

Conditions

RUNX1 Familial Platelet Disorder

Interventions

DRUG
PROCEDURE

No Results Yet

NCT06405932 | COMPLETED | NA

1691 participants

Study of the Intervention Effect of Self-help Training Camps in Promoting Mental Health Among Perinatal Women

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-26
Start Date:: 2024-09-11
Completion:: 2025-09-01

Conditions

Mental Health
Perinatal Depression

Interventions

COMBINATION_PRODUCT

No Results Yet

NCT06397144 | WITHDRAWN | PHASE1

0 participants

A Study on 2 Different Combination Tablets of Nirmatrelvir Plus Ritonavir to Compare Them With Marketed Paxlovid in Healthy Participants

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-26
Start Date:: 2025-08-15
Completion:: 2025-12-09

Conditions

Biological Availability
Healthy Participants

Interventions

DRUG

No Results Yet

NCT06391775 | TERMINATED | PHASE1/PHASE2

21 participants

Trial to Assess the Safety and Preliminary Efficacy of GEN1055 on Malignant Solid Tumors as Monotherapy and as Combination Therapy

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-26
Start Date:: 2024-05-14
Completion:: 2025-11-20

Conditions

Malignant Solid Tumor

Interventions

BIOLOGICAL
DRUG

No Results Yet

NCT06388148 | RECRUITING | NA

286 participants

Endovascular Treatment for eXtra-Large Ischemic Stroke

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-26
Start Date:: 2024-06-16
Completion:: 2026-10-31

Conditions

Stroke, Acute Ischemic

Interventions

DRUG
PROCEDURE

No Results Yet

NCT06387979 | SUSPENDED

285 participants

Advanced Development of Desorption Electrospray Ionization Mass Spectrometry for Intraoperative Molecular Diagnosis of Brain Cancer Using Pathology Biopsies

Study Type:: OBSERVATIONAL
Last Updated:: 2025-12-26
Start Date:: 2020-10-26
Completion:: 2026-10-15

Conditions

Glioma

Interventions

OTHER

No Results Yet

NCT06380738 | RECRUITING

250 participants

Real-World Clinical Experience of Patients With Metastatic Castration-Resistant Prostate Cancer Treated With Olaparib + Abiraterone (PROceed)

Study Type:: OBSERVATIONAL
Last Updated:: 2025-12-26
Start Date:: 2024-02-14
Completion:: 2027-01-31

Conditions

Metastatic Castration-resistant Prostate Cancer

No Results Yet

NCT06380530 | RECRUITING | NA

100 participants

Advanced Surgical Simulation Processes in the Correction of Skeletal Defects and Deformities

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-26
Start Date:: 2024-10-31
Completion:: 2028-05-31

Conditions

Musculoskeletal Deformity
Musculoskeletal Abnormalities
Musculoskeletal Disorder

Interventions

PROCEDURE

No Results Yet

NCT06377527 | RECRUITING

2000 participants

Establishing a Tumor Registry of Patients With Mesonephric-like Adenocarcinoma (MLA)

Study Type:: OBSERVATIONAL
Last Updated:: 2025-12-26
Start Date:: 2024-07-10
Completion:: 2035-12-28

Conditions

Mesonephric-like Adenocarcinoma

No Results Yet

NCT06374394 | COMPLETED | PHASE3

841 participants

A Study on the Immune Response and Safety of a Vaccine Against Respiratory Syncytial Virus (RSV) When Given Alone and Together With a COVID-19 mRNA Vaccine in Adults Aged 50 Years and Above

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-26
Start Date:: 2024-04-29
Completion:: 2024-11-01

Conditions

Respiratory Syncytial Virus Infections

Interventions

BIOLOGICAL

Results Available

NCT06361550 | RECRUITING | NA

200 participants

Nutritional Status Assessment and Dietary Recommendations Program (VENREDI)

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-26
Start Date:: 2023-11-02
Completion:: 2026-06-30

Conditions

Adherence to the Mediterranean Diet

Interventions

OTHER

No Results Yet

NCT06331468 | RECRUITING | PHASE2

20 participants

Hypofractionated Radiochemotherapy

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-26
Start Date:: 2025-06-26
Completion:: 2026-07-01

Conditions

Uterine Cervix Cancer

Interventions

DRUG
RADIATION

No Results Yet

NCT06322342 | COMPLETED | PHASE2

18 participants

Phase 2 Ascending Dose Safety and Efficacy Study of RVP-001, a Manganese-based MRI Contrast Agent

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-26
Start Date:: 2024-08-15
Completion:: 2025-12-19

Conditions

Central Nervous System (CNS) Lesions
Brain Metastases
Brain Neoplasms
Brain Neoplasms, Benign
Brain Tumor, Primary
Brain Tumor, Recurrent
Brain Tumors
Brain Cancer
Brain Tumor
Brain Neoplasm, Primary
Multiple Sclerosis
Multiple Sclerosis Brain Lesion
Neurofibroma
Acoustic Neuroma
CNS Tumor
CNS Lesion
CNS Metastases
CNS Cancer
CNS Lymphoma
Von Hippel Lindau
Meningioma
Glioma
Schwannomas
Neuroinflammation
Neoplasia

Interventions

DRUG

No Results Yet

NCT06311500 | COMPLETED | PHASE1/PHASE2

30 participants

Sleep Health Enhancement in Midlife Adults

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-26
Start Date:: 2024-02-13
Completion:: 2025-11-19

Conditions

Sleep Health
Midlife Adults

Interventions

BEHAVIORAL

No Results Yet

NCT06307470 | COMPLETED | NA

43 participants

Nurse-led Mind-body Intervention on Sexual Health for Breast Cancer Survivors

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-26
Start Date:: 2024-10-15
Completion:: 2025-11-30

Conditions

Women's Health: Neoplasm of Breast
Menopause, Premature
Body Image
Sexual Dysfunction
Cancer, Breast

Interventions

BEHAVIORAL

No Results Yet

NCT06263543 | RECRUITING | PHASE2

75 participants

Sequencing Antibody Drug Conjugates in ER+/HER2 LOW/ULTRA LOW MBC

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-26
Start Date:: 2024-06-17
Completion:: 2026-06-30

Conditions

Breast Cancer
Metastatic Breast Cancer
Advanced Breast Cancer
Hormone-receptor-positive Breast Cancer
Human Epidermal Growth Factor 2 Low Breast Cancer

Interventions

DRUG

No Results Yet

NCT06263270 | COMPLETED | PHASE1

19 participants

Evaluation of CYT-108, A Recombinant Protease Inhibitor, for Treatment of Mild To Moderate Primary Osteoarthritis Of The Knee

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-26
Start Date:: 2024-06-01
Completion:: 2025-03-15

Conditions

Osteoarthritis, Knee
Osteoarthritis

Interventions

BIOLOGICAL
OTHER

No Results Yet

NCT06252753 | RECRUITING

4490 participants

Observational Study Protocol: LIVER-R

Study Type:: OBSERVATIONAL
Last Updated:: 2025-12-26
Start Date:: 2023-03-16
Completion:: 2030-12-30

Conditions

Hepatobiliary Cancers

Interventions

OTHER

No Results Yet

NCT06212570 | NOT_YET_RECRUITING | NA

12 participants

KeyScope Study in Uganda

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-26
Start Date:: 2026-04-01
Completion:: 2027-03-30

Conditions

Abdominal Neoplasm

Interventions

DEVICE

No Results Yet

NCT06196463 | COMPLETED | NA

11 participants

Erector Spinae Plane (ESP) Block in Juvenile Idiopathic Scoliosis Surgery

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-26
Start Date:: 2023-09-11
Completion:: 2024-12-11

Conditions

Juvenile Idiopathic Scoliosis, Multiple Sites in Spine

Interventions

PROCEDURE

No Results Yet

NCT06184321 | RECRUITING | EARLY_PHASE1

30 participants

Alteplase Through an Indwelling Pleural Catheter for the Management of Symptomatic Septated Malignant Pleural Effusion

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-26
Start Date:: 2023-08-17
Completion:: 2027-02-02

Conditions

Hematopoietic and Lymphoid Cell Neoplasm
Malignant Solid Neoplasm

Interventions

BIOLOGICAL
DRUG

No Results Yet

NCT06175832 | RECRUITING | PHASE4

60 participants

PPOS (Progestin Primed Ovarian Stimulation) and Corifollitropin Alfa (CFA) Cross-over Study

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-26
Start Date:: 2025-01-27
Completion:: 2027-12-31

Conditions

Ovarian Stimulation
Quality of Life
Preimplantation Genetic Testing
Fertility Preservation

Interventions

DRUG

No Results Yet

NCT06159517 | TERMINATED

184 participants

Heart Lung Machine Registry

Study Type:: OBSERVATIONAL
Last Updated:: 2025-12-26
Start Date:: 2023-12-21
Completion:: 2025-04-30

Conditions

Cardiac Surgery
Thoracic Surgery
Vascular Surgery
Cardiopulmonary Bypass

No Results Yet

NCT06119061 | RECRUITING | PHASE4

20 participants

Telavancin Blood and Cerebrospinal Fluid Concentrations in Patients With External Ventricular Drainage

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-26
Start Date:: 2024-07-02
Completion:: 2026-12-31

Conditions

Subarachnoid Hemorrhage, Aneurysmal

Interventions

DRUG

No Results Yet

NCT06117527 | RECRUITING

50 participants

Placental Learning Model for Neurovascular Microsurgery for the Management of Intracranial Aneurysms

Study Type:: OBSERVATIONAL
Last Updated:: 2025-12-26
Start Date:: 2020-07-16
Completion:: 2028-02-29

Conditions

Intracranial Aneurysm

No Results Yet

NCT06075524 | RECRUITING

500 participants

Evaluation of Anti-PD-1 Therapy by Monitoring T Cell Responses in Melanoma, Lung and Other Cancer Types

Study Type:: OBSERVATIONAL
Last Updated:: 2025-12-26
Start Date:: 2015-06-15
Completion:: 2026-12-31

Conditions

Clinical Stage III Cutaneous Melanoma AJCC v8
Clinical Stage IV Cutaneous Melanoma AJCC v8
Locally Advanced Lung Carcinoma
Locally Advanced Malignant Solid Neoplasm
Locally Advanced Melanoma
Metastatic Lung Carcinoma
Metastatic Malignant Solid Neoplasm
Metastatic Melanoma
Stage III Lung Cancer AJCC v8
Stage IV Lung Cancer AJCC v8

Interventions

PROCEDURE
OTHER

No Results Yet

NCT06054607 | COMPLETED | NA

21 participants

Effect of Short-chain Fatty Acids on Aerobic Endurance

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-26
Start Date:: 2023-07-21
Completion:: 2025-05-01

Conditions

Aerobic Endurance
Metabolism

Interventions

DIETARY_SUPPLEMENT
OTHER

No Results Yet

NCT06032143 | ACTIVE_NOT_RECRUITING | NA

120 participants

Doulas as Environmental Educators and Partners Study

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-26
Start Date:: 2023-10-20
Completion:: 2026-01-30

Conditions

Health Knowledge, Attitudes, Practice

Interventions

BEHAVIORAL

No Results Yet

NCT06024317 | NOT_YET_RECRUITING | NA

800 participants

Leveraging Community Health Workers and a Digital Health System to Improve the Timeliness of Child Well Visits

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-26
Start Date:: 2026-03-01
Completion:: 2027-07-31

Conditions

Short Message Service (SMS)
Incentives
Knowledge, Attitudes, Practice
Preventive Services

Interventions

BEHAVIORAL

No Results Yet

NCT06019767 | COMPLETED | NA

59 participants

Peer-led Trauma Therapy for Re-entry

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-26
Start Date:: 2023-11-14
Completion:: 2025-12-12

Conditions

PTSD

Interventions

BEHAVIORAL

No Results Yet

NCT06015009 | COMPLETED | NA

40 participants

Symptom Management App for Children at the Early Stage of Cancer Survivorship and Their Caregivers

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-26
Start Date:: 2023-08-17
Completion:: 2025-01-02

Conditions

Oncology
Survivorship

Interventions

OTHER

No Results Yet