Clinical Trials Updated in 2025

NCT04990401 | COMPLETED | NA

65 participants

Behavioral Activation Teletherapy to Increase Physical Activity

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-23
Start Date:: 2021-08-31
Completion:: 2025-05-30

Conditions

Depression
Depressive Disorder
Depressive Symptoms
Depressive Episode

Interventions

BEHAVIORAL

No Results Yet

NCT04990167 | TERMINATED | PHASE2

11 participants

Tiotropium vs. Inhaled Corticosteroids in Children With Nonatopic Asthma Pilot Study (TioNAAP)

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-23
Start Date:: 2022-01-01
Completion:: 2025-10-31

Conditions

Asthma in Children

Interventions

DRUG

No Results Yet

NCT04982575 | COMPLETED | PHASE2

92 participants

Research Study to Look at How Well Cagrilintide Together With Semaglutide Works in People With Type 2 Diabetes

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-23
Start Date:: 2021-08-02
Completion:: 2022-07-07

Conditions

Diabetes Mellitus, Type 2

Interventions

DRUG

Results Available

NCT04975776 | ACTIVE_NOT_RECRUITING | NA

104 participants

Sleep Restriction Therapy for Insomnia in Primary Health Care

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-23
Start Date:: 2022-02-01
Completion:: 2027-08-30

Conditions

Insomnia

Interventions

BEHAVIORAL

No Results Yet

NCT04965766 | RECRUITING | PHASE2

139 participants

Patritumab Deruxtecan (U3-1402) in Unresectable Locally Advanced or Metastatic Breast Cancer

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-23
Start Date:: 2021-05-11
Completion:: 2027-04-11

Conditions

Metastatic Breast Cancer
Advanced Breast Cancer

Interventions

DRUG

No Results Yet

NCT04952766 | COMPLETED | PHASE4

196 participants

Study Evaluating SARS-CoV-2 (COVID-19) Humoral Response After BNT162b2 Vaccine in Immunocompromised Adults Compared to Healthy Adults

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-23
Start Date:: 2021-03-26
Completion:: 2022-02-06

Conditions

Kidney Transplant
Myeloma
Cancer
Hematologic Malignancy
Multiple Sclerosis
Hypergammaglobulinemia
Malignant Tumor
Hiv
Diabetes Type 2

Interventions

BIOLOGICAL

No Results Yet

NCT04937647 | RECRUITING

1650 participants

Evaluation of Neoplasia With Artificial Intelligence in Gastrointestinal Endoscopy

Study Type:: OBSERVATIONAL
Last Updated:: 2025-12-23
Start Date:: 2021-06-16
Completion:: 2026-06-03

Conditions

Gastrointestinal Neoplasms

Interventions

OTHER

No Results Yet

NCT04936035 | COMPLETED | PHASE2

394 participants

A Study to Evaluate Efficacy and Safety of ALN-AGT01 in Patients With Mild To-Moderate Hypertension

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-23
Start Date:: 2021-07-07
Completion:: 2023-04-04

Conditions

Hypertension

Interventions

DRUG

Results Available

NCT04933721 | ENROLLING_BY_INVITATION | PHASE3

139 participants

Open-label Berotralstat Access to HAE Patients Previously Enrolled in Berotralstat Studies

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-23
Start Date:: 2021-07-23
Completion:: 2031-08-31

Conditions

Hereditary Angioedema
HAE

Interventions

DRUG

No Results Yet

NCT04930822 | COMPLETED | NA

37 participants

Evaluation of Bioness Integrated Therapy System (BITS) Touch Screen Technology to Improve Field Awareness

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-23
Start Date:: 2021-01-08
Completion:: 2024-06-12

Conditions

Stroke
Neurologic Disorder
Traumatic Brain Injury
Acquired Brain Injury

Interventions

OTHER
DEVICE

Results Available

NCT04925752 | ACTIVE_NOT_RECRUITING | PHASE3

3292 participants

Study of Lenacapavir for HIV Pre-Exposure Prophylaxis in People Who Are at Risk for HIV Infection

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-23
Start Date:: 2021-06-28
Completion:: 2024-08-21

Conditions

Pre-Exposure Prophylaxis of HIV Infection

Interventions

DRUG

Results Available

NCT04914455 | COMPLETED

40 participants

Transhepatic Echography for Fluid Responsiveness After Cardiovascular Surgery

Study Type:: OBSERVATIONAL
Last Updated:: 2025-12-23
Start Date:: 2020-12-08
Completion:: 2021-06-04

Conditions

Inferior Vena Cava Abnormality
Fluid Responsiveness
Fluid Overload
Venous Congestion
Cardiovascular Surgery

Interventions

DIAGNOSTIC_TEST

No Results Yet

NCT04911036 | RECRUITING

240 participants

Study of the Effect of the Time of Diagnosis (Antenatal vs. Postnatal) on the Post-traumatic Reactions of Parents of Children Undergoing Oesophageal Atresia Surgery "

Study Type:: OBSERVATIONAL
Last Updated:: 2025-12-23
Start Date:: 2021-05-06
Completion:: 2027-05-31

Conditions

Atresia, Esophageal

Interventions

OTHER

No Results Yet

NCT04894253 | TERMINATED

7 participants

Immune Response to SARS-CoV-2 Vaccination in Systemic Lupus

Study Type:: OBSERVATIONAL
Last Updated:: 2025-12-23
Start Date:: 2021-06-07
Completion:: 2021-06-07

Conditions

Systemic Lupus

Interventions

BIOLOGICAL

No Results Yet

NCT04889118 | COMPLETED | PHASE3

131 participants

Safety and Efficacy Study of Pembrolizumab (MK-3475) Combined With Lenvatinib (MK-7902/E7080) as First-line Intervention in Adults With Advanced Melanoma (MK-7902-003/E7080-G000-312/LEAP-003)-China Extension Study

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-23
Start Date:: 2020-07-14
Completion:: 2023-01-18

Conditions

Malignant Melanoma

Interventions

BIOLOGICAL
DRUG

Results Available

NCT04863222 | RECRUITING | PHASE4

646 participants

Clinical and Radiographic Success of MTA vs Biodentine

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-23
Start Date:: 2021-11-12
Completion:: 2026-08-01

Conditions

Indirect Pulp Cap
Pulpotomy

Interventions

DEVICE
BIOLOGICAL

No Results Yet

NCT04845620 | COMPLETED | PHASE3

652 participants

Trial of PDE4 Inhibition With Roflumilast for the Management of Atopic Dermatitis (Integument-PED)

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-23
Start Date:: 2021-04-07
Completion:: 2023-06-01

Conditions

Atopic Dermatitis Eczema

Interventions

DRUG

Results Available

NCT04844684 | RECRUITING

30 participants

Evaluation of Cortisol and Bile Acids Metabolism in Obese Patients

Study Type:: OBSERVATIONAL
Last Updated:: 2025-12-23
Start Date:: 2023-03-30
Completion:: 2026-12-30

Conditions

Obesity

Interventions

OTHER

No Results Yet

NCT04832282 | ACTIVE_NOT_RECRUITING | NA

100 participants

Napoleon Measurement of Gastrojejunal Anastomosis

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-23
Start Date:: 2021-06-14
Completion:: 2025-06-30

Conditions

Gastric Bypass
Weight Regain

Interventions

DEVICE
OTHER

No Results Yet

NCT04826744 | RECRUITING

550 participants

Frequency of Palpebral Involvement in Adult With Atopic Dermatitis

Study Type:: OBSERVATIONAL
Last Updated:: 2025-12-23
Start Date:: 2021-09-01
Completion:: 2026-06-30

Conditions

Atopic Dermatitis

Interventions

OTHER

No Results Yet

NCT04804605 | COMPLETED | PHASE3

1220 participants

Open Label Extension Trial of PDE4 Inhibition With Roflumilast for the Management of Atopic Dermatitis

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-23
Start Date:: 2021-02-25
Completion:: 2024-05-28

Conditions

Atopic Dermatitis Eczema

Interventions

DRUG

Results Available

NCT04784234 | TERMINATED | NA

12 participants

Vision Preservation and Restoration Following a 6 Month Trial of GlaucoCetin

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-23
Start Date:: 2021-02-01
Completion:: 2022-10-27

Conditions

Primary Open Angle Glaucoma

Interventions

DIETARY_SUPPLEMENT
OTHER

No Results Yet

NCT04783181 | ACTIVE_NOT_RECRUITING | PHASE1/PHASE2

8 participants

A Study of Gene Therapy for Classic Congenital Adrenal Hyperplasia (CAH)

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-23
Start Date:: 2021-07-01
Completion:: 2029-02-28

Conditions

Congenital Adrenal Hyperplasia

Interventions

BIOLOGICAL

No Results Yet

NCT04776252 | ACTIVE_NOT_RECRUITING | PHASE3

2000 participants

Open-label, Follow-up of Doravirine/Islatravir (DOR/ISL 100 mg/0.75mg) for Participants With Human Immunodeficiency Virus-1 (HIV-1) Infection (MK-8591A-033)

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-23
Start Date:: 2021-09-15
Completion:: 2029-05-29

Conditions

HIV-1 Infection

Interventions

DRUG

No Results Yet

NCT04760769 | COMPLETED | PHASE3

992 participants

Open-label Trial in Parkinson's Disease (PD)

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-23
Start Date:: 2021-02-24
Completion:: 2025-12-01

Conditions

Parkinson Disease

Interventions

DRUG

No Results Yet

NCT04746313 | COMPLETED

71 participants

Prevalence of Hyperprolactinemia in Systemic Scleroderma

Study Type:: OBSERVATIONAL
Last Updated:: 2025-12-23
Start Date:: 2021-03-01
Completion:: 2021-05-12

Conditions

Sclerosis, Systemic
Scleroderma
Hyperprolactinemia

Interventions

BIOLOGICAL

No Results Yet

NCT04727489 | RECRUITING

3800 participants

Study of the Genetic Factors Involved in Autism and Related Disorders

Study Type:: OBSERVATIONAL
Last Updated:: 2025-12-23
Start Date:: 2021-03-30
Completion:: 2036-03-31

Conditions

Autism Spectrum Disorder

Interventions

GENETIC

No Results Yet

NCT04704115 | RECRUITING

62 participants

The Therapy of Large Endometrioma

Study Type:: OBSERVATIONAL
Last Updated:: 2025-12-23
Start Date:: 2021-01-21
Completion:: 2026-12-31

Conditions

Endometrioma
Endometriosis Ovary

No Results Yet

NCT04679285 | COMPLETED

9 participants

Minimal Residual Disease Evaluation on Cryopreserved Ovarian Fragments in Younger Patients Treated for Acute Myeloid Leukemia

Study Type:: OBSERVATIONAL
Last Updated:: 2025-12-23
Start Date:: 2021-04-26
Completion:: 2022-09-04

Conditions

Acute Myeloid Leukemia

No Results Yet

NCT04673669 | COMPLETED | NA

46 participants

Measurement of the Strength of the Posterior Tibial Muscle by Hand-held Dynamometer

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-23
Start Date:: 2021-03-23
Completion:: 2022-03-11

Conditions

Valgus Foot Deformity

Interventions

DIAGNOSTIC_TEST

No Results Yet

NCT04657120 | COMPLETED | NA

698 participants

Safety and Efficiency of the YEARS Algorithm Versus Computed Tomography Pulmonary Angiography Alone for Suspected Pulmonary Embolism in Patients With Malignancy

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-23
Start Date:: 2019-06-01
Completion:: 2025-08-23

Conditions

Pulmonary Embolism
Embolism
Embolism and Thrombosis
Vascular Diseases
Cardiovascular Diseases
Lung Diseases
Respiratory Tract Diseases
Cancer
Diagnosis

Interventions

PROCEDURE

No Results Yet

NCT04655365 | ACTIVE_NOT_RECRUITING | PHASE2

50 participants

Detecting Metastases by PyL PET/CT in Subjects Starting Enzalutamide for Untreated Castration Resistant Prostate Cancer.

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-23
Start Date:: 2022-03-22
Completion:: 2025-11-01

Conditions

Prostate Cancer

Interventions

DRUG

No Results Yet

NCT04645251 | RECRUITING

500 participants

Polycystic Liver Disease Registry (UK)

Study Type:: OBSERVATIONAL
Last Updated:: 2025-12-23
Start Date:: 2021-01-21
Completion:: 2030-12-01

Conditions

Polycystic Liver Disease

No Results Yet

NCT04616664 | COMPLETED

158 participants

Diagnostic Accuracy of the "LLIFT", a Novel Non-invasive Biomarker for the Diagnosis of Non Alcoholic Fatty Liver (NAFL) and SteatoHepatitis (NASH) in a Population With High Risk of Metabolic Syndrome"

Study Type:: OBSERVATIONAL
Last Updated:: 2025-12-23
Start Date:: 2021-02-16
Completion:: 2024-01-17

Conditions

Obesity
NASH - Nonalcoholic Steatohepatitis

No Results Yet

NCT04601129 | COMPLETED

60 participants

Advantage of a Fast-recovery Protocol for Minimally Invasive Kidney Surgery

Study Type:: OBSERVATIONAL
Last Updated:: 2025-12-23
Start Date:: 2020-08-01
Completion:: 2023-03-06

Conditions

Renal Cell Carcinoma

Interventions

PROCEDURE

No Results Yet

NCT04589013 | COMPLETED

106 participants

Prediction of Response to Treatment With Immunotherapy + Chemotherapy in Non-Small Cell Lung Cancer

Study Type:: OBSERVATIONAL
Last Updated:: 2025-12-23
Start Date:: 2020-11-19
Completion:: 2023-09-29

Conditions

Non-small Cell Lung Cancer

No Results Yet

NCT04587739 | RECRUITING | PHASE1

30 participants

Neoadjuvant Hypofractionated Stereotactic Body Radiation Therapy Prior to Surgery for Hepatocellular Carcinoma: a Feasibility Study.

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-23
Start Date:: 2021-01-31
Completion:: 2028-01-31

Conditions

Hepatocellular Carcinoma

Interventions

COMBINATION_PRODUCT

No Results Yet

NCT04583800 | RECRUITING

600 participants

Prediction of Heart Failure and Cognitive Decline in Type 2 Diabetes

Study Type:: OBSERVATIONAL
Last Updated:: 2025-12-23
Start Date:: 2021-06-22
Completion:: 2026-06-30

Conditions

Diabetes Mellitus, Type 2
Heart Failure
Cognitive Decline

No Results Yet

NCT04583475 | COMPLETED

163 participants

Real-life Study of How to Intensify Treatment With Xolair (OMALIZUMAB) in Chronic Spontaneous Urticaria

Study Type:: OBSERVATIONAL
Last Updated:: 2025-12-23
Start Date:: 2021-02-25
Completion:: 2023-06-22

Conditions

Spontaneous Urticaria, Chronic

No Results Yet

NCT04578834 | COMPLETED | PHASE3

518 participants

Study of Efficacy and Safety of LNP023 in Primary IgA Nephropathy Patients

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-23
Start Date:: 2021-01-25
Completion:: 2025-09-19

Conditions

IgA Nephropathy

Interventions

DRUG

No Results Yet