Prediction of Response to Treatment With Immunotherapy + Chemotherapy in Non-Small Cell Lung Cancer
NCT04589013 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 106
Last updated 2025-12-23
Summary
This study seeks to evaluate a multiparametric test including 6 immunohistochemical markers (PD-L1, CD8, FoxP3, PD1, CD163, CD15) to predict the cumulative incidence of death or progression on treatment with pembrolizumab+first line chemotherapy in metastatic non-small cell lung cancer, regardless of the PD-L1 status and in the absence of ALK, ROS1 or EGFR alteration.
Conditions
Sponsors & Collaborators
-
University Hospital, Lille
lead OTHER
Principal Investigators
-
Sarah Humez · University Hospital, Lille
Eligibility
- Min Age
- 18 Years
- Sex
- ALL
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2020-11-19
- Primary Completion
- 2023-09-29
- Completion
- 2023-09-29
Countries
- France
Study Locations
More Related Trials
-
irAE Prediction of Anti-PD-1/L1 in Lung Cancer
NCT05288569 ·Status: UNKNOWN
-
Immune-Marker Platform for Patients With Advanced Lung Cancer
NCT07150598 ·Status: NOT_YET_RECRUITING
-
cDC1 Prognostic and Predictive Role in Non-Small-Cell Lung Cancer Patients Receiving Immune Checkpoint Inhibitors
NCT04069442 ·Status: WITHDRAWN
-
LIquid Biopsy to prEdict Responses To First-line immunotherapY in Metastatic Non-small Cell LUNG Cancer. LIBERTY LUNG
NCT04790682 ·Status: RECRUITING ·Phase: NA
-
Investigation on Predictive Molecular Markers of Efficacy for Front-line Immunochemotherapy in Advanced NSCLC
NCT04858828 ·Status: UNKNOWN
-
Pilot Study of the Contribution of Fractional Exhaled Nitric Oxide as a Prognostic Marker of Response to Anti-PD-L1 Immunotherapy in Non-small Cell Lung Cancer
NCT05985330 ·Status: RECRUITING
-
Immunological Markers Predictive of Response and Toxicity to Checkpoint Inhibitors in Non-small Cell Lung Cancer
NCT04918836 ·Status: UNKNOWN
-
Prospective Evaluation of Immunological, Molecular-genetic, Image-based and Microbial Analyzes to Characterize Tumor Response and Control in Patients With Inoperable Stage III NSCLC Treated With Chemoradiotherapy Followed by Consolidation Therapy With Durvalumab
NCT05027165 ·Status: UNKNOWN
-
Immune Signature Analysis of Disease Progression in Post Immunotherapy Lung Cancer Patients
NCT05415358 ·Status: ACTIVE_NOT_RECRUITING
-
Prospective Cohort Study Evaluating 18FDG PET-CT for the Early Prediction of the Efficacy of Immunotherapy Associated or Not With Chemotherapy in Patients With Locally Advanced or Metastatic Non-Small Cell Broncho-Pulmonary Carcinoma
NCT06833229 ·Status: RECRUITING
-
Tumor Associated Neutrophils as a Biomarker of Chemo-immunotherapy Response in Locally Advanced Non-small Cell Lung Cancer : a Model Based on Neoadjuvant Strategy
NCT06974097 ·Status: NOT_YET_RECRUITING
-
A Non Interventional Pilot Study on Machine Learning for ILD Detection Based on the Patient Data From Digital Devices in Unresectable Stage III Non-Small Cell Lung Cancer Patients Receiving Durvalumab
NCT04884269 ·Status: COMPLETED
-
PD-L1 Expression in Lung Cancer
NCT04992715 ·Status: UNKNOWN ·Phase: PHASE2
-
Epidemiologic Multicenter Prospective Study in Advanced NSCLC (Non Small Cell Lung Cancer) Patients With PDL1 (Protein Death Ligand 1) Expression.
NCT02785562 ·Status: COMPLETED ·Phase: NA
-
French National Observatory of the Patients With Non-small Cell Lung (NSCLC) and Molecular Testings
NCT01700582 ·Status: COMPLETED
-
Study of Longitudinal Plasma PD-L1 Testing With Immunotherapy in Lung Cancer
NCT06849518 ·Status: RECRUITING ·Phase: NA
-
A Study for Identification of Predictive Immune Biomarker for Atezolizumab Therapy in NSCLC Patients
NCT04312308 ·Status: COMPLETED
-
A Clinico-biological Database of Lung Cancers
NCT03387865 ·Status: RECRUITING
-
Predictive Multimodal Signatures Associated With Response to Treatment and Prognosis of Patients With Stage IV Non-small Cell Lung Cancer
NCT04994795 ·Status: ACTIVE_NOT_RECRUITING
-
A Translational Study Investigating PD-L1 Expression After Radiotherapy for Non-small Cell Lung Cancer
NCT03258788 ·Status: COMPLETED
-
Construction of a Prognostic and Prediction Model for Perioperative Immunotherapy in NSCLC: a Multi - Omics Perspective
NCT06856798 ·Status: NOT_YET_RECRUITING
-
Prediction of Response to PD-L1 Inhibitor After Chemoradiotherapy in Limited-Stage Small-Cell Lung Cancer Using Multi-omics-based Liquid Biopsy
NCT06869239 ·Status: RECRUITING
-
Molecular Profiling and Dynamic Changes of ctDNA in Unresectable Locally Advanced NSCLC
NCT05641870 ·Status: UNKNOWN
-
Identification of a Predictive Metabolic Signature of Response to Immune Checkpoint Inhibitors in Non-Small Cell Lung Carcinoma
NCT04189679 ·Status: COMPLETED
-
Immune Checkpoint Inhibitors in Advanced Non-small Cell Lung Cancer and Discovery of New Biomarkers
NCT03658460 ·Status: COMPLETED