Clinical Trials Updated in 2025

NCT05566574 | ACTIVE_NOT_RECRUITING | PHASE1/PHASE2

49 participants

A Study of RP-3500 in Combination With Standard Radiation Therapy in People With Solid Tumor Cancer

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-17
Start Date:: 2022-09-30
Completion:: 2026-09-30

Conditions

Solid Tumor
Metastatic Cancer

Interventions

DRUG
RADIATION

No Results Yet

NCT05550727 | ACTIVE_NOT_RECRUITING | NA

342 participants

The PorchLight Project

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-17
Start Date:: 2022-09-23
Completion:: 2026-10-30

Conditions

Memory Loss
Alzheimer Disease
Dementia

Interventions

OTHER

No Results Yet

NCT05549219 | COMPLETED | PHASE2

27 participants

24-Week Study to Assess the PD, Safety, Tolerability, and PK of GLM101 in Participants With PMM2-CDG

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-17
Start Date:: 2022-11-29
Completion:: 2025-11-04

Conditions

Pmm2-CDG
Phosphomannomutase 2 Deficiency

Interventions

DRUG

No Results Yet

NCT05493605 | RECRUITING | NA

150 participants

Cardiac Involvement in Wilson's Disease

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-17
Start Date:: 2023-03-02
Completion:: 2026-03-31

Conditions

Wilson's Disease

Interventions

PROCEDURE

No Results Yet

NCT05488431 | RECRUITING | PHASE2

121 participants

Cholesterol and Inflammation Lowering Via Bempedoic Acid, an ACL-inhibiting Regimen in HIV Trial (CLEAR HIV Trial)

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-17
Start Date:: 2023-03-01
Completion:: 2028-03-01

Conditions

Dyslipidemias
Cardiovascular Diseases
HIV Infections
Atherosclerosis

Interventions

DRUG
OTHER

No Results Yet

NCT05485155 | RECRUITING | PHASE2

15 participants

Zemaira Eosinophilic Esophagitis Pilot Study

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-17
Start Date:: 2025-05-15
Completion:: 2026-10-31

Conditions

Eosinophilic Esophagitis

Interventions

DRUG

No Results Yet

NCT05482958 | COMPLETED

210 participants

DECIDE-CV Using AI

Study Type:: OBSERVATIONAL
Last Updated:: 2025-12-17
Start Date:: 2022-07-29
Completion:: 2025-09-15

Conditions

Type 2 Diabetes

Interventions

DEVICE

No Results Yet

NCT05477082 | ACTIVE_NOT_RECRUITING

27 participants

Blood Biomarkers in Pediatric Kidney Transplant Recipients

Study Type:: OBSERVATIONAL
Last Updated:: 2025-12-17
Start Date:: 2023-08-21
Completion:: 2025-11-16

Conditions

Rejection of Kidney Allograft

Interventions

OTHER

No Results Yet

NCT05472948 | RECRUITING | PHASE2

36 participants

Surufatinib and Sintilimab in Combination With Capecitabine for Metastatic Adenocarcinoma of Small Intestine or Appendix Carcinoma

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-17
Start Date:: 2023-02-01
Completion:: 2027-12-30

Conditions

Adenocarcinoma of Small Intestine
Appendix Carcinoma
Metastatic

Interventions

DRUG

No Results Yet

NCT05470322 | WITHDRAWN | NA

0 participants

Efficacy and Tolerability of a Fractional Ablative Erbium Laser for Axillary Scarring for Hidradenitis Suppurativa Patients

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-17
Start Date:: 2026-01-31
Completion:: 2027-07-31

Conditions

Hidradenitis Suppurativa
Scarring

Interventions

DEVICE

No Results Yet

NCT05450965 | RECRUITING | PHASE2

37 participants

Study of PLK1 Inhibitor, Onvansertib, in Relapsed Small Cell Lung Cancer

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-17
Start Date:: 2022-07-19
Completion:: 2027-08-31

Conditions

Small-cell Lung Cancer
Small Cell Lung Carcinoma

Interventions

DRUG

No Results Yet

NCT05444127 | RECRUITING

150 participants

Oral Health and Wilson's Disease: SOMAWI

Study Type:: OBSERVATIONAL
Last Updated:: 2025-12-17
Start Date:: 2023-05-17
Completion:: 2026-10-31

Conditions

Wilson Disease

Interventions

OTHER

No Results Yet

NCT05396222 | NOT_YET_RECRUITING | NA

18 participants

A Prospective Study of the Safety and Efficacy of 3D-printed Non-rigid Biomimetic Implant in Cervical and Thoracolumbar Spine

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-17
Start Date:: 2027-01-01
Completion:: 2027-01-01

Conditions

Spinal Tumor

Interventions

DEVICE

No Results Yet

NCT05386563 | COMPLETED | NA

12 participants

taVNS on Pupillary Response and Perceptual Learning

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-17
Start Date:: 2022-05-18
Completion:: 2022-11-22

Conditions

Pupillary Response

Interventions

PROCEDURE

No Results Yet

NCT05384132 | RECRUITING | NA

76 participants

Novel Dental Gel as an Adjunct to Scaling and Root Planing

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-17
Start Date:: 2022-10-14
Completion:: 2027-10-30

Conditions

Plaque, Dental
Periodontal Diseases
Gingival Diseases
Gingival Pocket
Gum Bleed

Interventions

OTHER

No Results Yet

NCT05370885 | TERMINATED | PHASE2

114 participants

VE202 in Patients With Mild-to-Moderate Ulcerative Colitis

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-17
Start Date:: 2023-05-08
Completion:: 2025-08-29

Conditions

Ulcerative Colitis
Colitis, Ulcerative

Interventions

BIOLOGICAL
DRUG
OTHER

No Results Yet

NCT05348915 | TERMINATED | PHASE3

242 participants

A Study to Evaluate the Long-term Safety of Inclacumab Administered to Participants With Sickle Cell Disease

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-17
Start Date:: 2022-03-29
Completion:: 2025-11-07

Conditions

Sickle Cell Disease
Vaso-occlusive Crisis
Vaso-occlusive Pain Episode in Sickle Cell Disease

Interventions

DRUG

No Results Yet

NCT05344859 | COMPLETED | NA

88 participants

GODART Pilot and Feasibility

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-17
Start Date:: 2023-05-15
Completion:: 2025-10-31

Conditions

Diabetes Mellitus, Type 2

Interventions

BEHAVIORAL

No Results Yet

NCT05342636 | COMPLETED | PHASE1/PHASE2

90 participants

A Study of Combination Therapies With or Without Pembrolizumab (MK-3475) and/or Chemotherapy in Participants With Advanced Esophageal Cancer (MK-3475-06A)

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-17
Start Date:: 2022-07-27
Completion:: 2025-12-05

Conditions

Esophageal Squamous Cell Carcinoma (ESCC)

Interventions

BIOLOGICAL
DRUG

No Results Yet

NCT05327985 | TERMINATED

21 participants

Three-dimensional Analysis of Obliquus Capitis Inferior Muscle Function in the Rotatory Form of Cervical Dystonia

Study Type:: OBSERVATIONAL
Last Updated:: 2025-12-17
Start Date:: 2024-09-10
Completion:: 2025-07-08

Conditions

Cervical Dystonia

No Results Yet

NCT05309928 | COMPLETED | PHASE1

13 participants

Phase 1 Study of the Pharmacokinetics of Amoxicillin in Pregnancy

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-17
Start Date:: 2023-08-29
Completion:: 2025-01-16

Conditions

Pregnancy Related

Interventions

DRUG

No Results Yet

NCT05273970 | ENROLLING_BY_INVITATION | NA

10 participants

Electrochemical and Electrophysiological Study

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-17
Start Date:: 2022-09-07
Completion:: 2027-02-28

Conditions

Cognition
Medically Intractable Epilepsy

Interventions

OTHER

No Results Yet

NCT05259605 | RECRUITING

1650 participants

Observational Study for Assessing Treatment and Outcome of Patients With Primary Brain Tumours Using cIMPACT-NOW and 2021 WHO Classification

Study Type:: OBSERVATIONAL
Last Updated:: 2025-12-17
Start Date:: 2023-03-21
Completion:: 2027-12-30

Conditions

Glioma
Glioneuronal Tumor
Choroid Plexus Tumor
Pineal Tumors
Germ Cell Tumor
Tumor of the Sellar Region
Diffuse Midline Glioma, H3 K27M-Mutant
Ependymoma
Embryonal Tumor
Pineal Tumor
Hemangiopericytoma
Hemangioblastoma
Melanocytic Tumor of CNS

Interventions

OTHER

No Results Yet

NCT05255003 | RECRUITING | PHASE4

50 participants

STrategies for Anticoagulation in Patients With thRombocytopenia and Cancer-associated Thrombosis

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-17
Start Date:: 2022-08-29
Completion:: 2026-12-31

Conditions

Cancer-associated Thrombosis
Thrombocytopenia

Interventions

BIOLOGICAL

No Results Yet

NCT05248204 | COMPLETED | NA

51 participants

Scotchbond Universal Plus Compared to Scotchbond Universal for Posterior Class I & II Restorations With Filtek Universal

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-17
Start Date:: 2022-06-14
Completion:: 2025-03-06

Conditions

Cavities of Teeth
Dental Decay

Interventions

DEVICE

Results Available

NCT05248191 | COMPLETED | PHASE1

23 participants

FMT for Postop Crohn's Disease

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-17
Start Date:: 2022-04-20
Completion:: 2023-12-25

Conditions

Crohn Disease

Interventions

BIOLOGICAL

No Results Yet

NCT05220241 | COMPLETED | NA

51 participants

Investigation of the Persistence of SARS-CoV-2 in the Olfactory Mucosa of Patients With Prolonged Symptoms of COVID-19

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-17
Start Date:: 2022-07-01
Completion:: 2025-06-20

Conditions

SARS-CoV-2 Infection
Cognitive Disorder

Interventions

BIOLOGICAL

No Results Yet

NCT05183165 | RECRUITING | NA

20 participants

Description of the Copper Concentration in Breast Milk in Women Treated for Wilson's Disease

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-17
Start Date:: 2022-05-11
Completion:: 2026-08-31

Conditions

Wilson's Disease

Interventions

OTHER

No Results Yet

NCT05171478 | RECRUITING

20 participants

Full-Field Optical Coherence Tomography (FFOCT) for Evaluation of Bronchoscopic Small Biopsy Specimens

Study Type:: OBSERVATIONAL
Last Updated:: 2025-12-17
Start Date:: 2021-12-09
Completion:: 2026-12-08

Conditions

Lung Cancer
Sarcoidosis

Interventions

DIAGNOSTIC_TEST

No Results Yet

NCT05166850 | RECRUITING | NA

2900 participants

Preventative Intervention for Cholera for 7 Days

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-17
Start Date:: 2021-12-22
Completion:: 2026-12-22

Conditions

Cholera
Water-Related Diseases
Diarrhea Infectious

Interventions

BEHAVIORAL
OTHER

No Results Yet

NCT05166785 | ACTIVE_NOT_RECRUITING | NA

238 participants

BRInging the Diabetes Prevention Program to GEriatric Populations

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-17
Start Date:: 2022-10-05
Completion:: 2026-05-31

Conditions

Pre Diabetes

Interventions

OTHER

No Results Yet

NCT05145309 | NOT_YET_RECRUITING | PHASE2

45 participants

Value of Potassium Magnesium Citrate in Preventing and Treating Hypertension in African Americans

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-17
Start Date:: 2026-11-15
Completion:: 2031-12-01

Conditions

Hypertension

Interventions

DRUG

No Results Yet

NCT05117255 | RECRUITING | NA

256 participants

Validating an Autonomous Interactive Internet-Based Delivery of an Empirically Supported Cognitive Behavioral Therapy for Comorbidity

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-17
Start Date:: 2022-01-04
Completion:: 2027-03-01

Conditions

Generalized Anxiety Disorder
Panic Disorder
Social Anxiety Disorder
Alcohol Use Disorder
Depression

Interventions

BEHAVIORAL

No Results Yet

NCT05114720 | COMPLETED | PHASE3

559 participants

Moxifloxacin in Adjuvant Treatment of Patients With Operable Breast Cancer

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-17
Start Date:: 2021-11-11
Completion:: 2025-11-27

Conditions

Breast Cancer

Interventions

DRUG

No Results Yet

NCT05084196 | RECRUITING | PHASE3

300 participants

Melatonin for Prevention of Kidney Injury

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-17
Start Date:: 2023-06-05
Completion:: 2027-06-01

Conditions

Acute Kidney Injury
Adverse Drug Event

Interventions

DRUG
OTHER

No Results Yet

NCT05056376 | COMPLETED | NA

368 participants

Effectiveness and Cost-Effectiveness of Fully-Automated Digital vs. Human Coach-Based Diabetes Prevention Programs

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-17
Start Date:: 2021-10-01
Completion:: 2024-12-16

Conditions

PreDiabetes
Hyperglycemia
Glucose, High Blood
Overweight
Prediabetic State
Impaired Glucose Tolerance
Obesity
Weight Loss
Lifestyle, Healthy
Lifestyle Risk Reduction
Lifestyle, Sedentary

Interventions

BEHAVIORAL

Results Available

NCT05005026 | RECRUITING | NA

250 participants

Virtual Walking Intervention for Neuropathic Pain in Spinal Cord Injury

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-17
Start Date:: 2021-11-23
Completion:: 2026-09-30

Conditions

Spinal Cord Injuries
Neuropathic Pain

Interventions

OTHER

No Results Yet

NCT04975841 | COMPLETED | NA

9 participants

Inclusion Body Myositis Treatment With Celution Processed Adipose Derived Regenerative Cells

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-17
Start Date:: 2022-03-10
Completion:: 2025-09-26

Conditions

Inclusion Body Myositis

Interventions

DEVICE

No Results Yet

NCT04971889 | ACTIVE_NOT_RECRUITING | NA

291 participants

Diabetes Medical Nutrition Therapy in Southeastern African American Women

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-17
Start Date:: 2021-08-03
Completion:: 2025-10-31

Conditions

Type 2 Diabetes

Interventions

BEHAVIORAL

No Results Yet

NCT04970810 | COMPLETED | NA

512 participants

My Diabetes, My Community

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-17
Start Date:: 2021-07-29
Completion:: 2024-10-31

Conditions

Type 2 Diabetes

Interventions

BEHAVIORAL

Results Available