Clinical Trials Updated in 2025

NCT05152927 | COMPLETED | NA

79 participants

Near Infrared Autofluorescence (NIRAF) Detection for Identifying Parathyroid Glands During Parathyroidectomy

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-15
Start Date:: 2022-01-10
Completion:: 2024-11-30

Conditions

Parathyroid Diseases
Parathyroid Dysfunction
Parathyroid Neoplasms
Parathyroid Adenoma
Hypercalcemia
Neoplasms, Glandular and Epithelial
Endocrine Gland Neoplasms
Adenoma
Hyperparathyroidism
Hyperparathyroidism, Primary

Interventions

DEVICE

Results Available

NCT05128734 | NOT_YET_RECRUITING | PHASE2

40 participants

Temozolomide Monotherapy or in Combination With Olaparib in Patients With Triple Negative Breast Cancer (TNBC)

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-15
Start Date:: 2026-04-01
Completion:: 2028-04-01

Conditions

Breast Cancer Triple Negative

Interventions

DRUG

No Results Yet

NCT05111288 | RECRUITING | NA

120 participants

Influence of Pulse Electromagnetic Field Therapy on Myocardial Ischemia

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-15
Start Date:: 2022-05-18
Completion:: 2026-08-31

Conditions

Coronary Artery Disease
Myocardial Infarction

Interventions

DEVICE

No Results Yet

NCT05095727 | ACTIVE_NOT_RECRUITING | PHASE1/PHASE2

15 participants

A Study of mRNA-3745 in Adult and Pediatric Participants With Glycogen Storage Disease Type 1a (GSD1a)

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-15
Start Date:: 2022-06-01
Completion:: 2026-11-30

Conditions

Glycogen Storage Disease

Interventions

DRUG

No Results Yet

NCT05091034 | ACTIVE_NOT_RECRUITING | NA

374 participants

CAMP Air: Efficacy and Cost-effectiveness in Urban Adolescents

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-15
Start Date:: 2021-11-08
Completion:: 2026-06-30

Conditions

Asthma

Interventions

BEHAVIORAL

No Results Yet

NCT05085366 | TERMINATED | PHASE3

7454 participants

A Study to Evaluate the Efficacy, Safety, and Immunogenicity of mRNA-1647 Cytomegalovirus (CMV) Vaccine in Healthy Participants 16 to 40 Years of Age

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-15
Start Date:: 2021-10-26
Completion:: 2025-11-04

Conditions

Cytomegalovirus Infection

Interventions

BIOLOGICAL

No Results Yet

NCT05084248 | COMPLETED | PHASE4

48 participants

Vitamin D Deficiency in Adults Following a Major Burn Injury

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-15
Start Date:: 2022-09-29
Completion:: 2025-08-18

Conditions

Vitamin D Deficiency
Burns

Interventions

DRUG

No Results Yet

NCT05077748 | COMPLETED

202 participants

An 18-year Follow-up Study on OSA in a Population-based Cohort

Study Type:: OBSERVATIONAL
Last Updated:: 2025-12-15
Start Date:: 2021-10-20
Completion:: 2025-09-30

Conditions

Epidemiology
Natural History
Obstructive Sleep Apnea
Cardiovascular Complication
Neurocognitive Dysfunction

Interventions

OTHER

No Results Yet

NCT05040360 | RECRUITING | PHASE2

141 participants

Testing the Use of Chemotherapy After Surgery for High-Risk Pancreatic Neuroendocrine Tumors

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-15
Start Date:: 2022-05-05
Completion:: 2027-03-31

Conditions

Metastatic Malignant Neoplasm in the Liver
Pancreatic Neuroendocrine Tumor
Stage I Pancreatic Neuroendocrine Tumor AJCC v8
Stage II Pancreatic Neuroendocrine Tumor AJCC v8
Stage III Pancreatic Neuroendocrine Tumor AJCC v8

Interventions

DRUG

No Results Yet

NCT04982419 | RECRUITING | PHASE2/PHASE3

240 participants

Remote Ischemic Preconditioning for Renal and Cardiac Protection in Congestive Heart Failure (RICH) Trial

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-15
Start Date:: 2021-11-01
Completion:: 2028-03-31

Conditions

Acute Kidney Injury
Heart Failure
Contrast Induced Nephropathy
Coronary Angiography
Percutaneous Coronary Intervention

Interventions

DEVICE

No Results Yet

NCT04965064 | RECRUITING | PHASE2

22 participants

Trial of Neratinib Plus Capecitabine in Subjects With HER2-Negative Metastatic Breast Cancer With Brain Metastases and Abnormally Active HER2 Signaling

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-15
Start Date:: 2022-09-23
Completion:: 2026-09-01

Conditions

Breast Cancer

Interventions

DRUG

No Results Yet

NCT04948203 | ACTIVE_NOT_RECRUITING | PHASE2/PHASE3

60 participants

Assessing the Efficacy of Sirolimus in Patients With COVID-19 Pneumonia for Prevention of Post-COVID Fibrosis

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-15
Start Date:: 2021-07-09
Completion:: 2026-12-31

Conditions

Pulmonary Fibrosis
COVID-19 Pneumonia
Long COVID

Interventions

DRUG

No Results Yet

NCT04909203 | COMPLETED | NA

56 participants

iKinnect2.0 for Juvenile Justice Involved Youth at Risk for Suicide

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-15
Start Date:: 2023-06-01
Completion:: 2025-10-21

Conditions

Child Behavior Disorders
Suicide and Self-harm

Interventions

DEVICE

No Results Yet

NCT04906460 | RECRUITING | PHASE1/PHASE2

26 participants

Open-label Study of WVE-N531 in Patients With Duchenne Muscular Dystrophy (FORWARD-53)

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-15
Start Date:: 2021-09-28
Completion:: 2026-06-27

Conditions

Duchenne Muscular Dystrophy

Interventions

DRUG

No Results Yet

NCT04884412 | COMPLETED | NA

128 participants

Deep Brain Stimulation for Parkinson's Disease: Probabilistic STN Targeting Under General Anaesthesia Without Micro-electrode Recordings vs Current Targeting Procedure

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-15
Start Date:: 2021-11-10
Completion:: 2025-11-18

Conditions

Parkinson Disease

Interventions

PROCEDURE

No Results Yet

NCT04830059 | COMPLETED | NA

93 participants

The Joint Effect of Air Pollution and Exercise on Cognitive Function

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-15
Start Date:: 2020-11-01
Completion:: 2021-10-30

Conditions

Exercise
Air Pollution
Cognition
Health Promotion

Interventions

BEHAVIORAL

No Results Yet

NCT04810689 | TERMINATED | PHASE2

10 participants

Pilot Trial of XFBD, a TCM, in Persons With COVID-19

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-15
Start Date:: 2021-03-01
Completion:: 2022-06-20

Conditions

Covid19

Interventions

DRUG
OTHER

Results Available

NCT04770532 | COMPLETED | PHASE3

526 participants

A Research Study to Compare Two Types of Insulin, a New Weekly Insulin, Insulin Icodec and an Available Daily Insulin, Insulin Degludec, in People With Type 2 Diabetes Who Use Daily Insulin

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-15
Start Date:: 2021-03-05
Completion:: 2022-01-27

Conditions

Diabetes Mellitus, Type 2

Interventions

DRUG

Results Available

NCT04738474 | COMPLETED | NA

78 participants

Assessing and Promoting Resilience in Patients With Adult Congenital Heart Disease

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-15
Start Date:: 2023-03-15
Completion:: 2024-07-25

Conditions

Congenital Heart Disease

Interventions

BEHAVIORAL
OTHER

Results Available

NCT04703179 | ENROLLING_BY_INVITATION

5000 participants

Rare and Undiagnosed Disease Research Biorepository

Study Type:: OBSERVATIONAL
Last Updated:: 2025-12-15
Start Date:: 2020-11-20
Completion:: 2026-11-30

Conditions

Undiagnosed Disease
Rare Diseases

Interventions

OTHER

No Results Yet

NCT04696575 | RECRUITING | PHASE2

28 participants

Lamivudine in Combination With Chemoimmunotherapy for the Treatment of Extensive Stage Small Cell Lung Cancer

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-15
Start Date:: 2021-07-02
Completion:: 2027-07-01

Conditions

Extensive Stage Lung Small Cell Carcinoma

Interventions

BIOLOGICAL
DRUG

No Results Yet

NCT04694079 | COMPLETED | PHASE4

104 participants

Ventricular Tachycardia Ablation and Myocardial Scar Characterization With Magnetic Resonance

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-15
Start Date:: 2020-08-03
Completion:: 2025-07-17

Conditions

Ventricular Tachycardia
Myocardial Fibrosis

Interventions

PROCEDURE

No Results Yet

NCT04690933 | COMPLETED

400 participants

AntiCMV molécules Monitoring in Real-life in Stem Cell Recipients

Study Type:: OBSERVATIONAL
Last Updated:: 2025-12-15
Start Date:: 2020-09-24
Completion:: 2025-09-24

Conditions

Hematopoietic Stem Cell Transplantation
Cytomegalovirus Infections
Antivirals
Antiviral Drug Resistance

Interventions

OTHER

No Results Yet

NCT04684862 | ACTIVE_NOT_RECRUITING | NA

100 participants

Infusion System for Hepatic Cancer

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-15
Start Date:: 2021-02-08
Completion:: 2029-07-31

Conditions

Colorectal Cancer Metastatic to Liver
Intrahepatic Cholangiocarcinoma

Interventions

DEVICE

No Results Yet

NCT04674462 | ACTIVE_NOT_RECRUITING | PHASE4

101 participants

Understanding Poor Vaccine Responses to Hepatitis B Vaccination

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-15
Start Date:: 2022-07-07
Completion:: 2026-07-31

Conditions

Vaccine Reaction

Interventions

BIOLOGICAL

No Results Yet

NCT04580446 | COMPLETED | PHASE1

24 participants

HYHOPE: De-intensified Hypofractionated Radiation Therapy for HPV-associated Oropharynx Cancer

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-15
Start Date:: 2020-12-03
Completion:: 2024-12-20

Conditions

Human Papillomavirus-Related Carcinoma
Oropharyngeal Cancer

Interventions

RADIATION

Results Available

NCT04563507 | RECRUITING | PHASE2

102 participants

Combined Immunotherapies in Metastatic ER+ Breast Cancer

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-15
Start Date:: 2020-11-12
Completion:: 2027-10-31

Conditions

Breast Cancer

Interventions

RADIATION
DRUG

No Results Yet

NCT04520347 | ENROLLING_BY_INVITATION

10000 participants

IVTCC 2.0: A Prospective Multicenter Ventricular Tachycardia Catheter Ablation Registry

Study Type:: OBSERVATIONAL
Last Updated:: 2025-12-15
Start Date:: 2018-12-01
Completion:: 2026-12-31

Conditions

Ventricular Arrhythmia
Ventricular Tachycardia
Premature Ventricular Contraction (PVC)
Cardiomyopathy

No Results Yet

NCT04390399 | ACTIVE_NOT_RECRUITING | PHASE2

328 participants

Combination Immunotherapy Plus Standard-of-Care Chemotherapy Versus Standard-of-Care Chemotherapy for the Treatment of Locally Advanced or Metastatic Pancreatic Cancer

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-15
Start Date:: 2020-07-21
Completion:: 2025-10-13

Conditions

Pancreatic Cancer

Interventions

BIOLOGICAL
DRUG
PROCEDURE

No Results Yet

NCT04389827 | COMPLETED

5999 participants

Global Kidney Patient Trials Network

Study Type:: OBSERVATIONAL
Last Updated:: 2025-12-15
Start Date:: 2020-05-05
Completion:: 2025-04-30

Conditions

Kidney Diseases

No Results Yet

NCT04387305 | NOT_YET_RECRUITING | PHASE3

2000 participants

Traumatic Injury Clinical Trial Evaluating Tranexamic Acid in Children: An Efficacy Study

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-15
Start Date:: 2026-10-01
Completion:: 2031-03-31

Conditions

Brain Injuries, Traumatic
Wounds and Injury
Hemorrhage
Trauma Injury

Interventions

DRUG

No Results Yet

NCT04338516 | COMPLETED | NA

54 participants

Ridge Preservation Using a Ossix™ Bone vs Bio-Oss® Collagen

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-15
Start Date:: 2019-11-01
Completion:: 2021-12-30

Conditions

TEETH EXTRACTION

Interventions

DEVICE

Results Available

NCT04318145 | TERMINATED | PHASE2

15 participants

Study to Evaluate Sex Differences in the Acute Effects of PL-3994 in Heart Failure Subjects

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-15
Start Date:: 2020-11-12
Completion:: 2023-12-08

Conditions

Heart Failure With Preserved Ejection Fraction

Interventions

DRUG

No Results Yet

NCT04274140 | ACTIVE_NOT_RECRUITING

260 participants

Maternal Obesity and Offspring Neurodevelopment

Study Type:: OBSERVATIONAL
Last Updated:: 2025-12-15
Start Date:: 2019-10-03
Completion:: 2026-08-30

Conditions

Healthy

No Results Yet

NCT04268199 | RECRUITING | PHASE2

100 participants

A Multicentre, Non-Blinded Study Exploring Self-Administration of Chemotherapy in the Home Environment

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-15
Start Date:: 2020-05-29
Completion:: 2026-12-31

Conditions

Myeloma
Myeloma Multiple

Interventions

DRUG

No Results Yet

NCT04259411 | COMPLETED | NA

51 participants

MitraClip China PMS

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-15
Start Date:: 2021-12-06
Completion:: 2024-05-29

Conditions

Mitral Regurgitation

Interventions

DEVICE

Results Available

NCT04242134 | ACTIVE_NOT_RECRUITING | NA

784 participants

Drug-coating Balloon Angioplasties for True Coronary Bifurcation Lesions

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-15
Start Date:: 2020-09-08
Completion:: 2024-06-27

Conditions

Coronary Artery Disease

Interventions

DEVICE

No Results Yet

NCT04210089 | RECRUITING | NA

100 participants

Total Contact Soft Cast in Diabetic Foot Ulcers

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-15
Start Date:: 2020-10-13
Completion:: 2026-10-01

Conditions

Diabetic Foot Ulcer
Diabetes Mellitus
Foot Ulcer
Foot Ulcer, Diabetic
Ulcer
Ulcer Foot
Ulcer, Leg
Ankle Ulcer

Interventions

DEVICE

No Results Yet

NCT04198623 | COMPLETED | PHASE2

40 participants

Efficacy of Montelukast in Reducing the Incidence and Severity of Monoclonal Antibodies Associated Infusion Reactions

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-15
Start Date:: 2020-03-20
Completion:: 2024-07-31

Conditions

Infusion Reaction
Monoclonal Antibody

Interventions

DRUG

Results Available

NCT04187027 | ACTIVE_NOT_RECRUITING | NA

40 participants

Efficacy Of Pulsed Electromagnetic Field Therapy On Neurogenic Bladder in Children With Myelomeningocele

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-15
Start Date:: 2025-05-27
Completion:: 2025-11-19

Conditions

Neurogenic Bladder

Interventions

DEVICE

No Results Yet