Clinical Trials Updated in 2025

NCT05427578 | COMPLETED

90 participants

Brain Markers of Depression Vulnerability: the Case of Prefrontal Haemodynamic Response

Study Type:: OBSERVATIONAL
Last Updated:: 2025-12-11
Start Date:: 2021-08-01
Completion:: 2024-11-29

Conditions

Depression

Interventions

OTHER

No Results Yet

NCT05406024 | COMPLETED

30 participants

Feasibility Study CORPPS

Study Type:: OBSERVATIONAL
Last Updated:: 2025-12-11
Start Date:: 2023-04-03
Completion:: 2024-04-19

Conditions

Esophageal Neoplasm
Laryngeal Neoplasms

Interventions

DEVICE

No Results Yet

NCT05384860 | COMPLETED | NA

484 participants

Incorporating Acupuncture Into ERAS for Ambulatory Total Hip Replacement (THR) Surgery

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-11
Start Date:: 2022-07-06
Completion:: 2025-04-04

Conditions

Acupuncture
Hip Surgery
Opioid Use

Interventions

DEVICE
OTHER

No Results Yet

NCT05363527 | COMPLETED | PHASE1

40 participants

Aging and Reward System Response to Inflammation and Anxiety Study

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-11
Start Date:: 2023-03-29
Completion:: 2025-12-08

Conditions

Anhedonia
Inflammation
Anxiety
Aging
Depression

Interventions

BIOLOGICAL

No Results Yet

NCT05340270 | ACTIVE_NOT_RECRUITING | PHASE2

150 participants

PD-1 Inhibitor Plus GP as Neoadjuvant Therapy for Locoregionally Advanced Nasopharyngeal Carcinoma

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-11
Start Date:: 2022-07-15
Completion:: 2026-03-29

Conditions

Nasopharyngeal Carcinoma
Neoadjuvant Therapy
PD-1 Inhibitor

Interventions

DRUG

No Results Yet

NCT05330338 | ACTIVE_NOT_RECRUITING | NA

600 participants

Genetics of Ventriculo-arterial Discordance

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-11
Start Date:: 2022-09-07
Completion:: 2025-06-24

Conditions

Heart Defects, Congenital

Interventions

BIOLOGICAL

No Results Yet

NCT05320692 | ACTIVE_NOT_RECRUITING | PHASE3

423 participants

A Study of TACE Combined With Camrelizumab Plus Rivoceranib (Apatinib) in Patients With Incurable Hepatocellular Carcinoma

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-11
Start Date:: 2022-08-09
Completion:: 2026-07-30

Conditions

Hepatocellular Carcinoma

Interventions

DRUG
PROCEDURE

No Results Yet

NCT05274815 | COMPLETED | PHASE3

305 participants

Study to Evaluate Efficacy and Safety of Tezepelumab in Reducing Oral Corticosteroid Use in Adult Patients With Severe Asthma

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-11
Start Date:: 2022-05-17
Completion:: 2024-09-09

Conditions

Asthma

Interventions

BIOLOGICAL

Results Available

NCT05235100 | COMPLETED | PHASE2

30 participants

Preoperative IMRT With Concurrent Apatinib for Localised Extremity or Trunk Sarcoma （SPARE-02）

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-11
Start Date:: 2021-09-01
Completion:: 2024-08-31

Conditions

Sarcoma,Soft Tissue
Extremity
Trunk
Intensity-modulated Radiotherapy
Targetd Therapy
Major Wound Complications

Interventions

DRUG

No Results Yet

NCT05224934 | RECRUITING | NA

50 participants

Preoperative Ultra-hypofractionated Radiotherapy Followed by Surgery for Retroperitoneal Sarcoma (FUSION-01)

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-11
Start Date:: 2022-01-01
Completion:: 2027-12-31

Conditions

Soft Tissue Sarcoma
Retroperitoneal Sarcoma
Radiotherapy Side Effect
Ultra-hypofractionated Radiotherapy
Stereotactic Ablative Radiotherapy

Interventions

RADIATION

No Results Yet

NCT05187897 | RECRUITING | NA

3000 participants

CHV-NEO: Community-based Digital Communication to Support Neonatal Health

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-11
Start Date:: 2024-01-10
Completion:: 2026-06-30

Conditions

Neonatal Death
Perinatal Death

Interventions

BEHAVIORAL

No Results Yet

NCT05183074 | RECRUITING | NA

50 participants

MR-linac Guided Ultra-hypofractionated RT for Prostate Cancer (SMART-P01 and SMART-P02)

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-11
Start Date:: 2021-02-01
Completion:: 2027-12-31

Conditions

Prostate Cancer
Radiotherapy Side Effect
Magnetic Resonance-linac
Stereotactic Ablative RT
Adaptive Radiotherapy
Localised Disease
Oligometastatic Disease

Interventions

DEVICE

No Results Yet

NCT05171777 | COMPLETED | PHASE2

179 participants

A Study to Evaluate Participant and Healthcare Professional Reported Preference for Subcutaneous Atezolizumab Compared With Intravenous Atezolizumab Formulation in Participants With Non-Small Cell Lung Cancer

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-11
Start Date:: 2022-04-04
Completion:: 2023-11-09

Conditions

Non-small Cell Lung Cancer

Interventions

DRUG

Results Available

NCT05144373 | COMPLETED | NA

51 participants

Role of Early Motor Experience in Infants With Down Syndrome

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-11
Start Date:: 2022-01-01
Completion:: 2025-08-31

Conditions

Down Syndrome

Interventions

BEHAVIORAL

No Results Yet

NCT05142475 | RECRUITING | EARLY_PHASE1

50 participants

A Study of GC101 TIL in Advanced Breast Cancer (10hospital)

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-11
Start Date:: 2021-11-19
Completion:: 2026-12-20

Conditions

Breast Cancer
Treatment Side Effects
Advanced Breast Cancer
Effects of Immunotherapy

Interventions

BIOLOGICAL

No Results Yet

NCT05131828 | COMPLETED | PHASE2

70 participants

CCMR Two: A Phase IIa, Randomised, Double-blind, Placebo-controlled Trial of the Ability of the Combination of Metformin and Clemastine to Promote Remyelination in People With Relapsing-remitting Multiple Sclerosis Already on Disease-modifying Therapy

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-11
Start Date:: 2022-03-08
Completion:: 2025-03-31

Conditions

Multiple Sclerosis

Interventions

DRUG

No Results Yet

NCT05116384 | RECRUITING | NA

50 participants

Renal Denervation + PVI vs PVI Alone for Persistent AF

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-11
Start Date:: 2023-07-30
Completion:: 2026-06-30

Conditions

Atrial Fibrillation

Interventions

DEVICE

No Results Yet

NCT05098197 | RECRUITING | EARLY_PHASE1

50 participants

A Study of GC101 TIL in Advanced Hepatobiliary-Pancreatic Cancers (10hospital)

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-11
Start Date:: 2021-09-26
Completion:: 2026-09-25

Conditions

Advanced Liver Cancers
Tumor Infiltrating Lymphocyte
Treatment Side Effects
Effects of Immunotherapy
Advanced Pancreatic Cancers

Interventions

BIOLOGICAL

No Results Yet

NCT05098184 | RECRUITING | EARLY_PHASE1

50 participants

A Study of GC101 TIL in Advanced Melanoma (10hospital)

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-11
Start Date:: 2021-09-26
Completion:: 2026-09-25

Conditions

Advanced Melanoma
Tumor Infiltrating Lymphocyte
Treatment Side Effects
Effects of Immunotherapy

Interventions

BIOLOGICAL

No Results Yet

NCT05098171 | RECRUITING | EARLY_PHASE1

50 participants

A Study of GC201 TIL in Advanced Gynecologic Tumors (10hospital)

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-11
Start Date:: 2021-09-26
Completion:: 2026-09-25

Conditions

Advanced Gynecologic Tumors
Signal Switch Receptor Modified TIL
Treatment Side Effects
Effects of Immunotherapy

Interventions

BIOLOGICAL

No Results Yet

NCT05063981 | COMPLETED

15 participants

Treatment With Mepolizumab on Patients With Severe Refractory Eosinophilic Asthma

Study Type:: OBSERVATIONAL
Last Updated:: 2025-12-11
Start Date:: 2021-11-25
Completion:: 2023-09-29

Conditions

Severe Eosinophilic Asthma

Interventions

DRUG

No Results Yet

NCT05043025 | COMPLETED | NA

116 participants

Patient Positions for Locating the Cricothyroid Membrane

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-11
Start Date:: 2022-07-01
Completion:: 2024-12-30

Conditions

Cricothyroid Membrane

Interventions

OTHER

No Results Yet

NCT05028712 | RECRUITING | NA

36 participants

Development of a Multi-sensory Rehabilitation Program for People With Ultra Low Vision

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-11
Start Date:: 2024-03-08
Completion:: 2026-01-31

Conditions

Low Vision Blindness
Visual Impairment
Quality of Life
Functional Visual Loss

Interventions

BEHAVIORAL

No Results Yet

NCT04941456 | COMPLETED | NA

26 participants

Does Endurance Improve With the Use of Passy-Muir Valve for Patients With Tracheostomy?

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-11
Start Date:: 2021-07-29
Completion:: 2024-06-24

Conditions

PMV
Exercise Endurance
Tracheostomy

Interventions

OTHER
DEVICE

Results Available

NCT04938206 | TERMINATED | NA

63 participants

DIStinguishing ChildrEn at Low Risk of Severe infectioN in Case of Febrile Neutropenia-7: Impact Study of a Clinical Decision Rule

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-11
Start Date:: 2021-01-27
Completion:: 2024-10-10

Conditions

Neutropenia, Febrile

Interventions

PROCEDURE

No Results Yet

NCT04898543 | ACTIVE_NOT_RECRUITING | PHASE1

50 participants

QUILT-3.076: Study of Autologous M-CENK in Subjects With Locally Advanced or Metastatic Solid Tumors

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-11
Start Date:: 2021-06-21
Completion:: 2026-05-31

Conditions

Metastatic Solid Tumor

Interventions

BIOLOGICAL
OTHER

No Results Yet

NCT04840888 | COMPLETED | PHASE1

82 participants

A Study of LY3484356 in Healthy Female Participants

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-11
Start Date:: 2021-04-26
Completion:: 2022-04-12

Conditions

Healthy

Interventions

DRUG

Results Available

NCT04823650 | COMPLETED

87 participants

Monitoring Activity And Gait In Children

Study Type:: OBSERVATIONAL
Last Updated:: 2025-12-11
Start Date:: 2021-08-23
Completion:: 2024-10-28

Conditions

Child, Preschool
Child
Adolescent

Interventions

DEVICE

Results Available

NCT04811027 | COMPLETED | PHASE2

171 participants

Combination Study With Eftilagimod Alpha (a Soluble LAG-3 Fusion Protein) and Pembrolizumab in Patients With Recurrent or Metastatic HNSCC

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-11
Start Date:: 2021-08-27
Completion:: 2024-03-11

Conditions

HNSCC

Interventions

DRUG

No Results Yet

NCT04798781 | COMPLETED | PHASE2

16 participants

Safety and Efficacy of Telatinib in Combination With Keytruda in Subjects With Advanced Stomach and Gastroesophageal Junction Cancers or Hepatocellular Carcinoma

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-11
Start Date:: 2021-07-28
Completion:: 2024-02-14

Conditions

Gastric Cancer
Hepatocellular Carcinoma

Interventions

DRUG

Results Available

NCT04793685 | RECRUITING | PHASE2

150 participants

Prazosin for Alcohol Use Disorder With Withdrawal Symptoms

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-11
Start Date:: 2021-07-01
Completion:: 2026-06-30

Conditions

Alcohol Withdrawal

Interventions

DRUG
BEHAVIORAL

No Results Yet

NCT04752293 | RECRUITING

125 participants

Pediatric Hypertension and the Renin-Angiotensin SystEm (PHRASE)

Study Type:: OBSERVATIONAL
Last Updated:: 2025-12-11
Start Date:: 2021-05-19
Completion:: 2026-12-31

Conditions

Hypertension
Left Ventricular Hypertrophy
Left Ventricular Dysfunction
Left Atrial Dilatation
Left Ventricular Diastolic Dysfunction
Kidney Diseases
Kidney Injury
Kidney Dysfunction
Sodium Urine High
Blood Pressure Disorders
Uric Acid Retention
Angiotensin Hypertension
Autonomic Dysfunction
Autonomic Imbalance
Pediatric Kidney Disease
Pediatric Obesity
Proteinuria
Albuminuria

No Results Yet

NCT04742621 | RECRUITING

20 participants

Liver Transplantation for Unresectable Liver Limited Colorectal Metastases

Study Type:: OBSERVATIONAL
Last Updated:: 2025-12-11
Start Date:: 2020-09-30
Completion:: 2034-07-27

Conditions

Unresectable Liver-limited Colorectal Metastases

Interventions

PROCEDURE

No Results Yet

NCT04686786 | TERMINATED | PHASE2

105 participants

An Open-label Extension Trial of CVL-865 as Adjunctive Therapy in the Treatment of Focal Onset Seizures

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-11
Start Date:: 2020-12-08
Completion:: 2024-12-05

Conditions

Seizures

Interventions

DRUG

Results Available

NCT04665271 | COMPLETED | NA

453 participants

Acceptability and Efficacy of Zemedy App Versus Education and Relaxation Training App for IBS

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-11
Start Date:: 2021-03-01
Completion:: 2023-12-30

Conditions

Irritable Bowel Syndrome

Interventions

BEHAVIORAL

No Results Yet

NCT04540497 | ACTIVE_NOT_RECRUITING | PHASE3

135 participants

A Study of Inebilizumab Efficacy and Safety in IgG4- Related Disease

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-11
Start Date:: 2020-12-04
Completion:: 2024-04-09

Conditions

IgG4 Related Disease

Interventions

DRUG
OTHER

Results Available

NCT04497428 | TERMINATED | NA

160 participants

Sensory Basis of Speech Motor Learning

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-11
Start Date:: 2019-08-01
Completion:: 2025-07-31

Conditions

Speech
Consolidation

Interventions

BEHAVIORAL
OTHER

No Results Yet

NCT04483466 | ACTIVE_NOT_RECRUITING | PHASE3

150 participants

Methotrexate Treatment of Arthritis Caused by Chikungunya Virus (MARCH)

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-11
Start Date:: 2023-07-18
Completion:: 2027-08-30

Conditions

Investigate the Effect(s) of Methotrexate Treatment on Arthritis Disease Severity

Interventions

DRUG

No Results Yet

NCT04402632 | COMPLETED | NA

600 participants

Embolization of the Middle Meningeal Artery With ONYX™ Liquid Embolic System for Subacute and Chronic Subdural Hematoma

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-11
Start Date:: 2020-10-27
Completion:: 2024-12-19

Conditions

Subdural Hematoma

Interventions

PROCEDURE
DEVICE
OTHER

No Results Yet

NCT04400591 | AVAILABLE

Nonconforming Lisocabtagene Maraleucel Expanded Access Protocol

Study Type:: EXPANDED_ACCESS
Last Updated:: 2025-12-11

Conditions

Lymphoma, Large B-Cell, Diffuse

Interventions

BIOLOGICAL

No Results Yet