Clinical Trials Updated in 2025

NCT07270159 | COMPLETED | NA

75 participants

Effect of Probiotics, Double Antibiotic Paste, and Calcium Hydroxide on Postoperative Pain in Irreversible Pulpitis: A Randomized Trial

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-08
Start Date:: 2025-06-01
Completion:: 2025-10-30

Conditions

Root Canal Treatment
Irreversible Pulpitis With Apical Periodontitis
Pulpitis - Irreversible
Post Operative Pain, Acute

Interventions

DRUG

No Results Yet

NCT07270146 | COMPLETED | PHASE4

360 participants

Effectiveness and Safety of Guilu Erxian Oral Liquid in the Treatment of Oligozoospermia and Asthenospermia With Syndrome of Shen (Kidney) Essence Deficiency

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-08
Start Date:: 2022-10-08
Completion:: 2025-02-10

Conditions

Mild and Moderate Oligozoospermia Asthenospermia or Oligoasthenospermia and the Syndrome Differentiation Type is Shen (Kidney) Essence Deficiency

Interventions

DRUG

No Results Yet

NCT07270120 | NOT_YET_RECRUITING | PHASE1

30 participants

Senolytics for Secondary Progressive MS

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-08
Start Date:: 2026-01-15
Completion:: 2027-01-15

Conditions

Multiple Sclerosis (MS) Secondary Progressive

Interventions

DRUG

No Results Yet

NCT07270107 | COMPLETED | NA

20 participants

Bobath Instruction in Physiotherapy: Virtual Reality Versus Traditional Methods

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-08
Start Date:: 2025-05-01
Completion:: 2025-05-28

Conditions

Physical Therapy
Education
Virtual Reality
Neurorehabilitation

Interventions

DEVICE
OTHER

No Results Yet

NCT07270094 | COMPLETED | NA

84 participants

Effect of Dual Task in Aquatic Physical Therapy in Older Adults

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-08
Start Date:: 2025-04-21
Completion:: 2025-08-29

Conditions

Healthy Older Adults

Interventions

BEHAVIORAL

No Results Yet

NCT07270055 | NOT_YET_RECRUITING | NA

56 participants

Swaddy, a Neonatal Positioning Device.

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-08
Start Date:: 2025-12-31
Completion:: 2027-12-31

Conditions

Stress

Interventions

DEVICE

No Results Yet

NCT07270042 | NOT_YET_RECRUITING | NA

20 participants

Evaluation the Efficacy of Zinc on Botulinum Toxin A Injection

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-08
Start Date:: 2025-12-01
Completion:: 2026-09-01

Conditions

Hyperactive Masseter Muscle

Interventions

DRUG

No Results Yet

NCT07270003 | RECRUITING | NA

60 participants

A Prospective, Single-arm, Open-label Clinical Trial to Evaluate the Efficacy and Safety of Ivarmacitinib in the Treatment of Palmoplantar Pustulosis

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-08
Start Date:: 2025-10-01
Completion:: 2026-10-01

Conditions

Palmoplantar Pustulosis (PPP)

Interventions

DRUG

No Results Yet

NCT07269964 | RECRUITING | NA

30 participants

At-Home tDCS as Maintenance Therapy

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-08
Start Date:: 2024-10-01
Completion:: 2026-08-29

Conditions

MDD
Severe Depression
Major Depressive Episode

Interventions

DEVICE

No Results Yet

NCT07269951 | COMPLETED

95 participants

The Bone Thickness of Infrazygomatic Crest Was Measured on CBCTs

Study Type:: OBSERVATIONAL
Last Updated:: 2025-12-08
Start Date:: 2025-09-24
Completion:: 2025-09-30

Conditions

Miniscrew Placement

No Results Yet

NCT07269912 | NOT_YET_RECRUITING

400 participants

Application of Multimodal MRI in Histological Grading and Prognostic Assessment of Rectal Cancer

Study Type:: OBSERVATIONAL
Last Updated:: 2025-12-08
Start Date:: 2027-11-01
Completion:: 2027-11-01

Conditions

Rectal Neoplasms
Prognosis

Interventions

DIAGNOSTIC_TEST

No Results Yet

NCT07269899 | RECRUITING | PHASE1

12 participants

A Phase I Study of WTX212A Monotherapy or in Combination With Radiotherapy in Patients With Advanced Solid Tumors

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-08
Start Date:: 2025-11-25
Completion:: 2027-02-28

Conditions

Solid Tumor Cancer
Cancer

Interventions

DRUG
RADIATION

No Results Yet

NCT07269886 | COMPLETED

79 participants

BIOMARKERS FOR DRUG SELECTION IN DEPRESSION

Study Type:: OBSERVATIONAL
Last Updated:: 2025-12-08
Start Date:: 2022-08-18
Completion:: 2022-10-16

Conditions

Depression - Major Depressive Disorder

No Results Yet

NCT07269860 | COMPLETED | NA

27 participants

Impact of Osteopathic Manipulative Medicine on Sentinal Lymph Node Biopsy Dye and Tracer Uptake

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-08
Start Date:: 2025-07-09
Completion:: 2025-10-30

Conditions

Breast Cancer

Interventions

PROCEDURE

No Results Yet

NCT07269691 | NOT_YET_RECRUITING | PHASE3

194 participants

RaSOLVE: 125I Radioactive Seed Marking Effects on Pathological Complete Response Rate and Prognosis Post-Neoadjuvant Therapy in Early/Advanced Breast Cancer

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-08
Start Date:: 2025-12-01
Completion:: 2027-12-01

Conditions

Breast Cancer Early Stage Breast Cancer (Stage 1-3)
Breast Cancer

Interventions

DEVICE
DRUG

No Results Yet

NCT07269639 | NOT_YET_RECRUITING | PHASE1/PHASE2

20 participants

Golcadomide, Poseltinib, and Rituximab for Relapsed/Refractory Diffuse Large B-cell Lymphoma

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-08
Start Date:: 2026-01-01
Completion:: 2027-12-01

Conditions

Large B-Cell Lymphoma (LBCL)

Interventions

DRUG

No Results Yet

NCT07269626 | RECRUITING | PHASE2

47 participants

PULSAR in Systemic Therapy for Pancreatic Cancer

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-08
Start Date:: 2025-11-14
Completion:: 2027-12-31

Conditions

Locally Advanced Pancreatic Ductal Adenocarcinoma
Borderline Resectable Pancreatic Ductal Adenocarcinoma
Oligometastatic Pancreatic Ductal Adenocarcinoma

Interventions

RADIATION

No Results Yet

NCT07269574 | NOT_YET_RECRUITING

600 participants

Impact of Dietary Patterns on Prognosis of Ovarian Cancer Patients During PARPi Maintenance

Study Type:: OBSERVATIONAL
Last Updated:: 2025-12-08
Start Date:: 2025-11-27
Completion:: 2026-11-30

Conditions

Ovarian Cancer
Fallopian Tube Cancers
Primary Peritoneal Carcinoma
High-grade Serous Ovarian Cancer

No Results Yet

NCT07269561 | RECRUITING

50000 participants

Headache Registration and Followup Initiated by Tongji Hospital, HUST

Study Type:: OBSERVATIONAL
Last Updated:: 2025-12-08
Start Date:: 2024-01-01
Completion:: 2028-12-31

Conditions

Headache
Comorbidities

No Results Yet

NCT07269548 | RECRUITING

30 participants

Evaluation of the Healing of the Pilonidal Cyst After 1940 nm Laser Treatment

Study Type:: OBSERVATIONAL
Last Updated:: 2025-12-08
Start Date:: 2025-10-03
Completion:: 2026-06-30

Conditions

Pilonidal Cyst/Fistula

Interventions

PROCEDURE

No Results Yet

NCT07269535 | NOT_YET_RECRUITING

500 participants

A Prospective Validation Study of Radiomics in the Differential Diagnosis of Uterine Leiomyoma and Uterine Sarcoma

Study Type:: OBSERVATIONAL
Last Updated:: 2025-12-08
Start Date:: 2025-11-30
Completion:: 2050-01-01

Conditions

Uterine Fibroid
Uterine Sarcoma
AI (Artificial Intelligence)
Radiomic
Prospective Observational Study
MRI

Interventions

OTHER

No Results Yet

NCT07269522 | COMPLETED | NA

60 participants

Arthroscopic Anterior Cruciate Ligament Reconstruction by Hamstring Graft With and Without Platelet-Rich Plasma

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-08
Start Date:: 2022-01-15
Completion:: 2023-06-30

Conditions

Anterior Cruciate Ligament Injury

Interventions

PROCEDURE

No Results Yet

NCT07269509 | NOT_YET_RECRUITING | NA

276 participants

Evaluation of the Efficacy and Safety of an Intensified Strategy of Intratonsillar Immunotherapy (ITIT) for Allergic Rhinitis: A Multicenter, Randomized, Double-blind, Controlled Trial

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-08
Start Date:: 2025-12-30
Completion:: 2028-12-31

Conditions

Allergic Rhinitis

Interventions

PROCEDURE

No Results Yet

NCT07269431 | WITHHELD

[Trial of device that is not approved or cleared by the U.S. FDA]

Last Updated:: 2025-12-08

No Results Yet

NCT07269418 | ACTIVE_NOT_RECRUITING

36 participants

Optimization of Conoid Anatomical Reconstruction During Ligamentoplasty for Acromioclavicular Disjunction

Study Type:: OBSERVATIONAL
Last Updated:: 2025-12-08
Start Date:: 2024-03-28
Completion:: 2028-03-31

Conditions

Acromioclavicular; Dislocation
Ligament Repair or Reconstruction

No Results Yet

NCT07269379 | RECRUITING | NA

108 participants

Intradialytic Exercise With Blood Flow Restriction in Hemodialysis Patients

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-08
Start Date:: 2025-11-06
Completion:: 2028-05-06

Conditions

Dialysis Patients

Interventions

OTHER

No Results Yet

NCT07269314 | RECRUITING

200 participants

Introduction of Polymerase Chain Reaction (PCR) in Microbiology and Parasitology

Study Type:: OBSERVATIONAL
Last Updated:: 2025-12-08
Start Date:: 2023-09-01
Completion:: 2026-09-01

Conditions

Malaria, Pneumocystis, Leishmania

No Results Yet

NCT07269288 | NOT_YET_RECRUITING

1500 participants

The Correlation and Mechanistic Study of GGCX Gene With Prognosis in Acute Ischemic Stroke

Study Type:: OBSERVATIONAL
Last Updated:: 2025-12-08
Start Date:: 2026-01-25
Completion:: 2026-08-31

Conditions

Acute Ischemic Stroke

Interventions

COMBINATION_PRODUCT

No Results Yet

NCT07269249 | RECRUITING

50 participants

Real-world Efficacy and Safety of Neoadjuvant Dostarlimab in Patients With dMMR/MSI-H Locally Advanced Rectal Cancer

Study Type:: OBSERVATIONAL
Last Updated:: 2025-12-08
Start Date:: 2025-09-01
Completion:: 2027-01-31

Conditions

Locally Advanced Rectal Cancer (LARC)

Interventions

DRUG

No Results Yet

NCT07269236 | ENROLLING_BY_INVITATION

2000 participants

Prospective Real-World Study of Multimodal AI

Study Type:: OBSERVATIONAL
Last Updated:: 2025-12-08
Start Date:: 2025-10-01
Completion:: 2030-09-30

Conditions

Pancancer

No Results Yet

NCT07269197 | COMPLETED

67 participants

Association of SGLT2 Inhibitors Therapy With Elastographic and Molecular Markers of Liver Injury in Type 2 Diabetes

Study Type:: OBSERVATIONAL
Last Updated:: 2025-12-08
Start Date:: 2024-03-22
Completion:: 2025-10-10

Conditions

Non-Alcoholic Fatty Liver Disease
Diabetes Mellitus, Type 2

Interventions

DRUG

No Results Yet

NCT07269184 | NOT_YET_RECRUITING | NA

60 participants

Impact of Ultrasound Guidance on Central Neuraxial Block Success in Patients With Non-Palpable Vertebral Anatomy

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-08
Start Date:: 2025-12-01
Completion:: 2026-03-01

Conditions

Epidural Analgesia
Ultrasound Assistance

Interventions

PROCEDURE

No Results Yet

NCT07269171 | NOT_YET_RECRUITING | NA

15 participants

The Effect of Supplementary Foods Containing Trypsin, Chymotrypsin and Serratia Peptidase on Healing After Impacted Wisdom Tooth Surgery

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-08
Start Date:: 2025-12-01
Completion:: 2026-02-28

Conditions

Oral Health Care

Interventions

PROCEDURE

No Results Yet

NCT07269158 | NOT_YET_RECRUITING | PHASE1/PHASE2

160 participants

A Phase IIb Randomized Clinical Trial of Immune Checkpoint Inhibitor-based Maintenance Therapy in Patients With Advanced Biliary Tract Cancer

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-08
Start Date:: 2025-12-31
Completion:: 2029-09-30

Conditions

Biliary Tract Neoplasms
Advanced Cancer
Immunotherapy

Interventions

DRUG

No Results Yet

NCT07269132 | ENROLLING_BY_INVITATION | NA

50 participants

Applying the ADDIE Model to Develop a Multimedia Program to Enhance Chemotherapy Knowledge and Self-Efficacy Among Intensive Care Unit Nurses

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-08
Start Date:: 2025-11-01
Completion:: 2026-07-30

Conditions

Nurse
Self-Efficacy
eLearning
Chemotherapy
ICU

Interventions

OTHER

No Results Yet

NCT07269067 | NOT_YET_RECRUITING

60 participants

Automated vs Manual Flow-cytometry Gating for Measurable Residual Disease in Acute Myeloid Leukaemia (DUALFLOW)

Study Type:: OBSERVATIONAL
Last Updated:: 2025-12-08
Start Date:: 2026-01-31
Completion:: 2027-07-31

Conditions

Leukemia, Myeloid, Acute

Interventions

DIAGNOSTIC_TEST

No Results Yet

NCT07269028 | COMPLETED | NA

248 participants

Personalised and Gamification-based Decision Aid (DA): a Randomized Controlled Pilot Study About Colorectal Cancer (CRC) Screening

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-08
Start Date:: 2023-05-15
Completion:: 2024-12-31

Conditions

Colo-rectal Cancer

Interventions

OTHER

No Results Yet

NCT07269015 | NOT_YET_RECRUITING | NA

66 participants

CGM Accuracy in Pregnancy Study

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-08
Start Date:: 2025-12-31
Completion:: 2026-12-31

Conditions

Pregestational Diabetes
Continuous Glucose Monitoring

Interventions

DEVICE
PROCEDURE

No Results Yet

NCT07269002 | COMPLETED | NA

3600 participants

Clinical Pharmacist Impact Study

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-08
Start Date:: 2025-03-15
Completion:: 2025-09-15

Conditions

Medication Safety
Preventable Medication Harm
Pharmacotherapy Optimization

Interventions

OTHER

No Results Yet

NCT07268976 | COMPLETED | NA

30 participants

Jackfruit Effects on Adipokines and Cognition in Boxers

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-08
Start Date:: 2025-01-07
Completion:: 2025-02-10

Conditions

Exercise Physiology
Cognitive Function
Adipokine Response
Brain-Derived Neurotrophic Factor (BDNF)
Irisin
Omentin-1

Interventions

DIETARY_SUPPLEMENT

No Results Yet