Impact of Dietary Patterns on Prognosis of Ovarian Cancer Patients During PARPi Maintenance

Summary

The goal of this retrospective observational study is to evaluate the relationship between different dietary patterns (specifically low-carbohydrate diets) and the prognosis of patients with high-grade serous ovarian cancer (HGSOC) receiving first-line PARP inhibitor (PARPi) maintenance therapy. The main questions it aims to answer are:

* Is there an association between dietary patterns and patients' Progression-Free Survival (PFS)?
* Is there an association between dietary patterns and Overall Survival (OS)? This is a multicenter, retrospective cohort study. Researchers will review electronic medical records from 14 tertiary hospitals in China to identify women who received first-line PARP inhibitor maintenance for advanced high-grade serous ovarian cancer between 2020 and 2025, and collect information on baseline characteristics, treatments and follow-up outcomes.

Researchers will compare patients with a "low-carbohydrate diet pattern" to those with a "regular/high-carbohydrate diet pattern" to see if there are differences in treatment outcomes and survival.

Participants will:

* Have their clinical, pathological, and treatment data collected from electronic medical records.
* Complete a retrospective Food Frequency Questionnaire (FFQ) via phone or clinic visit to recall their dietary habits during the maintenance treatment period.
* Optionally provide a blood sample for nutrition and metabolic analysis. (For participants at the main study center only) No experimental drugs or specific diets will be given in this study. All anti-cancer treatments are decided by the treating physicians as part of routine clinical care.

Conditions

• Ovarian Cancer
• Fallopian Tube Cancers
• Primary Peritoneal Carcinoma
• High-grade Serous Ovarian Cancer

Sponsors & Collaborators

• West China Second University Hospital

  collaborator OTHER

• Peking University People's Hospital

  collaborator OTHER

• Cancer Hospital Chinese Academy of Medical Science, Shenzhen Center

  collaborator OTHER

• Union Hospital, Tongji Medical College, Huazhong University of Science and Technology

  collaborator OTHER

• The Affiliated Hospital of Qingdao University

  collaborator OTHER

• Qilu Hospital of Shandong University

  collaborator OTHER

• Shanghai First Maternity and Infant Hospital

  collaborator OTHER

• First Affiliated Hospital, Sun Yat-Sen University

  collaborator OTHER

• The First Affiliated Hospital of Soochow University

  collaborator OTHER

• Henan Provincial People's Hospital

  collaborator OTHER

• The First Affiliated Hospital of Henan University of Science and Technology

  collaborator OTHER

• Women's Hospital of Zhejiang University

  collaborator UNKNOWN

• Sun Yat-sen University Cancer Centre

  collaborator UNKNOWN

• Tongji Hospital

  lead OTHER

Eligibility

Min Age

18 Years

Max Age

75 Years

Sex

FEMALE

Healthy Volunteers

No

Timeline & Regulatory

Start

2025-11-27

Primary Completion

2026-11-30

Completion

2026-12-31