Clinical Trials Updated in 2025

NCT05784402 | COMPLETED | PHASE1

264 participants

A Research Study to Compare How Much Semaglutide is Found in the Blood With Different Tablets of Oral Semaglutide in Healthy Participants

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-02
Start Date:: 2023-03-16
Completion:: 2024-02-23

Conditions

Healthy Participants

Interventions

DRUG

No Results Yet

NCT05767060 | COMPLETED | PHASE1

86 participants

BAT7104 Injection in Patients With Advanced Malignant Tumors.

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-02
Start Date:: 2022-01-20
Completion:: 2024-12-11

Conditions

Advanced Malignant Tumor

Interventions

DRUG

No Results Yet

NCT05760794 | ACTIVE_NOT_RECRUITING | NA

52 participants

Barbed-suture Efficiency Study for Sacrocolpopexy

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-02
Start Date:: 2023-06-21
Completion:: 2027-12-31

Conditions

Prolapse; Female

Interventions

PROCEDURE

No Results Yet

NCT05752916 | COMPLETED | PHASE4

570 participants

Intravenous Thrombolysis With rhTNK-tPA for Acute Non-large Vessel Occlusion in Extended Time Window

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-02
Start Date:: 2023-06-02
Completion:: 2025-10-28

Conditions

Acute Ischemic Stroke

Interventions

DRUG

No Results Yet

NCT05751018 | RECRUITING | PHASE2

18 participants

Phase II Clinical Study of Pyrotinib in First-line Treatment of Primary HER2-amplified/Mutated Advanced Non-small Cell Lung Cancer

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-02
Start Date:: 2021-12-08
Completion:: 2026-12-31

Conditions

Non-small Cell Lung Cancer

Interventions

DRUG

No Results Yet

NCT05734768 | RECRUITING

60 participants

Impact of Preterm Birth on Symptoms of Anxiety and Depression in Parents, and on the Precursors of Cognition, Including Social Cognition in Their Child

Study Type:: OBSERVATIONAL
Last Updated:: 2025-12-02
Start Date:: 2023-11-28
Completion:: 2027-02-28

Conditions

Parental Anxiety Following Premature Birth

Interventions

BEHAVIORAL

No Results Yet

NCT05725967 | ENROLLING_BY_INVITATION

5000 participants

Endoscopic Metabolic and Bariatric Therapies

Study Type:: OBSERVATIONAL
Last Updated:: 2025-12-02
Start Date:: 2022-07-08
Completion:: 2028-05-28

Conditions

Obesity
Obesity, Morbid
Obesity Associated Disorder
Bariatric Surgery Candidate
Fistula, Gastric
Roux-en-y Anastomosis Site
Ulcer, Gastric
Abdominal Pain
Abdominal Obesity
Complication of Surgical Procedure
Complication of Treatment
Complication,Postoperative
Weight Gain
Weight Loss
Leak, Anastomotic
Delayed Gastric Emptying Following Procedure

Interventions

PROCEDURE
DEVICE

No Results Yet

NCT05723601 | ACTIVE_NOT_RECRUITING | PHASE4

21 participants

Preference of Women With Recurrent Urinary Tract Infection for Vaginal Estradiol Tablet vs Cream

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-02
Start Date:: 2024-01-12
Completion:: 2027-01-31

Conditions

Recurrent Urinary Tract Infection

Interventions

DRUG

No Results Yet

NCT05716334 | COMPLETED

201 participants

Biosimilars of Rituximab in ANCA-associated Vasculitis Compared to the Originator

Study Type:: OBSERVATIONAL
Last Updated:: 2025-12-02
Start Date:: 2021-06-15
Completion:: 2025-09-15

Conditions

ANCA-associated Vasculitis
Granulomatosis With Polyangiitis
Microscopic Polyangiitis

No Results Yet

NCT05706610 | COMPLETED | NA

70 participants

A Pilot Feasibility Trial of a Tailored Intervention to Improve Adherence in Adolescents and Young Adults With Cancer

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-02
Start Date:: 2023-02-23
Completion:: 2024-11-30

Conditions

Cancer
Adherence, Medication

Interventions

BEHAVIORAL

Results Available

NCT05664971 | COMPLETED | PHASE1/PHASE2

119 participants

JS004 Combined With Toripalimab and With Standard Chemotherapy Treat Patients With Advanced Lung Cancer

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-02
Start Date:: 2023-02-09
Completion:: 2025-10-23

Conditions

Advanced Lung Cancer

Interventions

BIOLOGICAL
DRUG

No Results Yet

NCT05664412 | RECRUITING | NA

40 participants

Using Transcranial Alternating Current Stimulation to Improve Executive Function in 22q11.2 Deletion Syndrome

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-02
Start Date:: 2023-10-20
Completion:: 2026-12-31

Conditions

22Q11 Deletion Syndrome
tACS

Interventions

DEVICE

No Results Yet

NCT05659251 | ACTIVE_NOT_RECRUITING | PHASE2

48 participants

Serplulimab Combined With Chemotherapy in Patients With Resectable Esophageal Squamous Cell Carcinoma

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-02
Start Date:: 2022-12-01
Completion:: 2024-10-31

Conditions

Esophageal Squamous Cell Carcinoma
Neoadjuvant Therapy

Interventions

COMBINATION_PRODUCT
PROCEDURE
OTHER

No Results Yet

NCT05649176 | COMPLETED | NA

40 participants

Lifestyle Intervention for Improving Insulin Resistance and Concern for Health

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-02
Start Date:: 2023-02-13
Completion:: 2025-10-27

Conditions

Insulin Sensitivity
Apathy

Interventions

OTHER

No Results Yet

NCT05642819 | RECRUITING

200 participants

REVOLUTION Surgery (REVOLUTION Surgery)

Study Type:: OBSERVATIONAL
Last Updated:: 2025-12-02
Start Date:: 2023-10-01
Completion:: 2027-12-31

Conditions

Cachexia
Oesophageal Cancer
Gastric Cancer
Pancreatic Cancer
Colorectal Cancer

No Results Yet

NCT05636748 | RECRUITING

120 participants

The Origin and Role of Thromboembolism in the Pathogenesis of Ischaemic Stroke

Study Type:: OBSERVATIONAL
Last Updated:: 2025-12-02
Start Date:: 2023-02-28
Completion:: 2026-08-01

Conditions

Stroke
PET
Thrombosis

Interventions

DIAGNOSTIC_TEST

No Results Yet

NCT05626816 | RECRUITING | NA

52 participants

Acute Genital Nerve Stimulation for Neurogenic Bowel Dysfunction in Individuals Living With Spinal Cord Injury

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-02
Start Date:: 2023-03-21
Completion:: 2025-12-31

Conditions

Fecal Incontinence

Interventions

DEVICE
DIAGNOSTIC_TEST

No Results Yet

NCT05622175 | WITHDRAWN | PHASE1

0 participants

Safety and Preliminary Signs of Efficacy of F8IL10 for Intra-articular Treatment

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-02
Start Date:: 2023-03-31
Completion:: 2025-12-31

Conditions

Rheumatoid Arthritis

Interventions

DRUG

No Results Yet

NCT05620407 | ACTIVE_NOT_RECRUITING | PHASE3

513 participants

A Study to Evaluate Effectiveness and Safety of Deucravacitinib (BMS-986165) Compared With Placebo in Participants With Active Systemic Lupus Erythematosus

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-02
Start Date:: 2023-01-12
Completion:: 2026-10-19

Conditions

Systemic Lupus Erythematosus

Interventions

DRUG
OTHER

No Results Yet

NCT05618327 | ACTIVE_NOT_RECRUITING | PHASE1

104 participants

Phase I Clinical Study of JS203 in Patients With Relapsed/Refractory B-cell Non-Hodgkin's Lymphoma

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-02
Start Date:: 2023-02-13
Completion:: 2026-12-30

Conditions

Relapsed/Refractory B-cell Non-Hodgkin's Lymphoma

Interventions

DRUG

No Results Yet

NCT05612074 | ACTIVE_NOT_RECRUITING | EARLY_PHASE1

10 participants

Methemoglobin Concentration in High Dose Inhaled Nitric Oxide

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-02
Start Date:: 2023-10-16
Completion:: 2026-11-30

Conditions

Healthy Subjects

Interventions

DRUG

No Results Yet

NCT05610605 | COMPLETED | NA

235 participants

Education for Prevention and Treatment of Frailty

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-02
Start Date:: 2022-03-30
Completion:: 2023-09-01

Conditions

Frailty
Frail Elderly Syndrome

Interventions

OTHER

Results Available

NCT05597865 | COMPLETED | NA

95 participants

Assessing the Feasibility of Economic Approaches to Prevent Substance Abuse Among Adolescents

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-02
Start Date:: 2023-10-12
Completion:: 2024-06-06

Conditions

Adolescent Drinking
HIV/AIDS
Drug Use

Interventions

BEHAVIORAL

Results Available

NCT05595369 | COMPLETED | PHASE2

963 participants

RECOVER-VITAL: Platform Protocol to Measure the Effects of Antiviral Therapies on Long COVID Symptoms

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-02
Start Date:: 2023-07-26
Completion:: 2024-08-06

Conditions

Long COVID
Long Covid19

Interventions

DRUG

Results Available

NCT05566561 | COMPLETED | NA

60 participants

Para-sartorial Compartment Block in Knee Surgery

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-02
Start Date:: 2022-10-19
Completion:: 2025-08-10

Conditions

Knee Osteoarthritis
Knee Injuries
Knee Disease
Knee Arthritis

Interventions

DRUG

No Results Yet

NCT05550207 | COMPLETED | PHASE3

100 participants

Open-Label Study of AXS-07 for the Acute Treatment of Migraine in Adults With a Prior Inadequate Response to an Oral CGRP Inhibitor (EMERGE)

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-02
Start Date:: 2022-08-31
Completion:: 2024-11-27

Conditions

Migraine

Interventions

DRUG

No Results Yet

NCT05543993 | COMPLETED

150 participants

COVID Booster in Pregnancy and Lactation

Study Type:: OBSERVATIONAL
Last Updated:: 2025-12-02
Start Date:: 2022-09-29
Completion:: 2024-06-10

Conditions

COVID-19

Interventions

DRUG

No Results Yet

NCT05507814 | COMPLETED | NA

141 participants

Temporal Window and Episodic Future Thinking in CUD

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-02
Start Date:: 2022-11-30
Completion:: 2025-11-24

Conditions

Cocaine Use Disorder

Interventions

BEHAVIORAL

No Results Yet

NCT05469438 | COMPLETED

30 participants

IMAS Optimization and Applicability in Acute and Subacute Stroke.

Study Type:: OBSERVATIONAL
Last Updated:: 2025-12-02
Start Date:: 2021-10-29
Completion:: 2023-08-31

Conditions

Acute Stroke

Results Available

NCT05454033 | COMPLETED | PHASE3

198 participants

A Study to Assess Adverse Events and Effectiveness of Intradermally Injected JUVÉDERM® VOLITE™ Gel Filler in Adult Participants in China With Fine Lines Around the Mouth

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-02
Start Date:: 2022-09-07
Completion:: 2024-09-03

Conditions

Perioral Lines

Interventions

DEVICE
OTHER

No Results Yet

NCT05440916 | COMPLETED | PHASE2

50 participants

Palliative RadIotherapy of Multiple Metastatic Sites Before First Line of Systemic Therapy With Immune Checkpoint Inhibitors and Chemotherapy in Metastatic Non-Small-Cell Lung Cancer

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-02
Start Date:: 2022-07-14
Completion:: 2025-01-13

Conditions

Carcinoma, Non-Small-Cell Lung
Metastatic Lung Non-Small Cell Carcinoma
Non Small Cell Lung Cancer

Interventions

RADIATION
DRUG

No Results Yet

NCT05433116 | ACTIVE_NOT_RECRUITING | PHASE2

50 participants

Pembrolizumab and Lenvatinib After Definitive Chemoradiation of Locally Advanced HNSCC

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-02
Start Date:: 2023-05-25
Completion:: 2026-01-31

Conditions

Head and Neck Squamous Cell Carcinoma

Interventions

DRUG

No Results Yet

NCT05432232 | COMPLETED | NA

20 participants

The HistoSonics Investigational System for Treatment of Primary Solid Renal Tumors Using Histotripsy

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-02
Start Date:: 2023-03-23
Completion:: 2024-12-28

Conditions

Renal Cancer
Tumor, Solid
Kidney Cancer
Tumor
Tumor, Benign
Kidney Neoplasms

Interventions

DEVICE

Results Available

NCT05387863 | RECRUITING | NA

40 participants

Decision Aid (DA) for Renal Patients

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-02
Start Date:: 2022-09-12
Completion:: 2026-06-30

Conditions

Kidney Tumor
Renal Cancer

Interventions

OTHER

No Results Yet

NCT05382858 | COMPLETED | NA

27 participants

PSA Versus STN DBS for TD-PD

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-02
Start Date:: 2022-06-01
Completion:: 2025-04-24

Conditions

Parkinson Disease

Interventions

DEVICE

No Results Yet

NCT05366725 | COMPLETED

106 participants

A Study to Learn About the Study Medicine (Called Avelumab) in People With Advanced Urothelial Cancer After Chemotherapy

Study Type:: OBSERVATIONAL
Last Updated:: 2025-12-02
Start Date:: 2022-06-29
Completion:: 2024-06-27

Conditions

Urothelial Cancer

Interventions

DRUG

Results Available

NCT05344274 | RECRUITING | PHASE4

90 participants

Retinal Blood Flow and Autoregulation

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-02
Start Date:: 2022-05-23
Completion:: 2027-09-30

Conditions

Glaucoma

Interventions

DIAGNOSTIC_TEST
BIOLOGICAL

No Results Yet

NCT05317390 | RECRUITING | NA

1000 participants

Clinical Validation of DystoniaNet Deep Learning Platform for Diagnosis of Isolated Dystonia

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-02
Start Date:: 2022-06-01
Completion:: 2028-04-30

Conditions

Dystonia
Drug Induced Dystonia
Parkinson Disease
Essential Tremor
Dyskinesias
Myoclonus
Tic Disorders
Torticollis
Ulnar Nerve Entrapment
Temporomandibular Joint Disorders
Dysphonia

Interventions

DIAGNOSTIC_TEST

No Results Yet

NCT05307835 | ACTIVE_NOT_RECRUITING | PHASE1

27 participants

Neoantigen Vaccine in Esophagus Cancer Patients Following Neoadjuvant Therapy and Surgical Resection

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-02
Start Date:: 2021-12-02
Completion:: 2026-06-30

Conditions

Resectable Esophageal Cancer

Interventions

BIOLOGICAL

No Results Yet

NCT05307094 | ACTIVE_NOT_RECRUITING | NA

44 participants

Optimizing Intervention Options for Toddlers With Early Social Communication Delays

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-02
Start Date:: 2022-01-15
Completion:: 2025-05-31

Conditions

Autism Sibling

Interventions

BEHAVIORAL

No Results Yet