Clinical Trials Updated in 2025

NCT05507658 | COMPLETED | PHASE2

28 participants

Tislelizumab Combined With XELOX as Neoadjuvant Therapy for G/GEJ Adenocarcinoma

Study Type:: INTERVENTIONAL
Last Updated:: 2025-11-28
Start Date:: 2022-07-18
Completion:: 2023-07-02

Conditions

Locally Advanced Gastric Adenocarcinoma

Interventions

DRUG

No Results Yet

NCT05499975 | ACTIVE_NOT_RECRUITING | NA

180 participants

Comprehensive Health Assessment for my Cancer Treatment Plan

Study Type:: INTERVENTIONAL
Last Updated:: 2025-11-28
Start Date:: 2023-07-24
Completion:: 2025-04-30

Conditions

Cancer
Older Adults

Interventions

OTHER

No Results Yet

NCT05492903 | ACTIVE_NOT_RECRUITING | NA

140 participants

COMmunity of Practice And Safety Support for Navigating Pain (COMPASS-NP)

Study Type:: INTERVENTIONAL
Last Updated:: 2025-11-28
Start Date:: 2023-08-21
Completion:: 2025-04-11

Conditions

Pain Management
Ergonomics
Wounds and Injuries

Interventions

BEHAVIORAL

No Results Yet

NCT05480800 | COMPLETED | PHASE1/PHASE2

155 participants

A Study to Evaluate Safety, Reactogenicity, and Immune Response of GVGH iNTS-TCV Vaccine Against Invasive Nontyphoidal Salmonella and Typhoid Fever

Study Type:: INTERVENTIONAL
Last Updated:: 2025-11-28
Start Date:: 2022-09-13
Completion:: 2024-09-02

Conditions

Salmonella Infections

Interventions

DRUG
OTHER
BIOLOGICAL
COMBINATION_PRODUCT

Results Available

NCT05467540 | COMPLETED | NA

52 participants

Spinery® A Novel Radio-Frequency Tumor Ablation Device for Spine Metastatic Tumors

Study Type:: INTERVENTIONAL
Last Updated:: 2025-11-28
Start Date:: 2022-07-11
Completion:: 2024-02-15

Conditions

Vertebral Metastasis

Interventions

DEVICE

Results Available

NCT05445349 | COMPLETED

163 participants

Breathing Parameter Measurements for Lung Deposition Simulation

Study Type:: OBSERVATIONAL
Last Updated:: 2025-11-28
Start Date:: 2022-09-01
Completion:: 2024-06-30

Conditions

Asthma
COPD

Interventions

DEVICE

No Results Yet

NCT05424562 | ACTIVE_NOT_RECRUITING

210 participants

A Study to Assess Change in Disease State in Adult Participants With Acute Myeloid Leukemia (AML) Ineligible for Intensive Chemotherapy Receiving Oral Venetoclax Tablets in Canada

Study Type:: OBSERVATIONAL
Last Updated:: 2025-11-28
Start Date:: 2022-09-07
Completion:: 2027-03-31

Conditions

Acute Myeloid Leukemia

No Results Yet

NCT05411614 | RECRUITING | NA

120 participants

Hybrid Ablation of Atrial Fibrillation in Heart Failure

Study Type:: INTERVENTIONAL
Last Updated:: 2025-11-28
Start Date:: 2022-06-25
Completion:: 2026-05-31

Conditions

Persistent Atrial Fibrillation
Atrial Fibrillation, Persistent
Atrial Arrhythmia
Atrial Fibrillation
Heart Failure
Left Ventricular (LV) Systolic Dysfunction

Interventions

DEVICE

No Results Yet

NCT05383170 | COMPLETED | PHASE1/PHASE2

6 participants

A Study to Evaluate the Safety and Efficacy of CyPep-1 in Combination With Pembrolizumab for the Treatment of Advanced or Metastatic Cancers

Study Type:: INTERVENTIONAL
Last Updated:: 2025-11-28
Start Date:: 2023-03-21
Completion:: 2024-09-23

Conditions

Advanced Head and Neck Squamous Cell Carcinoma
Advanced Breast Cancer
Advanced Melanoma

Interventions

DRUG

Results Available

NCT05381597 | RECRUITING | PHASE2/PHASE3

200 participants

5-Fluorouracil and Calcipotriene for Treatment of Low Grade Skin Cancer

Study Type:: INTERVENTIONAL
Last Updated:: 2025-11-28
Start Date:: 2022-10-15
Completion:: 2027-06-30

Conditions

Superficial Basal Cell Carcinoma
Squamous Cell Carcinoma in Situ

Interventions

DRUG

No Results Yet

NCT05377632 | COMPLETED | NA

40 participants

Comparing Two Different Approaches in Robotic-Assisted Renal Surgery

Study Type:: INTERVENTIONAL
Last Updated:: 2025-11-28
Start Date:: 2022-05-15
Completion:: 2024-12-15

Conditions

Renal Tumor

Interventions

PROCEDURE

No Results Yet

NCT05351151 | COMPLETED | NA

50 participants

Pain Reduction in Maxillomandibular Surgery Using Maxillary and Mandibular Nerve Blocks

Study Type:: INTERVENTIONAL
Last Updated:: 2025-11-28
Start Date:: 2022-05-23
Completion:: 2023-03-29

Conditions

Pain, Post Operative
Regional Anesthesia

Interventions

PROCEDURE

No Results Yet

NCT05347693 | COMPLETED | PHASE4

186 participants

Continuing Sodium Zirconium Cyclosilicate (SZC) After Discharge Study

Study Type:: INTERVENTIONAL
Last Updated:: 2025-11-28
Start Date:: 2022-03-24
Completion:: 2024-12-10

Conditions

Hyperkalaemia
Chronic Kidney Disease

Interventions

DRUG

Results Available

NCT05329922 | COMPLETED | NA

161 participants

Assistant for LIstening and Communication Enhancement

Study Type:: INTERVENTIONAL
Last Updated:: 2025-11-28
Start Date:: 2022-10-01
Completion:: 2025-08-14

Conditions

Hearing Disability

Interventions

BEHAVIORAL

No Results Yet

NCT05326399 | RECRUITING

369 participants

Renal Biopsies in Post-liver Transplantation Patients With Renal Impairment

Study Type:: OBSERVATIONAL
Last Updated:: 2025-11-28
Start Date:: 2022-06-01
Completion:: 2027-05-31

Conditions

Liver Transplantation
Renal Insufficiency, Chronic

Interventions

BEHAVIORAL

No Results Yet

NCT05319093 | TERMINATED

26 participants

Observational Study of the Effect of Ozanimod on Fatigue in Multiple Sclerosis Patients

Study Type:: OBSERVATIONAL
Last Updated:: 2025-11-28
Start Date:: 2022-04-01
Completion:: 2024-07-23

Conditions

Fatigue
Multiple Sclerosis

Interventions

DRUG

No Results Yet

NCT05278247 | NOT_YET_RECRUITING | NA

50 participants

Sensing Oxygen Saturations Using Abdominal NIRS With an Investigational Realtime Device (Songbird)

Study Type:: INTERVENTIONAL
Last Updated:: 2025-11-28
Start Date:: 2026-02-01
Completion:: 2027-09-30

Conditions

NEC

Interventions

DIAGNOSTIC_TEST

No Results Yet

NCT05252416 | TERMINATED | PHASE1

50 participants

(VELA) Study of BLU-222 in Advanced Solid Tumors

Study Type:: INTERVENTIONAL
Last Updated:: 2025-11-28
Start Date:: 2022-04-07
Completion:: 2025-07-04

Conditions

Advanced Solid Tumors
HR+ Breast Cancer
CCNE1 Amplification
HER2-negative Breast Cancer
Ovarian Cancer
Endometrial Cancer
Gastric Cancer
Esophageal Adenocarcinoma
Carcinosarcoma

Interventions

DRUG

No Results Yet

NCT05237648 | COMPLETED | NA

42 participants

Assessing the Effects of Patient Self-Rating of Voice Quality on Voice Therapy Attendance and Outcomes

Study Type:: INTERVENTIONAL
Last Updated:: 2025-11-28
Start Date:: 2023-01-19
Completion:: 2024-10-22

Conditions

Dysphonia

Interventions

OTHER

No Results Yet

NCT05212948 | COMPLETED | PHASE3

9902 participants

A Study of S-268019 for the Prevention of COVID-19

Study Type:: INTERVENTIONAL
Last Updated:: 2025-11-28
Start Date:: 2021-12-25
Completion:: 2022-12-19

Conditions

SARS-CoV-2

Interventions

DRUG

Results Available

NCT05179863 | RECRUITING

500000 participants

Swiss Rare Disease Registry (SRDR)

Study Type:: OBSERVATIONAL
Last Updated:: 2025-11-28
Start Date:: 2018-01-01
Completion:: 2071-01-31

Conditions

Rare Diseases

No Results Yet

NCT05166655 | ENROLLING_BY_INVITATION | NA

40 participants

DBS Recordings to Characterize Movement Facilitation in Parkinson's Disease

Study Type:: INTERVENTIONAL
Last Updated:: 2025-11-28
Start Date:: 2022-03-03
Completion:: 2026-09-30

Conditions

Parkinson Disease

Interventions

BEHAVIORAL

No Results Yet

NCT05160675 | COMPLETED

2760 participants

Nutrition, Microbiome and Bone Health During Early Life Related to Health

Study Type:: OBSERVATIONAL
Last Updated:: 2025-11-28
Start Date:: 2021-09-03
Completion:: 2025-09-08

Conditions

Healthy

Interventions

OTHER

No Results Yet

NCT05148299 | COMPLETED | PHASE2

12 participants

A Study of Pegcetacoplan for Patients With Transplant-associated Thrombotic Microangiopathy After Hematopoietic Stem Cell Transplantation

Study Type:: INTERVENTIONAL
Last Updated:: 2025-11-28
Start Date:: 2022-02-01
Completion:: 2024-12-08

Conditions

Transplant-Associated Thrombotic Microangiopathy

Interventions

DRUG

Results Available

NCT05113017 | RECRUITING

40 participants

The Effectiveness and Safety of SBRT in the Treatment of Patients With MPLC After Surgery (SMILE)

Study Type:: OBSERVATIONAL
Last Updated:: 2025-11-28
Start Date:: 2021-07-01
Completion:: 2026-12-31

Conditions

The Efficacy and Safety of SBRT in MPLC

Interventions

OTHER

No Results Yet

NCT05008211 | COMPLETED | NA

124 participants

Information-Motivation-Behavioral Skills Model-based Intervention to Domiciliary Non-invasive Ventilation of Patients

Study Type:: INTERVENTIONAL
Last Updated:: 2025-11-28
Start Date:: 2021-09-16
Completion:: 2024-10-16

Conditions

Hypercapnic Respiratory Failure
Noninvasive Ventilation

Interventions

OTHER

No Results Yet

NCT04954274 | ACTIVE_NOT_RECRUITING | PHASE3

366 participants

Improvement of Live Babies Rates After ICSI, Using cpFT

Study Type:: INTERVENTIONAL
Last Updated:: 2025-11-28
Start Date:: 2021-07-29
Completion:: 2026-07-29

Conditions

Infertility
Oocyte
Pregnancy

Interventions

DRUG

No Results Yet

NCT04940065 | COMPLETED

367 participants

Special Drug-use Surveillance for Kesimpta for s.c. Injection 20 mg Pen

Study Type:: OBSERVATIONAL
Last Updated:: 2025-11-28
Start Date:: 2021-06-30
Completion:: 2024-12-12

Conditions

Relapsing-remitting Multiple Sclerosis
Active Secondary Progressive Multiple Sclerosis

Interventions

OTHER

No Results Yet

NCT04903041 | SUSPENDED

300000 participants

A Cardiac Registry to Evaluate and Manage the hsTnI Categorical CVD Risk in Subjects Undergoing Preventive Health Checks (PHC).

Study Type:: OBSERVATIONAL
Last Updated:: 2025-11-28
Start Date:: 2019-09-12
Completion:: 2029-09-12

Conditions

Cardiovascular Diseases

No Results Yet

NCT04898829 | COMPLETED | NA

7 participants

Evaluation of PKU Explore France

Study Type:: INTERVENTIONAL
Last Updated:: 2025-11-28
Start Date:: 2022-05-18
Completion:: 2025-10-31

Conditions

Phenylketonurias

Interventions

DIETARY_SUPPLEMENT

No Results Yet

NCT04877977 | RECRUITING

1000 participants

Long-term Observation of Participants With Mood Disorders

Study Type:: OBSERVATIONAL
Last Updated:: 2025-11-28
Start Date:: 2021-08-17
Completion:: 2028-10-01

Conditions

Depression
Suicide Risk

No Results Yet

NCT04874064 | RECRUITING

130 participants

TRIple Negative Breast Cancer Markers In Liquid Biopsies Using Artificial Intelligence

Study Type:: OBSERVATIONAL
Last Updated:: 2025-11-28
Start Date:: 2019-12-05
Completion:: 2027-12-31

Conditions

Breast Cancer

Interventions

OTHER

No Results Yet

NCT04823377 | ACTIVE_NOT_RECRUITING | NA

364 participants

Impact of a Process Optimizing the Decision to Continue or Stop Cancer Treatments in Patients With Advanced Non-small Cell Lung Cancer.

Study Type:: INTERVENTIONAL
Last Updated:: 2025-11-28
Start Date:: 2021-09-24
Completion:: 2026-09-23

Conditions

Carcinoma, Non-Small-Cell Lung
Advanced Cancer

Interventions

OTHER

No Results Yet

NCT04771286 | COMPLETED | PHASE1

6 participants

A Study in Healthy Men to Find Out How BI 1015550 is Taken up and Handled by the Body

Study Type:: INTERVENTIONAL
Last Updated:: 2025-11-28
Start Date:: 2021-03-25
Completion:: 2021-05-17

Conditions

Healthy

Interventions

DRUG

Results Available

NCT04761588 | COMPLETED | NA

14 participants

Evaluation of TYR Sphere in France

Study Type:: INTERVENTIONAL
Last Updated:: 2025-11-28
Start Date:: 2021-12-01
Completion:: 2024-12-31

Conditions

Tyrosinemia
AKU

Interventions

DIETARY_SUPPLEMENT

No Results Yet

NCT04681417 | RECRUITING | PHASE2/PHASE3

225 participants

Ocular Conservative Treatment for Retinoblastoma : Efficacy of the New Management Strategies and Visual Outcome

Study Type:: INTERVENTIONAL
Last Updated:: 2025-11-28
Start Date:: 2021-03-25
Completion:: 2035-01-20

Conditions

Retinoblastoma

Interventions

DRUG
DEVICE

No Results Yet

NCT04670510 | COMPLETED | NA

46 participants

Fitness for Brain Optimization for Late-Life Depression

Study Type:: INTERVENTIONAL
Last Updated:: 2025-11-28
Start Date:: 2021-08-04
Completion:: 2025-10-22

Conditions

Depression in Old Age

Interventions

OTHER

No Results Yet

NCT04650100 | COMPLETED | NA

64 participants

Analgesic Effectiveness of PENG Block in Programmed Hip Arthroplasty Surgery

Study Type:: INTERVENTIONAL
Last Updated:: 2025-11-28
Start Date:: 2020-12-14
Completion:: 2021-07-08

Conditions

Postoperative Pain

Interventions

PROCEDURE

No Results Yet

NCT04624477 | ACTIVE_NOT_RECRUITING

450 participants

Active Surveillance and Surgery Outcomes in Low Risk Papillary Thyroid Cancer

Study Type:: OBSERVATIONAL
Last Updated:: 2025-11-28
Start Date:: 2021-02-03
Completion:: 2034-12-31

Conditions

Papillary Thyroid Cancer
Papillary Thyroid Carcinoma
Papillary Microcarcinoma of the Thyroid

No Results Yet

NCT04602377 | RECRUITING | PHASE2

27 participants

Addition of Pembrolizumab to the Standard of Care Chemotherapy in Patient With SCCOHT

Study Type:: INTERVENTIONAL
Last Updated:: 2025-11-28
Start Date:: 2021-08-04
Completion:: 2026-06-30

Conditions

Small Cell Ovarian Carcinoma

Interventions

DRUG

No Results Yet