Clinical Trials

NCT05136170 | COMPLETED | PHASE3

85 participants

Study to Evaluate Safety and Efficacy of Cenegermin (Oxervate®) vs Vehicle in Severe Sjogren's Dry Eye Disease

Study Type:

INTERVENTIONAL

Last Updated:

2025-11-26

Start Date:

2022-01-27

Completion:

2023-05-24

Conditions

• Dry Eye Disease

Interventions

• DRUG
• OTHER

Results Available

NCT05127044 | COMPLETED | NA

44 participants

Characterization of Pre-Term Neonatal Skin

Study Type:

INTERVENTIONAL

Last Updated:

2025-11-26

Start Date:

2023-10-13

Completion:

2024-08-17

Conditions

• Skin Disorder

Interventions

• DEVICE
• DIAGNOSTIC_TEST

Results Available

NCT05121519 | COMPLETED | NA

200 participants

Does Eliminating Coffee Avoid Fibrillation?

Study Type:

INTERVENTIONAL

Last Updated:

2025-11-26

Start Date:

2021-10-20

Completion:

2025-06-05

Conditions

• Atrial Fibrillation
• Coffee

Interventions

• OTHER

No Results Yet

NCT05076370 | COMPLETED | EARLY_PHASE1

7 participants

Safety and Tolerability of Cannabidiol Among Persons With Opioid Use Disorder Receiving Methadone or Buprenorphine

Study Type:

INTERVENTIONAL

Last Updated:

2025-11-26

Start Date:

2021-12-08

Completion:

2024-06-28

Conditions

• Addiction

Interventions

• DRUG

Results Available

NCT05066854 | TERMINATED | NA

36 participants

INterest of the Negative Predictive Value of Integrons in Choosing a Narrow-spectrum Empirical anTibiotic Treatment vs Usual Empirical Antibiotic Treatment for Urinary Tract infectionS in the PEDiatric Emergency Department

Study Type:

INTERVENTIONAL

Last Updated:

2025-11-26

Start Date:

2022-10-18

Completion:

2025-11-17

Conditions

• Urinary Tract Infections in Children

Interventions

• PROCEDURE

No Results Yet

NCT05025787 | COMPLETED | PHASE2

55 participants

A Study to Evaluate the Safety and Efficacy of CNTX-6970 in Subjects With Knee Osteoarthritis Pain.

Study Type:

INTERVENTIONAL

Last Updated:

2025-11-26

Start Date:

2021-10-25

Completion:

2024-06-11

Conditions

• Knee Osteoarthritis

Interventions

• DRUG

Results Available

NCT05023785 | RECRUITING | NA

336 participants

The HIMALAYAS Trial and Lifestyle Changes in Pediatric, Adolescent and Young Adult Cancer Survivors Study: A Multicentre Randomized Controlled Trial

Study Type:

INTERVENTIONAL

Last Updated:

2025-11-26

Start Date:

2024-01-01

Completion:

2026-09-30

Conditions

• Heart Failure
• Cardiotoxicity
• Cancer

Interventions

• BEHAVIORAL

No Results Yet

NCT04986358 | COMPLETED | NA

479 participants

Short and Medium Term Postoperative Complications After Hallux Valgus Surgery

Study Type:

INTERVENTIONAL

Last Updated:

2025-11-26

Start Date:

2022-01-05

Completion:

2024-10-19

Conditions

• Hallux Valgus

Interventions

• OTHER

No Results Yet

NCT04971785 | COMPLETED | PHASE2

457 participants

Study of Semaglutide, and Cilofexor/Firsocostat, Alone and in Combination, in Adults With Cirrhosis Due to Nonalcoholic Steatohepatitis (NASH)

Study Type:

INTERVENTIONAL

Last Updated:

2025-11-26

Start Date:

2021-08-09

Completion:

2024-11-12

Conditions

• Nonalcoholic Steatohepatitis

Interventions

• DRUG

Results Available

NCT04940325 | ACTIVE_NOT_RECRUITING | PHASE2

100 participants

Datopotamab Deruxtecan (Dato-DXd, DS-1062a) in Advanced and/or Unresectable Non-Small Cell Lung Cancer

Study Type:

INTERVENTIONAL

Last Updated:

2025-11-26

Start Date:

2021-05-12

Completion:

2028-04-30

Conditions

• Metastatic Lung Cancer
• Advanced Non Small Cell Lung Cancer
• Unresectable Non-small Lung Cancer

Interventions

• DRUG

No Results Yet

NCT04931251 | COMPLETED | NA

258 participants

Addressing Cancer-Related Financial Toxicity in Rural Oncology Care Settings

Study Type:

INTERVENTIONAL

Last Updated:

2025-11-26

Start Date:

2021-11-11

Completion:

2025-07-31

Conditions

• Neoplasms
• Carcinoma

Interventions

• BEHAVIORAL

No Results Yet

NCT04925882 | COMPLETED | NA

100 participants

Erector Spinae Plane Block in Lumbar Release Surgery

Study Type:

INTERVENTIONAL

Last Updated:

2025-11-26

Start Date:

2022-01-03

Completion:

2022-12-19

Conditions

• Hernia Lumbar
• Lumbar Canal Stenosis
• Spinal Cord Compression

Interventions

• PROCEDURE

No Results Yet

NCT04916470 | COMPLETED | PHASE3

617 participants

Research Study to Look at How Well Semaglutide Works in People Living With Heart Failure, Obesity and Type 2 Diabetes

Study Type:

INTERVENTIONAL

Last Updated:

2025-11-26

Start Date:

2021-06-15

Completion:

2023-10-11

Conditions

• Heart Failure With Preserved Ejection Fraction (HFpEF) and Diabetes Mellitus, Type 2

Interventions

• DRUG

No Results Yet

NCT04887337 | TERMINATED | NA

2 participants

Early arthroscoPic Stabilization veRsus rehabilitatiOn of the Shoulder in Adolescents With a trauMatic First-time Anterior Shoulder Dislocation ePisode

Study Type:

INTERVENTIONAL

Last Updated:

2025-11-26

Start Date:

2022-09-19

Completion:

2025-10-24

Conditions

• Shoulder Dislocation

Interventions

• PROCEDURE
• OTHER

No Results Yet

NCT04857593 | COMPLETED | NA

37 participants

Online Singing Interventions for Postnatal Depression in Times of Social Isolation: a Single Arm Study

Study Type:

INTERVENTIONAL

Last Updated:

2025-11-26

Start Date:

2021-01-04

Completion:

2022-03-31

Conditions

• Postnatal Depression
• Social Isolation

Interventions

• BEHAVIORAL

Results Available

NCT04842162 | RECRUITING | PHASE2

65 participants

Study Evaluating Near-infrared Imaging Coupled With Indocyanine Green for Intraoperative Control of Resection Margins in ENT Surgery

Study Type:

INTERVENTIONAL

Last Updated:

2025-11-26

Start Date:

2020-12-15

Completion:

2026-11-30

Conditions

• Head and Neck Cancer

Interventions

• DRUG

No Results Yet

NCT04830046 | COMPLETED

146 participants

Covid-19 Vaccine Responsiveness in MM and Waldenstrom

Study Type:

OBSERVATIONAL

Last Updated:

2025-11-26

Start Date:

2021-04-15

Completion:

2021-09-14

Conditions

• Multiple Myeloma
• Waldenstrom Macroglobulinemia
• Immune System Disorder
• Covid19

No Results Yet

NCT04826523 | COMPLETED

150 participants

Study of Oral Venetoclax Tablets to Evaluate Adverse Events and Change in Disease Activity in Participants Above 19 Years of Age With Acute Myeloid Leukemia (AML)

Study Type:

OBSERVATIONAL

Last Updated:

2025-11-26

Start Date:

2021-04-05

Completion:

2025-10-20

Conditions

• Acute Myeloid Leukemia (AML)

No Results Yet

NCT04788056 | WITHDRAWN | NA

0 participants

Parasternal Subpectoral Plane Blocks for Cardiac Surgery Via a Midline Sternotomy

Study Type:

INTERVENTIONAL

Last Updated:

2025-11-26

Start Date:

2021-06-30

Completion:

2022-06-30

Conditions

• Pain, Postoperative

Interventions

• PROCEDURE

No Results Yet

NCT04785989 | RECRUITING

16 participants

In Vivo Metabolic Profiling of CLL (Chronic Lymphocytic Leukemia)

Study Type:

OBSERVATIONAL

Last Updated:

2025-11-26

Start Date:

2022-06-13

Completion:

2026-10-31

Conditions

• Chronic Lymphocytic Leukemia

Interventions

• OTHER

No Results Yet

NCT04735393 | COMPLETED | PHASE3

757 participants

A Multi-Center, Double-Masked, Randomized, Vehicle-Controlled, Parallel-Group Clinical Trial Evaluating the Safety of Reproxalap Ophthalmic Solution in Subjects With Dry Eye Disease

Study Type:

INTERVENTIONAL

Last Updated:

2025-11-26

Start Date:

2021-01-26

Completion:

2022-10-11

Conditions

• Dry Eye Disease

Interventions

• DRUG

Results Available

NCT04730960 | COMPLETED

86 participants

Comparison of Cervical Region Characteristics of People With Smartphone Addiction

Study Type:

OBSERVATIONAL

Last Updated:

2025-11-26

Start Date:

2021-07-15

Completion:

2021-12-05

Conditions

• Neck Pain
• Postural; Defect
• Young Adult
• Technology

No Results Yet

NCT04699474 | COMPLETED | NA

45 participants

Protocol for Rapid Onset of Mobilization in Patients With Traumatic Spinal Cord Injury

Study Type:

INTERVENTIONAL

Last Updated:

2025-11-26

Start Date:

2021-04-01

Completion:

2024-07-31

Conditions

• Spinal Cord Injuries

Interventions

• DEVICE

No Results Yet

NCT04570332 | COMPLETED | PHASE2

42 participants

BO-112 With Pembrolizumab in Unresectable Malignant Melanoma

Study Type:

INTERVENTIONAL

Last Updated:

2025-11-26

Start Date:

2020-12-30

Completion:

2023-10-03

Conditions

• Melanoma

Interventions

• DRUG
• PROCEDURE

Results Available

NCT04525716 | RECRUITING

300000 participants

The Effect of the Covid-19 Pandemic Among Operated Patients

Study Type:

OBSERVATIONAL

Last Updated:

2025-11-26

Start Date:

2020-01-01

Completion:

2027-12-31

Conditions

• Covid19
• Surgery

Interventions

• OTHER

No Results Yet

NCT04505007 | COMPLETED | NA

29 participants

Guideline-Directed Medical Therapy in Patients After Implantation of Implantable Cardioverter Defibrillators to Improve Long-Term Outcomes

Study Type:

INTERVENTIONAL

Last Updated:

2025-11-26

Start Date:

2021-06-01

Completion:

2023-12-01

Conditions

• Heart Failure
• ICD

Interventions

• OTHER

No Results Yet

NCT04484012 | RECRUITING | PHASE2

36 participants

Modified Immune Cells (CD19 CAR T Cells) and Acalabrutinib for the Treatment of Relapsed or Refractory Mantle Cell Lymphoma

Study Type:

INTERVENTIONAL

Last Updated:

2025-11-26

Start Date:

2020-12-31

Completion:

2026-09-02

Conditions

• Recurrent Mantle Cell Lymphoma
• Refractory Mantle Cell Lymphoma

Interventions

• DRUG
• BIOLOGICAL

No Results Yet

NCT04401917 | ACTIVE_NOT_RECRUITING | EARLY_PHASE1

26 participants

Evaluation of Neuroinflammation FNOS PET/CT in HIV (+) and (-) Subjects With OUD and Healthy Controls

Study Type:

INTERVENTIONAL

Last Updated:

2025-11-26

Start Date:

2020-12-07

Completion:

2026-12-07

Conditions

• HIV Infections
• Opioid Use

Interventions

• DRUG

No Results Yet

NCT04393038 | TERMINATED | PHASE2/PHASE3

509 participants

ABX464 in Treating Inflammation and Preventing Acute Respiratory Failure in Patients With COVID-19

Study Type:

INTERVENTIONAL

Last Updated:

2025-11-26

Start Date:

2020-07-01

Completion:

2021-03-05

Conditions

• COVID-19

Interventions

• DRUG

Results Available

NCT04388839 | ACTIVE_NOT_RECRUITING | PHASE2

12 participants

Evolutionary Therapy for Rhabdomyosarcoma

Study Type:

INTERVENTIONAL

Last Updated:

2025-11-26

Start Date:

2020-12-29

Completion:

2026-08-31

Conditions

• Rhabdomyosarcoma

Interventions

• DRUG

No Results Yet

NCT04380649 | ACTIVE_NOT_RECRUITING | NA

5 participants

Development and Test of a Headset for BCI Until Obtaining an Efficient and Comfortable System That Can be Used in Daily Practice by ALS People

Study Type:

INTERVENTIONAL

Last Updated:

2025-11-26

Start Date:

2023-02-13

Completion:

2024-08-12

Conditions

• Amyotrophic Lateral Sclerosis
• Motor Neuron Disease
• Spinal Cord Diseases
• Alternative Communication Devices
• Neurodegenerative Diseases
• Nervous System Diseases
• Neuromuscular Diseases

Interventions

• DEVICE

No Results Yet

NCT04225611 | RECRUITING | PHASE1/PHASE2

6 participants

Therapeutic Contact Lens Drug Delivery System (TCL-DDS) in Patients With Recurrent Cystoid Macular Edema

Study Type:

INTERVENTIONAL

Last Updated:

2025-11-26

Start Date:

2021-03-15

Completion:

2027-12-31

Conditions

• Cystoid Macular Edema

Interventions

• DRUG

No Results Yet

NCT04193059 | ACTIVE_NOT_RECRUITING | PHASE3

1560 participants

Study Comparing EC-T Verses PCb in the Adjuvant Chemotherapy of Non-triple Negative Breast Cancer

Study Type:

INTERVENTIONAL

Last Updated:

2025-11-26

Start Date:

2019-12-20

Completion:

2026-07-31

Conditions

• Breast Cancer

Interventions

• DRUG

No Results Yet

NCT04175119 | COMPLETED | NA

157 participants

Tracking Information Flow in the Brain

Study Type:

INTERVENTIONAL

Last Updated:

2025-11-26

Start Date:

2019-11-25

Completion:

2025-02-27

Conditions

• Healthy Volunteer

Interventions

• DEVICE

No Results Yet

NCT04166877 | RECRUITING | PHASE4

156 participants

Magnesium Infusion for Pain Management in Critically Ill Trauma Patients

Study Type:

INTERVENTIONAL

Last Updated:

2025-11-26

Start Date:

2019-12-07

Completion:

2026-12-31

Conditions

• Trauma
• Acute Pain

Interventions

• DRUG

No Results Yet

NCT04165083 | COMPLETED | PHASE2

102 participants

KEYMAKER-U01 Substudy 2: Efficacy and Safety Study of Pembrolizumab (MK-3475) When Used With Investigational Agents in Treatment-naïve Participants With Anti-programmed Cell Death Receptor Ligand 1 (PD-L1) Positive Advanced Non-small Cell Lung Cancer (NSCLC) (MK-3475-01B/KEYMAKER-U01B)

Study Type:

INTERVENTIONAL

Last Updated:

2025-11-26

Start Date:

2019-12-19

Completion:

2025-10-31

Conditions

• Carcinoma, Non-Small-Cell Lung

Interventions

• BIOLOGICAL

No Results Yet

NCT04070183 | COMPLETED | NA

389 participants

POST Facilitation for Community Dwelling Older Adults (POST-RCT)

Study Type:

INTERVENTIONAL

Last Updated:

2025-11-26

Start Date:

2020-05-11

Completion:

2025-07-29

Conditions

• Anxiety
• Depression
• Post Traumatic Stress Disorder
• Satisfaction

Interventions

• BEHAVIORAL

No Results Yet

NCT04026178 | COMPLETED | PHASE4

11 participants

Immunogenicity of Metreleptin in Patients With Generalized Lipodystrophy

Study Type:

INTERVENTIONAL

Last Updated:

2025-11-26

Start Date:

2018-11-14

Completion:

2024-10-31

Conditions

• Generalized Lipodystrophy

Interventions

• DRUG

Results Available

NCT04010968 | COMPLETED | PHASE2

120 participants

Evaluation of Risk-Adapted and MRD-Driven Strategy for Untreated Fit Patients With Intermediate Risk Chronic Lymphocytic Leukemia

Study Type:

INTERVENTIONAL

Last Updated:

2025-11-26

Start Date:

2019-09-27

Completion:

2023-04-03

Conditions

• Intermediate Risk Chronic Lymphocytic Leukemia
• Fit Patients
• Risk-Adapted and MRD-Driven Strategy

Interventions

• DRUG

No Results Yet

NCT03998735 | ACTIVE_NOT_RECRUITING | PHASE1

55 participants

Nornicotine in Smokeless Tobacco as a Precursor for Carcinogen Exposure

Study Type:

INTERVENTIONAL

Last Updated:

2025-11-26

Start Date:

2021-10-19

Completion:

2025-08-01

Conditions

• Smokeless Tobacco

Interventions

• DRUG

No Results Yet