Clinical Trials Updated in 2025

NCT05940675 | COMPLETED | NA

1372 participants

Generation Healthy Kids: A Cluster-randomized Trial of a Multi-component, Multi-setting Intervention

Study Type:: INTERVENTIONAL
Last Updated:: 2025-11-26
Start Date:: 2023-08-14
Completion:: 2025-06-30

Conditions

Childhood Obesity
Well-Being, Psychological
Physical Inactivity
Sleep
Screen Time
Diet Habit

Interventions

BEHAVIORAL

No Results Yet

NCT05920759 | COMPLETED | NA

16 participants

Sex-specific Effect of Restricted Sleep on Brain Health

Study Type:: INTERVENTIONAL
Last Updated:: 2025-11-26
Start Date:: 2023-10-01
Completion:: 2025-07-01

Conditions

Cerebrovascular Circulation

Interventions

DIAGNOSTIC_TEST

No Results Yet

NCT05911802 | RECRUITING

500 participants

Prognostic Analyses on a Validation Series of Patients With Waldenström's Disease

Study Type:: OBSERVATIONAL
Last Updated:: 2025-11-26
Start Date:: 2023-08-11
Completion:: 2030-06-15

Conditions

Waldenstrom's Disease
Prognostic Index

No Results Yet

NCT05885594 | ACTIVE_NOT_RECRUITING | EARLY_PHASE1

4 participants

Imaging Inflammation With Alcohol Use Disorder: an [18F]NOS Study

Study Type:: INTERVENTIONAL
Last Updated:: 2025-11-26
Start Date:: 2023-08-08
Completion:: 2027-03-15

Conditions

Alcohol Use Disorder

Interventions

DRUG

No Results Yet

NCT05884658 | RECRUITING | NA

200 participants

Hysterectomy by Transvaginal Natural Orifice Transluminal Endoscopic Surgery Versus or Laparoscopic Hysterectomy

Study Type:: INTERVENTIONAL
Last Updated:: 2025-11-26
Start Date:: 2024-12-23
Completion:: 2026-06-30

Conditions

Hysterectomy, Vaginal

Interventions

PROCEDURE

No Results Yet

NCT05867173 | RECRUITING | NA

200 participants

Perceptual Consequences of Cochlear Implant Electrode-neuron Interfaces

Study Type:: INTERVENTIONAL
Last Updated:: 2025-11-26
Start Date:: 2022-09-16
Completion:: 2027-03-31

Conditions

Deafness

Interventions

OTHER

No Results Yet

NCT05856552 | RECRUITING | NA

5370 participants

The Health and Social Consequences of Depression Among the Elderly

Study Type:: INTERVENTIONAL
Last Updated:: 2025-11-26
Start Date:: 2024-11-20
Completion:: 2028-12-31

Conditions

Depression
Functional Impairment

Interventions

BEHAVIORAL

No Results Yet

NCT05848323 | COMPLETED | NA

21 participants

Prospective Case Series to Refine Standalone Cognitive Behavioral Therapy Components for Multiple Sclerosis Fatigue

Study Type:: INTERVENTIONAL
Last Updated:: 2025-11-26
Start Date:: 2023-10-30
Completion:: 2024-09-25

Conditions

Multiple Sclerosis
Fatigue

Interventions

BEHAVIORAL

Results Available

NCT05842343 | TERMINATED | NA

14 participants

Food Intake and IgA Microbiota in Anorexia Nervosa

Study Type:: INTERVENTIONAL
Last Updated:: 2025-11-26
Start Date:: 2023-10-13
Completion:: 2023-11-28

Conditions

Anorexia Nervosa
Healthy Volunteer

Interventions

OTHER

No Results Yet

NCT05841628 | RECRUITING | NA

15 participants

Tolerability of 532 nm Laser Treatment of Port Wine Stains

Study Type:: INTERVENTIONAL
Last Updated:: 2025-11-26
Start Date:: 2023-05-01
Completion:: 2026-12-31

Conditions

Port-Wine Stain

Interventions

DEVICE

No Results Yet

NCT05837650 | COMPLETED | NA

30 participants

Emotional Awareness and Expression Therapy (EAET) as a Novel Migraine Treatment

Study Type:: INTERVENTIONAL
Last Updated:: 2025-11-26
Start Date:: 2023-04-01
Completion:: 2025-03-31

Conditions

Migraine Disorders

Interventions

BEHAVIORAL

No Results Yet

NCT05822830 | COMPLETED | PHASE3

751 participants

A Study of Tirzepatide (LY3298176) in Participants With Obesity or Overweight With Weight Related Comorbidities

Study Type:: INTERVENTIONAL
Last Updated:: 2025-11-26
Start Date:: 2023-04-21
Completion:: 2024-11-13

Conditions

Obesity
Overweight

Interventions

DRUG

Results Available

NCT05806749 | ACTIVE_NOT_RECRUITING | PHASE1

16 participants

Immunological Tolerance in Patients With Mismatched Kidney Transplants

Study Type:: INTERVENTIONAL
Last Updated:: 2025-11-26
Start Date:: 2023-07-07
Completion:: 2028-08-31

Conditions

End Stage Kidney Disease
Immunological Tolerance
Kidney Transplant Failure and Rejection
Chronic Kidney Diseases

Interventions

COMBINATION_PRODUCT

No Results Yet

NCT05798481 | COMPLETED | EARLY_PHASE1

14 participants

Effect of Sublingually Generated S-nitroso-N-acetylcysteine on Systemic Blood Pressure.

Study Type:: INTERVENTIONAL
Last Updated:: 2025-11-26
Start Date:: 2024-03-27
Completion:: 2025-04-29

Conditions

Hypertension
Cardiovascular Diseases

Interventions

DRUG

No Results Yet

NCT05795595 | COMPLETED | PHASE1/PHASE2

19 participants

A Safety and Efficacy Study Evaluating CTX131 in Adult Subjects With Relapsed or Refractory Solid Tumors

Study Type:: INTERVENTIONAL
Last Updated:: 2025-11-26
Start Date:: 2023-03-13
Completion:: 2025-09-18

Conditions

Clear Cell Renal Cell Carcinoma
Cervical Carcinoma
Esophageal Carcinoma
Pancreatic Adenocarcinoma
Malignant Pleural Mesothelioma

Interventions

BIOLOGICAL

No Results Yet

NCT05777889 | RECRUITING

12 participants

Infrared Images for Spinal Cord Stimulation in Complex Regional Pain Syndrome Patients

Study Type:: OBSERVATIONAL
Last Updated:: 2025-11-26
Start Date:: 2023-02-22
Completion:: 2027-02-28

Conditions

Complex Regional Pain Syndromes

Interventions

OTHER

No Results Yet

NCT05757427 | COMPLETED | NA

73 participants

Pilot Clinical Evaluation of a Microwave Imaging System for Breast Cancer Detection

Study Type:: INTERVENTIONAL
Last Updated:: 2025-11-26
Start Date:: 2023-03-09
Completion:: 2024-06-13

Conditions

Breast Cancer

Interventions

DEVICE

Results Available

NCT05738096 | RECRUITING | EARLY_PHASE1

30 participants

Trigeminal Evoked Responses to Improve Rhizotomy

Study Type:: INTERVENTIONAL
Last Updated:: 2025-11-26
Start Date:: 2023-11-01
Completion:: 2026-11-01

Conditions

Trigeminal Neuralgia
Rhizotomy

Interventions

OTHER

No Results Yet

NCT05721287 | COMPLETED | PHASE1

48 participants

A Phase 1, Randomized, Placebo-Controlled Safety and Tolerability Study Of Intravenous SBS-1000 in Healthy Adults

Study Type:: INTERVENTIONAL
Last Updated:: 2025-11-26
Start Date:: 2023-01-30
Completion:: 2023-08-15

Conditions

Pain
Acute Pain

Interventions

DRUG

No Results Yet

NCT05668390 | COMPLETED | PHASE3

553 participants

Safety and Efficacy of STALORAL® Birch 300 IR in a Paediatric Population With Birch Pollen-induced ARC w/o Asthma

Study Type:: INTERVENTIONAL
Last Updated:: 2025-11-26
Start Date:: 2023-09-20
Completion:: 2025-08-06

Conditions

Allergic Rhinoconjunctivitis
Birch Pollen Allergy

Interventions

DRUG

No Results Yet

NCT05600309 | COMPLETED | PHASE3

94 participants

A Study of Coformulated Favezelimab/Pembrolizumab (MK-4280A) Versus Standard of Care in Subjects With Previously Treated Metastatic PD-L1 Positive Colorectal Cancer (MK-4280A-007)-China Extension Study

Study Type:: INTERVENTIONAL
Last Updated:: 2025-11-26
Start Date:: 2022-06-14
Completion:: 2024-08-15

Conditions

Colorectal Cancer

Interventions

BIOLOGICAL
DRUG

Results Available

NCT05589376 | ENROLLING_BY_INVITATION

20000 participants

You and Me Healthy

Study Type:: OBSERVATIONAL
Last Updated:: 2025-11-26
Start Date:: 2022-09-08
Completion:: 2027-12-31

Conditions

COVID-19

No Results Yet

NCT05584202 | TERMINATED | PHASE2

68 participants

Study to Evaluate the Safety, Reactogenicity, and Effectiveness of mRNA-1273.214 SARS-CoV-2 (COVID-19) Vaccine in Infants

Study Type:: INTERVENTIONAL
Last Updated:: 2025-11-26
Start Date:: 2022-09-30
Completion:: 2024-11-15

Conditions

SARS-CoV-2

Interventions

BIOLOGICAL
OTHER

Results Available

NCT05525507 | RECRUITING | PHASE1

10 participants

Delayed Immunological Tolerance in Patients With Well-functioning Pre-existing HLA-matched Kidney Transplants

Study Type:: INTERVENTIONAL
Last Updated:: 2025-11-26
Start Date:: 2022-12-21
Completion:: 2026-12-31

Conditions

End Stage Kidney Disease
Immunological Tolerance
Kidney Transplant Failure and Rejection
Chronic Kidney Diseases

Interventions

COMBINATION_PRODUCT

No Results Yet

NCT05492032 | RECRUITING | NA

150 participants

Cumulative and Booster Effects of Multisession Prefrontal Transcranial Direct Current Stimulation in Adolescents With ASD

Study Type:: INTERVENTIONAL
Last Updated:: 2025-11-26
Start Date:: 2022-06-02
Completion:: 2026-09-30

Conditions

Transcranial Direct Current Stimulation
Autistic Spectrum Disorder
Electroencephalography
Booster Effects

Interventions

DEVICE
BEHAVIORAL

No Results Yet

NCT05489614 | COMPLETED | PHASE1

33 participants

A Study to Evaluate the Pharmacokinetics, Safety, and Pharmacodynamics of Olpasiran in Participants With Normal Renal Function and Participants With Various Degrees of Renal Impairment

Study Type:: INTERVENTIONAL
Last Updated:: 2025-11-26
Start Date:: 2022-09-13
Completion:: 2023-10-24

Conditions

Renal Impairment

Interventions

DRUG

No Results Yet

NCT05464836 | TERMINATED | PHASE2

2 participants

Phase II Study to Evaluate Safety and Efficacy of CB-103 With Venetoclax in Adolescent and Young Adult Patients With Relapsed/Refractory T-ALL or T-LBL

Study Type:: INTERVENTIONAL
Last Updated:: 2025-11-26
Start Date:: 2023-04-06
Completion:: 2024-08-12

Conditions

Leukemia, Lymphoblastic
Leukemia

Interventions

DRUG

Results Available

NCT05458011 | COMPLETED | PHASE3

365 participants

A Randomized, Double-Blind, Placebo-Controlled Study With an Open-Label Period on Efficacy and Safety of Fremanezumab in Chinese Adults With Migraine

Study Type:: INTERVENTIONAL
Last Updated:: 2025-11-26
Start Date:: 2022-09-30
Completion:: 2024-01-31

Conditions

Migraine

Interventions

DRUG

Results Available

NCT05441592 | COMPLETED | PHASE4

107 participants

A Randomized Control Trial Assessing the Effect of Topical Tranexamic Acid on Risk of Hematoma in Breast Surgery

Study Type:: INTERVENTIONAL
Last Updated:: 2025-11-26
Start Date:: 2022-08-15
Completion:: 2024-10-22

Conditions

Hematoma Postoperative

Interventions

DRUG
OTHER

Results Available

NCT05436834 | COMPLETED | PHASE3

1807 participants

A Study to Evaluate the Safety and Immunogenicity of the mRNA COVID-19 Vaccines in Healthy Children Between 6 Months to Less Than 6 Years of Age

Study Type:: INTERVENTIONAL
Last Updated:: 2025-11-26
Start Date:: 2022-06-21
Completion:: 2025-10-20

Conditions

SARS-CoV-2

Interventions

BIOLOGICAL

No Results Yet

NCT05393388 | ACTIVE_NOT_RECRUITING

111 participants

Tau Pet Imaging in the Aging Brain Cohort Dedicated to Diversity Study

Study Type:: OBSERVATIONAL
Last Updated:: 2025-11-26
Start Date:: 2022-07-06
Completion:: 2027-05-31

Conditions

Cognitive Decline
Alzheimer Disease

Interventions

DRUG

No Results Yet

NCT05388656 | COMPLETED | PHASE4

40 participants

Estrogen Variability and Irritability During the Menopause Transition

Study Type:: INTERVENTIONAL
Last Updated:: 2025-11-26
Start Date:: 2022-06-15
Completion:: 2024-12-17

Conditions

Menopause
Irritable Mood

Interventions

DRUG

Results Available

NCT05371912 | COMPLETED | NA

16 participants

Enhancement of Behavioral and Cognitive Outcomes in Autism Spectrum Disorder Via Neurostimulation

Study Type:: INTERVENTIONAL
Last Updated:: 2025-11-26
Start Date:: 2022-03-15
Completion:: 2023-10-31

Conditions

Autism Spectrum Disorder

Interventions

DEVICE

Results Available

NCT05346380 | COMPLETED | PHASE1/PHASE2

38 participants

Near-Infrared Perfusion During Minimally Invasive Thoracic Surgery Download

Study Type:: INTERVENTIONAL
Last Updated:: 2025-11-26
Start Date:: 2020-10-29
Completion:: 2025-06-03

Conditions

Lung Neoplasms
Esophageal Lesion

Interventions

DEVICE
DRUG

No Results Yet

NCT05287464 | RECRUITING

1220 participants

International Multicentric Study ARON-1

Study Type:: OBSERVATIONAL
Last Updated:: 2025-11-26
Start Date:: 2022-03-10
Completion:: 2024-06-01

Conditions

Metastatic Renal Cell Carcinoma (mRCC)

Interventions

DRUG

No Results Yet

NCT05279898 | COMPLETED | NA

70 participants

Perioperative Multimodal General AnesTHesia Focusing on Specific CNS Targets in Patients Undergoing carDiac surgERies

Study Type:: INTERVENTIONAL
Last Updated:: 2025-11-26
Start Date:: 2023-02-28
Completion:: 2024-06-30

Conditions

Postoperative Delirium
Hemodynamic Instability
Pain
Neurocognitive Dysfunction

Interventions

DEVICE
DRUG

Results Available

NCT05236465 | RECRUITING | NA

100 participants

A 3-day Course for CFS/ME

Study Type:: INTERVENTIONAL
Last Updated:: 2025-11-26
Start Date:: 2022-03-21
Completion:: 2027-01-01

Conditions

Chronic Fatigue Syndrome
Myalgic Encephalomyelitis

Interventions

BEHAVIORAL

No Results Yet

NCT05232877 | ACTIVE_NOT_RECRUITING | NA

27 participants

Effects of t-DCS and Cognitive Training on Apathy in Elderly With Minor Neurocognitive Impairment

Study Type:: INTERVENTIONAL
Last Updated:: 2025-11-26
Start Date:: 2022-04-05
Completion:: 2025-04-04

Conditions

Apathy
Neurocognitive Disorders

Interventions

OTHER

No Results Yet

NCT05205967 | ACTIVE_NOT_RECRUITING

14633 participants

REFLECTION: A Clinical Practice Learning Program for Galleri®

Study Type:: OBSERVATIONAL
Last Updated:: 2025-11-26
Start Date:: 2021-08-23
Completion:: 2025-09-30

Conditions

Early Detection of Cancer
Cancer

Interventions

OTHER

No Results Yet

NCT05195359 | COMPLETED | NA

637 participants

The Effects of a Personalized Sleep Improvement App From SleepScore Labs

Study Type:: INTERVENTIONAL
Last Updated:: 2025-11-26
Start Date:: 2023-01-31
Completion:: 2023-08-15

Conditions

Health Behavior

Interventions

BEHAVIORAL

Results Available