Clinical Trials Updated in 2025

NCT06680284 | RECRUITING

60 participants

Toronto Western Hospital (TWH) Waste Audit

Study Type:: OBSERVATIONAL
Last Updated:: 2025-11-20
Start Date:: 2023-07-27
Completion:: 2025-12-31

Conditions

Audit of Medical Waste Disposal

Interventions

OTHER

No Results Yet

NCT06677918 | COMPLETED | PHASE1

40 participants

Clinical Trial Investigating the Effects of EP395 Following an Inhaled Endotoxin Challenge in Healthy Adults

Study Type:: INTERVENTIONAL
Last Updated:: 2025-11-20
Start Date:: 2025-02-20
Completion:: 2025-08-25

Conditions

Healthy Volunteer

Interventions

DRUG

No Results Yet

NCT06677450 | COMPLETED | NA

42 participants

Effectiveness of Pain Neuroscience Education in Rotator Cuff Related Shoulder Pain

Study Type:: INTERVENTIONAL
Last Updated:: 2025-11-20
Start Date:: 2024-12-01
Completion:: 2025-11-01

Conditions

Rotator Cuff Related Shoulder Pain
Impingement Syndrome
Shoulder Tendinopathy

Interventions

OTHER

No Results Yet

NCT06674928 | COMPLETED

500 participants

Developmental Trajectory of Gene and Life Participation in Children With Developmental Delay

Study Type:: OBSERVATIONAL
Last Updated:: 2025-11-20
Start Date:: 2024-07-01
Completion:: 2024-10-31

Conditions

Genetics
Life Participation

No Results Yet

NCT06662266 | ENROLLING_BY_INVITATION | NA

60 participants

Induce XT™ Bone Graft in Foot and Ankle Fusion

Study Type:: INTERVENTIONAL
Last Updated:: 2025-11-20
Start Date:: 2025-05-12
Completion:: 2026-11-01

Conditions

Surgery
Foot Deformities
Ankle Arthropathy

Interventions

DEVICE

No Results Yet

NCT06661954 | COMPLETED | NA

18 participants

Comparison of Sacral Interface Pressure in Healthy Volunteers on Two Dynamic Pressure-Prevention Support Surfaces

Study Type:: INTERVENTIONAL
Last Updated:: 2025-11-20
Start Date:: 2024-10-11
Completion:: 2024-10-23

Conditions

Healthy Volunteer
Pressure Distribution

Interventions

DEVICE

Results Available

NCT06653153 | ACTIVE_NOT_RECRUITING | PHASE3

1400 participants

A Study of Remternetug (LY3372993) in Early Alzheimer's Disease (TRAILRUNNER-ALZ 3)

Study Type:: INTERVENTIONAL
Last Updated:: 2025-11-20
Start Date:: 2024-10-24
Completion:: 2029-04-30

Conditions

Alzheimer's Disease

Interventions

DRUG

No Results Yet

NCT06652672 | RECRUITING | NA

341 participants

Sentinel Node and Organ-sparing Surgery in Stage I Colon Carcinoma

Study Type:: INTERVENTIONAL
Last Updated:: 2025-11-20
Start Date:: 2024-12-12
Completion:: 2030-12-12

Conditions

Colon Cancer
Colon Adenocarcinoma
Sentinel Lymph Node
Sentinel Lymph Node Biopsy
Colon Neoplasms
Colon Neoplasm
Fluorescence
Fluorescence Guided Surgery
Fluorescence Laparoscopy
Fluorescence-guided Resection
Colon Surgery
Indocyanine Green (ICG)

Interventions

PROCEDURE

No Results Yet

NCT06649435 | COMPLETED

131 participants

Seerlinq: Non-invasive LVFP Monitoring in HF

Study Type:: OBSERVATIONAL
Last Updated:: 2025-11-20
Start Date:: 2023-03-01
Completion:: 2023-12-01

Conditions

Heart Failure
Photoplethysmography
Right Heart Catheterization

Interventions

PROCEDURE

No Results Yet

NCT06642909 | ACTIVE_NOT_RECRUITING | PHASE2

135 participants

A Phase II Study of Zuberitamab Injection in Patients With Primary Membranous Nephropathy

Study Type:: INTERVENTIONAL
Last Updated:: 2025-11-20
Start Date:: 2024-11-13
Completion:: 2027-03-31

Conditions

Primary Membranous Nephropathy

Interventions

DRUG

No Results Yet

NCT06641414 | RECRUITING | PHASE3

490 participants

Lisaftoclax (APG-2575) Combined With Azacytidine (AZA) in the Treatment of Patients With Higher-risk Myelodysplastic Syndrome (GLORA-4).

Study Type:: INTERVENTIONAL
Last Updated:: 2025-11-20
Start Date:: 2025-01-22
Completion:: 2029-06-30

Conditions

Higher-risk Myelodysplastic Syndrome

Interventions

DRUG
OTHER

No Results Yet

NCT06630702 | RECRUITING | NA

5 participants

Application of Thoracic Epidural SCS for Managing FOG in Patients With Advanced Parkinson's Disease

Study Type:: INTERVENTIONAL
Last Updated:: 2025-11-20
Start Date:: 2024-09-20
Completion:: 2027-12-31

Conditions

Parkinson Disease
Freezing of Gait
Spinal Cord Stimulation

Interventions

DEVICE

No Results Yet

NCT06628206 | RECRUITING | PHASE1

48 participants

Safety and Pharmacokinetics of LPX-TI641 in Rheumatoid Arthritis and Psoriatic Arthritis

Study Type:: INTERVENTIONAL
Last Updated:: 2025-11-20
Start Date:: 2024-12-15
Completion:: 2025-12-15

Conditions

Rheumatoid Arthritis (RA)
Psoriatic Arthritis (PsA)

Interventions

DRUG

No Results Yet

NCT06606899 | COMPLETED | NA

60 participants

A Comparison Between Oral Melatonin With Nasal Sevoflurane Versus Oral Chloral Hydrate With Nasal Sevoflurane in Sedation of Children Undergoing Brain MRI

Study Type:: INTERVENTIONAL
Last Updated:: 2025-11-20
Start Date:: 2024-09-20
Completion:: 2024-12-30

Conditions

Sedation for Children Undergoing MRI

Interventions

DRUG

No Results Yet

NCT06599580 | RECRUITING | NA

2400 participants

Mother Screening for Relapse Using Mid-upper Arm Circumference Among Children Recovered From Severe Acute Malnutrition (Full Scale Trial)

Study Type:: INTERVENTIONAL
Last Updated:: 2025-11-20
Start Date:: 2025-03-20
Completion:: 2027-11-30

Conditions

Malnutrition, Child
Malnutrition, Infant
Malnutrition or Risk of Malnutrition
Hemoglobin Level Measurement
Anemia

Interventions

BEHAVIORAL
OTHER

No Results Yet

NCT06597981 | RECRUITING | NA

144 participants

Dyadic Sport Stacking Program for Mild Dementia and Their Family Caregivers

Study Type:: INTERVENTIONAL
Last Updated:: 2025-11-20
Start Date:: 2024-09-19
Completion:: 2026-02-28

Conditions

Dementia
Family Caregivers
Dyadic Intervention
Health Related Quality of Life
Cognition

Interventions

BEHAVIORAL
OTHER

No Results Yet

NCT06583031 | COMPLETED | PHASE1

385 participants

Study to Evaluate the Safety and Immune Response of an Investigational Vaccine for the Prevention of RSV (Respiratory Syncytial Virus) and (hMPV) Human Metapneumovirus Infection in Participants Aged 60 to 75 Years

Study Type:: INTERVENTIONAL
Last Updated:: 2025-11-20
Start Date:: 2024-10-09
Completion:: 2025-10-09

Conditions

RSV Infection
hMPV

Interventions

BIOLOGICAL

No Results Yet

NCT06577831 | COMPLETED | NA

50 participants

Dynamic Monitoring and Characterization of Pelvic by 3D Ultrafast MRI

Study Type:: INTERVENTIONAL
Last Updated:: 2025-11-20
Start Date:: 2022-02-25
Completion:: 2025-02-24

Conditions

Pelvic Deformity

Interventions

DIAGNOSTIC_TEST

No Results Yet

NCT06576570 | ENROLLING_BY_INVITATION | NA

30 participants

Evaluation and Modification of Surgeon Ergonomics in the Operation Room Using Artificial Intelligence Analytics

Study Type:: INTERVENTIONAL
Last Updated:: 2025-11-20
Start Date:: 2024-10-21
Completion:: 2026-10-15

Conditions

Work Related Upper Limb Disorder
Musculoskeletal Pain

Interventions

BEHAVIORAL

No Results Yet

NCT06560671 | RECRUITING | NA

252 participants

Compare the Patient Satisfaction and Effectiveness After Novel Application-based or Conventional Health Education of Bowel Preparation for Colonoscopy

Study Type:: INTERVENTIONAL
Last Updated:: 2025-11-20
Start Date:: 2024-08-01
Completion:: 2025-12-31

Conditions

Colo-rectal Cancer
Colon Lesion

Interventions

OTHER

No Results Yet

NCT06536634 | RECRUITING | NA

34 participants

Effects and Mechanisms of Sensory Afferent Electrostimulation on Upper Limb Function in Patients With Hemiparesis

Study Type:: INTERVENTIONAL
Last Updated:: 2025-11-20
Start Date:: 2025-01-01
Completion:: 2027-10-01

Conditions

Hemiparesis
Unilateral Cerebral Palsy

Interventions

OTHER

No Results Yet

NCT06535893 | RECRUITING | PHASE2

100 participants

Sustainable and Efficient Platform Trial of New Therapeutic Development for Early Breast Cancer

Study Type:: INTERVENTIONAL
Last Updated:: 2025-11-20
Start Date:: 2024-07-30
Completion:: 2027-06-30

Conditions

Breast Cancer

Interventions

DRUG

No Results Yet

NCT06534970 | RECRUITING

50 participants

Assessment of Facial Symmetry After Facial Reconstruction Using Three-dimensional Stereophotogrammetry

Study Type:: OBSERVATIONAL
Last Updated:: 2025-11-20
Start Date:: 2025-06-03
Completion:: 2027-06-30

Conditions

Facial Reconstruction

Interventions

DEVICE
OTHER

No Results Yet

NCT06534008 | COMPLETED | NA

33 participants

Strive Cardio for Endometrial Cancer Survivors

Study Type:: INTERVENTIONAL
Last Updated:: 2025-11-20
Start Date:: 2024-07-23
Completion:: 2025-11-17

Conditions

Endometrial Cancer
Cardiovascular Diseases

Interventions

BEHAVIORAL

No Results Yet

NCT06529744 | RECRUITING

500 participants

Improving Prognostic Confidence in Neurodegenerative Diseases Causing Dementia Using Peripheral Biomarkers and Integrative Modeling

Study Type:: OBSERVATIONAL
Last Updated:: 2025-11-20
Start Date:: 2023-11-11
Completion:: 2026-11-30

Conditions

Dementia
Alzheimer Disease
Dementia With Lewy Bodies
Vascular Dementia
Frontotemporal Dementia
Mild Cognitive Impairment
Corticobasal Syndrome
Progressive Supranuclear Palsy
Parkinson Disease
Primary Progressive Aphasia

No Results Yet

NCT06526156 | ACTIVE_NOT_RECRUITING

55 participants

Hypobaric L5-S1 Study

Study Type:: OBSERVATIONAL
Last Updated:: 2025-11-20
Start Date:: 2024-07-22
Completion:: 2025-03-20

Conditions

Anesthesia
Anesthesia, Local

Interventions

DRUG

No Results Yet

NCT06523179 | RECRUITING | NA

500 participants

Evaluation of Risk of hEpatocellular Carcinoma

Study Type:: INTERVENTIONAL
Last Updated:: 2025-11-20
Start Date:: 2018-01-01
Completion:: 2030-01-01

Conditions

NASH
HCC
Genetic Predisposition

Interventions

OTHER

No Results Yet

NCT06500676 | RECRUITING | PHASE1/PHASE2

407 participants

A Study of GFH375 in Patients With Advanced Solid Tumors With KRAS G12D Mutations

Study Type:: INTERVENTIONAL
Last Updated:: 2025-11-20
Start Date:: 2024-07-09
Completion:: 2028-07-31

Conditions

KRAS G12D Mutations
Advanced Solid Tumors

Interventions

DRUG

No Results Yet

NCT06496490 | RECRUITING | PHASE2

270 participants

A Clinical Trial of TQB2102 for Injection in Non-small Cell Lung Cancer With HER2 Gene Abnormality

Study Type:: INTERVENTIONAL
Last Updated:: 2025-11-20
Start Date:: 2024-08-06
Completion:: 2026-06-30

Conditions

Non-Small Cell Lung Cancer

Interventions

DRUG

No Results Yet

NCT06495645 | RECRUITING | NA

1000 participants

Miss Rate of Gastric Neoplasms Under Computer-aided Endoscopy

Study Type:: INTERVENTIONAL
Last Updated:: 2025-11-20
Start Date:: 2024-11-01
Completion:: 2026-09-01

Conditions

Gastric Neoplasm
Artificial Intelligence

Interventions

DEVICE

No Results Yet

NCT06493279 | ACTIVE_NOT_RECRUITING | PHASE1

9 participants

Evaluate the Safety and Efficacy of Intrathecal Injection of RJK002 in Patients With Amyotrophic Lateral Sclerosis

Study Type:: INTERVENTIONAL
Last Updated:: 2025-11-20
Start Date:: 2024-09-24
Completion:: 2026-11-30

Conditions

Amyotrophic Lateral Sclerosis Als

Interventions

DRUG

No Results Yet

NCT06472661 | RECRUITING | EARLY_PHASE1

11 participants

FUSA With Intratumoral PolyICLC in Regionally Advanced Resectable Melanoma

Study Type:: INTERVENTIONAL
Last Updated:: 2025-11-20
Start Date:: 2024-09-27
Completion:: 2026-08-31

Conditions

Advanced Melanoma

Interventions

DEVICE
DRUG

No Results Yet

NCT06471842 | RECRUITING

200 participants

Study of the Prevalence of Pediatric Eating Disorders in Inherited Metabolic Diseases With Dietary Treatment

Study Type:: OBSERVATIONAL
Last Updated:: 2025-11-20
Start Date:: 2024-08-21
Completion:: 2026-08-31

Conditions

Inherited Metabolism Disease

Interventions

OTHER

No Results Yet

NCT06470776 | COMPLETED | NA

154 participants

Chatbot Counselling for Smoking Cessation in Youths

Study Type:: INTERVENTIONAL
Last Updated:: 2025-11-20
Start Date:: 2024-07-07
Completion:: 2025-06-25

Conditions

Tobacco Use
Smoking Cessation

Interventions

BEHAVIORAL

No Results Yet

NCT06469983 | RECRUITING | NA

118 participants

Robotic vs. Traditional Verticalization in Patients With Severe Acquired Brain Injury: a Randomized Controlled Trial

Study Type:: INTERVENTIONAL
Last Updated:: 2025-11-20
Start Date:: 2024-12-02
Completion:: 2026-06-30

Conditions

Acquired Brain Injury
Disorder of Consciousness

Interventions

DEVICE
BEHAVIORAL

No Results Yet

NCT06451640 | COMPLETED | PHASE2

59 participants

A Extension Clinical Study of TQC2731 Injection in the Treatment of Chronic Sinusitis With Nasal Polyps

Study Type:: INTERVENTIONAL
Last Updated:: 2025-11-20
Start Date:: 2024-07-04
Completion:: 2025-10-17

Conditions

Chronic Rhinosinusitis With Nasal Polyps

Interventions

DRUG

No Results Yet

NCT06427421 | RECRUITING | NA

80 participants

Characterization of Autoreactive Regulatory and Conventional CD4 T Cells in Recent Onset Type 1 Diabetes and Control Individuals

Study Type:: INTERVENTIONAL
Last Updated:: 2025-11-20
Start Date:: 2025-05-06
Completion:: 2027-05-31

Conditions

Type 1 Diabetes

Interventions

BIOLOGICAL

No Results Yet

NCT06426316 | RECRUITING | NA

396 participants

The Role of Cytokines and Regulatory T Lymphocytes in Migraine Pathophysiology.

Study Type:: INTERVENTIONAL
Last Updated:: 2025-11-20
Start Date:: 2025-06-02
Completion:: 2027-04-30

Conditions

Pain
Autoimmune Diseases
Migraine Disorders
Multiple Sclerosis
Endometriosis
Rheumatoid Arthritis
Crohn Disease
Lupus Erythematosus

Interventions

BIOLOGICAL

No Results Yet

NCT06426121 | COMPLETED

394 participants

Clinical Validation of BACTEC™ Plus Aerobic/F Culture Vials Compared With Equivalent Product

Study Type:: OBSERVATIONAL
Last Updated:: 2025-11-20
Start Date:: 2024-06-26
Completion:: 2025-10-23

Conditions

Sepsis

Interventions

DIAGNOSTIC_TEST

No Results Yet

NCT06420739 | ACTIVE_NOT_RECRUITING

100 participants

The Semaglutide Study

Study Type:: OBSERVATIONAL
Last Updated:: 2025-11-20
Start Date:: 2024-03-25
Completion:: 2025-11-30

Conditions

Fasting

Interventions

DIAGNOSTIC_TEST

No Results Yet