Clinical Trials Updated in 2025

NCT05176002 | ACTIVE_NOT_RECRUITING | PHASE1/PHASE2

25 participants

Camrelizumab in Combination With Radiotherapy for Neoadjuvant Esophageal Carcinoma.

Study Type:: INTERVENTIONAL
Last Updated:: 2025-11-19
Start Date:: 2021-11-10
Completion:: 2023-09-30

Conditions

Esophageal Neoplasm
Immunotherapy
Radiotherapy

Interventions

DRUG

No Results Yet

NCT05153382 | RECRUITING | NA

60 participants

Dialectical Behavior Therapy for Youth With and/or at Familial Risk for Bipolar Disorder

Study Type:: INTERVENTIONAL
Last Updated:: 2025-11-19
Start Date:: 2021-11-01
Completion:: 2026-11-30

Conditions

Bipolar Disorder

Interventions

BEHAVIORAL

No Results Yet

NCT05153369 | RECRUITING | NA

60 participants

Three-level Model of DBT-informed Care for Youth With and/or at Familial Risk for Bipolar Disorder (DB3)

Study Type:: INTERVENTIONAL
Last Updated:: 2025-11-19
Start Date:: 2021-11-01
Completion:: 2026-03-31

Conditions

Bipolar Disorder

Interventions

BEHAVIORAL

No Results Yet

NCT05142826 | COMPLETED | NA

62 participants

Investigation of Strategies to Reduce the Impact of the Relative Age Effect in Kindergarten

Study Type:: INTERVENTIONAL
Last Updated:: 2025-11-19
Start Date:: 2022-06-01
Completion:: 2024-11-30

Conditions

Attention Deficit Hyperactivity Disorder

Interventions

BEHAVIORAL
OTHER

Results Available

NCT05138432 | RECRUITING | NA

200 participants

More Fresh Fruit and Vegetable Prescription Program for Families With Type 2 Diabetes Mellitus

Study Type:: INTERVENTIONAL
Last Updated:: 2025-11-19
Start Date:: 2021-11-29
Completion:: 2026-06-01

Conditions

Type 2 Diabetes

Interventions

BEHAVIORAL

No Results Yet

NCT05132036 | COMPLETED | NA

46 participants

Lung Ultrasound Assessment of Fluid Overload in Haemodialysis Patients

Study Type:: INTERVENTIONAL
Last Updated:: 2025-11-19
Start Date:: 2021-11-09
Completion:: 2022-06-01

Conditions

Lung Ultrasound
Hemodialysis Complication

Interventions

OTHER

No Results Yet

NCT05105984 | COMPLETED

54 participants

Evaluation of a Free-breathing Cardiac Cine-MRI Sequence With Image Reconstructions by Deep-Learning in Ischemic Heart Disease

Study Type:: OBSERVATIONAL
Last Updated:: 2025-11-19
Start Date:: 2022-04-14
Completion:: 2023-04-24

Conditions

Magnetic Resonance Imaging
Cardiac Magnetic Resonance Imaging
Deep-Learning
Left Ventricular Ejection Fraction

No Results Yet

NCT05103189 | COMPLETED | NA

28 participants

4D-flow Cardiac MRI to Assess Pulmonary Arterial Pressure in Pulmonary Hypertension

Study Type:: INTERVENTIONAL
Last Updated:: 2025-11-19
Start Date:: 2021-10-21
Completion:: 2023-07-01

Conditions

Pulmonary Hypertension
Magnetic Resonance Imaging
Pulmonary Arterial Pressure
Right Heart Catheterization
Echocardiography

Interventions

OTHER

No Results Yet

NCT05091099 | COMPLETED | PHASE4

44 participants

The Optimal Sequential Therapy After Long Term Denosumab Treatment

Study Type:: INTERVENTIONAL
Last Updated:: 2025-11-19
Start Date:: 2022-01-10
Completion:: 2025-11-14

Conditions

Osteoporosis

Interventions

DRUG

No Results Yet

NCT05072236 | COMPLETED | NA

108 participants

Effects of Adding Different Drugs for Preventing Cough Induced by Bronchoscopic Spraying of Local Anesthetics

Study Type:: INTERVENTIONAL
Last Updated:: 2025-11-19
Start Date:: 2022-05-09
Completion:: 2024-06-30

Conditions

Lung Diseases
Total Intravenous Anesthesia
Bronchoscopic Interventions

Interventions

PROCEDURE

No Results Yet

NCT05055479 | COMPLETED

14 participants

Nosocomial Outbreak of BHRe in an Intensive Care Unit During SARS-CoV-2 Pandemic

Study Type:: OBSERVATIONAL
Last Updated:: 2025-11-19
Start Date:: 2021-08-01
Completion:: 2022-01-01

Conditions

Enterobacteriaceae Infections
Hospital-Acquired Infection

No Results Yet

NCT05052723 | COMPLETED | PHASE2

21 participants

Cabozantinib and Pembrolizumab in Metastatic Pancreas

Study Type:: INTERVENTIONAL
Last Updated:: 2025-11-19
Start Date:: 2022-01-04
Completion:: 2024-11-05

Conditions

Pancreatic Cancer

Interventions

DRUG

Results Available

NCT05046158 | COMPLETED | NA

135 participants

Diabetic Foot Ulcers-Comparing Transforming Powder to Standard of Care

Study Type:: INTERVENTIONAL
Last Updated:: 2025-11-19
Start Date:: 2021-08-16
Completion:: 2025-11-06

Conditions

Diabetic Foot Ulcer

Interventions

DEVICE
OTHER

No Results Yet

NCT05045235 | ACTIVE_NOT_RECRUITING

1500 participants

Optimization of Drug Prescriptions in the Care Pathway for the Elderly, With the Final Objective of Reducing the Iatrogenic Risk

Study Type:: OBSERVATIONAL
Last Updated:: 2025-11-19
Start Date:: 2021-09-01
Completion:: 2025-09-01

Conditions

Iatrogenic Effect
Prescription
Follow-up
Consultation

No Results Yet

NCT05023252 | COMPLETED | NA

87 participants

Mobile Self-Tracking of Mental Health

Study Type:: INTERVENTIONAL
Last Updated:: 2025-11-19
Start Date:: 2021-10-18
Completion:: 2024-07-22

Conditions

Schizophrenia
Bipolar Disorder
Schizoaffective Disorder
Post-traumatic Stress Disorder

Interventions

OTHER

Results Available

NCT05016882 | COMPLETED | PHASE2

698 participants

Research Study on Whether a Combination of 2 Medicines (NNC0194 0499 and Semaglutide) Works in People With Non-alcoholic Steatohepatitis (NASH)

Study Type:: INTERVENTIONAL
Last Updated:: 2025-11-19
Start Date:: 2021-08-31
Completion:: 2024-12-17

Conditions

Non-alcoholic Steatohepatitis

Interventions

DRUG

No Results Yet

NCT05008783 | COMPLETED | PHASE3

610 participants

A Study of AK104 in the First-line Treatment of Locally Advanced Unresectable or Metastatic G/GEJ Adenocarcinoma

Study Type:: INTERVENTIONAL
Last Updated:: 2025-11-19
Start Date:: 2021-09-17
Completion:: 2024-12-06

Conditions

Gastric Adenocarcinoma
Gastroesophageal Junction Adenocarcinoma

Interventions

DRUG

No Results Yet

NCT04982276 | RECRUITING | PHASE1/PHASE2

138 participants

A Study of AK109 and AK104 in Advanced Gastric Adenocarcinoma or Gastroesophageal Junction Adenocarcinoma

Study Type:: INTERVENTIONAL
Last Updated:: 2025-11-19
Start Date:: 2021-08-23
Completion:: 2025-12-30

Conditions

Gastric Adenocarcinoma and Gastroesophageal Junction Adenocarcinoma

Interventions

DRUG
BIOLOGICAL

No Results Yet

NCT04982237 | ACTIVE_NOT_RECRUITING | PHASE3

445 participants

A Study of AK104 Plus Platinum-containing Chemotherapy±Bevacizumab as First-line Treatment for Persistent, Recurrent, or Metastatic Cervical Cancer

Study Type:: INTERVENTIONAL
Last Updated:: 2025-11-19
Start Date:: 2021-08-27
Completion:: 2025-12-30

Conditions

Cervical Cancer

Interventions

BIOLOGICAL
DRUG

No Results Yet

NCT04962776 | RECRUITING | PHASE4

90 participants

Preoperative Coadministration of Low-concentration Carbohydrate and Nitrates Loading vs Low- Concentration Carbohydrate Loading Alone in Patients Undergoing Open Gynecological Surgeries

Study Type:: INTERVENTIONAL
Last Updated:: 2025-11-19
Start Date:: 2021-08-01
Completion:: 2026-04-30

Conditions

Length of Hospital Stay

Interventions

DRUG
OTHER

No Results Yet

NCT04933435 | RECRUITING | NA

78 participants

Interventional Radiology Liver Directed Therapies and Hypofractionated Image-Guided Radiation Therapy in Veteran and Non-Veteran, Non-surgical Hepatocellular Carcinoma Patients

Study Type:: INTERVENTIONAL
Last Updated:: 2025-11-19
Start Date:: 2020-11-12
Completion:: 2027-02-28

Conditions

Liver Cancer

Interventions

OTHER

No Results Yet

NCT04882839 | RECRUITING | PHASE2

15 participants

Evaluating the Feasibility, Safety and Efficacy of Psychotherapy Assisted Psilocybin for Treatment of Severe OCD

Study Type:: INTERVENTIONAL
Last Updated:: 2025-11-19
Start Date:: 2024-11-25
Completion:: 2026-06-01

Conditions

Obsessive-compulsive Disorder

Interventions

COMBINATION_PRODUCT

No Results Yet

NCT04862637 | COMPLETED

48 participants

Detecting the Changes of Swallowing Function in Oral Cancer Patients

Study Type:: OBSERVATIONAL
Last Updated:: 2025-11-19
Start Date:: 2022-09-15
Completion:: 2025-06-10

Conditions

Swallowing Function

No Results Yet

NCT04854499 | TERMINATED | PHASE2

193 participants

Study of Magrolimab Combination Therapy in Patients With Head and Neck Squamous Cell Carcinoma

Study Type:: INTERVENTIONAL
Last Updated:: 2025-11-19
Start Date:: 2021-09-07
Completion:: 2024-10-02

Conditions

Head and Neck Squamous Cell Carcinoma

Interventions

DRUG

Results Available

NCT04828330 | COMPLETED

416 participants

Flares of Low Back Pain With Activity Research Study

Study Type:: OBSERVATIONAL
Last Updated:: 2025-11-19
Start Date:: 2021-03-25
Completion:: 2024-10-24

Conditions

Low Back Pain

Results Available

NCT04762732 | ACTIVE_NOT_RECRUITING | NA

138 participants

The Use of iNPWT for Management of ALT Flap Donor Site Wound

Study Type:: INTERVENTIONAL
Last Updated:: 2025-11-19
Start Date:: 2021-04-08
Completion:: 2026-06-30

Conditions

Incisional Negative Pressure Wound Therapy

Interventions

DEVICE

No Results Yet

NCT04760353 | COMPLETED | NA

80 participants

The Effect of a Probiotic Mixture in Obese Patients With Irritable Bowel Syndrome

Study Type:: INTERVENTIONAL
Last Updated:: 2025-11-19
Start Date:: 2021-11-10
Completion:: 2025-10-17

Conditions

IBS - Irritable Bowel Syndrome
Obesity

Interventions

DIETARY_SUPPLEMENT
OTHER

No Results Yet

NCT04688905 | ACTIVE_NOT_RECRUITING

30 participants

Diagnosing Heart Failure With Preserved Ejection Fraction in Patients With Unexplained Dyspnea (Diagnose-HFpEF)

Study Type:: OBSERVATIONAL
Last Updated:: 2025-11-19
Start Date:: 2020-09-09
Completion:: 2023-08-04

Conditions

Dyspnea

Interventions

DIAGNOSTIC_TEST

No Results Yet

NCT04628936 | COMPLETED | PHASE2

18 participants

Open-label Extension to the Phase 2 Crossover Study (PRESIDIO) Evaluating KZR-616 in Patients With PM and DM.

Study Type:: INTERVENTIONAL
Last Updated:: 2025-11-19
Start Date:: 2020-11-04
Completion:: 2023-03-10

Conditions

Polymyositis
Dermatomyositis

Interventions

DRUG

Results Available

NCT04591093 | RECRUITING | NA

32 participants

Auditory Performances With Different Stimulation Depths in Cochlear Implanted Subjects Using a Fine Structure Strategy

Study Type:: INTERVENTIONAL
Last Updated:: 2025-11-19
Start Date:: 2021-07-10
Completion:: 2026-09-30

Conditions

Sensorineural Hearing Loss, Bilateral

Interventions

DEVICE

No Results Yet

NCT04581304 | ACTIVE_NOT_RECRUITING | NA

36 participants

The Use of Bio-Oss Collagen for Sinus Augmentation Using the Transcrestal Approach.

Study Type:: INTERVENTIONAL
Last Updated:: 2025-11-19
Start Date:: 2020-10-15
Completion:: 2026-12-17

Conditions

Bone Loss
Missing Teeth

Interventions

DEVICE

No Results Yet

NCT04572633 | ACTIVE_NOT_RECRUITING | NA

47 participants

The HistoSonics System for Treatment of Primary and Metastatic Liver Tumors Using Histotripsy

Study Type:: INTERVENTIONAL
Last Updated:: 2025-11-19
Start Date:: 2021-01-27
Completion:: 2023-01-09

Conditions

Liver Neoplasms
Hepatocellular Carcinoma
Liver Metastases

Interventions

DEVICE

Results Available

NCT04565054 | ACTIVE_NOT_RECRUITING | PHASE3

1260 participants

Adjuvant Therapy With Abemaciclib + SOC ET vs. SOC ET in Clinical or Genomic High Risk, HR+/HER2- EBC

Study Type:: INTERVENTIONAL
Last Updated:: 2025-11-19
Start Date:: 2020-09-02
Completion:: 2028-06-30

Conditions

Breast Cancer Female

Interventions

DRUG

No Results Yet

NCT04482140 | TERMINATED

15 participants

Post Approval Study to Evaluate the Safety and Performance of GENTA-FOIL Resorb® in Hand Surgery

Study Type:: OBSERVATIONAL
Last Updated:: 2025-11-19
Start Date:: 2024-10-14
Completion:: 2025-11-07

Conditions

Tissue Adhesions, Surgery-Induced

Interventions

DEVICE

No Results Yet

NCT04470037 | COMPLETED | PHASE2

61 participants

Multidisciplinary Study of Novel NMDA Modulation for Neurodegenerative Disorder

Study Type:: INTERVENTIONAL
Last Updated:: 2025-11-19
Start Date:: 2016-04-30
Completion:: 2024-12-31

Conditions

Parkinson's Disease With Dementia

Interventions

DRUG

No Results Yet

NCT04469491 | ACTIVE_NOT_RECRUITING | PHASE2

74 participants

Treatment of COVID-19 by Nebulization of Inteferon Beta 1b Efficiency and Safety Study

Study Type:: INTERVENTIONAL
Last Updated:: 2025-11-19
Start Date:: 2020-09-20
Completion:: 2023-06-16

Conditions

COVID-19
INTERFERON
NEBULIZATION

Interventions

DRUG

No Results Yet

NCT04469231 | ACTIVE_NOT_RECRUITING | NA

175 participants

The Synergy Disc To Anterior Cervical Discectomy and Fusion

Study Type:: INTERVENTIONAL
Last Updated:: 2025-11-19
Start Date:: 2020-10-30
Completion:: 2025-06-19

Conditions

Cervical Degenerative Disc Disease

Interventions

DEVICE

No Results Yet

NCT04454489 | COMPLETED | PHASE2

21 participants

Quad Shot Radiotherapy in Combination With Immune Checkpoint Inhibition

Study Type:: INTERVENTIONAL
Last Updated:: 2025-11-19
Start Date:: 2021-02-25
Completion:: 2025-02-18

Conditions

Advanced Head and Neck Squamous Cell Carcinoma
Recurrent Head and Neck Squamous Cell Carcinoma
Metastatic Head-and-neck Squamous-cell Carcinoma
Stage III Cutaneous Squamous Cell Carcinoma of the Head and Neck
Locally Advanced Head and Neck Squamous Cell Carcinoma
Stage IV Cutaneous Squamous Cell Carcinoma of the Head and Neck

Interventions

DRUG
RADIATION

Results Available

NCT04452630 | TERMINATED

80 participants

Cardiovascular Consequences After COVID-19

Study Type:: OBSERVATIONAL
Last Updated:: 2025-11-19
Start Date:: 2020-06-23
Completion:: 2023-02-01

Conditions

Cardiovascular Consequences After an Episode of COVID 19

Interventions

OTHER

No Results Yet

NCT04370509 | TERMINATED | PHASE2

6 participants

Pembrolizumab With or Without Axitinib for Clear Cell Kidney Cancer in Patients Undergoing Surgery

Study Type:: INTERVENTIONAL
Last Updated:: 2025-11-19
Start Date:: 2021-02-09
Completion:: 2025-02-28

Conditions

Metastatic Clear Cell Renal Cell Carcinoma
Recurrent Clear Cell Renal Cell Carcinoma
Stage III Renal Cell Cancer AJCC v8
Stage IV Renal Cell Cancer AJCC v8
Clear Cell Renal Cell Carcinoma

Interventions

DRUG
PROCEDURE
BIOLOGICAL

Results Available