Clinical Trials Updated in 2025

NCT06004115 | RECRUITING | PHASE4

165 participants

Processes and Circuitry Underlying Threat Sensitivity as a Treatment Target for Co-morbid Anxiety and Depression

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-31
Start Date:: 2023-11-08
Completion:: 2027-12-31

Conditions

Depression, Anxiety
Fear
Depression
Anxiety and Fear
Anxiety Disorders
Anxious Depression

Interventions

DRUG
OTHER

No Results Yet

NCT05966831 | TERMINATED | NA

21 participants

Metacognitive Self Control and Job Interview Training

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-31
Start Date:: 2023-08-01
Completion:: 2024-12-09

Conditions

Self-Control
Recidivism

Interventions

BEHAVIORAL

No Results Yet

NCT05919901 | SUSPENDED | NA

600 participants

Multi-level School-based Intervention to Improve HPV Vaccine Uptake and Completion in South Africa

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-31
Start Date:: 2024-07-26
Completion:: 2026-06-30

Conditions

HPV

Interventions

OTHER

No Results Yet

NCT05905003 | ACTIVE_NOT_RECRUITING

2617 participants

AMP SCZ® Observational Study: PREDICT-DPACC

Study Type:: OBSERVATIONAL
Last Updated:: 2025-10-31
Start Date:: 2022-06-02
Completion:: 2027-04-30

Conditions

Clinical High Risk
Psychosis
Remission
Conversion

No Results Yet

NCT05787782 | COMPLETED | NA

60 participants

Validation of the Masimo INVSENSOR00063 in Febrile and Afebrile Subejcts

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-31
Start Date:: 2023-02-23
Completion:: 2023-03-02

Conditions

Fever

Interventions

DEVICE

Results Available

NCT05749952 | COMPLETED | NA

10 participants

Digital Weight Bearing Shape Capture Socket Technology

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-31
Start Date:: 2023-03-06
Completion:: 2023-07-18

Conditions

Amputation
Prosthesis User
Residual Limbs

Interventions

DEVICE

Results Available

NCT05736211 | COMPLETED | NA

43 participants

Organization-level Youth Engagement Approach for Substance Misuse Prevention

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-31
Start Date:: 2024-03-14
Completion:: 2025-07-01

Conditions

Drug Use
Substance Use
Opioid Use
Substance Misuse

Interventions

BEHAVIORAL

Results Available

NCT05672186 | COMPLETED | NA

262 participants

Mobile Food Market Cluster Randomized Trial

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-31
Start Date:: 2023-01-12
Completion:: 2025-10-09

Conditions

Healthy Diet
Nutrition, Healthy

Interventions

BEHAVIORAL
OTHER

No Results Yet

NCT05655910 | RECRUITING | NA

50 participants

Enhanced Nutritional Optimization in LVAD Trial

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-31
Start Date:: 2022-09-22
Completion:: 2026-10-31

Conditions

Heart Failure
Gut Microbiome
Nutritional Deficiency

Interventions

DIETARY_SUPPLEMENT

No Results Yet

NCT05479370 | COMPLETED | PHASE3

366 participants

Immunogenicity Trial of 3 Influenza Vaccines

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-31
Start Date:: 2022-09-29
Completion:: 2023-04-14

Conditions

Influenza Vaccination

Interventions

BIOLOGICAL

No Results Yet

NCT05390580 | COMPLETED | NA

40 participants

Neuromodulation Using Vagus Nerve Stimulation Following Ischemic Stroke as Therapeutic Adjunct

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-31
Start Date:: 2022-09-26
Completion:: 2024-08-23

Conditions

Acute Ischemic Stroke

Interventions

DEVICE

Results Available

NCT05367245 | RECRUITING | PHASE2

120 participants

Ca-Mg Butyrate in GWI

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-31
Start Date:: 2024-01-15
Completion:: 2026-10-10

Conditions

Gulf War Illness
Chronic Fatigue
Neurocognitive Dysfunction

Interventions

DRUG

No Results Yet

NCT05344092 | COMPLETED | NA

13 participants

Designing a Mobile App to Support Academic Success for Student Veterans

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-31
Start Date:: 2023-06-01
Completion:: 2024-08-30

Conditions

Mental Health
Depression
Post-Traumatic Stress Disorder
Anxiety
Substance Use Disorder

Interventions

BEHAVIORAL

Results Available

NCT05311527 | COMPLETED | NA

15 participants

UroLift System With SAbR for Prostate Cancer and BPH

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-31
Start Date:: 2023-01-11
Completion:: 2025-10-29

Conditions

Prostate Cancer

Interventions

DEVICE
RADIATION

No Results Yet

NCT05309993 | TERMINATED | NA

27 participants

INvestigation of TENS Efficacy Versus Posterior Tibial Nerve Stimulation for Overactive Bladder

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-31
Start Date:: 2022-06-30
Completion:: 2025-08-01

Conditions

Overactive Bladder
Overactive Bladder Syndrome
Urinary Urge Incontinence
Urinary Bladder, Overactive
Urinary Incontinence, Urge

Interventions

DEVICE

No Results Yet

NCT05270356 | COMPLETED

195 participants

MINDS Imaging Ancillary Study

Study Type:: OBSERVATIONAL
Last Updated:: 2025-10-31
Start Date:: 2021-05-27
Completion:: 2025-05-31

Conditions

Adult Congenital Heart Disease

Interventions

OTHER

No Results Yet

NCT05244239 | RECRUITING | PHASE1

22 participants

Palliative Radiotherapy With Lurbinectedin in Patients With Extensive Stage Small Cell Lung Cancer

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-31
Start Date:: 2022-07-27
Completion:: 2026-07-28

Conditions

Extensive Stage Lung Small Cell Carcinoma
Stage IV Lung Cancer AJCC v8

Interventions

DRUG
RADIATION

No Results Yet

NCT05178069 | RECRUITING | PHASE2

60 participants

LGG Supplementation in Patients With AUD and ALD

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-31
Start Date:: 2022-06-01
Completion:: 2026-08-31

Conditions

Alcohol Use Disorder
Alcohol-associated Liver Disease

Interventions

DRUG
DIETARY_SUPPLEMENT

No Results Yet

NCT05164055 | ACTIVE_NOT_RECRUITING | PHASE4

17 participants

Avalglucosidase Alfa French Post-trial Access for Participants With Pompe Disease (PTA Avalglucosidase)

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-31
Start Date:: 2022-07-11
Completion:: 2026-09-30

Conditions

Glycogen Storage Disease Type II

Interventions

DRUG

No Results Yet

NCT05145010 | ENROLLING_BY_INVITATION | PHASE2

300 participants

Extension Study of Infigratinib in Children With Achondroplasia (ACH)

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-31
Start Date:: 2021-12-06
Completion:: 2031-12-01

Conditions

Achondroplasia

Interventions

DRUG

No Results Yet

NCT05103280 | COMPLETED | NA

10 participants

Improving Walking in Peripheral Artery Disease

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-31
Start Date:: 2021-10-01
Completion:: 2024-09-30

Conditions

Peripheral Artery Disease

Interventions

OTHER

Results Available

NCT05071976 | ACTIVE_NOT_RECRUITING | NA

15 participants

A Study of Near-Infrared Fluorescence Imaging With ICG During Reconstructive Gynecologic Surgery

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-31
Start Date:: 2021-09-24
Completion:: 2026-10-24

Conditions

Gynecologic Surgery

Interventions

DIAGNOSTIC_TEST

No Results Yet

NCT05057247 | COMPLETED | PHASE2

26 participants

Duvelisib Plus Docetaxel In Recurrent/Metastatic HNSCC

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-31
Start Date:: 2021-10-14
Completion:: 2023-10-01

Conditions

Squamous Cell Carcinoma of the Head and Neck (SCCHN)
Recurrent Squamous Cell Carcinoma of the Head and Neck
Metastatic Head and Neck Cancer
Advanced Head and Neck Cancer
Advanced Head and Neck Squamous Cell Carcinoma

Interventions

DRUG

Results Available

NCT04964960 | TERMINATED | PHASE2

3 participants

Pembro+Chemo in Brain Mets

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-31
Start Date:: 2022-05-19
Completion:: 2023-06-19

Conditions

Lung Cancer
Lung Cancer Metastatic
Brain Cancer
Cancer

Interventions

DRUG

Results Available

NCT04893577 | COMPLETED | PHASE2

10 participants

EDTA Eye Drops Compared to Abreva for Herpes Simplex Virus Eruptions

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-31
Start Date:: 2022-01-20
Completion:: 2024-08-31

Conditions

Herpes Simplex Oral

Interventions

DRUG

Results Available

NCT04803877 | ACTIVE_NOT_RECRUITING | PHASE2

48 participants

SARC038: Phase 2 Study of Regorafenib and Nivolumab in Osteosarcoma

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-31
Start Date:: 2021-06-04
Completion:: 2025-11-30

Conditions

Osteosarcoma
Osteosarcoma in Children
Osteosarcoma Recurrent
Osteosarcoma Metastatic

Interventions

DRUG

No Results Yet

NCT04798339 | ACTIVE_NOT_RECRUITING | PHASE1/PHASE2

13 participants

Canakinumab With Darbepoetin Alfa in PTs With Lower-Risk MDS Who Have Failed ESA

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-31
Start Date:: 2021-03-30
Completion:: 2025-05-26

Conditions

Myelodysplastic Syndromes

Interventions

DRUG

No Results Yet

NCT04786119 | COMPLETED | NA

126 participants

Study to Evaluate the Safety and Effectiveness of REAL INTELLIGENCE™ CORI™ in Knee Arthroplasty Procedures

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-31
Start Date:: 2021-02-17
Completion:: 2023-10-27

Conditions

Arthroplasty
Replacement
Knee

Interventions

DEVICE

Results Available

NCT04724252 | RECRUITING | PHASE2/PHASE3

60 participants

Gabapentin to Reduce Opioid Use Postoperatively (GROUP) in Children

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-31
Start Date:: 2021-08-23
Completion:: 2026-12-31

Conditions

Pain, Postoperative

Interventions

DRUG
OTHER

No Results Yet

NCT04658186 | COMPLETED | PHASE2

496 participants

A 18-month Study to Evaluate the Efficacy, Safety, Tolerability and Pharmacokinetics of Oral UCB0599 in Study Participants With Early-stage Parkinson's Disease

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-31
Start Date:: 2020-12-30
Completion:: 2024-09-06

Conditions

Early-stage Parkinson's Disease

Interventions

DRUG

Results Available

NCT04501653 | COMPLETED | EARLY_PHASE1

11 participants

Precision Functional Brain Mapping in Psilocybin

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-31
Start Date:: 2021-06-01
Completion:: 2023-03-19

Conditions

Psilocybin

Interventions

DRUG

No Results Yet

NCT04485104 | TERMINATED | PHASE3

3 participants

Assessment of Adjunctive Cannabidiol Oral Solution (GWP42003-P) in Children With Tuberous Sclerosis Complex (TSC), Dravet Syndrome (DS), or Lennox-Gastaut Syndrome (LGS) Who Experience Inadequately-controlled Seizures

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-31
Start Date:: 2021-05-19
Completion:: 2025-01-28

Conditions

Seizure in Participants With Tuberous Sclerosis Complex
Seizure in Participants With Dravet Syndrome
Seizure in Participants With Lennox-Gastaut Syndrome

Interventions

DRUG

Results Available

NCT04456439 | NO_LONGER_AVAILABLE

Intermediate-size Expanded Access Program (EAP), Mesenchymal Stromal Cells (MSC) for Multisystem Inflammatory Syndrome in Children (MIS-C) Associated With Coronavirus Disease (COVID-19)

Study Type:: EXPANDED_ACCESS
Last Updated:: 2025-10-31

Conditions

Multisystem Inflammatory Syndrome in Children (MIS-C) Associated With Coronavirus Disease (COVID-19)

Interventions

BIOLOGICAL
DRUG

No Results Yet

NCT04417127 | COMPLETED | NA

1200 participants

Harambee: Integrated Community-based HIV/NCD Care & Microfinance Groups in Kenya

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-31
Start Date:: 2020-11-26
Completion:: 2023-09-21

Conditions

HIV/AIDS
Noncommunicable Diseases
Hypertension
Diabetes

Interventions

OTHER

Results Available

NCT04409353 | COMPLETED | NA

413 participants

Virtual Reality Therapy for Chronic Low Back Pain

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-31
Start Date:: 2020-09-21
Completion:: 2023-10-17

Conditions

Chronic Low Back Pain

Interventions

DEVICE

Results Available

NCT04352244 | RECRUITING

40 participants

The Physiology of Human Brown Adipose Tissue

Study Type:: OBSERVATIONAL
Last Updated:: 2025-10-31
Start Date:: 2020-03-05
Completion:: 2027-06-30

Conditions

Adipose Tissue, Brown
Adipose Tissue
Obesity

Interventions

PROCEDURE
DIAGNOSTIC_TEST
GENETIC

No Results Yet

NCT04344860 | COMPLETED | PHASE3

20 participants

Prevent Postpartum Hemorrhage in Women With Von Willebrand Disease: The VWD-WOMAN Trial

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-31
Start Date:: 2021-06-04
Completion:: 2024-08-28

Conditions

Von Willebrand Diseases
Postpartum Hemorrhage

Interventions

DRUG

Results Available

NCT04311762 | ACTIVE_NOT_RECRUITING | PHASE1

16 participants

Phase 1 Trial of Endobronchial Ultrasound-Guided Transbronchial Needle Injection of Cisplatin for Stage IV Lung Cancer

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-31
Start Date:: 2020-02-01
Completion:: 2029-03-01

Conditions

Lung Cancer Metastatic

Interventions

DRUG

No Results Yet

NCT04231539 | COMPLETED | NA

15 participants

Pharmacokinetics, Subjective Effects, and Abuse Liability of Nicotine Salt-Based Vaping Products With Tobacco or Unflavored E-liquids, SALTVAPE Study

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-31
Start Date:: 2020-02-18
Completion:: 2024-07-10

Conditions

Nicotine Dependence

Interventions

DRUG
DEVICE

Results Available

NCT04110756 | RECRUITING | NA

200 participants

ChangeGradients: Promoting Adolescent Health Behavior Change

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-31
Start Date:: 2024-02-12
Completion:: 2026-07-31

Conditions

Alcohol Drinking
Self Efficacy
Adolescent Behavior
Risk-Taking
Cancer

Interventions

BEHAVIORAL

No Results Yet