Clinical Trials Updated in 2025

NCT04220866 | COMPLETED | PHASE2

18 participants

Study of Intratumoral (IT) Ulevostinag (MK-1454) in Combination With Intravenous (IV) Pembrolizumab (MK-3475) Compared to IV Pembrolizumab Alone as the First Line Treatment of Metastatic or Unresectable, Recurrent Head and Neck Squamous Cell Carcinoma (HNSCC) (MK-1454-002)

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-29
Start Date:: 2020-03-04
Completion:: 2022-09-30

Conditions

Head and Neck Squamous Cell Carcinoma (HNSCC)

Interventions

DRUG
BIOLOGICAL

Results Available

NCT04182763 | COMPLETED | NA

77 participants

CoA-Z in Pantothenate Kinase-associated Neurodegeneration (PKAN)

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-29
Start Date:: 2019-12-04
Completion:: 2024-09-01

Conditions

Pantothenate Kinase-Associated Neurodegeneration

Interventions

OTHER

Results Available

NCT04143659 | ACTIVE_NOT_RECRUITING | PHASE1

136 participants

A Study to Evaluate the PK and PD of IM or SQ Injections of Levonorgestrel Butanoate (LB) for Female Contraception

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-29
Start Date:: 2020-03-03
Completion:: 2026-03-26

Conditions

Healthy Women
Female Contraception

Interventions

BIOLOGICAL

No Results Yet

NCT04130867 | COMPLETED

4 participants

Rehabilitation Manometry Study

Study Type:: OBSERVATIONAL
Last Updated:: 2025-10-29
Start Date:: 2020-11-11
Completion:: 2021-04-21

Conditions

Oropharyngeal Dysphagia

Interventions

PROCEDURE

No Results Yet

NCT04087096 | COMPLETED | PHASE4

36 participants

Denosumab to Prevent High-Turnover Bone Loss After Bariatric Surgery

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-29
Start Date:: 2020-08-24
Completion:: 2024-08-06

Conditions

Bariatric Surgery Candidate
Bone Loss

Interventions

DRUG

Results Available

NCT03984994 | COMPLETED | NA

14 participants

Muscle Capillarization and Sarcopenia

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-29
Start Date:: 2021-11-01
Completion:: 2024-04-30

Conditions

Sarcopenia

Interventions

OTHER

Results Available

NCT03897465 | COMPLETED | NA

183 participants

Lomatuell Pro® Versus UrgoTul® in the Management of Acute Wounds

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-29
Start Date:: 2019-02-11
Completion:: 2020-12-06

Conditions

Acute Wounds

Interventions

DEVICE

Results Available

NCT03858309 | COMPLETED | NA

26 participants

Influence of Yogic Breathwork on CSF Circulation

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-29
Start Date:: 2019-07-10
Completion:: 2019-11-25

Conditions

CSF Circulation

Interventions

BEHAVIORAL

Results Available

NCT03814356 | ACTIVE_NOT_RECRUITING | PHASE1

10 participants

Stimulant Therapy Targeted to Individualized Connectivity Maps to Promote ReACTivation of Consciousness

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-29
Start Date:: 2020-08-24
Completion:: 2024-04-01

Conditions

Brain Injury Traumatic Severe (Diagnosis)
Coma
Consciousness, Level Altered
Anoxic Brain Injury

Interventions

DRUG

Results Available

NCT03758625 | COMPLETED | PHASE1

40 participants

Comparison of Dendritic Cell-Based Therapeutic Vaccine Strategies for HIV Functional Cure

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-29
Start Date:: 2019-01-02
Completion:: 2025-02-19

Conditions

HIV Infections

Interventions

BIOLOGICAL

No Results Yet

NCT03544983 | ENROLLING_BY_INVITATION | NA

240 participants

Genetic Education in BRCA Families

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-29
Start Date:: 2020-05-01
Completion:: 2026-12-31

Conditions

BRCA1 Mutation
BRCA2 Mutation

Interventions

BEHAVIORAL

No Results Yet

NCT03484299 | RECRUITING | PHASE1

20 participants

Chemotherapy and Irreversible Electroporation in the Treatment of Advanced Pancreatic Adenocarcinoma

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-29
Start Date:: 2018-05-30
Completion:: 2026-07-31

Conditions

Pancreas Cancer

Interventions

PROCEDURE
DRUG

No Results Yet

NCT03480646 | COMPLETED | PHASE1/PHASE2

175 participants

ProSTAR: A Study Evaluating CPI-1205 in Patients With Metastatic Castration Resistant Prostate Cancer

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-29
Start Date:: 2017-11-15
Completion:: 2021-02-03

Conditions

Metastatic Castration Resistant Prostate Cancer (mCRPC)

Interventions

DRUG

Results Available

NCT03396575 | TERMINATED | PHASE1

11 participants

Brain Stem Gliomas Treated With Adoptive Cellular Therapy During Focal Radiotherapy Recovery Alone or With Dose-intensified Temozolomide (Phase I)

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-29
Start Date:: 2018-07-17
Completion:: 2025-03-20

Conditions

Diffuse Intrinsic Pontine Glioma (DIPG)
Brain Stem Glioma

Interventions

BIOLOGICAL
DRUG

No Results Yet

NCT03396367 | COMPLETED | NA

196 participants

Prevention and Risk: Treatment With a New Emphasis on Relationships

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-29
Start Date:: 2018-02-14
Completion:: 2024-02-21

Conditions

Adherence, Medication
Risk Reduction
Drug Use
Sex, Anal
HIV/AIDS

Interventions

BEHAVIORAL

Results Available

NCT03268954 | COMPLETED | PHASE3

454 participants

Pevonedistat Plus Azacitidine Versus Single-Agent Azacitidine as First-Line Treatment for Participants With Higher-Risk Myelodysplastic Syndromes (HR MDS), Chronic Myelomonocytic Leukemia (CMML), or Low-Blast Acute Myelogenous Leukemia (AML)

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-29
Start Date:: 2017-11-28
Completion:: 2021-05-28

Conditions

Myelodysplastic Syndrome
Leukemia, Myelomonocytic, Chronic
Leukemia, Myeloid, Acute

Interventions

DRUG

Results Available

NCT03192462 | COMPLETED | PHASE1/PHASE2

37 participants

TAA Specific Cytotoxic T Lymphocytes in Patients With Pancreatic Cancer

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-29
Start Date:: 2018-01-18
Completion:: 2020-06-15

Conditions

Pancreatic Cancer

Interventions

BIOLOGICAL

Results Available

NCT03168971 | COMPLETED | NA

26 participants

Managing Anxiety From Cancer (MAC): Testing an Intervention for Anxiety in Older Adults With Cancer and Their Caregivers

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-29
Start Date:: 2019-01-23
Completion:: 2025-10-27

Conditions

Anxiety
Depression
Quality of Life

Interventions

BEHAVIORAL

No Results Yet

NCT03128424 | COMPLETED | NA

60 participants

TORUS I Clinical Study

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-29
Start Date:: 2016-02-29
Completion:: 2020-07-31

Conditions

Peripheral Arterial Disease

Interventions

DEVICE

Results Available

NCT03095066 | COMPLETED | PHASE2

168 participants

Study to Assess the Efficacy, Safety, and Tolerability of AVP-786 for the Treatment of Neurobehavioral Disinhibition Including Aggression, Agitation, and Irritability in Participants With Traumatic Brain Injury

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-29
Start Date:: 2017-05-30
Completion:: 2022-08-22

Conditions

Neurobehavioral Disinhibition

Interventions

DRUG

Results Available

NCT03080974 | RECRUITING | PHASE2

10 participants

Immunotherapy and Irreversible Electroporation in the Treatment of Advanced Pancreatic Adenocarcinoma

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-29
Start Date:: 2017-08-14
Completion:: 2028-06-01

Conditions

Pancreatic Adenocarcinoma

Interventions

DRUG
PROCEDURE

No Results Yet

NCT03036488 | COMPLETED | PHASE3

1174 participants

Study of Pembrolizumab (MK-3475) Plus Chemotherapy vs Placebo Plus Chemotherapy as Neoadjuvant Therapy and Pembrolizumab vs Placebo as Adjuvant Therapy in Participants With Triple Negative Breast Cancer (TNBC) (MK-3475-522/KEYNOTE-522)

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-29
Start Date:: 2017-03-07
Completion:: 2025-10-14

Conditions

Triple Negative Breast Neoplasms

Interventions

BIOLOGICAL
DRUG

No Results Yet

NCT03010176 | COMPLETED | PHASE1

156 participants

Study of Ulevostinag (MK-1454) Alone or in Combination With Pembrolizumab (MK-3475) in Participants With Advanced/Metastatic Solid Tumors or Lymphomas (MK-1454-001)

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-29
Start Date:: 2017-02-03
Completion:: 2022-04-21

Conditions

Solid Tumors
Lymphoma

Interventions

DRUG
BIOLOGICAL

Results Available

NCT02881554 | TERMINATED | NA

41 participants

Sulfur Colloid SPECT/CT in Measuring Liver Function in Patients With Primary or Metastatic Liver Cancer Undergoing Radiation Therapy or Surgery

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-29
Start Date:: 2016-12-21
Completion:: 2024-07-31

Conditions

Hepatocellular Carcinoma
Intrahepatic Cholangiocarcinoma
Stage IV Liver Cancer
Stage IVA Liver Cancer
Stage IVB Liver Cancer
Vascular Thrombosis

Interventions

PROCEDURE
DRUG

Results Available

NCT02773082 | RECRUITING | NA

50 participants

DBS for Obsessive-Compulsive Disorder

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-29
Start Date:: 2024-07-06
Completion:: 2030-01-01

Conditions

Obsessive-Compulsive Disorder (OCD)

Interventions

DEVICE

No Results Yet

NCT02677051 | ACTIVE_NOT_RECRUITING | PHASE2

48 participants

Sulforaphane in a New Jersey (NJ) Population of Individuals With Autism

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-29
Start Date:: 2016-02-29
Completion:: 2025-12-31

Conditions

Autism
Autistic Disorder
Autism Spectrum Disorder
Autistic Behavior

Interventions

DRUG

No Results Yet

NCT02549820 | ACTIVE_NOT_RECRUITING | NA

14 participants

Fetoscopic Endoluminal Tracheal Occlusion in Severe Left Congenital Diaphragmatic Hernia

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-29
Start Date:: 2015-07-31
Completion:: 2025-05-01

Conditions

Congenital Diaphragmatic Hernia
Pulmonary Hypoplasia

Interventions

DEVICE

No Results Yet

NCT02443987 | COMPLETED | NA

43 participants

Time Interval Between TVT and First Void (TIBT) Study

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-29
Start Date:: 2015-08-31
Completion:: 2016-07-31

Conditions

Stress Urinary Incontinence

Interventions

OTHER

Results Available

NCT02346747 | ACTIVE_NOT_RECRUITING | PHASE2

92 participants

A Trial of Vigil for Participants With Ovarian Cancer

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-29
Start Date:: 2015-02-28
Completion:: 2028-12-31

Conditions

Ovarian Cancer
Ovarian Neoplasms

Interventions

BIOLOGICAL
OTHER

No Results Yet

NCT02284126 | COMPLETED | PHASE3

1103 participants

Topical Vancomycin for Neurosurgery Wound Prophylaxis

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-29
Start Date:: 2014-10-31
Completion:: 2019-11-30

Conditions

Infection
Surgery
Nervous System Diseases

Interventions

DRUG

Results Available

NCT02159560 | COMPLETED | NA

240 participants

Uniport and Multiport Epidural Catheters in Post-surgical Patients

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-29
Start Date:: 2014-06-30
Completion:: 2021-12-31

Conditions

Post-operative Pain

Interventions

DEVICE

Results Available

NCT02010840 | COMPLETED | NA

388 participants

The Effect of a Father Inclusive Psychoeducation Program on Postnatal Depression

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-29
Start Date:: 2014-05-31
Completion:: 2018-01-31

Conditions

Pregnancy

Interventions

BEHAVIORAL

Results Available

NCT01886794 | TERMINATED | PHASE4

7 participants

Hormonal Status on Blood Flow and Tissue in Pelvic Organ Prolapse

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-29
Start Date:: 2013-06-06
Completion:: 2023-12-11

Conditions

Pelvic Floor Disorders

Interventions

DRUG

Results Available

NCT01667120 | WITHDRAWN | PHASE2

0 participants

The Use of Ketorolac in Surgical Neonates

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-29
Start Date:: 2012-07-31
Completion:: 2018-12-31

Conditions

Postoperative Pain Control in Surgical Neonates

Interventions

DRUG

No Results Yet

NCT01397708 | COMPLETED | PHASE1/PHASE2

26 participants

Safety Study of Adenovirus Vector Engineered to Express hIL-12 in Combination With Activator Ligand to Treat Melanoma

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-29
Start Date:: 2011-08-31
Completion:: 2014-09-30

Conditions

Melanoma

Interventions

BIOLOGICAL
DRUG

Results Available

NCT01095731 | COMPLETED | PHASE2

60 participants

The Effects of Tiopronin on 3-Aminopropanal Level & Neurologic Outcome After Aneurysmal Subarachnoid Hemorrhage

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-29
Start Date:: 2010-04-30
Completion:: 2012-07-31

Conditions

Aneurysmal Subarachnoid Hemorrhage

Interventions

DRUG

Results Available

NCT00855036 | TERMINATED

100 participants

Prospective Evaluation of Blunt Renal Injury in Children

Study Type:: OBSERVATIONAL
Last Updated:: 2025-10-29
Start Date:: 2008-08-31
Completion:: 2025-08-31

Conditions

Renal Injury

Interventions

OTHER

No Results Yet

NCT00726232 | TERMINATED | PHASE2

73 participants

Study to Determine the Safety and Efficacy of INCB018424 in Patients With Polycythemia Vera or Essential Thrombocythemia

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-29
Start Date:: 2008-08-20
Completion:: 2010-06-20

Conditions

Myeloproliferative Neoplasm (MPN)

Interventions

DRUG

Results Available

NCT00291096 | RECRUITING

3000 participants

High Risk Breast Clinic: Protocol for Women at Increased Risk for Developing Breast Cancer

Study Type:: OBSERVATIONAL
Last Updated:: 2025-10-29
Start Date:: 1989-08-31
Completion:: 2027-12-31

Conditions

Breast Cancer

No Results Yet

NCT00215813 | TEMPORARILY_NOT_AVAILABLE

Ampligen in Chronic Fatigue Syndrome

Study Type:: EXPANDED_ACCESS
Last Updated:: 2025-10-29

Conditions

Chronic Fatigue Syndrome

Interventions

DRUG

No Results Yet