Clinical Trials Updated in 2025

NCT05963022 | COMPLETED | PHASE3

206 participants

A Study of Tirzepatide (LY3298176) in Chinese Participants With Type 2 Diabetes (SURPASS-CN-MONO)

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-21
Start Date:: 2023-08-21
Completion:: 2024-10-09

Conditions

Type 2 Diabetes

Interventions

DRUG

Results Available

NCT05928936 | RECRUITING | PHASE2

156 participants

Neurovascular Regulation During Exercise in Humans With Chronic Kidney Disease: Sympatholysis in CKD

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-21
Start Date:: 2022-11-11
Completion:: 2028-06-01

Conditions

Chronic Kidney Disease

Interventions

DRUG
BEHAVIORAL

No Results Yet

NCT05904470 | COMPLETED | PHASE2

275 participants

A Phase 2, Safety and Efficacy of Bemnifosbuvir (BEM) and Ruzasvir (RZR) in Subjects With Chronic HCV

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-21
Start Date:: 2023-05-30
Completion:: 2024-12-09

Conditions

Chronic Hepatitis C Virus
Hepatitis C, Chronic
Hepatitis C
Hepatic Cirrhosis
HCV

Interventions

DRUG

Results Available

NCT05901831 | COMPLETED | PHASE3

241 participants

A Study to Learn How Well the Study Treatment Finerenone Works and How Safe it is in People With Long-term Decrease in the Kidneys' Ability to Work Properly (Chronic Kidney Disease) Together With Type 1 Diabetes

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-21
Start Date:: 2024-02-26
Completion:: 2025-08-20

Conditions

Chronic Kidney Disease
Type 1 Diabetes Mellitus

Interventions

DRUG
OTHER

No Results Yet

NCT05807321 | RECRUITING | NA

24 participants

Fecobionics in Biofeedback Therapy in Dyssynergia Patients

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-21
Start Date:: 2023-10-03
Completion:: 2027-01-01

Conditions

Dyssynergia
Constipation

Interventions

DEVICE

No Results Yet

NCT05732038 | COMPLETED | NA

93 participants

STRIDE: Stress Reduction in Dementia Caregivers

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-21
Start Date:: 2023-02-20
Completion:: 2024-06-03

Conditions

Caregiver Stress

Interventions

BEHAVIORAL

No Results Yet

NCT05689164 | TERMINATED | PHASE3

7 participants

A Study to Understand the Long-term Safety and Effects of an Experimental Gene Therapy for Duchenne Muscular Dystrophy.

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-21
Start Date:: 2023-03-13
Completion:: 2025-09-24

Conditions

Duchenne Muscular Dystrophy

Interventions

BIOLOGICAL

No Results Yet

NCT05688423 | ACTIVE_NOT_RECRUITING | NA

480 participants

Integrated Care and Treatment for Severe Infectious Diseases and Substance Use Disorders Among Hospitalized Patients

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-21
Start Date:: 2024-01-05
Completion:: 2027-04-03

Conditions

Injection Site Infection
Substance Use Disorders

Interventions

BEHAVIORAL

No Results Yet

NCT05630963 | RECRUITING

228 participants

Beyond Monoamines: The Role of the Nociceptin/Orphanin FQ Receptor in Major Depression

Study Type:: OBSERVATIONAL
Last Updated:: 2025-10-21
Start Date:: 2021-12-29
Completion:: 2026-10-28

Conditions

Major Depressive Disorder

Interventions

DEVICE
DRUG

No Results Yet

NCT05599165 | COMPLETED | NA

40 participants

Speech Perception in Bimodal Hearing

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-21
Start Date:: 2021-10-25
Completion:: 2025-07-31

Conditions

Hearing Loss, Sensorineural

Interventions

OTHER

No Results Yet

NCT05564416 | WITHDRAWN | PHASE2

0 participants

Testing Anti-Cancer Drugs Erdafitinib With or Without Atezolizumab in Patients With Localized Bladder Cancer Not Able to Receive Cisplatin Chemotherapy, NERA Trial

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-21
Start Date:: 2023-10-12
Completion:: 2024-01-01

Conditions

Bladder Carcinoma
Bladder Urothelial Carcinoma
Muscle Invasive Bladder Carcinoma
Renal Pelvis and Ureter Urothelial Carcinoma
Stage II Bladder Cancer AJCC v8
Stage III Bladder Cancer AJCC v8
Stage IVA Bladder Cancer AJCC v8
Urothelial Carcinoma

Interventions

BIOLOGICAL
PROCEDURE
DRUG

No Results Yet

NCT05560451 | ACTIVE_NOT_RECRUITING | NA

298 participants

Telehealth-delivered Peer Support to Improve Quality of Life Among Veterans With Multimorbidity

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-21
Start Date:: 2023-10-19
Completion:: 2026-09-30

Conditions

Multimorbidity

Interventions

BEHAVIORAL

No Results Yet

NCT05547503 | COMPLETED | PHASE1

64 participants

Phase I Single Ascending Dose and Multiple Ascending Doses of Oral AFA-281 in Healthy Volunteers

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-21
Start Date:: 2023-04-11
Completion:: 2024-12-04

Conditions

Pain, Neuropathic
Pain, Inflammatory

Interventions

DRUG

No Results Yet

NCT05477485 | TERMINATED | NA

4 participants

Antiretroviral Improvement Among Medicaid Enrollees

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-21
Start Date:: 2023-04-27
Completion:: 2024-05-31

Conditions

Human Immunodeficiency Virus

Interventions

BEHAVIORAL
OTHER

Results Available

NCT05468489 | ACTIVE_NOT_RECRUITING | PHASE3

200 participants

To Evaluate Efficacy and Safety of Serplulimab + Chemotherapy (Carboplatin- Etoposide) in US Patients With ES-SCLC

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-21
Start Date:: 2022-11-18
Completion:: 2026-02-28

Conditions

Extensive Stage Small Cell Lung Cancer

Interventions

DRUG

No Results Yet

NCT05466539 | COMPLETED | PHASE4

3 participants

Chronic Exertional Compartment Syndrome (CECS) Treated With Abobotulinumtoxin A

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-21
Start Date:: 2024-04-25
Completion:: 2025-08-13

Conditions

Compartment Syndrome of Leg

Interventions

DRUG

No Results Yet

NCT05429372 | TERMINATED | PHASE2

10 participants

Study of Fordadistrogene Movaparvovec in Early Stage Duchenne Muscular Dystrophy

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-21
Start Date:: 2022-08-08
Completion:: 2025-10-03

Conditions

Muscular Dystrophy, Duchenne

Interventions

GENETIC

No Results Yet

NCT05412069 | RECRUITING | NA

155 participants

Trial to Evaluate Fecobionics in Fecal Incontinence (FI) (NORMAL and ABNORMAL-FI)

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-21
Start Date:: 2023-02-15
Completion:: 2026-12-01

Conditions

Normal Subjects
Fecal Incontinence

Interventions

DEVICE

No Results Yet

NCT05412030 | COMPLETED | PHASE2

388 participants

A Phase 2 Study to Evaluate the Safety, Tolerability, and Immune Response of AFX3772 Vaccine in Healthy Infants

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-21
Start Date:: 2022-06-16
Completion:: 2025-09-18

Conditions

Pneumonia, Bacterial
Pneumococcal Infections
Pneumonia, Pneumococcal

Interventions

BIOLOGICAL

No Results Yet

NCT05380050 | RECRUITING | NA

63 participants

Comparing Telehealth to In-person a Combined Metacognitive Training in Veterans With mTBI/PTSD

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-21
Start Date:: 2022-11-01
Completion:: 2026-10-30

Conditions

Brain Injury
Cognition
PTSD
Intervention

Interventions

BEHAVIORAL

No Results Yet

NCT05262270 | COMPLETED | PHASE2

427 participants

Extended-Release Naltrexone and Monthly Extended-Release Buprenorphine for Cocaine Use Disorder (CURB-2)

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-21
Start Date:: 2023-04-18
Completion:: 2025-06-27

Conditions

Cocaine Use Disorder

Interventions

DRUG

No Results Yet

NCT05214768 | COMPLETED | PHASE3

48 participants

A Study to Evaluate the Efficacy and Safety of CC-93538 in Adult and Adolescent Japanese Participants With Eosinophilic Gastroenteritis

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-21
Start Date:: 2022-03-04
Completion:: 2024-07-02

Conditions

Eosinophilic Gastroenteritis

Interventions

DRUG

Results Available

NCT05169489 | TERMINATED | PHASE1

15 participants

A Study of bbT369 in Relapsed and/or Refractory B Cell Non-Hodgkin's Lymphoma (NHL)

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-21
Start Date:: 2022-01-24
Completion:: 2025-09-19

Conditions

Diffuse Large B Cell Lymphoma (DLBCL)

Interventions

BIOLOGICAL

No Results Yet

NCT05103527 | ACTIVE_NOT_RECRUITING | NA

30 participants

Dorsal Root Ganglion Stimulation for the Treatment of Arthritic Knee Pain

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-21
Start Date:: 2022-01-01
Completion:: 2025-08-14

Conditions

Knee Osteoarthritis
Knee Pain Chronic
Knee Arthritis
Knee Arthropathy

Interventions

DEVICE

No Results Yet

NCT05081219 | COMPLETED | PHASE2

47 participants

SNIFF - Combo INI+EMPA Trial

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-21
Start Date:: 2021-09-14
Completion:: 2024-09-17

Conditions

Mild Cognitive Impairment
Cognitive Impairment
Alzheimer Disease

Interventions

DRUG
DEVICE

Results Available

NCT05049850 | TERMINATED | PHASE2

3 participants

A Study to Investigate DSA Rebound in Patients Treated With Imlifidase Prior to Transplantation

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-21
Start Date:: 2022-12-16
Completion:: 2024-02-05

Conditions

Kidney Transplantation in Highly Sensitized Patients

Interventions

DRUG

Results Available

NCT05030350 | TERMINATED | PHASE3

481 participants

Open-label Safety Trial of PH94B in Social Anxiety Disorder (SAD)

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-21
Start Date:: 2021-10-01
Completion:: 2022-09-23

Conditions

Social Anxiety Disorder

Interventions

DRUG

Results Available

NCT05028972 | RECRUITING | NA

1050 participants

Hearing Impairment, Strategies and Outcomes in VA Emergency Departments

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-21
Start Date:: 2021-12-08
Completion:: 2026-09-30

Conditions

Hearing Loss
Emergency Service
Hospital Readmission

Interventions

OTHER

No Results Yet

NCT05017701 | TERMINATED

5 participants

Feasibility of Bridge for Post-Operative Pain Management in Hip Arthroplasty

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-21
Start Date:: 2022-04-26
Completion:: 2022-11-19

Conditions

Pain, Postoperative

Interventions

DEVICE

Results Available

NCT04910425 | WITHDRAWN | PHASE2

0 participants

PSMA-Targeted 18F-DCFPyL PET/MRI for the Detection of Prostate Cancer

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-21
Start Date:: 2023-06-17
Completion:: 2026-06-17

Conditions

Prostate Carcinoma

Interventions

DRUG
PROCEDURE

No Results Yet

NCT04903470 | RECRUITING | NA

130 participants

Defecation Patterns in Constipated Patients

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-21
Start Date:: 2022-12-19
Completion:: 2026-12-30

Conditions

Constipation by Outlet Obstruction

Interventions

DRUG

No Results Yet

NCT04671680 | TERMINATED

20 participants

CNAP vs IABP in Pregnant Women With Placenta Accreta

Study Type:: OBSERVATIONAL
Last Updated:: 2025-10-21
Start Date:: 2021-01-15
Completion:: 2025-06-01

Conditions

Placenta Accreta
Blood Pressure
Hemorrhage
Hemorrhage, Postpartum

Interventions

DEVICE

No Results Yet

NCT04551066 | TERMINATED | PHASE3

252 participants

To Evaluate the Efficacy and Safety of Parsaclisib and Ruxolitinib in Participants With Myelofibrosis (LIMBER-313)

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-21
Start Date:: 2021-05-24
Completion:: 2023-08-03

Conditions

Myelofibrosis
Primary Myelofibrosis
Post Essential Thrombocythemia Myelofibrosis
Post Polycythemia Vera Myelofibrosis

Interventions

DRUG

Results Available

NCT04497116 | COMPLETED | PHASE1/PHASE2

276 participants

Study of RP-3500, Camonsertib, in Advanced Solid Tumors

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-21
Start Date:: 2020-07-22
Completion:: 2025-06-13

Conditions

Advanced Solid Tumor

Interventions

DRUG

Results Available

NCT04495699 | COMPLETED

94 participants

Asymptomatic Renal Calculi in Recurrent Urinary Tract Infections

Study Type:: OBSERVATIONAL
Last Updated:: 2025-10-21
Start Date:: 2020-09-09
Completion:: 2025-09-01

Conditions

Urinary Tract Infections
Kidney Stone

Interventions

OTHER

No Results Yet

NCT04446650 | ACTIVE_NOT_RECRUITING | PHASE1/PHASE2

31 participants

A Study of Fedratinib in Japanese Subjects With DIPSS (Dynamic International Prognostic Scoring System)- Intermediate or High-risk Primary Myelofibrosis (PMF), Post-polycythemia Vera Myelofibrosis (Post-PV MF), or Post-essential Thrombocythemia Myelofibrosis (Post-ET MF)

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-21
Start Date:: 2020-10-12
Completion:: 2023-10-05

Conditions

Primary Myelofibrosis

Interventions

DRUG

No Results Yet

NCT04445662 | COMPLETED | NA

184 participants

Financial Incentives for Homeless Smokers: A Community-based RCT

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-21
Start Date:: 2021-06-10
Completion:: 2024-08-01

Conditions

Tobacco Smoking

Interventions

BEHAVIORAL
DRUG

Results Available

NCT04435366 | COMPLETED | PHASE3

448 participants

A Phase 3 Safety and Efficacy Study of Intravitreal Administration of Zimura (Complement C5 Inhibitor)

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-21
Start Date:: 2020-06-22
Completion:: 2022-07-25

Conditions

Geographic Atrophy
Macular Degeneration

Interventions

DRUG

Results Available

NCT04373785 | NOT_YET_RECRUITING | PHASE1/PHASE2

52 participants

NG101m Adjuvant Therapy in Glioblastoma Patients

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-21
Start Date:: 2027-01-01
Completion:: 2030-07-30

Conditions

Glioblastoma Multiforme

Interventions

RADIATION
DRUG

No Results Yet

NCT04266795 | COMPLETED | PHASE2

164 participants

A Study of Pevonedistat and Venetoclax Combined With Azacitidine to Treat Acute Myeloid Leukemia (AML) in Adults Unable to Receive Intensive Chemotherapy

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-21
Start Date:: 2020-10-13
Completion:: 2022-09-06

Conditions

Acute Myeloid Leukemia (AML)

Interventions

DRUG

Results Available