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Financial Incentives for Homeless Smokers: A Community-based RCT

NCT04445662 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 184

Last updated 2025-10-21

Study results available
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Summary

This community-based randomized controlled trial will test the effect of contingent financial rewards on smoking abstinence among homeless-experienced adult cigarette smokers. Participants will be recruited from 3 Boston Health Care for the Homeless Program locations: a shelter clinic, a day center clinic, and a medical center clinic. All participants will be offered a varenicline prescription and tobacco coaching. Incentive arm participants will receive escalating financial rewards for saliva cotinine levels \<30 ng/ml, assessed 10 times over 12 weeks. Embedded qualitative interviews will explore the mechanisms of on-treatment and post-treatment effects of financial incentives on smoking abstinence in the context of homelessness.

Conditions

  • Tobacco Smoking

Interventions

BEHAVIORAL

Financial incentives

Escalating financial rewards for saliva cotinine levels \<30 ng/mL, assessed 10 times over 12 weeks

DRUG

Varenicline

* Day 1 - 3: 0.5 mg daily * Day 4 - 7: 0.5 mg twice daily * Day 8 - Week 12: 1 mg twice daily * Dose/schedule may be adjusted based on medical history and clinician judgement

BEHAVIORAL

Tobacco coaching

5 one-on-one tobacco cessation coaching sessions over 12 weeks

Sponsors & Collaborators

  • National Cancer Institute (NCI)

    collaborator NIH

  • National Institutes of Health (NIH)

    collaborator NIH

  • Massachusetts General Hospital

    lead OTHER

Principal Investigators

  • Travis Baggett, MD · Massachusetts General Hospital

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2021-06-10
Primary Completion
2024-08-01
Completion
2024-10-24

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04445662 on ClinicalTrials.gov